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Liesbet Geris (Ed.)

Computational Modeling in
Tissue Engineering
Series: Studies in Mechanobiology, Tissue Engineering and Biomaterials

Applies the principles of engineering and life sciences toward the

development of biological substitutes
Helps quantifying and optimizing micro-environmental signals to which cells
and tissues are exposed
Covers multiple applications from the heart and liver to cartilage and bones
One of the major challenges in tissue engineering is the translation of biological knowledge on
complex cell and tissue behavior into a predictive and robust engineering process. Mastering
this complexity is an essential step towards clinical applications of tissue engineering. This
volume discusses computational modeling tools that allow studying the biological complexity in
a more quantitative way. More specifically, computational tools can help in: (i) quantifying and
2013, XII, 444 p. optimizing the tissue engineering product, e.g. by adapting scaffold design to optimize micro-
environmental signals or by adapting selection criteria to improve homogeneity of the selected
Printed book cell population; (ii) quantifying and optimizing the tissue engineering process, e.g. by adapting
Hardcover bioreactor design to improve quality and quantity of the final product; and (iii) assessing the
149,99 € | £129.99 | $179.99 influence of the in vivo environment on the behavior of the tissue engineering product, e.g. by
[1]
160,49 € (D) | 164,99 € (A) | CHF investigating vascular ingrowth. The book presents examples of each of the above mentioned
165,00 areas of computational modeling. The underlying tissue engineering applications will vary from

Softcover blood vessels over trachea to cartilage and bone. For the chapters describing examples of the
first two areas, the main focus is on (the optimization of) mechanical signals, mass transport
130,83 € | £99.99 | $149.99
[1] and fluid flow encountered by the cells in scaffolds and bioreactors as well as on the
139,99 € (D) | 143,91 € (A) | CHF
144,00 optimization of the cell population itself.

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