DRUG USED IN VOMITING.

( ANTIEMETICS )

Motion sickness : Hyoscine, Cyclizine

Anticancer agents induced vomiting : Ondansetron, Metoclopramide, Corticosteroids

Postoperative vomiting n vomiting due to other causes: Metoclopramide, Ondansetron

Vomiting in pregnancy : Pyridoxine alone or Promethazine + Pyridoxine or Pyridoxine + Doxylamine

Vomiting in children : Corticosteroids plus 5HT3 receptor antagonist

5-HT3 Antagonist Dopamine Antimuscarinic Antihistamine Cannabinoids Antacids H2 receptor Miscellaneous

Antagonist antagonist
Ondansetron n -Metoclopromide n -Hyoscine -Cyclizine, -Nabilone, -Mg hydroxide n Al -Ranitidine, -corticosteroids
Granisetron Domperidome (scopolamine) Promethazine Dronabilone hydroxide Famotidine (Dexamethasone)
-Block serotogenic -Block DA2 receptor -block muscarinic -block H1 n M1 -prevent -acid neutralization -manage simple -inhibit PG
receptor (5-HT3) in in CTZ M1 receptor in receptor stimulation of CTZ -provide relief from nausea n vomiting synthesis
the periphery and -Cholinomimetics vestibular -ADR similar to -ADR: mood simple nausea n -synergistic with
center gut action -cause drowsiness, hyoscine changes, vomiting associated other antiemetics
-well tolerated, -cause dryness of mouth, drowsiness, with heart burn n in anticancer drug
headache,constipation Hyperprolactinemia blurred vision psychotic reaction, gastroesophageal induced vomiting
-prevent and treat of n Extra pyramidal -prevent n treat drug dependence reflux -Diapezam,
vomiting due to anti Syndrome (EPS) motion sickness, -reserved drug for Lorezepam
cancer agent, -not for motion sea sickness anticancer drug -control
radiation, sickness induced vomiting n anticipatory
postoperative -by prokinetic radiation sickness vomiting y sedative
mechanism action, they hasten n antianxiety action
-most effective gastric juice
-Corticosteroid n emptying n prevent
diapezam enhances its aspiration of gastric
activity contents into lung