1.

Interaction between antigen and the adaptive immune system at a site such as the skin can
be subdivided into?
a. 3 phase
b. 4 phase
c. 5 phase
d. 6 phase

Answer A ( AAO BCSC 2014-2015 ) 09 Intraocular inflammation and uveitis.pg 33

2. The initial recognition, transport, and presentation of antigenic substances to the adaptive
immune system. The term antigen refers to substances recognized by the immune system,
resulting in antibody production and development of "sensitized" T lymphocytes. The above
phase is the phase ?
a. Immune complex
b. afferent
c. processing
d. effector

Answer A ( AAO BCSC 2014-2015 ) 09 Intraocular inflammation and uveitis.pg 36

3. The conversion of the antigenic stimulus into an immunologic response through priming of
naive B and T lymphocytes within the lymph nodes and spleen constitutes the processing
phase of the immune response arc. This is also called ?
a. Activation
b. processing
c. Afferent
d. Immune complex

Answer A ( AAO BCSC 2014-2015 ) 09 Intraocular inflammation and uveitis.pg 37

4. T lymphocytes have an antigen receptor that detects antigen only when a trimolecular
complex is formed consisting of ? except
a. APC-HLA molecule
b. antigen fragment
c. T-lymphocyte antigen receptor
d. B lymphocytes

Answer D ( AAO BCSC 2014-2015 ) 09 Intraocular inflammation and uveitis.pg 38

5. T regulatory (Treg) cells form another subset of helper T cells; they are identified not by their
cytokine profile but by the simultaneous surface expression of?
a. CD4
b. CD24
c. Foxp4
d. CD10

Answer A ( AAO BCSC 2014-2015 ) 09 Intraocular inflammation and uveitis.pg 40

 6. These subsets are important because the different cytokines produced by different cell types
profoundly influence subsequent "downstream" immune processing, B-lymphocyte antibody
synthesis, and cell-mediated effector responses (see the following section). For example?
a. IFN-y, produced by Th1 lymphocytes
b. blocks the differentiation and activation of Th1 lymphocytes
c. IL-1, produced by Th2 lymphocytes, blocks the differentiation of Th1 lymphocytes
d. IFN-y, produce by Th2 lymphocytes

Answer A ( AAO BCSC 2014-2015 ) 09 Intraocular inflammation and uveitis.pg 41

7. In general, effector lymphocytes require 2 exposures to antigen. The initial exposure, often
called priming or activation, occurs in the lymph node. A second exposure, often called ?
a. Restimulation
b. Regeneration
c. Reactivation
d. Regression

Answer A ( AAO BCSC 2014-2015 ) 09 Intraocular inflammation and uveitis.pg 42

8. The picture desccribes the mechanism ?

a. Hypersensitivity reactions
b. Immunology
c. System immune
d. adaptive immunity

Answer D ( AAO BCSC 2014-2015 ) 09 Intraocular inflammation and uveitis.pg 42

9. Cytotoxic T lymphocytes are the other major type of effector T lymphocyte. Cytotoxic T
lymphocytes express.......and serve as effector cells for killing tumors or virally infected?
a. CD4
b. CD8
c. CD5
d. CD6

Answer B ( AAO BCSC 2014-2015 ) 09 Intraocular inflammation and uveitis.pg 42

 10. IgM produced during the effector phase of the primary response and released into the blood
is often too large a molecule to passively leak into a peripheral site. How the molecular
weight ?
a. at 900 kDa molecular weight
b. at 800 kDa molecular weight
c. at 600 kDa molecular weight
d. at 700 kDa molecular weight

Answer A ( AAO BCSC 2014-2015 ) 09 Intraocular inflammation and uveitis.pg 44

11. The traditional classification for describing the 4 mechanisms of adaptive immune-triggered
inflammatory responses consist of ?
a. cytotoxic antibodies
b. cell reaction
c. hypersensitivity
d. cell immunitiy

Answer A ( AAO BCSC 2014-2015 ) 09 Intraocular inflammation and uveitis.pg 44

12. The basic immunoglobulin structure is composed of 4 covalently bonded glycoprotein chains
that form a monomer of approximately ?
a. 160,000-180,000 daltons
b. 140,000-180,000 daltons
c. 150,000-180,000 daltons
d. 170,000-180,000 daltons

Answer C ( AAO BCSC 2014-2015 ) 09 Intraocular inflammation and uveitis.pg 45

13. Various regions of an antibody can themselves be antigenic. These antigenic sites are called
idiotopes, as distinguished from epitopes, the antigenic sites on foreign molecules.
Antibodies to idiotopes are called idiotypes. Anti-idiotypic antibodies might be important
feedback mechanisms for immune regulation. For example case?
a. Corneal ulcer
b. Behcet syndrome
c. Uveitis
d. keratitis

Answer C ( AAO BCSC 2014-2015 ) 09 Intraocular inflammation and uveitis.pg 46

14. Persistence of antigen within a site, coupled with infiltration of specific B lymphocytes and
local antibody formation, can produce a chronic inflammatory reaction with a complicated
histologic pattern, often demonstrating lymphocytic infiltration, plasma cell infiltration, and
granulomatous features. This process is sometimes called ?
a. chronic Arthus reaction
b. chronic autoimmune disorders
c. immune complex reactions
d. cell-mediated reaction
Answer A ( AAO BCSC 2014-2015 ) 09 Intraocular inflammation and uveitis.pg 48

15. the above mechanisme may contribute to the pathophysiology of certain namely ?
a. chronic autoimmune disorders
b. cytotoxic antibodies
c. immune complex reactions
d. cell-mediated reaction

Answer A ( AAO BCSC 2014-2015 ) 09 Intraocular inflammation and uveitis.pg 48

16. Ocular Inflammatory Diseases Thought to Require a Major Contribution of Th1-Mediated DH

Effector Mechanisms, Site cornea and sclera is:
a. Phlyctenulosis
b. infiltrates of blepharoconjunctivitis
c. Disciform keratitis after viral infection
d. Disciform keratitis after bakterial infection

Answer C ( AAO BCSC 2014-2015 ) 09 Intraocular inflammation and uveitis.pg 50

17. Relatively mild degrees of inflammation that would be harmless in the skin, for example, can
cause severe vision loss if they occur in the eye. Several immunoregulatory me chanisms
have arisen to modulate intraocular immune responses. In aggregate, these mechanisms are
called
a. immune addaptive
b. immune privilege
c. immune deviation
d. immune system

Answer C ( AAO BCSC 2014-2015 ) 09 Intraocular inflammation and uveitis.pg 62

18. anterior chamberassociated immune deviation, or ACAID represents an attenuated effector

arc. Additionally, the eye is protected from severe inflammation by ?
a. Pas ligand
b. effector blockade
c. immune privilege
d. immune deviation

Answer B ( AAO BCSC 2014-2015 ) 09 Intraocular inflammation and uveitis.pg 62