Techno Healthcare

White Paper

KEY CHALLENGES OF DELIVERING DRUGS WITH NEEDLES

(and how to overcome them with painless injection technology)

© Copyright 2018
AUDIENCE

The target audience for this white paper is primarily for sterile
injectable drugs manufactures, health insurance companies
and health care providers; nurses, doctors, pharmacists and
other healthcare professionals who find it difficult to manage
challenges of delivering injectable with needles. Especially
those related to needle stick accidents that are costing the U.S.
Healthcare System more than $1 billion annually.

2
Techno Healthcare
White Paper
KEY CHALLENGES OF DELIVERING DRUGS WITH NEEDLES
“At least 1,000 health
care workers are
estimated to contract
serious infections
annually from needle
stick and sharps
injuries”
ANS-Needle stick prevention
guide
“Prevention of
approximately 385,000
needle stick and other
sharps-related injuries
that occur each year,
can save U.S.
Healthcare System
more than $1 billion
annually”
CDC & Infection Control
Today Newsletter, August
22, 2013
(and how to overcome them with painless injection technology)
Executive Overview
Needle phobia and needle stick accidents are the main challenges in the
sterile injectable drugs industry. According to the Centers for Diseases
Control and Prevention (CDC), approximately 385,000 needle stick and
other sharps-related injuries occur each year in hospital-based situation.
At least 1,000 health care workers are estimated to contract serious
infections annually from needle stick and sharps injuries (ANS-Needle stick
prevention guide).
The US Infection Control Today Newsletter, on August 22, 2013, predicted
that prevention of needle stick injuries can save U.S. Healthcare System
more than $1 billion annually.
In the tradition way of delivering injectable, the healthcare providers are
at risk of being affected by hepatitis B virus (HBV), hepatitis C virus (HCV),
and human immunodeficiency virus (HIV), and more than 20 other
pathogens due to needle stick accidents (CDC). And they are always
wondering;
 How to avoid the risk of being infected by the needle stick accident
 How to manage the needle phobia patient, when the sterile
injectable drug is the only treatment available
In the current environment, the action of investing in a syringe needle
protection device and managing needle waste will not drive sterile
injectable drugs sales. Instead, it will be solutions that still bundle patients,
and healthcare providers will not want to use needles. For investing in
patients’ satisfaction and improving safety healthcare delivery, the
manufacturers of sterile injectable drugs need to find alternative ways of
delivering sterile injectable drugs without pain in a safe environment. And
they need to invest in a sterile injectable drugs kits that help the healthcare
providers to perform a task with greater ease and efficiency.
To reach this comfort in injection delivery. The health alternative way to
administer sterile injectable drugs should be safe, efficient and convenient
for both patients and healthcare providers.
© Copyright 2018 Techno Healthcare Consultant Ltd 1
Techno Healthcare
White Paper
“Elderly population is
estimated to grow to
over 16.8 % by the year
2020”
United States Census Bureau
“By age 17 in US, a
child will receive an
outrageous of 74 doses
of vaccines
(53 injections)”
Healthy home economist
update, on January 25 2018
“Compound annual
growth rate (CAGR) of
11.1% between 2017
and 2025 is expected.
Global sterile injectable
drugs market report.
Published January 2018
Rising of sterile injectable need and administration drawback
Economic growth and healthcare development have impacted better
diseases prevention, diagnoses and treatment. This health protection and
maintenance influenced the rise of life expectance of a human being. The
disease prevention, through vaccination, also contributed to high life
expectance.
However, the tradition procedure used in delivering vaccines, in checking
or treating some chronic diseases is painful. For example, the Diabetes &
Metabolism Journal reported the issues associated with needle injection
at an angle or making skinfolds during insulin administration. Knowing that
the elderly population is estimated to grow to over 16.8 % by the year
2020, according to the United States Census Bureau. A simplified injection
technique is suggested.
Furthermore, the healthy home economist update, on January 25, 2018,
reported that CDC added 3 more vaccines to Childhood Immunization
Schedule. This means that a child will receive an outrageous of 74 doses
(53 injections) by age 17. Unfortunately, the research published in the
Clinical Journal of Pain, on October 2015; parents were found lucking some
psychological training skills, which were needed to teach a child how to
cope with needle pain during vaccinations.
Since there is an increase of vaccination campaign and elder population,
the need of sterile injectable drugs or vaccines is obviously huge. The
recent global sterile injectable drugs market report, predicted a compound
annual growth rate (CAGR) of 11.1% between 2017 and 2025. And it will
secure a valuation of US$901.3 billion by the completion of the forecast
tenure. This report also highlighted that the sterile injectable drugs
markets revenue achieved US$387.1 billion in 2017.
Even if the need is growing, sterile injectable consumers continue to be
affected by the following disadvantages associated with needles use:
 The
Therisk
riskof
ofcross
crosscontamination
contaminationfrom fromneedle
needlestick
stickinjury
injury

 Under or overdosing which
Under or overdosing which results in poor injection technique
technique in
in
patients
patients
 Needle
Needlephobia
phobia
 Injection
Injectionsite
sitepain
pain
 Poor
Poorcompliance
complianceresulting
resultingininlong
longterm
termworsening
worseningof ofconditions
conditions

 Increased costs due to patients visiting the hospitals for injections
Increased costs due to patients visiting the hospitals for
© Copyright 2018 Techno Healthcare Consultant Ltd 2
Techno Healthcare
White Paper
“Both the working
individuals who
received needle-free
shots and healthcare
providers who provided
needle-free shots,
during the 2016-17
influenza seasons,
reported high
satisfaction of ease to
use of the technology
and having needle-free
delivery as an option”
Tara M, Chris G, and William
EG
Health choose of injectable consumers
Tara M, Chris G, and William EG, in their Expert View, they evaluated an
unmet need for increasing immunization coverage in US workplace
influenza clinics by offering needle-free injection technology. This offer
was an alternative to needle and syringe delivery, during the 2016-17
influenza seasons.
The working individuals, 18-64 years of age, who received needle-free
shots, completed 1,018 surveys. Their finding regarding satisfaction, the
likelihood of choosing a needle-free injection next year, and the likelihood
of recommending a needle-free injection to friends and family, supported
the needle-free injection technology shot.
 The majority of patients (97%) were satisfied with
the needle-free shot
 95% of patients responded that they would choose
needle-free again next year
 95% said they were likely to recommend needle-free
to friends and family
On another side, six surveys were completed by healthcare providers
following 2016-17 influenza seasons vaccinations. Their finding reported
both 100 % satisfaction of ease to use of the technology and having needle-
free delivery as an option.
In additionally, two-thirds (67%) of healthcare provider thought needle-
free could potentially increase immunization rates in their workplace
immunization program by greater than 10%.
How needle-free injection technology works
Needle-free injection technology produces an ultra-fine stream of fluid
which penetrates through the skin layers and delivers the drug very quickly
into the systemic circulation. The total time required to deliver an injection
is less than 1/3 of a second and occurs in three stages:
 Peak pressure phase - optimal pressure requires penetrating the
skin which lasts about < 0.025 sec;
 Dispersion phase - which lasts about 0.2 sec; and
 The drop-off phase - which lasts about < 0.05 sec. (C. Scanlon
Daniels, 2010)
© Copyright 2018 Techno Healthcare Consultant Ltd 3
Techno Healthcare
White Paper
Health benefits of needle-free injection technology

From our expertise in healthcare service delivery review, the needle-free

injectable technology can:

 Resolve stability problems – by reformulating everything from

vaccines to therapeutics proteins in solid formulations. A more
stable form which would not require refrigeration like the liquid
counterparts;
 Introduce various medicines (powder and liquid) into patients
without causing the problem of bleeding or bruising and minimal
skin response;
 Lower the administration time of injectable (injection time is less
than 1/3 of a second); for example in case of asthma crises, it can
save lives;
 Facilitate the self-administration at home;
 Increase compliance with dosage regimens and improved
outcomes;
 Reduce medical waste since it can be reused;
 Contribute to healthcare cost savings. For example; U.S. Healthcare
System can save more than $1 billion annually (The US Infection
Control Today Newsletter, August 22, 2013).

Emotional and rational benefits

In terms of painless benefits, needle-free injection technology does so

much more. In avoiding people’s physical and emotional pain, it also:

 Provides peace of mind and security before, during and after

delivering or receiving an injectable;
 Makes you feel more comfortable and confident in your career;
 Increases performance at work and gives more free time;
 Indicates the pharmaceutical care accountability;
 Rises respect for those who provided the sterile injectable drugs
with needle-free injection technology.

Quality control of needle-free injection technology

There can be various safety issues, this is why the production of needle-
free injection technology, is strictly controlled by the Food and Drug
Administration (FDA) in the USA.

© Copyright 2018 Techno Healthcare Consultant Ltd 4

Techno Healthcare
White Paper
“Global needle-free
injection system
market was valued at
$8,166 million in 2016.
And it is estimated to
reach $23,116 million
by 2023”
Global Opportunity Analysis
and Industry Forecast, 2017-
2023
Each manufacturer of needle-free injection technologies used for; powder,
liquid and depot or projectile injections, must conform to various
production standards and specifications.
However, announced and unannounced inspections may occur to ensure
that these companies are following good manufacturing practices.
Key needle-free injection technology manufactures
In the recent report on Global Opportunity Analysis and Industry Forecast, 2017-
2023, the global needle-free injection system market was valued at $8,166
million in 2016. And it is estimated to reach $23,116 million by 2023.
This report also listed the key players operating in the needle-free injection
system market:
 Antares Pharma, Inc.
 Endo International plc
 PenJet Corporation
 Crossject Needle-free Injection Systems
 PharmaJet
 Medical International Technology, Inc.
 INJEX Pharma AG
 National Medical Products Inc.
 Valeritas, Inc.
 European Pharma Group
© Copyright 2018 Techno Healthcare Consultant Ltd 5
Techno Healthcare
White Paper

About Techno Healthcare Consultant Ltd

Techno Healthcare passion is to write documents that add value to your
healthcare technology products. Those products could be drug, device,
and software used in the healthcare industry.

How techno healthcare documents add value to your products?

It is done by leading the problems your product overcomes, rather than

the actual solution itself. The following steps are respected;

 Description of new opportunity (pain-points) experienced by the

targeted audience, and how much it has grown
 Description of reasons behind that grown and problems linked to
this pain grown
 Description of new classic solutions that address the problems,
and even identifying what to look for in a solution without
mentioning your product name or company
 Description of your product as an IDEAL solution everyone can
benefit
 Highlighting emotional and rational benefits of choosing your
product

As a Managing Director of Techno Healthcare Consultant Ltd, when I talk

about adding value to your products. I mean to educate your current
customers or future customers through white papers.

To find out how we could help you add value to your healthcare
products, do contact Theophile Niyitanga, Managing Director – Techno
Healthcare Consultant Ltd.; Email: theo@techealthcopywriter.com

© Copyright 2018 Techno Healthcare Consultant Ltd 6