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Universidad Autónoma de Guadalajara A.C. © 2013.
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Universidad Autónoma de Guadalajara A. C. © 2013
GABA
POSTSYNAPTIC POTENTIALS inhibitory
neurotrans
EPSP & IPSP Deppress milter
CNS epilepsy
anxiety
EPSP
Release Neurotransmitter Interaction NT – receptor
activation of Na+ channels Vm depolarizes
IPSP
Release Neurotransmitter Interaction NT – receptor
increasing Cl- influx and/or K+ eflux Hyperpolarization
IPSP increase negativity beyond the normal Resting
membrane Potential
Universidad Autónoma de Guadalajara A. C. © 2013
PROPERTIES OF ELECTRICAL AND
CHEMICAL SYNAPSES
ELECTRICAL CHEMICAL
IONOTROPIC METABOTROPIC
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Universidad Autónoma de Guadalajara A. C. © 2013 secretion
Neurotransmitter
• Neurotransmitter - A substance which is
released locally and causes a change in post-
synaptic potential.
• Neuromodulator - A substance which acts to
modify the response of the synapse to a
neurotransmitter. Thorbytheactionof neurotransmitter
• Co-transmitter- A substance that coexists
with a NT in a given neuron. Acts on synaptic
sites on the same or different cells