Schematic Diagram

Predisposing Factor Precipitating Factor

-Age - Hypertension
-Genetic Factors
- Trop I: 26
-History of CVD
-Primary pregnancy - Hyperlipidemia
- SGPT: 13.0 (L)
- LDH: 512 (H)
- Labor Stress
- GDM

Endothelial lining of the

arteries are injured

Permeability of the vessel Platelets, WBC, and

to lipoproteins increases Fibrin converge at the
injured site.

Lipoprotein accumulated in
the intima of the arterial wall

T-Lymphocytes and monocytes

(that become macrophages)
infiltrate the area to ingest lipids
and die

Formation of dead fatty core

Formation of fibrous cap over dead fatty core

(plaque)
 Ion leak Plaque protrudes in lumen of the vessel

Plaques ruptures and causes

thrombus formation
Narrowed blood vessel (platelet aggregation + Fibrin)
obstructs/impedes blood flow
Occlusion of an artery

Decreased myocardial
perfusion/decreased
blood flow to the
myocardium

Unstable Myocardial ischemia

Angina (+) chest pain radiating
to the left shoulder
Partially ischemic Totally ischemic
Cells cells
Inadequate
supply of O2 Accumulation of Accumulation No
and nutrients waste products of waste supply of
products O2 and
Anaerobic nutrients
metabolism
-Inflammatory mediators No ATP
Reduced -Granulocyte Activation
ATP -O2-free Radical
Accumulation production Noncontractile
of lactate Loss of cell
Hypocontractile membrane
integrity

Inhibition of
Ion Pumps Cell Rupture

Altered
cell
membrane
integrity
Myocyte death /
Necrosis
 Myocardial Infaction
(Endocardium, -Unrelieved chest pain radiating to
midendocardium, the left shoulder for over a night
Fullthickness Myocardium) -Sever anxiety; SOB
(Inferolateral and -Troponin-I elevation
anterolateral wall)