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Drugs of aromatic series

Опис:
3c. pharm. chemistry
Перелік питань:
1. COONa

The structural formula corresponds to a drug:

A. Sodium salicylate
B. Benzoic acid
C. Salicylic acid
D. Sodium acetate
E. * Sodium benzoate
2. O
C
OH

The structural formula corresponds to a drug:

A. Acetic acid
B. Salicylic acid
C. Resorcinol
D. Phenol
E. * Benzoic acid
3. OH

The structural formula corresponds to a drug: OH

A. Methanol
B. Xeroform
C. Salicylic acid
D. Phenol
E. * Resorcinol
4. O

C
ONa

The structural formula corresponds to a drug: OH

A. Benzoic acid
B. Salicylic acid
C. Sodium benzoate
D. Sodium acetate
E. * Sodium salicylate
5. O
OH NH C

The structural formula corresponds to a drug: CH3

A. Procaine
B. Acetylsalicylic acid
C. Phenyl salicylate
D. Salicylanilide
E. * Paracetamol
6. O
C
HN

The structural formula corresponds to a drug: OH

A. Salicylic acid
B. Salicylamide
C. Acetylsalicylic acid
D. Phenyl salicylate
E. * Salicylanilide
7. O
C
NH2

The structural formula corresponds to a drug: OH

A. Salicylic acid
B. Acetylsalicylic acid
C. Phenyl salicylate
D. Salicylanilide
E. * Salicylamide
8. O
C
OH

O Ñ ÑÍ 3

The structural formula corresponds to a drug: O

A. Salicylic acid
B. Benzyl benzoate
C. Phenyl salicylate
D. Salicylanilide
E. * Acetylsalicylic acid
9. O
C
O C6H5

The structural formula corresponds to a drug: OH

A. Salicylic acid
B. Benzyl benzoate
C. Acetylsalicylic acid
D. Salicylanilide
E. * Phenyl salicylate
10. O
C
O CH3

The structural formula corresponds to a drug: OH

A. Salicylic acid

B. Acetylsalicylic acid
C. Phenyl salicylate
D. Salicylanilide
E. * Methylsalicylate
11. The structural formula corresponds to a drug:
Br Br

Br O Bi O Br . Bi2O3

OH

A. Bismuthite Br Br

B. Thymol
C. Resorcinol
D. Phenol
E. * Xeroform
12. CH3

OH

CH3 C CH3
The structural formula corresponds to a drug: H
A. Menthol
B. Xeroform
C. Resorcinol
D. Phenol
E. * Thymol
13.

The structural formula corresponds to a drug: OH

A. Glutamic acid
B. Benzoic acid
C. Thymol
D. Methionine
E. * Phenol
14. For identification of acetylsalicylic acid chemist used dilute sodium hydroxide
solution R. After boiling and next cooling he added dilute sulphuric acid R. What
product of reaction is formed?
A. Smoke
B. Opalescense
C. Green precipitate
D. Brown gas
E. * White precipitate
15. The pharmacopoeial method of assay for benzyl benzoate is back acid-base
titration of alkaline hydrolysis products.What is titrant in this method?

A. Silver nitrate
B. Sodium hydroxyde
C. Potassium hydroxyde
D. Perchloric acid
E. * Chloride acid
16. The physical method, which is used for the analysis of paracetamol, according to
A. Pharmacopoeia,
Polarimetry is:
B. Refractometry
C. Tin layer chromatography
D. Gas chromatography
E. * Melting point
17. The method of assay for salicylamide is:
A. Iodometry, direct titration
B. Cerymetry, back titration
C. Permanganatometry
D. Argentometry, back titration
E. * Modified Keldal method
18. At addition to phenyl salicylate several drops conc. H2SO4 and water the chemist
has felt a smell. What product is formed?
A. Benzoic acid
B. Thymol
C. Oxygen
D. Hydrogen
E. * Phenol
19. Salicylanilide use as agent:
A. Purgative
B. Anaestetic
C. Keratolytic
D. Analgesic and antipyretic
E. * Antibacterial
20. The molar weight of equivalent (Em) at assay of acetylsalicylic acid by means of
acidimetry after saponification alcoholic solution (back titration) equals:
A. Ì m.
B. Ì m./4
C. 2Ì. M.
D. Ì m./3
E. * Ì m./2
21. The chemical name of benzyl benzoate is:
A. 2-(Acetoxy)benzoic acid
B. o-Hydroxybenzamide
C. Phenylsalicylamide
D. p-Oxyphenylsalicylamide
E. * Phenylmethyl benzoate
22. The initial substance for synthesis oxaphenamide is:
A. Pyrogalol
B. Toluene
C. Resorcinol

D. Phenol
E. * Phenyl salicylate
23. Phenolic hydroxyl in paracetamol molecule it is possible to identify by means
A. reactions
FeCl with:
3, CuSO4

B. AgNO3, HNO3
C. FeCl2, KCl
D. HCl, NaNO3
E. * FeCl3, diazonium salts
24. What titrant can be used for assay of paracetamol by means of nitritometry
A. (directacid
Nitric titration)?
B. Sodium nitrite in the alkaline medium
C. Chloride acid
D. Sodium chloride
E. * Sodium nitrite in the acid medium
25. The Pharmacopoeial method of assay for definition methyl salicylate is:
A. Nitritometry
B. Permanganatometry
C. Iodometry
D. Alkalimetry after alkaline hydrolysis
E. * Acidimetry after preliminary alkaline hydrolysis
26. Methyl salicylate can be synthesed by means of boiling in the presence of
A. sulphatic acid:
Sodium benzoate with ethane
B. Sodium salicylate with methane
C. Resorcinil with ethanol
D. Benzoic acids with methanol
E. * Salicylic acid with methanol
27. What can be observed the chemist-analyst at addition to alcoholic solution of
phenyl salicylate solution iron (²²²) chloride FeCl3?
A. White smoke
B. Green solution
C. White precipitate
D. Allocation of poisoning gas
E. * Violet colouring of solution
28. Under the description salicylanilide represents:
A. White, crystalline powder or small, colourless crystals or shiny flakes
B. Amorphous substance of yellow colour with specific smell
C. White, crystalline powder or white or colourless, acicular crystals
D. White, crystalline powder or colourless crystals, odourless or with a very slight
E. * characteristic odour
White or yellowish crystal powder, baking taste.
29. What functional groups are available in a molecule salicylamide?
A. Keto-group, amide group
B. Integrally connected chlorine
C. Alcoholic hydroxyl, amino group
D. Amino group, benzene cycle
E. * Amide group, phenolic hydroxyl
30. Assay of acetylsalicylic acid, according to Pharmacopoeia, makes by means of
such method:

A. Alkalimetry, back titration

B. Argentometry
C. Acidimetry, non-aqueous direct titration
D. Alkalimetry in alcoholic solution, direct titration
E. * Acidimetry, after saponification alcoholic solution, back titration
31. The initial substances for synthesis benzyl benzoate is:
A. Pyrogalol
B. Toluene
C. Resorcinol
D. Phenol
E. * Sodium benzoate
32. Paracetamol in medical practice apply as means:
A. Purgative
B. Antimicrobial preservative
C. Keratolytic
D. Expectorant
E. * Analgesic and antipyretic.
33. The chemical name of oxaphenamide:
A. Phenylmethyl benzoate
B. Phenyl ester 2-oxybenzoic acid
C. Methyl 2-hydroxybenzoate
D. p-Acetaminophenol
E. * p-Oxyphenylsalicylamide
34. In the medical practice the benzoic acid use as agent:
A. Purgative
B. Anti-inflammatory; analgesic
C. Keratolytic
D. Expectorant
E. * Antimicrobial preservative
35. What indicator must be used, according to Pharmacopoeia, for assay of sodium
benzoate in the method of acidimetry, non-aqueous direct titration?
A. Any
B. Methyl orange
C. Phenolphthalein
D. Phenol red solution
E. * Naphtholbenzein solution
36. What pharmacopoeial method of assay for salicylic acid?
A. Acidimetry, non-aqueous back titration
B. Argentometry
C. Acidimetry, non-aqueous direct titration
D. Alkalimetry, back titration
E. * Alkalimetry in alcoholic solution, direct titration
37. For identification of sodium benzoate the chemist-analyst makes sublimation of
dug (some crystals of the crushed drug moisten with sulphatic acid R, cautiously
heat up a test tube bottom). What he observed?
A. Smoke
B. Opalescense

C. Green precipitate
D. Brown gas
E. * White scurf
38. At decarboxylation of salicylic acid (heating with concentrated sulphatic acid)
chemist-analyst observed allocation of gas bubles. What gas allocated?
A. Hydrogen
B. Sulphur dioxide
C. Carbon oxide
D. Oxygen
E. * Carbon dioxide
39. For identification of benzoic acid the chemist-analyst, according to
A. Pharmacopoeia,
Perchloric acid uses reaction with:
B. Potassium hydroxyde
C. Nitric acid
D. Wine acid
E. * Iron (²²²) chloride
40. For identification of ions of Sodium in sodium benzoate the chemist-analyst can
A. use reaction
Iron with:
(²²²) chloride
B. Potassium hydroxyde
C. Wine acid
D. Silver nitrate
E. * Methoxyphenylacetic acid reagent
41. Under the description sodium salicylate is:
A. Amorphous substance of yellow colour with specific smell
B. Black crystalline powder, acicular crystals
C. Green crystalline or granular powder or flakes
D. Colourless crystals, odourless or with a very slight characteristic odour
E. * White, crystalline powder or small, colourless crystals or shiny flakes
42. The initial substance for synthesis of sodium benzoate is:
A. Pyrocatechol
B. Toluene
C. Salicylic acid
D. Phenol
E. * Benzoic acid
43. The chemical name of salicylic acid:
A. Oxybenzene
B. Sodium benzenecarboxylate
C. Benzenecarboxylic acid
D. 2-Methyloxybenzenecarboxylic acid
E. * 2-Hydroxybenzenecarboxylic acid
44. In the medical practice sodium benzoate use as means:
A. Purgative
B. Anti-inflammatory; analgesic
C. Keratolytic
D. Antimicrobial preservative
E. * Expectorant

45. The equivalent weight (Em) at assay of salicylic acid by means of alkalimetry in
A. alcoholic
Ì m./2 solution is:
B. Ì m./3
C. Ì m./4
D. 2Ì. M.
E. * Ì m.
46. Pharmacopoeial method of assay for sodium benzoate is acidimetry, non-
aqueous direct titration. What titrant in this method?
A. Silver nitrate
B. Sodium thiosulphate
C. Potassium bromate
D. Chloride acid
E. * Perchloric acid
47. What formed at interaction sodium salicylate with chloride acid?
A. Pyrocatechol
B. Phenol
C. Benzoic acid
D. Toluene
E. * Salicylic acid
48. For identification of benzoic acid the chemist-analyst can uses reaction with:
A. Potassium hydroxyde
B. Wine acid
C. Sodium carbonate
D. Perchloric acid
E. * Silver nitrate
49. For identification of salicylic acid the chemist-analyst can uses reaction with:
A. Perchloric acid
B. Potassium hydroxyde
C. Wine acid
D. Sodium carbonate
E. * Iron (²²²) chloride
50. For identification of Sodium ions in sodium benzoate the chemist-analyst used
pyrochemical reaction. What colour of flame he observed?
A. White
B. Green
C. Yellow
D. Violet
E. * Brown
51. Under the description salicylic acid represents:
A. White, crystalline powder or small, colourless crystals or shiny flakes
B. Amorphous substance of yellow colour with specific smell
C. White, crystalline or granular powder or flakes
D. White, crystalline powder or colourless crystals, odourless or with a very slight
E. * characteristic odour
White, crystalline powder or white or colourless, acicular crystals
52. The initial substance for synthesis of benzoic acid is:
A. Pyrocatechol
B. Benzoic acid

C. Salicylic acid
D. Phenol
E. * Toluene
53. The chemical name of sodium salicylate:
A. Sodium benzenecarboxylate
B. Benzenecarboxylic acid
C. 2-Hydroxybenzenecarboxylic acid
D. Oxybenzene
E. * 2-Hydroxybenzenecarboxylate
54. In the medical practice salicylic acid use as means:
A. Purgative
B. Anti-inflammatory; analgesic
C. Expectorant
D. Antimicrobial preservative
E. * Keratolytic
55. What indicator must be used, according to Pharmacopoeia, for assay of sodium
benzoate in the method of acidimetry, non-aqueous direct titration?
A. Methyl orange
B. Phenolphthalein
C. Naphtholbenzein solution
D. Phenol red solution
E. * Determining the end-point potentiometrically
56. What pharmacopoeial method of assay for sodium benzoate?
A. Alkalimetry, back titration
B. Acidimetry, non-aqueous back titration
C. Argentometry
D. Alkalimetry in alcoholic solution, direct titration
E. * Acidimetry, non-aqueous direct titration
57. For identification of salicylic acid the chemist-analyst makes reaction formation
of aurin dye. He must used such reagents:
A. Potassium hydroxide and silver nitrate
B. Iron (²²²) chloride and bromine water
C. Solution of sodium carbonate and chloride acid
D. Perchloric acid and nitric acid
E. * Solution of formaldehyde in sulphatic acid concentrated
58. At decarboxylation of salicylic acid (heating above 160°C with sodium
A. carbonate)
Pyrocatechol is formed:
B. Toluene
C. Benzoic acid
D. Sodium salicylate
E. * Phenol
59. For identification of sodium benzoate acid the chemist-analyst can uses reaction
A. with: acid
Wine
B. Potassium hydroxyde
C. Sodium carbonate
D. Perchloric acid
E. * Iron (²²²) chloride

60. For identification of ions of Sodium in sodium benzoate the chemist-analyst can
A. use reaction
Potassium with:
hydroxyde
B. Iron (²²²) chloride
C. Silver nitrate
D. Wine acid
E. * Potassium hexahydroxostibat
61. Under the description the benzoic acid is:
A. Colourless liquid
B. Amorphous substance of yellow colour with specific smell
C. Colourless crystalline powder, acicular crystals
D. White, crystalline or granular powder or flakes
E. * White, crystalline powder or colourless crystals, odourless or with a very slight
62. characteristic odour for synthesis of sodium salicylate is:
The initial substance
A. Pyrocatechol
B. Toluene
C. Benzoic acid
D. Phenol
E. * Salicylic acid
63. The chemical name of sodium benzoate is:
A. Oxybenzene
B. 2-Hydroxybenzenecarboxylate
C. Benzenecarboxylic acid
D. 2-Hydroxybenzenecarboxylic acid
E. * Sodium benzenecarboxylate
64. In the medical practice sodium salicylate use as means:
A. Purgative
B. Keratolytic
C. Expectorant
D. Antimicrobial preservative
E. * Anti-inflammatory; analgesic
65. The molar weight of equivalent (Em) at assay of benzoic acid by means of
alkalimetry in alcoholic solution equals:
A. Ì m./3
B. Ì m./4
C. 2Ì. M.
D. Ì m./2
E. * Ì m.
66. The pharmacopoeial method of assay for sodium salicylate is acidimetry, non-
aqueous direct titration. What titrant in this method?
A. Silver nitrate
B. Sodium thiosulphate
C. Potassium bromate
D. Chloride acid
E. * Perchloric acid
67. For identification of benzoic acid the chemist-analyst used solution of silver
nitrate. What colour of formed precipitate he observed?
A. Brown

B. Green
C. Yellow
D. Violet
E. * White
68. What formed at interaction of sodium benzoate with chloride acid:
A. Pyrocatechol
B. Toluene
C. Sodium salicylate
D. Phenol
E. * Benzoic acid
69. For identification of sodium salicylate acid the chemist-analyst can uses reaction
A. with:
Potassium hydroxyde
B. Wine acid
C. Sodium carbonate
D. Perchloric acid
E. * Iron (²²²) chloride
70. For identification of ions of Sodium in sodium salicylate the chemist-analyst can
A. use reaction
Iron with:
(²²²) chloride
B. Potassium hydroxyde
C. Silver nitrate
D. Wine acid
E. * Methoxyphenylacetic acid reagent
71. Under the description sodium benzoate represents:
A. Grey crystalline powder
B. Amorphous substance of yellow colour with specific smell
C. Red crystalline powder, acicular crystals
D. Blue crystalline powder, odourless or with a very slight characteristic odour
E. * White, crystalline or granular powder or flakes
72. The initial substance for synthesis of salicylic acid is:
A. Pyrogalol
B. Toluene
C. Benzoic acid
D. Resorcinol
E. * Phenol
73. The chemical name of benzoic acid:
A. Oxybenzene
B. 2-Hydroxybenzenecarboxylate
C. 2-Hydroxybenzenecarboxylic acid
D. Sodium benzenecarboxylate
E. * Benzenecarboxylic acid
74. For identification of xeroform the chemist-analyst can use reaction with:
A. Barium sulphate
B. Tartaric acid
C. Silver nitrate
D. Chloroform in the alkaline medium
E. * Solution of sodium sulphide in chloride-acid medium

75. The molar weight of equivalent (Em) at assay of thymol (by means of
bromatometry, direct titration) equals:
A. Ì m.
B. Ì m./3
C. 2Ì. M.
D. Ì m./2
E. * Ì m./4
76. In medical to practice phenol use as means:
A. Antiseptic, disinfectant and vermicidal agent
B. Keratolytic.
C. Astringent, drying and antiseptic
D. Antiseptic, drying, expectorant
E. * Antiseptic; antimicrobial preservative; antipruritic
77. For identification of resorcinol, according to Pharmacopoeia, expert of Quality
Department of the pharmaceutical enterprise uses reaction with solution:
A. Calcium chloride
B. Copper sulphate in the alkaline medium
C. Sulphate barium
D. Silver nitrate in the acid medium
E. * Potassium hydrogen phthalate in the alkaline medium
78. For assay of phenol the chemist-analyst uses a method of bromatometry, back
titration with iodometric finishing. What indicator he used:
A. Methyl orange
B. Tropeolin 00
C. Methyl red
D. Phenolphthalein
E. * Solution of starch
79. The chemical name of xeroform:
A. Oxybenzene
B. Dihydroxybenzene
C. 3-Methyl-5-methylphenol
D. 5-Methyl-2-(methylethyl)phenol
E. * Bismuth tribromophenol basic with bismuth oxide
80. For synthesis of thymol it is possible to use such initial substance:
A. Phenylsalicylate
B. Phthalic acid
C. Benzol
D. Phenol
E. * 3-Metylphenol (m-cresol)
81. For assay of resorcinol, according to Pharmacopoeia, use method:
A. Cerymetry, direct titration
B. Iodometry, direct titration
C. Chelatometry, back titration
D. Bromatometry, direct titration
E. * Bromathometry, back titration with iodometric finishing
82. According to Pharmacopoeia, the resorcinol is:
A. Amorphous substance of yellow colour with specific smell

B. Colourless crystals
C. Colourless or faintly pink or faintly yellowish crystals or crystalline masses
D. Crystalline powder of yellow colour
E. * Colourless or slightly pinkish-grey, crystalline powder or crystals, turning red on
exposure to light and air
83. What titrant you must use for assay of xeroform in the chelatometry, direct
A. titration?
Sodium thiosulphate
B. Potassium bromate
C. Chloride acid
D. Silver nitrate
E. * Sodium EDTA
84. Pharmacopoeial method of assay for phenol is bromathometry, back titration
with iodometric finishing. What titrant you must add in buret?
A. Potassium bromide
B. Potassium bromate
C. Silver nitrate
D. Chloride acid
E. * Sodium thiosulphate
85. For identification of resorcinol the chemist-analyst can use reaction with:
A. Copper chloride
B. Barium sulphate
C. Tartaric acid
D. Silver nitrate
E. * Chloroform in the alkaline medium
86. Under the description phenol represents:
A. Colourless crystals
B. Amorphous substance of yellow colour with specific smell
C. Colourless or slightly pinkish-grey, crystalline powder or crystals, turning red on
exposure to light and air
D. Crystalline powder of yellow colour
E. * Colourless or faintly pink or faintly yellowish crystals or crystalline masses
87. For synthesis of thymol it is possible to use such initial substance:
A. Phenylsalicylate
B. Phthalic acid
C. Benzol
D. Phenol
E. * m-Cresol
88. The molar weight of equivalent (Em) at assay (chelatometry) of xeroform equals:
A. Ì m.
B. Ì m./3
C. Ì m./4
D. 2Ì. M.
E. * Ì m./2
89. In the medical to practice xeroformium use as means:
A. Antiseptic, disinfectant and vermicidal agent
B. Keratolytic
C. Antiseptic; antimicrobial preservative; antipruritic

D. Antiseptic, drying, expectorant

E. * Astringent, drying and antiseptic
90. The chemical name of thymol:
A. Oxybenzene
B. m-Dihydroxybenzene
C. Bismuth tribromophenol basic with bismuth oxide
D. 3-Methyl-5-methylphenol
E. * 5-Methyl-2-(methylethyl)phenol
91. For identification of phenolic hydroxyl, as chemical component structure of many
drugs, can be used reaction with:
A. Phenylhydrazine
B. Chloride acid
C. Ninhydrin
D. Nitric acid
E. * Lime chloride or bromine water in the presence of ammonia
92. The bromatometric definition of the phenols derivatives (phenol, resorcinol, etc.)
A. is based on reaction:
Reduction
B. Elimination
C. Addition
D. Oxydation
E. * Substitution