CARBOPROST

(Hemabate)
Pharmacologic Class: Oxytocics, Prostaglandins.
Therapeutic Class: Abortifacients; causes uterine contractions by directly stimulating the myometrium
Pregnancy Risk Category: C

HOW SUPPLIED INDICATIONS/DOSAGES

Injection: 250 mcg/ml. Test dose: IM (Adults); 100mcg
Abortifacients: IM (Adults);
PHARMACOKINETICS 250mcg every 1.5-3.5 hrs
Absorption: Well absorbed depending upon uterine response;
following IM administration. may be increased to 500mcg if
Distribution: Unknown. several doses of 250mcg produce
Metabolism: Unknown. inadequate response (not to exceed
Excretion: Unknown. 2 days of continuous therapy or total
dose of 12mg.)
Route Onset Peak Duration Refractory Postpartum Uterine
IM Unknown 16 hours Unknown Bleeding: IM (Adults); 250mcg; may
be repeated every 15-90 minutes (total
INDICATIONS/DOSAGES dose not to exceed 2mg.)
Test dose: IM (adults); 100mcg

ADVERSE REACTIONS ASSESSMENT

CNS: dizziness; headache
RESP: wheezing
GI: diarrhea, nausea, vomiting,
Abdominal pain, cramps
GU: UTERINE RUPTURE
SKIN: flushing
OTHER: fever, chills, shivering
INTERACTIONS
Drug-Drug: Augments the effects
of other Oxytocic agents.
CONTRAINDICATIONS/PRECAUTIONS
Contraindicated in:
Hypersensitivity, Acute pelvic inflammatory
disease, Active pulmonary, renal, or hepatic
disease
Use Cautiously in:
Uterine scarring, Asthma, Hypertension,
Hypotension, Cardiac disease, Adrenal
Disease, Anemia, Jaundice, Diabetes
Mellitis, Epilepsy
NURSING DIAGNOSIS
*Deficient Knowledge; related to
*Monitor frequency, duration, and force of
contractions and uterine resting tone. Notify
physician or other healthcare professional if
contractions are absent or last for more than
one minute.
*Monitor temperature, pulse, and blood pressure
periodically throughout course of therapy. Large
dose may cause hypertension. Temperature
elevation starting from 1-16hrs after initiation of
therapy and lasting for several hrs is not unusual.
*Auscultate breath sounds. Wheezing and
sensation of chest tightness may indicate a
hypersensitivity reaction.
*Assess for nausea, vomiting, and diarrhea.
Vomiting and diarrhea occur in about 2/3 of
patients. Premedication with antiemetic and
antidiarrheals is recommended.
*Monitor amount and type of vaginal discharge.
Notify physician or other healthcare professional
immediately if symptoms of hemorrhage
(increased bleeding, hypotension, pallor,
Tachycardia) occur.
EVALUATION
*Complete Abortion
Medication regimen. *Control of postpartum or post-abortal
hemorrhage.
PLANNING/IMPLEMENTATION
*Avoid contact w/ skin. Thoroughly
wash skin immediately after spillage.
*Opioid analgesic may be given for
uterine cramping.
*Store in refrigerator
*IM: Administer deep IM. Dose may
be repeated 1.5-3.5hrs. Rotate sites.

PATIENT TEACHING
*Explain purpose of vaginal
examinations (to assess for trauma
to cervix)
*Instruct patient to notify healthcare
Professional immediately if fever and
chills, foul-smelling vaginal discharge,
lower abdominal pain, or increased
bleeding occurs.