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Timing of the Diagnosis of Attention-

Deficit/Hyperactivity Disorder and


Autism Spectrum Disorder
Amir Miodovnik, MD, MPHa,b, Elizabeth Harstad, MD, MPHa,b, Georgios Sideridis, PhDa,b,c, Noelle Huntington, PhDa,b

abstract BACKGROUND AND OBJECTIVE: Symptoms of inattention, hyperactivity, and impulsivity are core features of
attention-deficit/hyperactivity disorder (ADHD). However, children with autism spectrum disorder
(ASD) often present with similar symptoms and may receive a diagnosis of ADHD first. We
investigated the relationship between the timing of ADHD diagnosis in children with ASD and the age
at ASD diagnosis.
METHODS:Data were drawn from the 2011–2012 National Survey of Children’s Health, which
asked parents to provide the age(s) at which their child received a diagnosis of ADHD and/or
ASD. Using weighted prevalence estimates, we examined the association between a previous
diagnosis of ADHD and the age at ASD diagnosis, while controlling for factors known to
influence the timing of ASD diagnosis.
Our study consisted of 1496 children with a current diagnosis of ASD as reported by
RESULTS:
parents of children ages 2 to 17 years. Approximately 20% of these children had initially been
diagnosed with ADHD. Children diagnosed with ADHD before ASD were diagnosed with ASD
∼3 years (95% confidence interval 2.3–3.5) after children in whom ADHD was diagnosed at
the same time or after ASD. The children with ADHD diagnosed first were nearly 30 times
more likely to receive their ASD diagnosis after age 6 (95% confidence interval 11.2–77.8).
The delay in ASD diagnosis was consistent across childhood and independent of ASD severity.
CONCLUSION: To
avoid potential delays in ASD diagnosis, clinicians should consider ASD in young
children presenting with ADHD symptoms.

a
WHAT’S KNOWN ON THIS SUBJECT: Many studies Division of Developmental Medicine, and cClinical Research Center, Boston Children’s Hospital, Boston,
Massachusetts; and bHarvard Medical School, Boston, Massachusetts
have suggested that autism spectrum disorder (ASD)
and attention-deficit/hyperactivity disorder (ADHD) Dr Miodovnik conceptualized and designed the study, conducted the analyses, drafted the initial manuscript,
and reviewed and revised the manuscript; Dr Harstad reviewed and revised the manuscript; Dr Sideridis
are commonly co-occuring neurodevelopmental
critically reviewed the analyses; Dr Huntington reviewed all analyses completed by Dr Miodovnik and
conditions. critically reviewed and revised the manuscript; and all authors approved the final manuscript as submitted.
WHAT THIS STUDY ADDS: In children with www.pediatrics.org/cgi/doi/10.1542/peds.2015-1502
co-occurring ASD and ADHD, an initial ADHD DOI: 10.1542/peds.2015-1502
diagnosis may be associated with delayed Accepted for publication Jul 6, 2015
ASD diagnosis and a higher likelihood of ASD Address correspondence to Amir Miodovnik, MD, MPH, Division of Developmental Medicine,
diagnosis older than 6 years of age. Clinicians 1 Autumn St, Boston, MA 02215. E-mail: amir.miodovnik@childrens.harvard.edu
should consider ASD when evaluating young PEDIATRICS (ISSN Numbers: Print, 0031-4005; Online, 1098-4275).
children presenting with ADHD symptoms. Copyright © 2015 by the American Academy of Pediatrics
FINANCIAL DISCLOSURE: The authors have indicated they have no financial relationships relevant to
this article to disclose.
FUNDING: No external funding.
POTENTIAL CONFLICT OF INTEREST: Dr Harstad has been the recipient of grants from SynapDx. The
other authors have indicated they have no potential conflicts of interest to disclose.

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ARTICLE PEDIATRICS Volume 136, number 4, October 2015
Although autism spectrum disorder received a diagnosis of ASD at or NSCH used a multistage cluster
(ASD) and attention-deficit/ after age 6 despite having undergone design based on a random
hyperactivity disorder (ADHD) are a comprehensive multidisciplinary digit–dialed sample of households
unique neurobiological conditions, assessment before age 6. Almost half with children younger than 18 years
they have been shown to share of the sample had demonstrated of age selected from each of the 50
genetic factors1–3 and neural ADHD features at the initial states and the District of Columbia.
pathways.4–6 They also exhibit many assessment. The authors suggest The respondent was a parent or
overlapping phenotypic features, several reasons for why ASD guardian in the household who was
including attentional and social diagnoses may have been missed at knowledgeable about the child’s
vulnerabilities7–9 and externalizing younger ages, including social and health. The overall response rate for
symptoms, such as impulsivity and pragmatic deficits that gradually 2011–2012 was 23%. A total of 95
hyperactivity.10,11 In addition, trend emerge as social demands increase 677 interviews were completed
analyses using data from the with age.26 from February 2011 through June
2011–2012 National Survey of 2012.12 Information about parent-
A larger population-based cohort in
Children’s Health (NSCH) reported reported ASD diagnosis was
Nova Scotia, Canada, used
dramatic increases in the prevalence obtained for 85 556 children ages 2
administrative health databases to
of both ASD and ADHD. The most to 17 years. For more information
obtain the age at ASD diagnosis for
recent estimates of parent-reported about NSCH, including its sample
884 children.27 In adjusted models,
diagnosis by a health care provider design, data collection procedures,
the 3 features related to age of
were 2% for ASD in children 6 to 17 and questionnaire content, visit
diagnosis were maternal age, county
http://www.cdc.gov/nchs/slaits/
years old12 and 11% for ADHD in of residence, and co-occurring ADHD.
nsch.htm.
children 4 to 17 years old.13 An ASD diagnosis occurred 1.29 years
ASD can be reliably diagnosed in later (95% confidence interval [CI]
Study Sample
children as young as 24 months14,15; 0.93–1.64) if a child had a comorbid
Children classified as having ASD
however, the median age at first ASD ADHD diagnosis compared with
a child without ADHD. Interestingly, were those for whom a parent
diagnosis remains older than 4
in almost 60% of these cases, an provided valid responses to the
years.16 Pringle et al17 found that
ADHD diagnosis had been following questions: “Has a doctor or
40% of 6- to 17-year-old children
documented some time before the other health care provider ever told
with special health care needs and
ASD diagnosis. you that [study child] had autism,
ASD were aged 6 years and older
Asperger disorder, pervasive
when first identified as having ASD. Although these studies suggest that developmental disorder, or other
This is well beyond the age when symptoms of ADHD may overshadow autism spectrum disorder?” “How old
signs and symptoms should clearly be or mask the symptoms of ASD, none was [study child] when you were first
notable and when behavioral have examined the relationship told by a doctor or other health care
therapies appear to be most between the age at ADHD diagnosis provider that [he/she] had autism or
effective.18–20 and the age at ASD diagnosis. We ASD?” and “Does [study child]
Numerous studies have identified hypothesized that a diagnosis of currently have autism or ASD?” To
family and child factors associated ADHD before ASD would be obtain the temporal order between
with disparities in the diagnosis of associated with delayed ASD ASD and ADHD diagnoses, a parent
ASD.21 Minority background, lower diagnosis compared with children had to provide a valid response to the
level of parent education, and who received an ADHD diagnosis at question: “How old was [study
disadvantaged socioeconomic the same time or after an ASD child] when you were first told by
circumstances have all been diagnosis or children with ASD only. a doctor or other health care
correlated with increased age of provider that [he/she] had ADD or
diagnosis.22,23 Levy et al24 identified ADHD?” Based on the responses
an association between later METHODS to these questions, we defined a
diagnosis of ASD and the presence of Data for this study were drawn from 3-level variable: (1) ADHD before
co-occurring developmental, the 2011–2012 NSCH public-use data ASD, (2) ADHD same/after ASD, and
psychiatric, and neurologic disorders. file. The NSCH is directed and funded (3) ASD only. Omissions to these
Similarly, 51% of children in Iceland by the Maternal and Child Health variables, including “refusal” or
diagnosed with ASD after age 6 had Bureau of the Health Resources and “don’t know” responses, or no
a previous non-ASD developmental Services Administration and is current ASD diagnosis were
diagnosis.25 A more recent study in administered by the National Center excluded. We set the lower limit of
Israel focused on children who for Health Statistics. The 2011–2012 diagnosis for ASD at 2 years 14,15

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PEDIATRICS Volume 136, number 4, October 2015 e831
and for ADHD at 3 years28–30 based independent variables. Adjusted odds 2.9-year delay (b = 2.87 t[1211] = 9.64,
on previous literature. ratios were obtained from P , .001) in the age at ASD diagnosis
multivariate logistic regression when compared with children with
Study Variables analysis using age at ASD diagnosis ASD only. The results of the
All sociodemographic variables were dichotomized at 6 years of age as the regression indicated that our full
acquired by parent report and binary dependent variable. The models explained 53% of the
included child gender, race (white, Boston Children’s Hospital variance (R2 = 0.53, F[2, 1210] =
black, other), ethnicity (Hispanic, Institutional Review Board exempted 59.51, P , .001). In contrast, the age
non-Hispanic), mother’s education this study as nonhuman subject at ASD diagnosis for the group with
(high school diploma or less, more research. ADHD same/after ASD was not
than high school diploma), parent- significantly different than it was for
reported ASD severity (mild, children with ASD only. We re-ran the
moderate, severe), and household RESULTS same model shifting which group
income (#200% of the federal The final sample included 1496 study served as the reference to directly
poverty level [FPL], 201%–400% children with a current ASD compare the 2 groups with comorbid
FPL, .400% FPL). Co-occurring diagnosis. For 705 (42.9%) of these ASD and ADHD. We found that ADHD
conditions of interest included children, the parent or caregiver before ASD was associated with a
parent-reported developmental delay, indicated that the child had also 3.2-year delay (b = 3.18, t[1211] = 9.86,
speech problems, and intellectual received an ADHD diagnosis and P , .001) in ASD diagnosis compared
disability. All study covariates have provided the age at ADHD diagnosis. with ADHD same/after ASD (Table 2).
been significantly associated with Of the children with co-occurring ASD Figure 1 illustrates how the gap in
variations in the timing of ASD and ADHD, 313 (44.5%) comprised age at ASD diagnosis between the 2
diagnosis in previous studies.21 We the ADHD before ASD group. The groups with ADHD remains fairly
also included child’s age at the time group with ADHD before ASD constant across early childhood and
the survey was completed to account contained a significantly smaller into adolescence.
for any secular trends in diagnostic proportion of children with speech
patterns for ASD or ADHD. Looking at the probability of
problems than the other 2 subgroups
receiving an ASD diagnosis after
(adjusted F[1.88, 2729] = 4.91, P =
Analytic Methods 6 years of age, children with ADHD
.009). Overall, children with ADHD
before ASD were 16.7 times more
All statistical data analyses were before ASD were ∼4 years older when
performed using SPSS version 22.0 likely to be diagnosed with ASD after
they received their ASD diagnosis
6 years of age (t[1211] = 6.38, P ,
(IBM SPSS Statistics, IBM (F[2, 1449] = 51.51, P , .001) and
Corporation, Chicago, IL) with SPSS .001) compared with children with
81% were diagnosed after age 6
ASD only and 29.5 (95% CI
Complex Samples, which accounted (adjusted F[1.79, 2595] = 35.15, P ,
for the complex survey design of 11.2–77.8) times more likely
.001). The 3 groups were similar in
NSCH, including clustering of children compared with children with ADHD
the distribution of other demographic
within households, stratification of same/after ASD (t[1211] = 6.86, P ,
characteristics. All of the factors listed
.001) (Table 2). Children with mild
households within states, and in Table 1 were included in our final
unequal sampling weights. Using and moderate autism were also more
models because a review of the
sample weights to calculate likely to be diagnosed after 6 years
literature had indicated they were
prevalence estimates and SEs better compared with severe presentations.
significantly associated with the
represents the noninstitutionalized Notably, whereas children with
timing of ASD diagnosis (Table 1).21
population of the United States. A .05 milder cases of ASD were more likely
Across study groups, the presence of to be diagnosed after 6 years of age,
level of significance was used in the
speech problems was associated with the disparity in age of ASD diagnosis
analyses. In comparing weighted
an ASD diagnosis occurring 1.2 years for the ADHD before ASD group was
proportions, significance was based
earlier, whereas children with an maintained across all severity levels
on the adjusted F statistic, a variant of
intellectual disability were diagnosed (Fig 2).
the second-order Rao Scott adjusted
with ASD 0.6 years earlier. Mild to
x2 statistic used for analyses with
moderate autism severity was
sample weights. We used the General
associated with later diagnosis DISCUSSION
Linear Model procedure within the
Complex Samples Module to examine compared with those with severe The American Academy of Pediatrics
the associations between the age at ASD. (AAP) guidelines endorse universal
ASD diagnosis and the 3 study groups Controlling for all covariates, ADHD screening for ASD at 18 and 24
while controlling for other before ASD was associated with a months of age.15 The AAP also

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e832 MIODOVNIK et al
TABLE 1 Demographic and Clinical Characteristics of Children Stratified by Study Group (n = 1451)
ADHD Before ASD, n = 313 ADHD Same/After ASD, n = 392 ASD Only, n = 746 P
a a a
n (%) n (%) n (%)
Gender
Boys 260 (87.6) 333 (88.8) 591 (81.0) .08
Girls 53 (12.4) 59 (11.2) 154 (19)
Co-occurring conditions
Developmental delay 201 (58.6) 262 (75.1) 540 (75.9) .05
Intellectual disability 57 (19.3) 89 (20.9) 176 (26.7) .45
Speech problems 154 (53.4) 244 (70.8) 523 (74.8) .01
Race
White 265 (78.5) 306 (84.9) 552 (70.3) .12
Black 14 (15.6) 24 (7.2) 67 (11.4)
Other 31 (6.0) 57 (7.9) 113 (18.3)
Ethnicity
Hispanic 16 (17.8) 36 (14.3) 79 (24.1) .48
Non-Hispanic 293 (82.2) 351 (85.7) 654 (75.9)
Mother’s education
# High school diploma 68 (20.9) 87 (28.1) 162 (24.1) .62
. High school diploma 213 (79.1) 262 (71.9) 525 (75.9)
Household income
#200% FPL 111 (37.4) 146 (40.6) 241 (35.3) .03
.200% to #400% FPL 104 (45.7) 100 (22.1) 229 (38.8)
.400% FPL 79 (16.9) 119 (37.3) 214 (25.9)
Autism severity
Mild 182 (54.4) 199 (54.9) 423 (50.6) .29
Moderate 104 (36.8) 153 (38.4) 223 (33.2)
Severe 24 (8.8) 40 (6.6) 96 (16.3)
ASD diagnosed . 6 y old 258 (81.4) 100 (20.2) 165 (22.3) ,.001
Age at survey completion, y, mean 6 SE 11.8 6 0.4 10.8 6 0.4 10.0 6 0.3 .003
ASD age at diagnosis, y, mean 6 SE 8.6 6 0.4 4.7 6 0.3 4.6 6 0.2 ,.001
ADHD age at diagnosis, y, mean 6 SE 5.7 6 0.2 6.0 6 0.2 .32
Significant findings are bolded.
a All prevalence estimates were weighted using survey weights provided by NSCH data set to account for the complex survey design and better represent the noninstitutionalized

population of the United States and District of Columbia.

recommends careful developmental ADHD. Perry34 estimated that at highly trained staff in research
surveillance at every well-child visit, least half of the patients referred to settings. The NSCH reflects what
a process that emphasizes eliciting him for Asperger disorder had occurs in the population at large.
parental concerns, considering family previously been diagnosed with Community-based primary care
history and observing the child ADHD. More recently, Mandell et al35 physicians are often the first to
during visits.31 Despite the push for reported 21% of Medicaid-eligible encounter parental concerns about
routine screening and surveillance in children with ASD seen in a mental their child’s development,36 yet the
primary care, our study of children 2 health clinic received a diagnosis of variability in presenting symptoms
to 17 years old found that, overall, ADHD before ASD. We found ∼20% makes it challenging to diagnose ASD
39.5% were not diagnosed until of children in our sample with ASD in young children.37 Parents are less
6 years or older, similar to the had been diagnosed with ADHD likely to express specific concerns
findings of other large surveillance before ASD. Although an association about social development before
studies16 and population surveys.17 between milder cases and a later age their child has been exposed to
Barkley32 maintained that it was of ASD diagnosis was supported by a consistent peer group,38,39 and the
common for children with pervasive our findings, the delay in diagnosis stereotypies and repetitive behaviors
developmental disorder, not for the ADHD before ASD group that are required for the diagnosis of
otherwise specified, to initially existed regardless of the age at ASD are often less pronounced at
receive a diagnosis of ADHD. Jensen ADHD diagnosis or the severity of younger ages.40 As a result, the
et al33 reported that 74% of the the child’s ASD. accuracy rate of ASD diagnosis
children diagnosed with pervasive Most of the evidence for making an among general pediatricians has
developmental disorder, not accurate diagnosis of ASD in young remained relatively low.41–43
otherwise specified, in their study children is based on studies Conversely, .40% of clinically
were originally diagnosed with conducted with experienced and evaluated children with ASD who are

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PEDIATRICS Volume 136, number 4, October 2015 e833
TABLE 2 Associations for Age at ASD Diagnosis and ASD Diagnosis . 6 y (n = 1212) reported using the Diagnostic and
b Coefficients for Age at ASD aOR for ASD Diagnosis .6 y Statistical Manual of Mental
Diagnosis, y (95% CI) (95% CI) Disorders, Fourth Edition criteria,
Gender and only 67% used standardized
Boys 0.07 (–0.78–0.91) 2.0 (0.83–4.71) rating scales in making the
Girls ref ref diagnosis.46 Because the
Co-occurring conditions prototypical behaviors and social
Developmental delay 20.62 (–1.25–0.02) 0.33 (0.18–0.62)**
Intellectual disability 20.55 (–1.05 to –0.05)* 0.51 (0.25–1.07)
deficits that characterize ASD may
Speech problems 21.20 (–1.86 to –0.54)*** 0.47 (0.25–0.86)* not manifest themselves in the
Race relatively short time frame allotted
White 0.08 (–0.47–0.63) 0.77 (0.32–1.85) for routine clinic visits,37 general
Black 20.04 (–0.74–0.66) 1.30 (0.39–4.32) practitioners may be inclined to
Other ref ref
Ethnicity
attribute maladaptive behaviors to
Hispanic 20.04 (–0.68–0.59) 1.16 (0.53–2.56) ADHD, the most common
Non-Hispanic ref ref neurobehavioral disorder of
Mother’s education childhood. This is especially true if
# High school diploma 0.37 (–0.20–0.93) 1.46 (0.65–3.30) they have more experience
. High school diploma ref ref
Household income
managing and treating ADHD, if they
#200% FPL 0.51 (–0.05–1.06) 1.82 (0.80–4.14) do not feel comfortable giving
.200% to #400% FPL 0.45 (–0.15–1.06) 1.27 (0.60–2.67) a diagnosis of ASD,47 or if they lack
.400% FPL ref ref access to specialists who can
Autism severity conduct comprehensive
Mild 1.69 (0.97–2.40)*** 7.53 (1.67–33.9)**
Moderate 1.33 (0.65–2.01)*** 6.47 (1.50–27.9)*
neurodevelopmental assessments.48
Severe ref ref However, ADHD is rarely an easy
Age at survey completion 0.33 (0.26–0.40)*** 1.41 (1.29–1.54)*** diagnosis to make in very young
ASD subgroups children.49,50 Although many of the
ADHD before ASD 2.87 (2.29–3.46)*** 16.7 (7.03–39.7)*** children in our study retained their
ADHD same/after ASD 20.31 (–0.86–0.24) 0.57 (0.28–1.15)
ASD only ref ref
ADHD diagnosis after their ASD
Adjusted for, gender, race, ethnicity, presence of developmental delay, speech problems, intellectual disability, maternal
diagnosis, 12.6% of those who were
education, household income, ASD severity, and age at survey completion. aOR, adjusted odds ratio. diagnosed at younger than 7 years of
*P , .05; **P , .01; ***P , .001. age reported having only ASD and
not ADHD at the time of survey
,6 years old have been found to adherence to the AAP guidelines for completion. Similarly, Law et al30
display symptoms of ADHD.26,44 ADHD diagnosis within primary care re-contacted children who had been
Published research suggests limited settings.45 Only 25% of pediatricians diagnosed with ADHD after
undergoing a multidisciplinary
consultation when they were
younger than 7 years; they found
that 7 years after the initial
evaluation, 11.4% of the children
reported having a current ASD
diagnosis but no longer carried the
original ADHD diagnosis.
Our findings are subject to several
limitations. First, the cross-sectional
design of the study precludes us
from making statements about the
causality of our associations.
Although the parent-reported
timing of ASD and ADHD diagnoses
allows us to examine the temporal
order of events, we cannot
FIGURE 1 prospectively control or account for
Predicted mean age at ASD diagnosis by age at ADHD diagnosis for ADHD before ASD (dark gray line) other intervening factors. Second,
and ADHD same/after ASD (light gray line). the indicators used here rely on

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e834 MIODOVNIK et al
diagnosis has a higher probability of
occurring late (ie, .6 years of age).
ASD that goes unrecognized and
untreated until the child is older may
negatively affect their long-term
prognosis.
Our findings have important
implications: (1) children with ADHD
before ASD may exhibit unique
dimensional traits that could bias
clinicians toward an ADHD diagnosis,
and (2) diagnostic criteria and
screening measures for ASD may
need to reflect the overlapping
symptomatology between ASD and
ADHD. However, prospective studies
are still needed to characterize the
overlapping and distinct phenotypic
presentations of individuals with
ADHD before ASD. For now, clinicians
should consider ASD when evaluating
young children presenting with ADHD
symptoms.

FIGURE 2
Mean age at ASD diagnosis stratified by parent-reported ASD severity (mild, moderate, severe).
Adjusted for gender, race, ethnicity, maternal education, household income, and child’s age at survey ABBREVIATIONS
completion. AAP: American Academy of
Pediatrics
ADHD: attention-deficit/
parent-reported diagnoses by conclusions in this report.12 Finally,
hyperactivity disorder
a health care provider, which is not information on the severity of ASD
ASD: autism spectrum disorder
only subject to recall bias but lacks at the time of diagnosis and the
CI: confidence interval
the validity of clinical assessment diagnostic subtype of ASD were not
FPL: Federal Poverty Level
using standardized measures. available. Therefore, we attempted
NSCH: National Survey of
Without collateral information from to control for this by using current
Children’s Health
medical records or teacher reports, parent-reported ASD severity as
what parents perceive as ADHD may a proxy for baseline ASD severity in
actually be within the normative our models. REFERENCES
range of behavior for young
children. However, a recent analysis 1. Ronald A, Simonoff E, Kuntsi J, Asherson
CONCLUSIONS P, Plomin R. Evidence for overlapping
indicated that parent-reported
genetic influences on autistic and ADHD
survey data produced similar We found a substantial number of
behaviours in a community twin sample.
estimates as those from insurance parents reporting an ADHD diagnosis J Child Psychol Psychiatry. 2008;49(5):
claims data for ADHD51 and parent- by a health care provider before an 535–542
reported diagnosis of autism was ASD diagnosis. Moreover, these
2. Taurines R, Schwenck C, Westerwald E,
also consistent between 2 nationally children were significantly older
Sachse M, Siniatchkin M, Freitag C. ADHD
representative surveys,52 providing when they received their ASD and autism: differential diagnosis or
evidence of convergent validity. diagnosis compared with other overlapping traits? A selective review.
Although NSCH estimates are children diagnosed with ASD. Our Atten Defic Hyperact Disord. 2012;4(3):
potentially subject to survey study supports the hypothesis that 115–139
nonresponse bias, analyses of receiving a diagnosis of ADHD before 3. Johnson MH, Gliga T, Jones E, Charman T.
nonresponse bias suggest that ASD may delay the diagnosis of ASD, Annual research review: Infant
differences between respondents and that this delay persists across age development, autism, and ADHD—early
and nonrespondents should not and severity of the ASD. Furthermore, pathways to emerging disorders. J Child
have a major impact on the if ADHD is diagnosed first, the ASD Psychol Psychiatry. 2015;56(3):228–247

Downloaded from pediatrics.aappublications.org at Univ of California San Diego on September 14, 2015
PEDIATRICS Volume 136, number 4, October 2015 e835
4. Brieber S, Neufang S, Bruning N, et al. 13. Visser SN, Danielson ML, Bitsko RH, et al. 23. Corsello CM, Akshoomoff N, Stahmer AC.
Structural brain abnormalities in Trends in the parent-report of health Diagnosis of autism spectrum disorders
adolescents with autism spectrum care provider-diagnosed and medicated in 2-year-olds: a study of community
disorder and patients with attention attention-deficit/hyperactivity disorder: practice. J Child Psychol Psychiatry.
deficit/hyperactivity disorder. J Child United States, 2003-2011. J Am Acad 2013;54(2):178–185
Psychol Psychiatry. 2007;48(12): Child Adolesc Psychiatry. 2014;53(1):
24. Levy SE, Giarelli E, Lee L-C, et al. Autism
1251–1258 34–46.e2
spectrum disorder and co-occurring
5. Christakou A, Murphy CM, Chantiluke K, 14. Lord C, Risi S, DiLavore PS, Shulman C, developmental, psychiatric, and medical
et al; MRC AIMS Consortium. Disorder- Thurm A, Pickles A. Autism from 2 to 9 conditions among children in multiple
specific functional abnormalities during years of age. Arch Gen Psychiatry. 2006; populations of the United States. J Dev
sustained attention in youth with 63(6):694–701 Behav Pediatr. 2010;31(4):267–275
attention deficit hyperactivity disorder 15. Johnson CP, Myers SM; American
(ADHD) and with autism. Mol Psychiatry. 25. Jónsdóttir SL, Saemundsen E,
Academy of Pediatrics Council on Antonsdóttir IS, Sigurdardóttir S, Ólason
2013;18(2):236–244 Children With Disabilities. Identification D. Children diagnosed with autism
6. Di Martino A, Zuo X-N, Kelly C, et al. and evaluation of children with autism spectrum disorder before or after the
Shared and distinct intrinsic functional spectrum disorders. Pediatrics. 2007; age of 6 years. Res Autism Spectr Disord.
network centrality in autism and 120(5):1183–1215 2011;5(1):175–184
attention-deficit/hyperactivity disorder. 16. Developmental Disabilities Monitoring
Biol Psychiatry. 2013;74(8):623–632 26. Davidovitch M, Levit-Binnun N, Golan D,
Network Surveillance Year 2010 Principal
Manning-Courtney P. Late diagnosis of
7. Simonoff E, Pickles A, Charman T, Investigators; Centers for Disease
autism spectrum disorder after initial
Chandler S, Loucas T, Baird G. Psychiatric Control and Prevention (CDC).
negative assessment by
disorders in children with autism Prevalence of autism spectrum disorder
a multidisciplinary team. J Dev Behav
spectrum disorders: prevalence, among children aged 8 years—autism
Pediatr. 2015;36(4):227–234
comorbidity, and associated factors in and developmental disabilities
a population-derived sample. J Am Acad monitoring network, 11 sites, United 27. Frenette P, Dodds L, MacPherson K,
Child Adolesc Psychiatry. 2008;47(8): States, 2010. MMWR Surveill Summ. Flowerdew G, Hennen B, Bryson S.
921–929 2014;63(2):1–21 Factors affecting the age at diagnosis of
17. Pringle B, Colpe LJ, Blumberg SJ, Avila autism spectrum disorders in Nova
8. Craig F, Lamanna AL, Margari F, Matera E,
RM, Kogan MD. Diagnostic history and Scotia, Canada. Autism. 2013;17(2):
Simone M, Margari L. Overlap between
treatment of school-aged children with 184–195
autism spectrum disorders and attention
deficit hyperactivity disorder: searching for autism spectrum disorder and special 28. Riddle MA, Yershova K, Lazzaretto D, et al.
distinctive/common clinical features. health care needs. NCHS Data Brief. The Preschool Attention-Deficit/
Autism Res. 2015;8(3):328–337 2012; (97):1–8 Hyperactivity Disorder Treatment Study
18. Vismara LA, Rogers SJ. Behavioral (PATS) 6-year follow-up. J Am Acad Child
9. Salazar F, Baird G, Chandler S, et al. Co-
occurring psychiatric disorders in treatments in autism spectrum disorder: Adolesc Psychiatry. 2013;52(3):264–278.
preschool and elementary school-aged what do we know? Annu Rev Clin Psychol. e2
children with autism spectrum disorder 2010;6:447–468 29. Harvey EA, Lugo-Candelas CI, Breaux RP.
[published online ahead of print March 19. Fernell E, Eriksson MA, Gillberg C. Early Longitudinal changes in individual
4, 2015]. J Autism Dev Disord. diagnosis of autism and impact on symptoms across the preschool years in
10. Mayes SD, Calhoun SL, Mayes RD, prognosis: a narrative review. Clin children with ADHD. J Clin Child Adolesc
Molitoris S. Autism and ADHD: Epidemiol. 2013;5:33–43 Psychol. 2015;44(4):580–594
overlapping and discriminating 20. Dawson G, Jones EJH, Merkle K, et al. 30. Law EC, Sideridis GD, Prock LA, Sheridan
symptoms. Res Autism Spectr Disord. Early behavioral intervention is MA. Attention-deficit/hyperactivity
2012;6(1):277–285 associated with normalized brain activity disorder in young children: predictors of
11. Mazurek MO, Handen BL, Wodka EL, in young children with autism. J Am diagnostic stability. Pediatrics. 2014;
Nowinski L, Butter E, Engelhardt CR. Age Acad Child Adolesc Psychiatry. 2012; 133(4):659–667
at first autism spectrum disorder 51(11):1150–1159
31. Council on Children With Disabilities;
diagnosis: the role of birth cohort, 21. Daniels AM, Mandell DS. Explaining Section on Developmental Behavioral
demographic factors, and clinical features. differences in age at autism spectrum Pediatrics; Bright Futures Steering
J Dev Behav Pediatr. 2014;35(9):561–569 disorder diagnosis: a critical review. Committee; Medical Home Initiatives for
12. Blumberg SJ, Bramlett MD, Kogan MD, Autism. 2014;18(5):583–597 Children With Special Needs Project
Schieve LA, Jones JR, Lu MC. Changes 22. Shattuck PT, Durkin M, Maenner M, et al. Advisory Committee. Identifying infants
in prevalence of parent-reported Timing of identification among children and young children with developmental
autism spectrum disorder in school- with an autism spectrum disorder: disorders in the medical home: an
aged U.S. children: 2007 to 2011-2012. findings from a population-based algorithm for developmental
Natl Health Stat Report. 2013;(65):1–11, surveillance study. J Am Acad Child surveillance and screening. Pediatrics.
1 p following 11 Adolesc Psychiatry. 2009;48(5):474–483 2006;118(1):405–420

Downloaded from pediatrics.aappublications.org at Univ of California San Diego on September 14, 2015
e836 MIODOVNIK et al
32. Barkley RA. A critique of current 40. Charman T, Baird G. Practitioner review: adolescents. Pediatrics. 2011;128(5):
diagnostic criteria for attention deficit diagnosis of autism spectrum disorder 1007–1022
hyperactivity disorder: clinical and in 2- and 3-year-old children. J Child
47. Crais ER, McComish CS, Humphreys BP,
research implications. J Dev Behav Psychol Psychiatry. 2002;43(3):289–305
Pediatr. 1990;11(6):343–352 et al. Pediatric healthcare professionals’
41. Dosreis S, Weiner CL, Johnson L, views on autism spectrum disorder
33. Jensen VK, Larrieu JA, Mack KK. Newschaffer CJ. Autism spectrum
screening at 12-18 months. J Autism Dev
Differential diagnosis between attention- disorder screening and management
deficit/hyperactivity disorder and Disord. 2014;44(9):2311–2328
practices among general pediatric
pervasive developmental disorder–not providers. J Dev Behav Pediatr. 2006;27 48. Zuckerman KE, Mattox K, Donelan K,
otherwise specified. Clin Pediatr (Phila). (suppl 2):S88–S94 Batbayar O, Baghaee A, Bethell C.
1997;36(10):555–561 Pediatrician identification of Latino
42. Self TL, Parham DF, Rajagopalan J.
34. Perry R. Early diagnosis of Asperger’s Autism spectrum disorder early children at risk for autism spectrum
disorder: lessons from a large clinical screening practices: a survey of disorder. Pediatrics. 2013;132(3):445–453
practice. J Am Acad Child Adolesc physicians. Communication Disorders
49. Langberg JM, Froehlich TE, Loren REA,
Psychiatry. 2004;43(11):1445–1448 Quarterly. 2015;36(4):195–207
Martin JE, Epstein JN. Assessing children
35. Mandell DS, Ittenbach RF, Levy SE, Pinto- 43. Stewart JR, Vigil DC, Ryst E, Yang W. with ADHD in primary care settings.
Martin JA. Disparities in diagnoses Refining best practices for the diagnosis Expert Rev Neurother. 2008;8(4):627–641
received prior to a diagnosis of autism of autism: a comparison between
spectrum disorder. J Autism Dev Disord. individual healthcare practitioner 50. Leslie LK, Weckerly J, Plemmons D,
2007;37(9):1795–1802 diagnosis and transdisciplinary Landsverk J, Eastman S. Implementing
36. Sandler AD, Brazdzuinas D, Cooley WC, assessment. Nevada Journal of Public the American Academy of Pediatrics
et al. Developmental surveillance and Health. 2014;11(1):1–12 attention-deficit/hyperactivity disorder
screening of infants and young children. 44. Gadow KD, DeVincent CJ, Pomeroy J. diagnostic guidelines in primary care
Pediatrics. 2001;108(1):192–196 ADHD symptom subtypes in children with settings. Pediatrics. 2004;114(1):129–140
37. Gabrielsen TP, Farley M, Speer L, pervasive developmental disorder. J 51. Visser SN, Danielson ML, Bitsko RH, Perou R,
Villalobos M, Baker CN, Miller J. Autism Dev Disord. 2006;36(2):271–283 Blumberg SJ. Convergent validity of parent-
Identifying autism in a brief observation. 45. Epstein JN, Kelleher KJ, Baum R, et al. reported attention-deficit/hyperactivity
Pediatrics. 2015;135(2). Available at: Variability in ADHD care in community- disorder diagnosis: a cross-study
www.pediatrics.org/cgi/content/full/135/ based pediatrics. Pediatrics. 2014;134(6): comparison. JAMA pediatrics. 2013;167(7):
2/e330 1136–1143 674–675
38. Daley TC. From symptom recognition to 46. Wolraich M, Brown L, Brown RT, et al;
diagnosis: children with autism in urban 52. Centers for Disease Control and
Subcommittee on Attention-Deficit/
India. Soc Sci Med. 2004;58(7):1323–1335 Prevention (CDC). Mental health in the
Hyperactivity Disorder; Steering
39. Perryman TY. Investigating disparities in Committee on Quality Improvement and United States: parental report of
the age of diagnosis of autism spectrum Management. ADHD: clinical practice diagnosed autism in children aged 4-17
disorders [PhD Dissertation]. Chapel Hill, guideline for the diagnosis, evaluation, years—United States, 2003-2004. MMWR
NC: The University of North Carolina at and treatment of attention-deficit/ Morb Mortal Wkly Rep. 2006;55(17):
Chapel Hill; 2009 hyperactivity disorder in children and 481–486

Downloaded from pediatrics.aappublications.org at Univ of California San Diego on September 14, 2015
PEDIATRICS Volume 136, number 4, October 2015 e837
Timing of the Diagnosis of Attention-Deficit/Hyperactivity Disorder and Autism
Spectrum Disorder
Amir Miodovnik, Elizabeth Harstad, Georgios Sideridis and Noelle Huntington
Pediatrics; originally published online September 14, 2015;
DOI: 10.1542/peds.2015-1502
Updated Information & including high resolution figures, can be found at:
Services http://pediatrics.aappublications.org/content/early/2015/09/08
/peds.2015-1502
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eficit:hyperactivity_disorder_adhd_sub
Autism/ASD
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PEDIATRICS is the official journal of the American Academy of Pediatrics. A monthly


publication, it has been published continuously since 1948. PEDIATRICS is owned, published,
and trademarked by the American Academy of Pediatrics, 141 Northwest Point Boulevard, Elk
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Downloaded from pediatrics.aappublications.org at Univ of California San Diego on September 14, 2015
Timing of the Diagnosis of Attention-Deficit/Hyperactivity Disorder and Autism
Spectrum Disorder
Amir Miodovnik, Elizabeth Harstad, Georgios Sideridis and Noelle Huntington
Pediatrics; originally published online September 14, 2015;
DOI: 10.1542/peds.2015-1502

The online version of this article, along with updated information and services, is
located on the World Wide Web at:
http://pediatrics.aappublications.org/content/early/2015/09/08/peds.2015-1502

PEDIATRICS is the official journal of the American Academy of Pediatrics. A monthly


publication, it has been published continuously since 1948. PEDIATRICS is owned,
published, and trademarked by the American Academy of Pediatrics, 141 Northwest Point
Boulevard, Elk Grove Village, Illinois, 60007. Copyright © 2015 by the American Academy
of Pediatrics. All rights reserved. Print ISSN: 0031-4005. Online ISSN: 1098-4275.

Downloaded from pediatrics.aappublications.org at Univ of California San Diego on September 14, 2015

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