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Useful Metrics and Their Application for Outsourcing Drug Discovery Chemistry
Robert A. Goodnow, Jr., Head of Global Medicinal Chemistry Outsourcing, Roche Research Center
Abstract
As the outsourcing of drug discovery chemistry continues to be commonly employed in meeting project milestones,
focus in this endeavor has shifted from the initial novelty to its efficient application for impact [1]. In any continuing
endeavor, one aspect for enhancing efficiency is the identification and interpretation of meaningful performance metrics.
Each chemistry outsourcing collaboration should be evaluated with a mutually well-understood set of performance
metrics that capture data on valued aspects of the collaboration. Since well run collaborations tend to respond and
deliver results according to stated performance metrics, it is important to start with the metrics that reflect the intrinsic
values for both partners.
Introduction
Recent estimates of the market size for the outsourcing of chemistry as it is applied to the discovery of drugs has been estimated at US$ 2
billion [2]. Further, it is estimated that 15% of US drug research and development investment is done outside the country [3]. These numbers
make clear the seriousness with which many organizations approach this strategy option for overcoming the multiple hurdles of drug
discovery. The challenging economic environment in which pharmaceutical and biotechnology companies must operate today will continue to
make the outsourcing of chemistry research an important strategy. As with any strategy, there are important considerations that one must take into account and
resolve in order to establish metrics for measuring and driving performance improvements of chemistry outsourcing for drug discovery. A set of objective metrics
is particularly important when comparing collaborations for best fit and performance.
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