HIDROKLROTHIAZID

PENGULANGAN 1

MENIT ABSORBAN RATA ABS KADAR F.KOREKSI KADAR % TERDISOLUSI RATA SD

0.096 1.0289028706 0.9260125836 0 0.9260125836 3.7040503343

5 0.093 0.0936667 0.9699174204 0.8729256783 0 0.8729256783 3.4917027133 3.5388910735 0.147345608
0.092 0.9502556036 0.8552300433 0 0.8552300433 3.420920173
0.13 1.6974046402 1.5276641762 0.0051445 1.5328086905 6.1312347621
10 0.131 0.131 1.7170664569 1.5453598112 0.0048496 1.5502093983 6.2008375934 6.201099751 0.069996436
0.132 1.7367282737 1.5630554463 0.0047513 1.5678067243 6.2712268974
0.18 2.6804954778 2.41244593 0.008487 2.4209329532 9.6837318128
15 0.18 0.174 2.6804954778 2.41244593 0.0085853 2.4210312623 9.6841250492 9.2594298073 0.73525321
0.162 2.3265827762 2.0939244986 0.0086836 2.10260814 8.41043256
0.314 5.3151789225 4.7836610303 0.0134025 4.7970635077 19.1882540307
30 0.316 0.314 5.354502556 4.8190523004 0.0134025 4.8324547778 19.3298191113 19.1858946127 0.145118594
0.312 5.275855289 4.7482697601 0.0116329 4.759902674 19.039610696
0.467 8.3234368856 7.491093197 0.0265759 7.5176690916 30.0706763665
45 0.466 0.4666667 8.3037750688 7.4733975619 0.0267725 7.5001700747 30.0006802989 30.0470821864 0.040187137
0.467 8.3234368856 7.491093197 0.0263793 7.5174724735 30.0698898938
0.634 11.606960283 10.446264255 0.0416172 10.4878814392 41.951525757
60 0.629 0.6316667 11.508651199 10.357786079 0.0415189 10.3993049548 41.5972198191 41.7862354175 0.178340518
0.632 11.56763665 10.410872985 0.0416172 10.4524901691 41.8099606764
 rata rata disolusi rata rata terdisolusi
45 40
40 35
f(x) = 0.6964509769x - 0.8159630563 f(x) = 0.6023602465x - 0.3373070508
35 R² = 0.9977213549 30 R² = 0.9934279998
30 25

% terdisolusi
% terdisolusi

25 Column I Column T
20
20 Linear (Column I) Linear (Column T)
15
15
10 10
5 5
0 0
0 10 20 30 40 50 60 70 0 10 20 30 40 50 60 70
waktu waktu

rata rata terdisolusi rata rataterdisolusi

70
60 f(x) = 0.8369377067x + 15.8899707 90 120
R² = 0.8426583531 80
50
70 f(x) = 0.6115434715x + 41.2437877655 100
% terdisolusi

40 Column AE 60 R² = 0.9255100189 Column AP

% terdisolusi 50 80
30 Linear (Column AE) Linear (Column AP)
40 60
20 30 Axis Title
10 20 40
10
0 0 20
0 10 20 30 40 50 60 70 0 10 20 30 40 50 60 70
0
waktu waktu
0
CAMPURAN FISIK F1

MENIT ABSORBAN RATA ABS KADAR F.KOREKSI KADAR % TERDISOLUSI RATA % SD MENIT
0.077 0.655328 0.589796 0 0.589796 2.3591820684
5 0.077 0.0763333333 0.655328 0.589796 0 0.589796 2.3591820684 2.3119937082 0.081733 5
0.075 0.616005 0.554404 0 0.554404 2.2176169878
0.107 1.245183 1.120665 0.00327664 1.123941 4.4957648447
10 0.109 0.1083333333 1.284506 1.156056 0.00327664 1.159332 4.6373299253 4.5898794075 0.081507 10
0.109 1.284506 1.156056 0.00308002 1.159136 4.6365434526
0.172 2.523201 2.270881 0.00622591 2.277107 9.1084270547
15 0.172 0.173 2.523201 2.270881 0.00642253 2.277303 9.1092135273 9.1797339101 0.122827 15
0.175 2.582186 2.323968 0.00642253 2.33039 9.3215611483
0.313 5.295517 4.765965 0.012616 4.778581 19.1143255997
30 0.309 0.3123333333 5.21687 4.695183 0.012616 4.707799 18.8311954385 19.0675304758 0.21676 30
0.315 5.334841 4.801357 0.01291093 4.814268 19.2570703893
0.43 7.59595 6.836355 0.02647759 6.862832 27.4513291388
45 0.434 0.4326666667 7.674597 6.907137 0.02608435 6.933222 27.7328863547 27.6398204221 0.163243 45
0.434 7.674597 6.907137 0.0266742 6.933811 27.7352457727
0.528 9.522808 8.570527 0.03797975 8.608507 34.4340267401
60 0.531 0.53 9.581793 8.623614 0.03837298 8.661987 34.6479473063 34.5766404509 0.123507 60
0.531 9.581793 8.623614 0.03837298 8.661987 34.6479473063
 rata-rata disolusi
120
100 f(x) = 6.5059014163x - 9.3462886604
R² = 0.8280596698
80
60 Column BB
Axis Title Linear (Column BB)
40
20
0
0 2 4 6 8 10 12 14 16 18 20
Axis Title
0
0 2 4 6 8 10 12 14 16 18 20
Axis Title
 F2

ABSORBAN RATA ABS KADAR F.KOREKSI KADAR % TERDISOLUSI RATA SD MENIT

0.213 3.329335431 2.99640189 0 2.996402 11.9856075501
0.212 0.212 3.309673614 2.97870625 0 2.978706 11.9148250098 11.9148250098 0.070783 5
0.211 3.290011797 2.96101062 0 2.961011 11.8440424695
0.307 5.177546205 4.65979158 0.01664668 4.676438 18.7057530476
0.302 0.310666667 5.079237122 4.57131341 0.01654837 4.587862 18.3514471097 18.9648957924 0.776173 10
0.323 5.492135273 4.94292175 0.01645006 4.959372 19.8374872198
0.578 10.50589855 9.45530869 0.02588773 9.481196 37.9247856862
0.577 0.577333333 10.48623673 9.43761306 0.02539619 9.463009 37.8520369642 37.8790391926 0.039832 15
0.577 10.48623673 9.43761306 0.02746068 9.465074 37.8602949273
0.746 13.80908376 12.4281754 0.05252949 12.4807 49.9228195045
0.74 0.742333333 13.69111286 12.3220016 0.05243118 12.37443 49.4977310263 49.6630213658 0.227758 30
0.741 13.71077468 12.3396972 0.05243118 12.39213 49.5685135667
0.821 15.28372002 13.755348 0.06904542 13.82439 55.2975737318
0.824 0.823666667 15.34270547 13.8084349 0.06845556 13.87689 55.5075619347 55.4848853061 0.177066 45
0.826 15.3820291 13.8438262 0.06855387 13.91238 55.6495202517
0.892 16.67970901 15.0117381 0.0764186 15.08816 60.3526268187
0.884 0.880333333 16.52241447 14.870173 0.07671353 14.94689 59.7875462053 59.5278791454 0.980712 60
0.865 16.14883995 14.533956 0.07691015 14.61087 58.4434644121
 F3

ABSORBAN RATA ABS KADAR F.KOREKSI KADAR % TERDISOLUSI RATA SD MENIT

0.65 11.92155 10.72939 0 10.7293944 42.9175776642
0.49 0.596333333 8.775659 7.898093 0 7.8980928 31.5923712151 39.1189146677 6.518274 5
0.649 11.90189 10.7117 0 10.7116988 42.8467951239
0.749 13.86807 12.48126 0.05960775 12.54087 50.1634801416
0.751 0.750666667 13.90739 12.51665 0.04387829 12.5605319 50.2421274086 50.2603473588 0.107145 10
0.752 13.92705 12.53435 0.05950944 12.5938586 50.3754345262
0.817 15.20507 13.68457 0.06934035 13.7539058 55.0156232796
0.83 0.823333333 15.46068 13.91461 0.06953696 13.9841457 55.9365827762 55.4645680954 0.460913 15
0.823 15.32304 13.79074 0.06963527 13.8603746 55.4414982304
0.256 4.174794 15.02926 0.07602536 15.1052821 60.4211285883
0.221 0.246666667 3.48663 12.55187 0.07730338 12.6291713 50.5166850177 57.7810709136 6.368894 30
0.263 4.312426 15.52473 0.07661522 15.6013498 62.4053991349
0.266 4.371412 15.73708 0.08349587 15.8205781 63.2823122297
0.274 0.277666667 4.528706 16.30334 0.0697326 16.3730751 65.4923004326 66.5708166208 3.940072 45
0.293 4.902281 17.64821 0.08624853 17.7344593 70.9378372002
0.333 5.688753 20.47951 0.08742823 20.5669406 82.2677624853
0.304 0.322 5.118561 18.42682 0.09057413 18.5173928 74.0695713724 79.1716817407 4.452045 60
0.329 5.610106 20.19638 0.09804562 20.2944278 81.1777113645
ABSORBAN RATA ABS KADAR F.KOREKSI KADAR % TERDISOLUSI RATA SD
0.06 0.321077 1.155879 0 1.1558788832 4.6235155328
0.08 0.0733333333 0.714314 2.57153 0 2.5715296893 10.2861187574 8.398584349 3.269305
0.08 0.714314 2.57153 0 2.5715296893 10.2861187574
0.123 1.559772 5.615179 0.006422 5.6216004719 22.4864018875
0.122 0.1246666667 1.54011 5.544396 0.014286 5.5586826583 22.2347306331 22.97925809 1.078969
0.129 1.677743 6.039874 0.014286 6.0541604404 24.2166417617
0.139 1.874361 6.7477 0.031195 6.7788950059 27.1155800236
0.143 0.1403333333 1.953008 7.03083 0.030802 7.0616319308 28.2465277232 27.49570848 0.650246
0.139 1.874361 6.7477 0.033555 6.7812544239 27.1250176956
0.15 2.090641 7.526308 0.037487 7.5637947306 30.2551789225
0.129 0.1386666667 1.677743 6.039874 0.03906 6.0789343295 24.3157373181 27.04846769 2.997955
0.137 1.835037 6.606134 0.037487 6.6436217066 26.5744868266
0.305 5.138223 18.4976 0.041813 18.5394140779 74.1576563114
0.311 0.316 5.256193 18.9223 0.033555 18.9558513567 75.8234054267 77.25426137 4.00838
0.332 5.669092 20.40873 0.036701 20.4454305938 81.7817223751
0.436 7.713921 27.77011 0.102764 27.87287849 111.4915139599
0.44 0.4396666667 7.792568 28.05324 0.105124 28.1583680692 112.6334722768 112.5469603 1.014959
0.443 7.851553 28.26559 0.113382 28.3789736532 113.5158946127
 HCT
WAKTU % TERDISOAUC WAKTU % TERDISOAUC
0 0 0 0 0 0
5 3.70405 9.260126 5 3.491703 8.729257
10 6.131235 24.58821 10 6.200838 24.23135
15 9.683732 39.53742 15 9.684125 39.71241
30 19.18825 216.5399 30 19.1859 216.5252
45 30.07068 369.442 45 30.00068 368.8994
60 41.95153 540.1665 60 41.59722 536.9843
JUMLAH 1199.534 JUMLAH 1195.082
AUC 26.65631 AUC 26.55737

CF
WAKTU % TERDISOAUC WAKTU % TERDISOAUC
0 0 0 0 0 0
5 2.359182 5.897955 5 2.359182 5.897955
10 4.495765 17.13737 10 4.63733 17.49128
15 9.108427 34.01048 15 9.109214 34.36636
30 19.11433 211.6706 30 18.8312 209.5531
45 27.45133 349.2424 45 27.73289 349.2306
60 34.43403 464.1402 60 34.64795 467.8563
JUMLAH 1082.099 JUMLAH 1084.396
AUC 24.04665 AUC 24.09768

F1
WAKTU % TERDISOLUSI AUC WAKTU % TERDISOLUSI AUC
0 0 0 0 0 0
5 11.9856075501 29.96402 5 11.9148250098 29.78706
10 18.7057530476 76.7284 10 18.3514471097 75.66568
15 37.9247856862 141.5763 15 37.8520369642 140.5087
30 49.9228195045 658.857 30 49.4977310263 655.1233
45 55.2975737318 789.1529 45 55.5075619347 787.5397
60 60.3526268187 867.3765 60 59.7875462053 864.7133
JUMLAH 2563.655 JUMLAH 2553.338
AUC 56.97012 AUC 56.74084

F2
WAKTU % TERDISOLUSI AUC WAKTU % TERDISOLUSI AUC
0 0 0 0 0 0
5 42.9175776642 107.2939 5 31.5923712151 78.98093
10 50.1634801416 232.7026 10 50.2421274086 204.5862
15 55.0156232796 262.9478 15 55.9365827762 265.4468
30 60.4211285883 865.7756 30 50.5166850177 798.3995
45 63.2823122297 927.7758 45 65.4923004326 870.0674
60 82.2677624853 1091.626 60 74.0695713724 1046.714
JUMLAH 3488.121 JUMLAH 3264.195
AUC 77.51381 AUC 72.53766

HCT CF F1 F2
#REF! #REF! 56.97012 76.9024
 WAKTU % TERDISOLUAUC
0 0 0
5 3.42092017 8.5523004326
10 6.2712269 24.230367676
15 8.41043256 36.704148643
30 19.3298191 208.05188753 HCT
45 30.0698899 370.49781754 1.2
60 41.8099607 539.09887928 1

% TERDISOLUSI
0.8
JUMLAH 1187.1354011
0.6
AUC 26.380786691 0.4
0.2
0
1
WAKTU

WAKTU % TERDISOLUAUC
0 0 0
5 2.21761699 5.5440424695
10 4.63654345 17.135401101
15 9.32156115 34.895261502
30 19.2570704 214.33973653
45 27.7352458 352.44237122
60 34.6479473 467.87394809
JUMLAH 1092.2307609
AUC 24.271794687

F3
WAKTU
WAKTU % TERDISOLUSI AUC 0
0 0 0 5
5 11.8440424695 29.6101062 10
10 19.8374872198 79.2038242 15
15 37.8602949273 144.244455 30
30 49.5685135667 655.716064
f1 45
70
45 55.6495202517 789.135254 60 60
60 58.4434644121 855.697385 50 JUMLAH
% terdisolusi

40 %
30 TERDIS
20 OLUSI
10
0
1
7
 f1
70
60
50

% terdisolusi
40 %
JUMLAH 2553.60709 30 TERDIS AUC
AUC 56.7468242 20 OLUSI
10
0

1
7
waktu

WAKTU % TERDISOLUSI AUC

0 0 0
5 42.8467951239 107.116988
10 50.3754345262 233.055574
15 55.4414982304 264.542332
30 62.4053991349 883.85173
45 70.9378372002 1000.07427
60 81.1777113645 1140.86661
JUMLAH 3629.50751
AUC 80.6557225

F3 DAERAH AUC ED
63.12199 waktu 0 0
5 5 #REF! #REF!
4-Jan 5 #REF! #REF!
t10-t15 5 #REF! #REF!
t15-t30 15 #REF! #REF!
t30-t45 15 #REF! #REF!
t45-t60 15 #REF! #REF!
jumlah #REF!
ED #REF!
 HCT
1.2
1
0.8
0.6 #REF!
0.4
0.2
0
1
WAKTU

CF

#R
EF
!
E
%
TD
S
R
IOU
LS
I

WAKTU

% TERDISOLUSI AUC WAKTU % TERDISOLUSI AUC WAKTU

0 0 0 0 0 0
4.6235155328 11.55879 5 10.2861187574 25.7153 5
22.4864018875 67.77479 10 22.2347306331 81.30212 10
27.1155800236 124.005 15 28.2465277232 126.2031 15
30.2551789225 430.2807 30 24.3157373181 394.217 30
74.1576563114 783.0963 45 75.8234054267 751.0436 45
111.49151396 1392.369 60 112.6334722768 1413.427 60
2809.084 JUMLAH 2791.908 JUMLAH
62.42409 AUC 62.04239 AUC

F2
%
TERD
ISOL
USI
O SI
LU

WAK
ERDIS

TU
%T

WAKTU
% TERDISOLUSI AUC
0 0
10.2861187574 25.7153
24.2166417617 86.2569
27.1250176956 128.3541
26.5744868266 402.7463 120 F3
81.7817223751 812.6716 100
113.515894613 1464.732 80 Colum
2920.476 nR
60 Colum
nQ
40

20
 100

80 Colum
nR
60 Colum
64.89947 nQ
40

20

0
1234567
 % TERDISOLUSI
WAKTU HCT CF F1 F2 F3 120
0 0 0 0 0 0
100
5 3.5389 2.312 11.91483 39.1189147 8.3985843
10 6.2011 4.5899 18.9649 50.2603474 22.979258 80

% Terdisolusi
15 9.2529 9.1797 37.87904 55.4645681 27.495708
60
30 19.1859 19.0675 49.66302 57.7810709 27.048468
45 30.047 27.6398 55.48489 66.5708166 77.254261 40
60 41.7862 34.5766 59.52788 79.1716817 112.54696
20
formula persamaan garis r r2
0
HCT y = 0,69x - 0,548 0.998499 0.997 0 5 10 15 20 25 30
CF y = 0,599x - 0,226 0.996995 0.994
F1 y = 0,962x + 10,66 0.92358 0.853
F2 y = 0,937x + 27,67 0.826438 0.683
F3 y = 1,750x - 1,866 0.962808 0.927
 120

100

80
% Terdisolusi

HCT
60
CF
F1
40
F2
F3
20

0
0 5 10 15 20 25 30 35 40 45 50 55 60 65 70
Waktu
 % TERDISOLUSI formula
WAKTU HCT CF F1 F2 F3 HCT
0 0 0 0 0 0 CF
5 3.5389 2.312 11.91483 39.11891 8.398584 F1
10 6.2011 4.5899 18.9649 50.26035 22.97926 F2
15 9.2529 9.1797 37.87904 55.46457 27.49571 F3
30 19.1859 19.0675 49.66302 57.78107 27.04847
45 30.047 27.6398 55.48489 66.57082 77.25426
60 41.7862 34.5766 59.52788 79.17168 112.547

120

100

80
% terdisolusi

60

40

20

0
0 5 10 15 20 25 30 35 40 45 50 55 60 65

waktu
 persamaan garis r r2
y = 0,69x - 0,548 0.99849887 0.997
y = 0,599x - 0,226 0.99699549 0.994
y = 0,962x + 10,66 0.92357999 0.853
y = 0,937x + 27,67 0.82643814 0.683
y = 1,750x - 1,866 0.96280839 0.927
 % TERDISOLUSI formula
WAKTU HCT CF F1 F2 F3 HCT
0 0 0 0 0 0 CF
5 3.5389 2.312 11.91483 39.118915 8.398584 F1
10 6.2011 4.5899 18.9649 50.260347 22.97926 F2
15 9.2529 9.1797 37.87904 55.464568 27.49571 F3
30 19.1859 19.0675 49.66302 57.781071 27.04847
45 30.047 27.6398 55.48489 66.570817 77.25426

% log terdisolusi
60 41.7862 34.5766 59.52788 79.171682 112.547

2.5
log
waktu HCT CF F1 F2 F3 2
0 0 0 0 0 0 1.5
5 0.5488682908 0.36398783 1.076088 1.5923868 0.924206
1
10 0.7924687349 0.66180322 1.27795 1.7012255 1.361336
0.5
15 0.9662778686 0.96282849 1.578399 1.7440156 1.439265
30 1.2829821765 1.28029376 1.696033 1.7617856 1.432143 0
0 5 10 15 20 25 3
45 1.477801117 1.4415349 1.744175 1.8232839 1.887922
w
60 1.6210328786 1.53878229 1.77472 1.8985699 2.051334
 persamaan garis r r2
y = 0,023x + 0,405 0.940213 0.844
y = 0,023x + 0,330 0.920326 0.847
y = 0,020x + 0,816 0.733485 0.538
y = 0,017x + 1,092 0.579655 0.336
y = 0,025x + 0,696 0.838451 0.703
% log terdisolusi

2.5

1.5

0.5

0
0 5 10 15 20 25 30 35 40 45 50 55 60 65 70

waktu
 % TERDISOLUSI Formula persamaan garis r r2
WAKTU HCT CF F1 F2 F3 HCT y = 0,837x - 0,120 0.998499 0.997
5 3.5389 2.312 11.91483 39.11891 8.398584 CF y = 0,813x - 0,260 0.995992 0.992
10 6.2011 4.5899 18.9649 50.26035 22.97926 F1 y = 0,769x + 2,282 0.939149 0.882
15 9.2529 9.1797 37.87904 55.46457 27.49571 F2 y = 0.408x + 5.589 0.964883 0.931
30 19.1859 19.0675 49.66302 57.78107 27.04847 F3 y = 1,263x + 0,107 0.943928 0.891
45 30.047 27.6398 55.48489 66.57082 77.25426

% terd isolu si
60 41.7862 34.5766 59.52788 79.17168 112.547

120

WAKTU 100
80
HCT CF F1 F2 F3
60
2.236068 3.5389 2.312 11.91483 39.11891 8.398584 40
3.162278 6.2011 4.5899 18.9649 50.26035 22.97926 20
3.872983 9.2529 9.1797 37.87904 55.46457 27.49571 0
1 2 3 4 5 6 7 8 9
5.477226 19.1859 19.0675 49.66302 57.78107 27.04847
6.708204 30.047 27.6398 55.48489 66.57082 77.25426 √waktu
7.745967 41.7862 34.5766 59.52788 79.17168 112.547
 % TERDISOLUSI formula
WAKTU HCT CF F1 F2 F3 HCT
5 3.5389 2.312 11.91483 39.11891 8.398584 CF
10 6.2011 4.5899 18.9649 50.26035 22.97926 F1
15 9.2529 9.1797 37.87904 55.46457 27.49571 F2
30 19.1859 19.0675 49.66302 57.78107 27.04847 F3
45 30.047 27.6398 55.48489 66.57082 77.25426
60 41.7862 34.5766 59.52788 79.17168 112.547
2.5

% Log Terdisolusi
WAKTU 1.5
HCT CF F1 F2 F3 1
0.69897 0.548868 0.363988 1.076088 1.592387 0.924206
1 0.792469 0.661803 1.27795 1.701225 1.361336 0.5
1.176091 0.966278 0.962828 1.578399 1.744016 1.439265 0
1.477121 1.282982 1.280294 1.696033 1.761786 1.432143 0.6 0.8 1 1.2 1
1.653213 1.477801 1.441535 1.744175 1.823284 1.887922 Log Wakt
1.778151 1.621033 1.538782 1.77472 1.89857 2.051334
 persamaan garis r r2
y = 1,004x - 0,188 0.997998 0.996
y = 1,118x - 0,409 0.995992 0.992
y = 0,663x + 0,664 0.960729 0.923
y = 0,245x + 1,434 0.968504 0.938
y = 0,921x + 0,321 0.942868 0.889

0
0.6 0.8 1 1.2 1.4 1.6 1.8 2

Log Waktu
 Formula orde 0 orde 1 Higuchi
Korsmeyer-peppas
HCT 0.9985 0.94021 0.998499 0.998
Campuran Fisik 0.997 0.92033 0.995992 0.99599
F1 0.92358 0.73348 0.939149 0.96073
F2 0.82644 0.57966 0.964883 0.9685
F3 0.96281 0.83845 0.943928 0.94287
 6 0.345
8 0.461 0.8
10 0.541 0.7 f(x) = 0.05085x + 0.0439

Absorban
R² = 0.9968935299
12 0.662 0.6
14 0.753
0.5
0.4
0.3
0.2
0.1
0
0 2 4 6 8 10 12 14

Konsentrasi (µg/ml)
 6 0.322
8 0.427
085x + 0.0439 10 0.528
8935299
12 0.627
14 0.737

0.8
0.7 f(x) = 0.0515x + 0.0132

Absorban
R² = 0.9997286061
0.6
0.5
10 12 14
0.4
/ml)
0.3
0.2
0.1
0
4 6 8 10 12 14

Konsentrasi (µg/ml)
12 14