CBD May Stop the Spread of Ovarian

Cancer
Ovarian cancer accounts for approximately 2% of all new cancer cases diagnosed each year. When
diagnosed early, before the onset of metastasis, which is the migration of cancer cells throughout the
body, ovarian cancer is fairly treatable. There is currently an urgent need, however, to find an effective
ovarian cancer treatment to prevent metastasis. Cannabidiol (CBD), one of the main components of
hemp, has been proven to be an effective anti-cancer treatment against multiple types of cancers in
various studies.
In 2017, Sullivan University College of Pharmacy in Louisville, Kentucky, researched the effects of CBD
therapy on ovarian cancer cells. When two types of cancer cell lines were treated with hemp extract
containing CBD, cancer cell migration was reduced. In one line, metastasis was significantly slowed
across all CBD dosages tested. The other line, when treated with 2.5-3.2 micrometers of CBD per cell,
showed a decrease in cell migration similar to the chemotherapy drug Cisplatin. Based on their results,
CBD showed definite anti-metastatic properties on ovarian cancer cells.

While more research is needed to ascertain the viability of using CBD for treating ovarian cancer,
preliminary research shows there is definite reason for continued study. We anticipate seeing more
studies examining the effects of CBD on cancer cells.

CBD Could be a New Treatment Therapy

for MS, According to New Study
Multiple Sclerosis, or MS, is a chronic disease in which damage occurs to the sheaths of nerve cells in the
brain and spinal cord. Often a progressive disease, symptoms can include pain, numbness, speech
impairment and fatigue. Researchers have begun to study cannabidiol (CBD) as a possible treatment
therapy, as CBD is one of the many compounds found in hemp and has a diverse pharmacological profile
with little to no adverse side effects.
The PI3K/AKT/m/TOR pathway, an intracellular signaling pathway which regulates cell cycles, has
become of interest to researchers studying MS, as it plays a major part in cellular quiescence,
proliferation, cancer and longevity. Neuroscientists at the Contrada Casazza, in Italy, conducted a study
in 2017 to examine the potential effects of cannabidiol on the PI3K/AKT/m/TOR pathway.

In their study, researchers induced mice with the most common model of MS. After the disease
symptoms began, the mice were treated with CBD at a rate of 10mg/kg of body weight daily and
observed for clinical signs of MS. After 28 days, the mice were euthanized and spinal tissues were
sampled. The results demonstrated a clear downregulation of the PI3K/AKT/m/TOR pathway and that
CBD was effectively able to restore it. Their data demonstrated the therapeutic efficacy of CBD, due to
the reduction of pro-inflammatory cytokines and the promotion of cell neuron survival. They concluded
their study by stating that the, “results provide an interesting discovery about the regulation of the
PI3K/AKT/m/TOR pathway by cannabidiol administration, that could be a new potential therapeutic target
for MS management.”