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  • BMBC 15

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    Ica Khairunnisa
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    The document discusses the NF-kB signaling pathway, which regulates genes involved in immune function, cellular survival, and development. NF-kB is a family of transcription factors that activate gene expression and are involved in inflammatory diseases and cancer. Knock-out studies in animals showed that NF-kB plays a critical role in health, as knock-outs of different subunits lead to embryonic lethality or immune defects. Dysregulation of the NF-kB pathway is associated with several inflammatory and autoimmune diseases as well as cancer. Advances in understanding NF-kB could lead to new treatment approaches for these conditions.

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    The document discusses the NF-kB signaling pathway, which regulates genes involved in immune function, cellular survival, and development. NF-kB is a family of transcription factors that activate gene expression and are involved in inflammatory diseases and cancer. Knock-out studies in animals showed that NF-kB plays a critical role in health, as knock-outs of different subunits lead to embryonic lethality or immune defects. Dysregulation of the NF-kB pathway is associated with several inflammatory and autoimmune diseases as well as cancer. Advances in understanding NF-kB could lead to new treatment approaches for these conditions.

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    14 visualizações23 páginas

    BMBC 15

    Enviado por

    Ica Khairunnisa
    The document discusses the NF-kB signaling pathway, which regulates genes involved in immune function, cellular survival, and development. NF-kB is a family of transcription factors that activate gene expression and are involved in inflammatory diseases and cancer. Knock-out studies in animals showed that NF-kB plays a critical role in health, as knock-outs of different subunits lead to embryonic lethality or immune defects. Dysregulation of the NF-kB pathway is associated with several inflammatory and autoimmune diseases as well as cancer. Advances in understanding NF-kB could lead to new treatment approaches for these conditions.

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    de 23

    ROLE OF NFKB

    SIGNALING PATHWAY IN
    INFLAMMATORY DISEASE
    AND CANCER
    Ferry Sandra
    History
    ➤ Discovered in 1986 in the laboratory of Dr. David Baltimore.
    ➤ Found as a nuclear factor in B cells.
    ➤ Found to transactivate the kappa light chain promoter.
    ➤ Later found to activate many genes.
    NF-kB in brief #1

    ➤ NF-κB regulation is essential to many aspects of our health


    including:
    ➤ the immune system
    ➤ cellular survival
    ➤ cellular development
    NF-kB in brief #2

    ➤ NF-kB is a heterodimeric transcription factor from the rel-


    family of transcription factors.
    ➤ Classic NF-kB is made up of two subunits termed p50 and
    p65.
    ➤ Other members include c-rel, RelB, p52, as well as the two
    precursors p105 and p100.
    ➤ Multiple subunits all interact to form a variety of factors with
    different apparent functions.
    ➤ Binds to a unique sequence found in the κB-responsive
    promoters (5’-GGGRNNYYCC-3’). G=Glycine, R=Arginine,
    N=Asparagine, Y=Tyrosine, and C=Cysteine.
    NF-kB and IkB Families
    NF-kB Signal Transduction
    Is NF-kB important?

    ➤ Through the use of Knock-Out animals the critical role NF-κB


    plays in health has been demonstrated.
    ➤ p65 KO : embryonic lethality.
    ➤ p50 KO : develops normally, but has B cell immune defects.
    ➤ RelB KO : develops normally, but has immune defects and
    changes in hematopoiesis.
    ➤ c-rel KO : develops normally, but B cells and T cells are
    unresponsive to certain activating signals.
    NF-kB plays important roles in various diseases

    ➤ Diseases associated with a dysregulation of NF-κB:


    ➤ Inflammatory bowl disease
    ➤ Rheumatoid Arthritis
    ➤ Atherosclerosis
    ➤ Systemic Lupus Erythematosus
    ➤ Cancer
    ➤ Diabetes
    ➤ Stroke
    ➤ Viral Infections (AIDS)
    ➤ Asthma
    ___________
    ___________________________________________________________________
    ___________________________________________________________________
    ___________________________________________________________________
    ____
    ____
    _______________________________________________________
    _______________________________________________________
    _______________________________________________________
    _______________________________________________________
    ____________
    _____________________

    _______________________

    Cell Mol Immunol. 2009; 6(5): 327-34


    _______

    Cell Signal 2002; 14(9): 771-8


    NF-kB upstream genetic modification to induce apoptosis in cancer cells

    __ ______________

    Cell Signal 2002; 14(9): 771-8


    __________

    Oral Sci Int. 2008; 5(2): 96-103


    ________

    Indones Biomed J. 2013; 5(3): 173-8


    Indones Biomed J. 2013; 5(3): 173-8
    Indones Biomed J. 2013; 5(3): 173-8
    J Clin Invest. 2001; 107(2): 135-42
    https://clinicaltrials.gov/ct2/results?term=NFkB+inflammatory+disease&Search=Search
    “
    Without advances, medicine regresses
    and reverts to witchcraft”

    -Arthur Kornberg
    Terima Kasih
    dan
    Semoga Bermanfaat

    ferrysandra@gmail.com

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