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Anti-LC1 completes ORGENTEC’s portfolio of automated diagnostic

tests for autoimmune liver diseases


Anti-LC1 – ORG 258 − 24 Alegria®Test Strips

Detection of autoantibodies plays a central role in the differential diagnosis of


inflammatory liver diseases such as autoimmune hepatitis (AIH), primary biliary cirrhosis
(PBC) and sclerosing cholangitis. By adding Anti-LC1 to our product portfolio ORGENTEC
Diagnostika now offers the most comprehensive panel of automated test kits for
differential diagnostics of autoimmune liver diseases.

Anti-LC1 (anti-liver cytosolic protein type 1) and anti-LKM-1 (anti-liver-kidney


microsome) are found in AIH type 2. Anti-LC1 may be the single antibody in up to
one third of the patients with AIH type 2, and antibodies to LC1 correspond to
disease severity. Anti-smooth muscle antibodies (ASMA), anti-nuclear antibodies
(ANA), and antibodies against the soluble liver antigen (anti-SLA) define AIH type 1.
Anti-mitochondrial antibodies (AMA-M2), Anti-Sp100, and Anti-gp210 are diagnostic
markers for PBC.

Anti-LC1 for Alegria® – the advantages:


• highly specific marker for AIH-2
• the only fully-automated test for Anti-LC1

®
complete set of markers for autoimmune liver diseases on Alegria : ANA, Anti-
SLA for improved performance in AIH-1 diagnostics, Anti-LKM-1 and Anti-LC1 for
accurate differentiation of AIH-2. AMA-M2, Anti-Sp100, and Anti-gp210 for reliable
diagnosis of PBC
• Alegria® tests can be combined with immunoblot Liver-9-Line 2nd Generation −
ORG 722
• fully automated “walk away” design, rapid analysis of single samples and up
to 30 different tests in 90 minutes
07-2015
Autoantibodies for differential diagnosis of autoimmune liver disease:

Literature:
1. D. P. Bogdanos et al. Autoantibodies and their antigens in autoimmune hepatitis. Semin. Liver Dis. 29; 241-253, 2009.
2. N. K. Gatselis, et al. Autoimmune hepatitis, one disease with many faces: etiopathogenetic, clinico-laboratory and
histological characteristics. World J. Gastroenterol. 21: 60-83, 2015.
3. P. Gueguen et al. Double reactivity against actin and alpha-actinin defines a severe form of autoimmune hepatitis type 1.
J. Clin. Immunol. 26; 495-505, 2006.
4. C. J. Hu et al. Primary biliary cirrhosis: what do autoantibodies tell us? World J. Gastroenterol. 16; 3616-3629, 2010.
5. G. Maggiore et al. Autoimmune diseases of the liver and biliary tract and overlap syndromes in childhood.
Minerva Gastroenterol. Dietol. 55; 53-70, 2009.
6. M. P. Manns and A. Vogel. Autoimmune hepatitis, from mechanisms to therapy. Hepatology 43; S132-S144, 2006
7. D. Vergani et al. Liver autoimmune serology: a consensus statement from the committee for autoimmune serology of
the International Autoimmune Hepatitis Group J. Hepatol. 41; 677-683, 2004.
07-2015

8. Zachou, K. et al, Review article: autoimmune hepatitis − current management and challenges. Aliment. Pharmacol.
Ther. 38: 887-913, 2013.