DURING LECTURE/DISCUSSION

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 Effector Mechanism of
Cell-mediated Immunity
S.Wahyuni, MD, PhD
Department of Parasitology,
Medical Faculty, Hasanuddin University

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Phagocytosis of microbes

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Presentation microbes to T cell

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Meeting point

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Clonal expansion & differentiation

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Effector cell escape from lymphatic vessel
to infected tissue

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Endothel allow T cell to go
to infected tissue area

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Adhesion molecules enriched cell x
permissive endothel = welcome !!!

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Migration

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• Migration of effector T
lymphocyte to the site of
infection is a function of
adhesion molecules
• Specificity of cell-
mediated immunity
against different
microbes is a function of
lymphocytes
• Elimination of microbes is
a function of activated
macrophages

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 Phagocytosis of microbes

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Contact of infected macrophag &
CD4+th1 effector T cells
Event
- TCR bind to complex
MHC2-protein
antigen
- CD40L bind with
CD40
- IFN-g produced by
Effector CD4+ bind to
IFN-g receptor
Result Macrophage
activation
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Activation of Macrophag

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Result of activation

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• DTH experiment in
human

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 Granulomatous inflammation
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Th1 & Th2 balance

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Effector CD8+ CTLs
• Recognize MHC
class1- peptide/
protein antigen
complex on
infected cell

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Cooperation of CD4+ and CD8+ T cells in defense
against intracellular microbes

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Evasion of cell-mediated immunity by
microbes

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Natural
killer cell

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Your turn Guys

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Resume
• Eradication of intracellular bacteria is done by:
Cell-mediated immunity
• 2 types of effector CMI: CD4+ Th1 & CTL
lymposites
• When MHC present protein /peptide antigen to
naïve t cell in draining lymphnoses, Effector t cell
generated & migrate to: the site of infection
• Migration of effector cells controlled by adhesion
molecules that will bind by their ligand in
endothel that had been produced due to
induction by microbes
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Resume
• CD4+ TH1 Lymphocyte eradicate intra vesicle microbes
by activating microcidal function of macrophage
• CD8+ T cells differentiate into CTLs that kills cell
containing microbe in cytoplasm mainly by inducing
DNA fragmentation & apoptosis CD8+ T cells
differentiate into CTLs that kills cell containing microbe
in cytoplasm mainly by inducing DNA fragmentation &
apoptosis
• CD4+ & CD8+ T cells often function cooperatively in
eradicating microbes
• Many patoghenic microbes have evolved mechanisms,
to resist cell mediated immunity

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Materials
• Basic Immunology; function & disorders of the
immuno system by Abbas (2007)
• Cellular & molecular immunology by Abbas
(2007)
• Immune system by Pieter Parham (2006)

Contact: wahyunim@indosat.net.id
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