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University of Groningan
Antonius Deusingiaan 2 .
9713 AW Groningen, The Matherlands
For personal use only.
ABSTRACT
Chpyryht 0 1980 by Mu
d Dakar. lac.
16 EOOW1UIS. LERK, AND BROERSHA
5 terotcx.
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I)(fROIWCTION
reduce the friction between tablet matcrlal and the die wal dur "9
tabicts- on the drug stabll ty. For this reason several new lubr cants
have been Introduced in the last 10-15 y e a r s . Alpar (4) reported the
succetful use o f polytetraf uorosthylene as a tablet lubricant. he
terlaily affect the dislntegratlm tlme and the strength o f the lac-
uas used. The best lubrlcatlng properties were obtained with 0.58
(crushing strength) were strongly influenced by both the nature and the
arate was used. Due to the hydrophlllc nature of the tablet exclpient!
f r o a d i r e c t c a r p r e s s i b l e s t a r c h ( S T A - S 1500) w i t h an increase i n
that the e f f e c t was dependent on both the nature and par i c l o siza
the m i x i n g process.
EXP€RlHEHTAL
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by nitrogen adsorption
18
.
Hixlng of ths blends of excipients with different lubricants was
wds about 20%. & f o r e blendlng the lubricants were sieved through a
I50 j n sieve.
TAB= LIJBPICIMS 21
-
Tablet d i a a e t e r and
Drug Dev Ind Pharm Downloaded from informahealthcare.com by Mcgill University on 01/06/15
force used w s 20 kW. The data for the rjection force represent the mean
of at l u s t ten coapressions.
i n a p r e l i m i n a r y test, placebo tablets were prepared by i n t r o -
2 kWs.
the d i s l n t e g r a t i o n time o f 6 i n d i v i d u a l t a b l a t s .
22 DOUIUIS, LEBK. AND BROERSHA
RESULTS M D DISCUSSION
25% STA-Rr I500 and 252 Elcana C 250 was prepared, f r a which tab-
Iigure 1 .
Xffoct of mixing tiw on t h o cruahing atroogth 02 tablets corprom-
a d I- blood. Of 5- lacto.. X.F.C.. 251 S T A - h ls00 and 15% Llco.a
0 150 with 1.0% of ratiouo lubricant..
TABLET LUBRICANTS 23
TABU I
2
Boemn VP 1.0 I /I
2
Cutina M 1.2 I /g
2
graph1t o 6.4 I /g
2
1-lowine 1.8 I /g
u g n o a i ~ matoarate 1 4 . 3 mA/g
2
p o l ~ t o t r a i l w r o ~ t b y l ~ a o2 . 0 I /g
2
Prkirol 1.6 I /g
2
aterotox 1 . 6 I /g
2
3.3 I /g
24 BOLJNLS. LEBL(, AND BROERSMA
a l u b r i c a n t b a r r i e r on the e x c i p l e n t p a r t i c l e s , nterfcring w th
For personal use only.
TABLE 2
0.5% gr8phi t o 8 b b b b
0.5% talc b b b b b b
1.0% t8lC b b b b b b
For personal use only.
0 . 5 % 1-leucimo b b b b b b
1.0% l-loucine b b b b b b
0 < 100
0 < loo
8- t 8 b l o t t l n c machino d r l v v a by b m d , b- inuufflcimnt l u b r l c a t i o n ,
c- i n s u f f i c i e n t flowabillty .
26 WUIUIS. LERK. AND BROERSUA
gave the best results when mixed f o r a short per od with the
For personal use only.
other vehicles.
TMLZ 3
T a b l e t Zorrulmtionm usrd.
The tables 4 and 5 sumarize the ejection force and Lablet proper-
TABLE 4
TABU 8
a ) t a b l o t t i n e ~ a c h l n odrivrn br band.
TABW LUBRIcMm 29
TABU 6
li1-t of l f x i a g with l u b r i c a n t on e j w t i o a f o r c e , c n a h l n g
r t r e l y t h , i r i a b i l i t y and d i a i n t e g r a t i o a tire, reapactiv.ly,
or puUIet-1 ta1.t..
tablet hardness, when the airing time was short. In comparison with
tOtK1US I ows
--
FOOTWOTES
Pa., U.S.A.
15. Hogupha, A l h a r .
REFERENCES
1. E. Nelson, S.H. Naqvi, L.W. Bussc and 1.. Higuchi, J. Am. Phara.
-
Phamacol. 2 1 , 6 s (1%9),
-
Ed. P r . 3 0 , 89 (1975).
16. J. P a r i s , t h e s i s P a r i s (1974).
-
Belg. 3 1 , 497 (1976).
(1977).
19. C.K. Bolhuls, C.F. Lcrk. H.T. Z l J l s t r a and A.H. dc Boer, Pharm.
-
Weekblad 110, 3 1 7 (1975).
TABLET IlIBBICANTS 33
20. C.F. Lerk, C.K. Bolhuir and S . S . Saedeaa. Phrn. Acta Halv. 52.
33 (1977).
-
24, 3 5 2 (1972).
-
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