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  • Anti-Arrhythmic Drug Actions Use Side Effects DDI & Contraindications Pharmacokinetics

    Enviado por

    Mohamed Khattab
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    drugs for heart

    Título original

    Antiarrhythmics 2

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    drugs for heart

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    17 visualizações1 página

    Anti-Arrhythmic Drug Actions Use Side Effects DDI & Contraindications Pharmacokinetics

    Enviado por

    Mohamed Khattab
    drugs for heart

    Direitos autorais:

    © All Rights Reserved
    Baixe no formato DOC, PDF, TXT ou leia online no Scribd
    Sinalizar o conteúdo como inadequado
    de 1

    Anti-arrhythmic drug Actions Use Side effects DDI & Contraindications Pharmacokinetics

    Quinidine Na channel blocker (IA) SVA (take digoxin 1st to Cinchonism: tinnitis, GI upset, Digoxin (quinidine reduces Hepatic metab (p450)
    Decr SA node depolarization slow AV node conduction) visual changes (diplopia - renal excretion of digoxin) Extensive prot binding
    Decr force of contraction seeing double), dizziness B-blockers
    Incr AV node conduction Hypotension Antihypertensives (cardiac
    Vasodilation (a-adren block) depression, vasodilation)
    Procainamide (Pronestyl) Same as quinidine Quinidine alternative Lupus like syndrome (slow Acetylated
    acetylators)
    Flecaininide (Tambocor) Na channel blocker (IC) A-fib (good eject fraction, Decr AV conduction (can cause
    Moricizine (Ethmozine) no ischem cardiomypathy) fatal ventricular arrhythmias)
    Propafenone (Rhthmoh) SVA
    Propanolol Beta-blocker (II) Sinus tachycardia Asthma Esmolol for acute
    Esmolol Diabetes mellitus situations
    Sotalol Severe CHF
    Amiodarone (cordarone) Affects K movement (III) SVT (A-fib) Minor: nausea, vomiting Hepatic metabolism
    Ventricular arrhythmias Serious: pulm fiborosis, Long half-life
    (last drug of choice) neuropathies, abnormal skin &
    eye pigmentation, hypothyroid
    state (decr cardiac function)
    Methanesulfonamides Affects K movement (III) A-fib Can prolong QT and cause Cimetidine (tagamet)
    (Dofetilide) A-flutter torsades de pointes Trimethoprim
    Ketoconazole
    Verapamil Ca channel blocker (IV) SVA
    Lidocaine (xylocaine) Na channel blocker (IB) Acute ventricular Neg inotropic effects: Hi 1st pass metabolism
    Preferentially acts on arrythmias (including vasodilation, reduced force of (mexiletine or
    abnormal heart tissue to digoxin-induced) contraction tocainide for oral use)
    prevent reentry CNS depressant effects:
    drowsiness, seizure
    Disopyramide (norpace) Na channel blocker (IA) Serious ventricular Atropine-like effects: dry Glaucoma
    arrythmias mouth, blurred vision, Big prostates
    tachycardia, confusion,
    hallucinations, constipation
    Adenosine (adenocard) Na channel blocker (I) SVT Pressor, then depressor effects Asthma Very brief half-life
    Adenosine receptor agonist Diagnostic tool to assess & reflex angina (low BP to (acute situations, IV)
    (hyperpolarizes cell) whether SVT is of atrial or reflex tachycardia to MI to
    Decr AV node conduction AV nodal origin angina)
    (slight effects on SV node) Bronchoconstriction
    Atropine & Beta-agonists Increases heart rate Sinus bradycardia
    (isoproterenol)

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