10/9/2018 Anti-infectives and the Lung | European Respiratory Society

Anti-infectives and the Lung

Edited by Stefano Aliberti, James D. Chalmers and Mathias W. Pletz

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Pulmonary infections are a major cause of morbidity and mortality worldwide. Adequate and timely
treatment of these infections is therefore of vital importance, especially when considering the
emerging problem of antimicrobial resistance. This Monograph provides a comprehensive up-to-date
overview of the use of anti-infectives in lung diseases, with chapters covering community- and
hospital-acquired pneumonia, exacerbations of asthma and chronic obstructive pulmonary disease,
tuberculosis and nontuberculous mycobacteria pulmonary disease, pleural infections, and fungal
diseases. Other chapters address antibiotic stewardship in the community and hospital settings, and
the use of antibiotics in speci c patient groups (e.g. critically ill and paediatric patients). Mechanisms
of action and resistance, diagnostic approaches, therapeutic options (e.g. combination therapy, dosing
and routes of administration), and the development of new drugs are also discussed.

ERS Monograph

Table of Contents Book Info

Preface v

Guest Editors vii

Introduction x

List of abbreviations xii

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1. Antibiotics for pulmonary infections: an overview 1

Abstract

2. Antibiotic resistance in pulmonary infections: mechanisms and 21

epidemiology
Abstract

3. Antibiotics in critical care: dosing, therapeutic drug monitoring and 44

continuous infusions
Abstract

4. Inhaled antibiotics in chronic airway infections 57

Abstract

5. Inhaled antibiotics in critical care 80

Abstract

6. Identifying patients with pneumonia due to MDR organisms coming from 97

the community
Abstract

7. Antibiotic stewardship in the community 111

Abstract

8. Antibiotic stewardship in the hospital setting 127

Abstract

9. Antibiotics in acute exacerbation of asthma and COPD 150

Abstract

10. Antifungals in pulmonary infections: to whom, when and how? 159

Abstract

11. Long-term oral antibiotic treatment: why, what, when and to whom? 185
Abstract

12. Macrolide therapy for patients with pneumonia: a triple-edged sword 206
Abstract

13. Treatment options for MDR- and XDR-TB 232

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14. Perspectives on antibiotic treatment of NTM pulmonary disease 245

Abstract

15. Antibiotics for pleural infections 253

Abstract

16. Antibiotics in interstitial lung diseases 264

Abstract

17. Insights into antibiotic use in children with CAP 276

Abstract

18. New antibiotic development for pulmonary infections: New Drugs for Bad 289
Bugs and beyond
Abstract

19. Combination antibiotic therapy and synergy in HAP and VAP 302
Abstract

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