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Ann M. Kosloske, MD, MPH*‡储; C. Lance Love, MD*; James E. Rohrer, PhD§; Jane F. Goldthorn, MD*‡储;
and Stuart R. Lacey, MD*‡储
ABSTRACT. Objective. To determine the accuracy of dectomy (5%) and perforation (17%) were achieved with-
a protocol for diagnosis of appendicitis in children based out the potential costs and radiation exposure of excess
on clinical evaluation by a pediatric surgeon with selec- imaging. Pediatrics 2004;113:29 –34; appendicitis, appen-
tive use of diagnostic imaging studies. We performed dectomy, pediatric surgeon, CT, computed tomography.
this study because 1) current reports in the medical, pe-
diatric, emergency medical, and surgical literature advo-
cate imaging, particularly computed tomography (CT), as ABBREVIATIONS. CT, computed tomography; US, ultrasound;
WBC, white blood cell.
the gold standard for diagnosis of appendicitis, and 2)
the value of pediatric surgical evaluation early in the
management of the child with possible appendicitis has
A
cute appendicitis is the most common surgi-
rarely been emphasized. cal emergency in children and adolescents in
Methods, Design, Setting, and Participants. Retro-
spective review of 356 children (mean age: 9.6 years;
the United States. In 1999, an estimated
range: 1–18 years) referred to a regional pediatric surgical 59 000 children ⬍15 years old were diagnosed with
center for possible appendicitis from 1999 through 2001. appendicitis.1 Despite its frequency, however, the
Interventions. Initial pediatric surgical evaluation diagnosis of appendicitis in a child is sometimes
consisted of history, physical examination, white blood difficult. Recent reports recommended imaging, par-
cell count, differential count, and urinalysis. Children ticularly computed tomography (CT) with rectal con-
diagnosed with appendicitis underwent appendectomy trast, as the optimal diagnostic study in both adults2
without additional studies; those with equivocal find- and children.3,4 One protocol used imaging (usually
ings received intravenous fluids, rest, and reevaluation both ultrasound [US] and CT scan with rectal con-
after 4 to 6 hours. Imaging was used selectively by the trast) in 78.5% of children with possible appendici-
pediatric surgeon.
Outcome Measures. Sensitivity, specificity, positive
tis.3,5 CT scanning was calculated as cost-effective in
predictive value, negative predictive value, and accuracy children based on a negative appendectomy rate of
of the protocol based on final diagnoses; rate of appen- 23%.6 Because in our west Texas pediatric surgical
diceal perforation; and rate of negative appendectomy. practice we rely on a clinically based strategy with
Results. Of 356 children evaluated for appendicitis, selective use of imaging, and because we considered
220 (62%) had an appendectomy. Two-hundred nine a 23% rate of negative appendectomy to be unaccept-
(95%) had histologically proven appendicitis, and 11 (5%) ably high, we undertook the present study. We re-
had a normal appendix. Of the 209 children with appen- viewed the outcomes of 356 children and adolescents
dicitis, 139 (66%) had acute appendicitis, 34 (16%) had referred to us for possible appendicitis over a 3-year
advanced appendicitis without perforation, and 36 (17%) period and calculated the accuracy of our diagnostic
had advanced appendicitis with perforation. Appendec-
tomy was performed after initial evaluation in 195 (89%)
strategy compared with the accuracy of imaging.
of the 220 children and after a period of supportive care
and observation in 25 (11%) of 220. One hundred thirty- METHODS
six children (38%) did not have an appendectomy and The pediatric surgeon authors (A.M.K., J.F.G., and S.R.L.) prac-
were discharged with other diagnoses. The sensitivity of tice in a west Texas city of 204 000 population, with a referral area
this protocol was 99%, specificity was 92%, positive pre- consisting of 62 primarily rural counties in west Texas and eastern
New Mexico. The total population served is 1.4 million. No other
dictive value was 95%, and negative predictive value was pediatric surgeon practiced in this area during the study period.
99%. The accuracy was 97% compared with an accuracy of Children and adolescents with possible appendicitis were referred
82% for ultrasound alone and 90% for CT scan alone. to the pediatric surgeon by a pediatrician, a family practitioner, or
Conclusions. These data show that a protocol based an emergency department physician. Patients were treated at 2
on clinical evaluation by a pediatric surgeon with selec- hospitals: Texas Tech University Hospital, a 325-bed teaching
tive use of imaging was highly accurate for the diagnosis hospital with an 88-bed pediatric hospital located on one floor,
of appendicitis in children. Low rates of negative appen- and Covenant Children’s Hospital, a 73-bed pediatric hospital that
is a separate wing of a 400-bed community hospital. The study
was approved by the institutional review boards of both hospitals.
From the Departments of *Surgery, ‡Pediatrics, and §Health Services Re- Residents in general surgery (Post-Graduate Year 4 or Post-Grad-
search, Texas Tech University, Health Sciences Center, Lubbock, Texas; and uate Year 2) assisted the 3 pediatric surgeons in the diagnosis and
储Covenant Children’s Hospital, Lubbock, Texas. treatment of all patients. The “diagnostic call,” however, was
Received for publication Mar 3, 2003; accepted Apr 10, 2003. made by the attending pediatric surgeon. Radiographic studies
Reprint requests to (A.M.K.) 1273 Par View Drive, Sanibel, FL 33957. E-mail: were performed by general radiologists at each hospital; there
akosloske@hotmail.com were no specialty-trained pediatric radiologists at either institu-
PEDIATRICS (ISSN 0031 4005). Copyright © 2004 by the American Acad- tion.
emy of Pediatrics. The strategy for diagnosis of appendicitis (Fig 1), agreed on by
mous influence on practice. Few reports have ques- after a period of observation represented a small
tioned the accuracy or wisdom of CT scanning for proportion of children who were observed (25 [16%]
appendicitis.9,12 Parents of a child with possible ap- of 152) and of children who underwent appendec-
pendicitis may request a CT scan because they have tomy (25 [11%] of 220). Although their rate of ad-
read about it in the lay press as the definitive test.13 vanced or perforated appendicitis was higher than
Evaluation by a pediatric surgeon early in the course that of our 195 children with appendectomy after
of a child with possible appendicitis has rarely been first evaluation (56% vs 29%; P ⫽ .0070), it could not
emphasized. be concluded that the period of observation was
Our data, however, support a diagnostic strategy responsible for the higher rate of advanced disease.
based primarily on the clinical acumen of a pediatric Many confounding factors could have influenced the
surgeon rather than imaging. Our sensitivity (99%), outcome in these 25 children. For example, the 25
specificity (93%), diagnostic accuracy (97%), and children may have represented a subgroup selected
negative appendectomy rate (5%) compare favorably by greater complexity of their clinical presentations.
with recent reports of imaging-based strategies in This hypothesis is supported by their high rates of
both adults and children (Table 3). Our rate of per- imaging studies, of incorrect or equivocal interpreta-
forated appendicitis (17%) compares favorably to tion of imaging studies, and of negative appendec-
other large pediatric series since 1995, the rates of tomy. Theoretically, the outcome of the observed
which have ranged from 15.5% to 47%.4,14 –18 Many patients might have been improved by more timely
different factors are associated with the perforation surgical decision making and more accurate inter-
rate, which in general varies inversely with age and pretation of imaging studies. Such refinements might
directly with duration of illness. Surprisingly, our shorten the period of observation and lower the rate
large proportion of children (40%) from rural coun- of advanced/perforated disease.
ties did not have an increased rate of perforation Because a missed diagnosis often leads to perfora-
compared with local children, despite their longer tion and complications, rates of negative appendec-
duration of symptoms. tomy of 12% to 18% are considered acceptable in
Because appendicitis is an evolving pathologic children.15,19 A recent nationwide study of ⬎261 000
process, and because early appendicitis may be im- appendectomies in both adults and children reported
possible to differentiate from other causes of abdom- a 15.3% rate of negative appendectomy20 and em-
inal pain in children, clinical reevaluation after a phasized the potential for enormous cost savings by
period of observation and supportive care may be a decrease in this rate. Our clinically based approach,
necessary. Cost analyses, however, may be biased with its low rate of negative appendectomy (5%),
toward testing to make the diagnosis at first encoun- may be more cost-effective than other diagnostic
ter; if appendicitis can be ruled out (by testing), the strategies. We did not perform a cost-effectiveness
patient may be sent home from the emergency de- analysis in this study because we did not have a
partment. In an urban setting, this strategy may be comparison group of children who did not receive
successful, especially if intravenous fluid resuscita- pediatric surgical evaluation early in their manage-
tion has been completed during the period of testing. ment for possible appendicitis.
In our rural west Texas population, however, dis- Protocols from tertiary medical centers may not be
charge home from the emergency department was generalizable. For example, an imaging protocol for
rarely an option. childhood appendicitis (US followed by CT with rec-
The 25 children who underwent appendectomy tal contrast) that originated from a large, urban, uni-
“The charges issues has become a focus of healthcare advocates, who have
flagged a major inequity in the billing system: While hospitals negotiate discounts
with insurers and HMOs that require payment of only a fraction of the listed
charges, they ask the uninsured to pay the full rates and then pursue them
aggressively to collect.”
Lagnado L. Hospitals urged to end harsh tactics for billing uninsured. Wall Street Journal, July 7, 2003
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