COAGULATION 15

The ACL TOPTM

Hemostasis Testing System:
Features and Technical
Description
The ACL TOPTM
Hemostasis Testing System:
Features and Technical
Description
Table of Contents

I. Overview Page 5

II. Technical Description Page 8

III. Main System Features Page 16

IV. Specification Table Page 22

V. Hemostasis Assays Page 23

VI. IL Monographs Page 24

 I. Overview 5

What It Is
The new ACL TOP hemostasis system from Instrumentation Laboratory is
a fully automated, benchtop, random-access analyzer, designed specifically
for in vitro coagulation and fibrinolysis diagnostic testing in the assessment
of thrombosis and hemostasis. As the new standard in hemostasis, the ACL
TOP works harder and smarter to meet the increasing demands of the high-
volume test lab, offering more capabilities while reducing time-consuming
QC and maintenance tasks.

What It Does
The ACL TOP combines flexibility, intelligence, ease-of-use and speed to
deliver complete “Testing Process Automation” for the demanding hemostasis
laboratory.
The ACL TOP system:
• Consolidates testing capabilities into one system
• Provides a complete solution for both routine and specialty assays
(clotting, chromogenic and immunoassays)
• Offers high throughput with up to 360 PT results per hour,
24 hours a day, 7 days a week
• Operates quickly and easily, with an expandable and versatile platform
that can be tailored to the needs of each laboratory
• Automates QC and maintenance, increasing productivity while
reducing workload
Developed by the leaders in intelligent automation, the ACL TOP offers high
performance for the high-volume lab.

How It Works
The ACL TOP system provides results for both direct hemostasis
measurements and calculated parameters. The ACL TOP performs
the following types of tests:
Coagulometric (Turbidimetric) Tests
Chromogenic (Absorbance) Tests
Immunological Tests
The following describes the operating principles for each of the three
types of tests. (For additional detail, please see the “ACL TOP Operator’s
Manual”.)

Coagulometric (Turbimetric) Measurements

The principle of coagulometric clot detection is used to measure and record
the amount of time required for a plasma specimen to clot. The technique
assesses coagulation endpoints by measuring change in optical density.
Chromogenic (Absorbance) Measurements
Chromogenic tests use the colorimetric principle of measuring absorbance
of light by the solution in a cuvette. The amount of light that reaches the
photodector is converted into an electrical signal that is proportional to
enzyme activity.
6

Immunological Measurements
The principle of immunological measurement is used to directly measure
and record the concentration of an analyte in a sample (and not its activity)
by measuring change in optical density. Although similar to the turbimetric
method, the immunological method relies on the formation of antigen-antibody
complexes to affect light transmission.
The ACL TOP testing process is fully automated, with on-board QC and
maintenance, enhancing performance and productivity. Please see below
for more on system features and benefits.

Why It Works (Better, Faster, and Easier)

The ACL TOP was developed based on feedback from the people who use
the instruments. Created by Instrumentation Laboratory (IL), who has been
at the forefront of diagnostic innovation for over 40 years, the ACL TOP
delivers what users asked for and more. Highly automated for high-throughput
screening, the ACL TOP works harder and does more, offering the following
features for a total solution:
Optimal Sample Management
• Parallel loading of racks; no sample queuing
• Continuous loading
• 120 samples on-board
• Simultaneous loading of different sample containers
• Closed-Tube Sampling (CTS) with cap-piercing module
• Barcode identification
• Sample presence detection
• Automatic sample predilution
• Factor parallelism testing with automatic multiple solutions
Automatic Checks and Validation
• Sample liquid level sensing
• Automatic rerun testing with possibility of extra sample predilution
for enhanced test linearity
• Automatic reflex testing
• Automatic results validation
Optimal Reagent Management
• Parallel loading of racks for reagents, calibrators, controls,
deficient plasma, and any required material
• Continuous loading
• Up to 60 materials on-board
• Barcoded vials for random loading and automatic identification,
including vial size, expiration date and lot
• Vial presence detection for non-barcoded materials
• Handling of multiple vials of the same material
Automatic Sensing and Tracking
• Reagent liquid level sensing
• Volume tracking
• Expiration date tracking
• Calibration stability tracking
Real-Time STAT Capability
• STAT samples loaded on any rack, in any position, at any time
• System ready to run 24 hours a day
• Expiration date tracking
• PT result in less than three minutes when processing one sample
from idle system status
 7

In addition to automation of the testing process, the ACL TOP takes care
of itself so users can minimize time performing QC and maintenance. QC
software allows for set-up of automatic QC analysis utilizing Westgard Rules.
Minimal maintenance is needed (less than five minutes daily), ordered by
the user, but performed by the system. Fully automatic maintenance is
provided for all other daily activities.
Last, the system’s user-friendly interface and intuitive controls make operation
fast and easy. The result is more capabilities, greater assurance of high
performance, with less effort.

ACL TOP Benefits

Here’s why the ACL TOP is the optimal choice for high throughput testing:
Complete
• Broad test menu and large capacity of materials on-board
• Consolidated workstation for routine and specialty assays: clotting,
chromogenic and immunoassays
• Specialty assays as easy as routine
Fast
• Continuous operation
• High throughput (up to 360 PT results per hour)
• Optical units capable of simultaneous reading of clotting and
chromogenic assays allows optimal throughput, independent of test mix
• Real-time processing of STAT samples
Friendly
• Powerful and intuitive Windows® 2000 software and touch-screen
• Automated reagent management, automated QC and automated
maintenance
• On-line help
Safe
• Transparent, locked covers for samples and reagents
• CTS-configuration option minimizes exposure to biohazards
• Barcoded vials for all materials
• Password-controlled user access and automatic logging of significant
events
Reliable
• 24 hours/7 days continuous operation
• State-of-the-art technology
• Extensive company history in instrument and reagent development
and manufacturing
Versatile
• Base configuration (Open-Tube Sampling)
• CTS configuration with cap-piercing module
• Laboratory Automation System (LAS) configuration offering direct
off-board sampling without mechanical interfaces
8
II. Technical Description

Hardware
The ACL TOP hardware was designed for efficiency and effectiveness in
the high-throughput hemostasis laboratory. IL’s innovative development
team limited the number of moving components without compromising
the throughput of the system. The end result is a reliable system, requiring
minimal maintenance, which meets the needs of the high-volume laboratory.
The hardware on the ACL TOP is divided into two modules:
1. Control module (CM)
Pentium-based processor used by the operator to interact with the system.
2. Analytical module (AM)
This module is composed of seven areas:
cuvette loading, sample area, cuvette shuttle, reagent area, optical
reading units, cuvette waste and the external clean solutions.
These components are highlighted below.

Analytical Module

Control Module Sample Area Reagent Area

Cuvette Cuvette External Rinse

Loading Area Waste Drawer and Clean
 9

Cuvette Loading
The cuvette loading area is on the left side of the analyzer. The cuvette,
composed of polystyrene, is uniquely designed. Four individual cuvettes are
molded together to form a cuvette strip. Ten strips are linked together to
form a cuvette clip. Ten clips are packaged together as a cuvette block.
The block is packaged to facilitate ease of entry into the cuvette loading
area. The area will accommodate two blocks at one time for a total of 800
on-board cuvettes.
The cuvette clips are loaded vertically. When the clip advances to the front, it
is moved to a horizontal position. The cuvette shuttle then grips one strip from
the clip and transports it for use. The cuvettes are used for either sample
predilutions or analysis.
The cuvette loading area is accessible at all times to the operator. This
allows for cuvette loading at any time while the system is idle or operating.
The system will alert the user when the cuvettes are running low and when
the loader is empty.

Cuvette Clip

Cuvette Strip Cuvette Block

10

Sample Area
The sample area is located to the right of the cuvette loading area. This
area contains the heated sample probe with a dedicated rinse bath, rack
positions for samples and diluents, and cuvette strip holders for dilutions
and incubation. It is visible through the tinted-glass safety panel on the front
of the analyzer and is maintained at ambient temperature. The safety panel
is monitored and locked for safety during sample processing, yet it provides
visible access to the area. This area accommodates the sample racks and
two diluent racks.
The samples are loaded in racks on-board the system. Each rack will hold
ten samples. The sample area will accommodate 12 racks, for a total of
120 samples. The racks contain barcode identification. The system alerts the
user if a specimen in a rack position cannot be identified. The racks also contain
spring clips that allow usage of sample tubes of varying sizes. In addition to
direct tubes, samples may be processed in cups or pour-off tubes. To process
in pour-off tubes, adapters are available for use. The diluent racks in this area
are located to the right of the 12 samples racks. Each rack can hold: sample
diluent, control, calibrator, quality control or clean material. This area can
accommodate two racks for a total of 16 materials.

Cuvette Hold Area Sample Cuvette Clean / Rinse

(room temperature) Probe Incubator Area Wells

Cuvette Load Area Sample Rack Area Diluent Rack Area

Sample Area (ACL TOP Base Model)

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Sample Rack

Any of the sample or diluent positions can be accessed by pressing a button

below the desired location on the analyzer. This activates the barcode reader
to position itself respectively. The barcode reader traverses the front of the
system along with a rigid curtain. The curtain ensures safety and maintains
the area at the optimal temperature during analysis. When the reader is
positioned, a rack can be inserted while the sample barcodes are read.
Positioning the reader beside the rack minimizes stray light from impacting
the barcode reading.
Once a rack is latched into position, the LED for the location turns green.
During analysis, it turns orange and the rack is locked and non-removable.
Upon completion of the analysis for all samples on the rack, the LED returns
to green. The rack can then be removed and replaced with a new rack of
samples to be processed.
Samples and materials in the sample area are aspirated using the sample
probe. The probe incorporates a sensor that recognizes the presence of
liquids and stops at the optimized liquid level. During aspiration and transport,
the probe heats the liquid to 37° C +/- 1° C. A Teflon® tube connects the
probe to a syringe pump that is capable of delivering 4 to 250 µL.
The samples and materials are aspirated and dispensed into a cuvette. The
cuvette strips are held in the sample area in two regions; one at ambient air
temperature and the other heated to 37° C. The ambient temperature area
can hold 14 cuvette strips and the incubated area can hold eight strips. In
these areas, dilutions and incubations of sample occur.

Cuvette Shuttle
The cuvette shuttle has a unique, highly efficient design for moving cuvette
strips throughout the system. The shuttle runs along the back of the analyzer
behind the sample and reagent areas. The shuttle grips the desired cuvette
strip, retracts it into its 37° C heated chamber, moves to the next desired
position and places the cuvette strip. The shuttle has access to all cuvette
areas at all times and can, therefore, move cuvettes to any position. The
system utilizes one shuttle for all cuvette transportation needs.
12

Reagent Area
The reagent area is located to the right of the sample area. This area has two
heated reagent probes, along with a corresponding rinse bath, rack positions
for reagents and diluents, eight cuvette strip incubators and four Optical
Read Units (ORU). It is visible through the tinted-glass safety panel on the
front. The reagent cooling area is maintained at approximately 15° C. The safety
panel is monitored and locked for safety during reagent aspiration, yet it provides
visible access to the area. This area accommodates the reagent racks and a
diluent rack.
The reagents are loaded in racks on-board the system. Each rack can hold
six reagent vials and the reagent area can accommodate six racks for a total
of 36 reagents. The racks contain barcode identification. The system alerts
the user if a specimen cannot be identified. The first two positions within
each rack have stirring capability; therefore, the system can accommodate
12 vials requiring reagent stirring. These positions can also be utilized for
non-stirred reagents.
The reagent rack area is divided into two regions. One region is for “intermediate”
reagents and the other is for “starter” reagents. The intermediate reagents
are those that are added first to the sample in the cuvette. They can then
be mixed and incubated with the sample. The reagent area contains eight
incubator positions to hold cuvette strips for dispensation and incubation of
intermediate reagents. The starter reagents are those that initiate the final
reaction. The starter reagents are dispensed when the cuvette strip is loaded
into one of the four ORUs. Incubators and ORUs are maintained at 37° C.
As an example, in the APTT test, the intermediate reagent is cephalin and the
starter reagent is calcium chloride. Reagent rack positions 1-4 are utilized for
the intermediate reagents and 3-6 for the starter. Positions 3-4 are crossover
positions that can be utilized for either. Separation of the reagents into two
types allows for both probes to be active simultaneously.

Reagent Area
 13

The diluent rack in this area is located to the left of the six reagent racks.
The rack can hold eight materials including: a reagent diluent, deficient
plasma or an intermediate reagent. This area, like the reagent rack area,
is maintained at approximately 15° C.
Any of the reagent or diluent positions can be accessed by pressing a
button below the desired location on the analyzer. This activates the barcode
reader to position itself respectively. The barcode reader traverses the front
of the system along with a rigid curtain. The curtain mantains the area at the
optimal temperature during analysis. Once the reader is positioned, a rack
can be inserted while the barcodes are read. Positioning the reader beside
the rack minimizes stray light from impacting the barcode reading. Once a
rack is latched into position, the LED for the location turns green. During
analysis, it turns orange and the rack is locked and non-removable. After the
barcode homes itself or is positioned in another location, the appropriate
reagent probe for the rack location checks the volume within each vial in
the rack. Following the reagent aspiration of the vials in a rack, the LED
returns to green. The reagent rack can then be removed and the reagents
refilled or changed.
Reagents and materials in the reagent area are aspirated using the appropriate
reagent probe. The probe incorporates a sensor that recognizes the presence
of liquid and stops at the optimized liquid level. During aspiration and transport,
the probes heat the liquid to 37° C +/- 1° C. A Teflon tube connects the
probe to a syringe pump that is capable of delivering 4-250 µL.

Reagent Rack Loading

14

Optical Read Unit (ORU)

The uniquely designed ORU contributes significantly to the system throughput
speed. The system has four ORUs. Each ORU accommodates one cuvette
strip; thus, 16 reactions can be read simultaneously. The design of the fiber
optics in the ORU allows each cuvette to be read at two wavelengths: 671 nm
and 405 nm. The sophisticated software then determines which reading to
utilize, based on the contents of the cuvette. Simultaneous readings allow a mix
of assays to be processed within a cuvette strip, utilizing different wavelengths.
This results in minimal cuvette wastage and enhances throughput.

Waste Systems
The used cuvettes are deposited into the cuvette waste bin (a drawer located
on the right side of the analyzer), containing a disposable liner that holds
up to 800 cuvette strips. The drawer is monitored for volume. The operator
is alerted visually and audibly when the drawer is nearly full. The drawer can
be removed and emptied at any time during operation without affecting test
processing.
The liquid waste collects within an internal accumulator that collects waste
from the sample and reagent rinse baths. The fluid collected is periodically
pumped out of the system. The fluid pumped out can be collected in an
external waste container or pumped directly to a drain. The external waste
container contains a level sensor. The operator is alerted visually and audibly
when the container is nearly full. The operator can empty the container at any
time during operation without affecting test processing.

Cuvette Waste Drawer

 15

System Rinse and Clean

The right side of the analyzer holds the bottle for the system rinse and
clean. The rinse is used for cleaning the probes between aspirations and
is packaged in a 4 L bottle. The clean solution is an acid cleaner used
to prevent carryover between reagent aspirations for particular tests.
The clean is automatically aspirated and utilized, based upon the testing
in process. It is packaged in a 500 mL bottle. Sensors monitor the level of
liquid in the bottles. The operator is alerted visually and audibly when the
containers are running low, allowing for the appropriate system actions.

System Rinse and Clean

16
III. Main System Features

The ACL TOP software was designed to compliment the Analytical Module
hardware. The program operates under a MS Windows 2000™ platform.
The universality of MS Windows simplifies training and integration of the
analyzer into the laboratory. Included in the software are several key features
that separate the ACL TOP from other systems. They are described below.

Reagent Management
The ACL TOP provides a completely automated reagent tracking system.
When the reagents are loaded on-board and the barcode is read, the system
takes complete control over management of the vial. First, it performs an
initial volume measurement. If the measurement increases by 30% over the
previous reading, the vial is considered to be new and the onboard stability
is reset. The system then counts down stability time from that point. When
the stability time is approaching zero, the operator is alerted, allowing time to
prepare a new vial. If the time reaches zero, an alarm is sounded and all
testing of that vial is flagged with a onboard stability flag. The system provides
the operator the ability to manually reset the stability time at any point. This is
useful if a vial is removed from the system, refrigerated and later returned.
In addition, the system will also monitor lot number expiration via the barcode.
When a lot is expired, the operator is warned. In certain situations, reagent lot
expirations may be extended by Instrumentation Laboratory, after testing. In
this case, through the system software, the operator can extend the expiration
date, thereby eliminating the warning when the reagent barcode is read.
The system also allows multiple vials of the same reagent on-board to be
entered. When this occurs, the vials are aspirated in a “first in-first out” fashion.

Reagent Rack Status Display

 17

Reagent Rack Detailed Display

Calibration
Calibration on the ACL TOP can be performed any time, including when the
system is running patient samples or calibrations for other tests. The user
has the option to set up each individual test for automatic calibration in
either hourly or test-count intervals. If this option is not used, the operator
can calibrate the tests as needed.
The system stores the last five calibrations for each test handled in a “first in-
first out” order. Once a calibration is complete, the system can auto-validate
the curve based upon user-selectable criteria. If the auto-validation option
is not used, the operator can manually validate the curve prior to use. The
system allows validation of any of the available five stored calibrations. Prior
to validation of any curve, the operator can view the clot curves.

Calibration Curve Details Display

18

Quality Control (QC)

The QC program on the system makes extensive use of automation and
implementation of “Westgard Rules.” The automated functions of QC are
similar to those for the calibration features, allowing QC to be performed at
any time or automatically on the system at set intervals. For automatic QC, the
operator can set the frequency in either hourly or test-count intervals. For
both manual and automatic QC, the bar-coded QC vials can be placed on
the system, eliminating the need to pour the QC material into sample cups.
QC can be set-up and run for both an active lot and an alternate lot of material.
The data generated for QC can be displayed in either a table or a Levey-
Jennings format. The user can select to view the data for a particular date
range or number of points. The QC review screen allows the operator to
review data for the active and alternate lot.

QC Graph Display

Sample Management
The powerful result database enhances the system’s ease of operation. The
database will hold 20,000 sample IDs. Each of these IDs can have 30 tests
associated with them. The database will, therefore, maintain 600,000
results. The IDs can be entered into the database either manually or, more
commonly, via the bi-directional host interface. The host interface can function
either using host query or dynamic download. The host query operates
without operator intervention. When a rack is introduced and the barcodes
are read, the host is automatically queried for the requests.
STAT samples are always given priority over routine samples onboard.
STAT samples can be placed in any rack and in any position within the rack
and do not need to be segregated. Even if they are mixed among routine
samples, the system can track them and process them with priority. STAT
PT results are available in as little as two and a half minutes.
Upon completion of the results, they are available for viewing, printing or
host-transmitting. The database on the system can be customized with four
views by the operator, providing flexibility to laboratory staff. For example,
the main database screen can be customized to meet the varying needs
of each shift. Results in the database can be filtered using multiple criteria to
 19

select specific samples or results. In addition, samples can be selected and

the results recalculated to reflect calibration updates on the system. For long-
term off-line result storage, the system provides the ability to export results into
data files in various formats (e.g., pdf). These files can then be viewed using
commonly available database programs on a separate computer system.

Factor Parallelism
Factor assays on the system can be processed using multiple dilutions.
The dilutions are automatically prepared by the system and the results are
checked for integrity and plotted against the calibration curve. If a sample
is void of factor inhibitors, the sample dilution curve and the calibration
curve will parallel each other. If a sample contains an inhibitor, the two
curves often intersect one another. In addition to the visual representation,
the ACL TOP utilizes algorithmic data checks to flag potential samples
with potential inhibitors.

Parallelism Display with No Inhibitor

Parallelism Display with Inhibitor

20

Clot Curves
The ACL TOP provides the ability to view clot signature curves for patients,
QC and calibrations. Clot curves visually demonstrate the reaction readings
that occur within a cuvette. They are a valuable aid to assess result concerns.
The system will maintain the last 100,000 clot curves in its database, managed
in a “first in-first out” fashion.

Sample Result Clot Curve

Auto-Validation of Results
The ACL TOP is ideally suited for high-volume, hemostasis laboratories
which process hundreds of samples each day. Generally, the results of
these samples fall within the normal range without any system flags. The
ACL TOP can be set-up to automatically validate these results. The results
can then be automatically transmitted to the host system. This feature eliminates
manual validation of results by an operator and decreases result turn-around
time. The criteria used for auto-validation can be customized.The user selects
from a list of errors and conditions for which results should not be automatically
validated. In addition to routine patient sample results, auto-validation can
also be set-up for factor parallelism and calibration curves.

Parallel Lot Testing

In the hemostasis laboratory, changes in lot numbers for controls and
reagents necessitate a cross-over study in which a result comparison is
run on the original and new lots. The ACL TOP facilitates this process by
providing an automated system to track the original and a new lot of
material for reagents and quality control liquids. The reagent alternate
lot allows calibration and sample processing for result evaluation. The
quality control liquids allow a new control range to be established, while
the original material is processed. Once a sufficient number of control
determinations have been performed, the alternate lot can be activated
and thus becomes the primary lot.
 21

Reflex Testing
Reflex testing is an automated method for evaluation of an initial set of
results and the triggering of additional testing, based upon evaluations of
rules. The reflex-testing program on the ACL TOP provides extensive flexibility
and options for setting up reflex testing. The system permits 100 reflex logic
definitions. Each of these definitions can have up to ten rules, which can
utilize numeric limits or error conditions. If rules are met, additional tests can
be added to the sample. Since each sample can have a maximum of 30
tests, up to 29 can be added if the sample initially had one test ordered.

Security
The ACL TOP security program allows each laboratory to define 100 unique
users for the system. Each user can then be assigned one of four access
levels: Administrator, Supervisor, Senior Operator or Operator. At the
Administrator level, the operator can define which level has access to each
submenu on the system. When a user logs onto the system, they are required
to enter a unique username and password. A user can only enter submenus
if their access level is equal to or greater than the level assigned for the
submenu. This flexible program allows each lab to customize the security
system. Actions performed on the ACL TOP are tracked by user, and therefore,
provide an audit trail for laboratory management.

Log File
All system modifications, warnings and errors on the ACL TOP are tracked in
the system log book. This provides an automated method for the laboratory
to maintain an audit trail for the analyzer and is also useful for trouble-shoo-
ting. The log book lists the date and time, user and a description for the last
10,000 entries. The log file is managed in a “first in-first out” fashion. When
the log book file is opened on the system, the user can easily sort, using
multiple sorting criteria. This makes it simple for the operator to monitor the
system for a certain action or time interval.
22
IV. Specification Table

Feature Description
Test menu Clotting, chromogenic and immunological assays
Continuous sample loading YES
Continuous reagent loading YES
Continuous operation YES
Samples transport system Racks
Samples on-board 120 (10 samples/rack)
Reagents transport system Racks
Reagents on-board 60 (44 refrigerated + 16 room temperature)
Reagents barcode reader YES (integrated)
Barcoded reagents YES (barcode includes lot, exp. date and vial size)
Cuvettes on-board 800
Total number of materials
(calibrators, QC, reagents) 1000
IL materials 500
User-programmable materials 500
Total number of applications 500
IL applications 250
User-programmable applications 250
Tests per sample 30
Profiles 100
Tests in a single profile 15
Throughput (Base model) PT tests/hour 360 (360 samples/hour)
APTT tests/hour 320 (320 samples/hour)
PT and APTT tests/hour 330 (165 samples/hour)
Sample predilution YES
Calibration curve predilution YES
Stored calibrations for each test 5
Factor parallelism YES
STAT capability YES (at any time in any position)
Rerun testing YES (configurable)
Reflex testing YES (configurable)
Reflex rules 100
Criteria in each single reflex rule 10
Tests generated by each
single reflex rule 29
 23

Feature Description
Quality Control program YES (with configurable multi-rules)
QC results in each statistic file Unlimited
Reaction curves in QC database 10,000
Displayable QC results 20,000
Results autovalidation YES
Patient samples results database 20,000 samples
Reportable units per test 4
Reaction curves in patient database 100,000
Results in AR database 5/test
Reaction curves in AR database 5/test
Results in NPP database 5/test
Reaction curves in NPP database 5/test
Security system YES (configurable)
Operators 100
Events log system YES
Messages in logbook 10,000
Bi-directional interface YES
Host query function YES
PC External
Operating system Windows 2000
Monitor 17” color LCD touch-screen (external)
Keyboard YES (external)
Mouse YES (external)
Printer YES (external)
User interface Windows-based, powerful, easy to use
Environmental conditions 15-32° C (59-89° F) with a relative humidity
of 5-85% (non-condensing)
Electrical requirements Voltage 100-240 V AC ±10%
Current 5-10 A
Frequency 47-63 Hz
Noise Emission 70 dBA
Dimensions (analyzer) WxDxH 151 cm x 76 cm x 73 cm
Weight (analyzer) 150 Kg
24
V. Hemostasis Assays

IL offers a broad and comprehensive panel of hemostasis assays.

PT
APTT
Fibrinogen
Thrombin Time
Intrinsic Factors
Extrinsic Factors
D-Dimer
Antithrombin
Protein C
Protein S
Factor V Leiden (APC-R)
Lupus Anticoagulant
von Willebrand Factor
Plasminogen
Plasmin Inhibitor
Heparin (UF and LMW)
HS-CRP

Please contact your local IL representative for information about the availability
of specific products and applications on the ACL TOP, in your area.
VI. IL Monographs 25

A series of monographs devoted to relevant topics in the field of hemostasis

are available from your local IL representative.

1. Monitoring of the Anticoagulant Therapy with Vitamin K Antagonists.

F. D’Agostino, G Cambiè, D. Fugazza, M. Nardella,
L. Bevilacqua, A. Lombardi, L. Preda.

2. Multicentre Assessment of a New High Sensitivity Thromboplastin for

Analysis of Patients Receiving Oral Anticoagulant Therapy.
A. Buggiani, N. Erba, B. Morelli, M. Spagnotto.

3. Protein C Activity Measurement. Evaluation of a New Snake Venom-Activated

Method (ProClot) in Comparison with a Thrombin-Activated Method.
A. Tripodi, F. Franchi, P.M. Mannucci.

4. A New Thromboplastin Based Method (IL Test Protein S) for the

Determination of Functional Protein S.
R.G. Malia, P.C. Cooper.

5. The Anticoagulants: Protein C And Protein S.

M.R. Ledford.

6. Coagulation Glossary.
E. Finotto, A. Lombardi, L. Preda, G. Semprini.

7. Algorithms for Diagnosis of Disorders in Hemostasis.

8. Quality Control. Practical Applications for the Clinical Laboratory.

D. Delucia.

9. APC Resistance.
F. Axelsson, S. Rosén.

10. D-Dimer.
J. Serra.

11. Design of a New Synthetic Phospholipid APTT Reagent: APTT-SP (liquid).

M. Rose.

12. Clot Signature Curves and the ACL Futura™.

K. Doubleday, S. Kumnick.

13. IL Test™ vWF: Ag, A Diagnostic Tool for von Willebrand Disease.
M. Piñol, J. Serra, E. Botta.

14. IL Test Free Protein S, A Diagnostic Tool for Protein S Deficiency.

M. Sales, B. Arza, S. Rosén.
26

Instrumentation Laboratory - A History of Innovation

IL has been at the forefront of discovery in diagnostics for over 40 years.
From critical care testing sites to high-volume laboratories, you can count
on IL for advanced technology and superior performance.
For more information about the ACL TOP, please contact your local IL
representative or visit us at www.ilww.com

ACL TOP is a trademark of Instrumentation Laboratory.

Windows is a registered trademark of Microsoft Corporation.
Teflon is a registered trademark of E.I. du Pont de Nemours and Company.
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Notes

All rights reserved - Printed in Italy - Grafica Briantea - 07/04

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