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TheJOURNAL
of PEDIATRICS
January 2019 Volume 204 Copyright © 2019 by Elsevier Inc.
Notes from the Association of Medical School Pediatric Department Chairs, Inc.
Challenges of Funding Pediatric Fellowship Programs—Invited Commentary from the Council of
Pediatric Subspecialties e
Melvin B. Heyman, MD, Pnina Weiss, MD, Debra Boyer, MD, MHPE, Jill Fussell, MD, Lisa Imundo, MD, Tandy Aye, MD,
Imad T. Jarjour, MD, Robert Spicer, MD, and James Bale, MD........................................................................................................................ 4
Editorials
Assessment of Body Mass Index in Infancy: It Is Time to Revise Our Guidelines
Jessica G. Woo, PhD, MHSA, and Stephen R. Daniels, MD, PhD.................................................................................................................... 10
Intravenous Immunoglobulin Versus Anti-D Immunoglobulin: When Better Treatment May Not Be
the Best Treatment
Sarah H. O’Brien, MD, MSc, Jenny M. Despotovic, DO, MSc, and Cindy E. Neunert, MD, MSc................................................................ 11
If You Build It, Will They Come? Getting Medical Professionals to Use the Bridge of Evidence for
Improved Recognition of Physical Child Abuse
Mary Clyde Pierce, MD........................................................................................................................................................................................ 13
Medical Progress
Early Recognition of Physical Abuse: Bridging the Gap between Knowledge and Practice
Rachel P. Berger, MD, MPH, and Daniel M. Lindberg, MD.............................................................................................................................. 16
The Journal of Pediatrics (ISSN 0022-3476) is published monthly by Elsevier Inc., 230 Park Avenue, Suite 800, New York, NY 10169-0901, USA. Periodicals
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The Journal of Pediatrics • www.jpeds.com
Original Articles
Growth and Intellectual Abilities of Six-Year-Old Children with Congenital Heart Disease e
Kristina Nadine Heye, MD, Valentin Rousson, PhD, Walter Knirsch, MD, Ingrid Beck, RN, Rabia Liamlahi, MD, Vera Bernet, MD,
Hitendu Dave, MD, and Beatrice Latal, MD, MPH, for the Heart and Brain Research Group..................................................................... 24
Lifestyle Habits, Dietary Factors, and the Metabolically Unhealthy Obese Phenotype in Youth e
Jean-Baptiste Roberge, MD, Andraea Van Hulst, PhD, Tracie A. Barnett, PhD, Vicky Drapeau, PhD, Andrea Benedetti, PhD,
Angelo Tremblay, PhD, and Mélanie Henderson, MD, PhD............................................................................................................................. 46
All Aboard Meal Train: Can Child-Friendly Menu Labeling Promote Healthier Choices
in Hospitals? e
Sanjukta Basak, MSc, MD, CM, Alissa Steinberg, RD, MHSc, CDE, Alison Campbell, RD, CDE, Annie Dupuis, PhD,
Shiyi Chen, MSc, Alisa Bar Dayan, RD, Susan Dello, RD, and Jill Hamilton, MD........................................................................................ 59
Antenatal Detection of Treatable Critical Congenital Heart Disease Is Associated with Lower
Morbidity and Mortality
Elza Cloete, MBChB, FRACP, Frank H. Bloomfield, MBChB, PhD, Lynn Sadler, MBChB, MPH, Monique W. M. de Laat, MD, PhD,
A. Kirsten Finucane, MBChB, FRACS, and Thomas L. Gentles, MBChB, FRACP........................................................................................ 66
50 Years Ago in The Journal Of Pediatrics – A New Disorder of Purine Metabolism with
Behavioral Manifestations
Ola Didrik Saugstad, MD, PhD...................................................................................................................................................................... 88
Intermittent Hypoxemia in Infants Born Late Preterm: A Prospective Cohort Observational Study e
Logan Zane John Williams, BMedSc(Hons), David McNamara, PhD, and Jane Marie Alsweiler, PhD....................................................... 89
Weaning of Moderately Preterm Infants from the Incubator to the Crib: A Randomized
Clinical Trial e
Seetha Shankaran, MD, Edward F. Bell, MD, Abbot R. Laptook, MD, Shampa Saha, PhD, Nancy S. Newman, RN,
S. Nadya J. Kazzi, MD, MPH, John Barks, MD, Barbara J. Stoll, MD, Rebecca Bara, RN, BSN, Jenna Gabrio, MPH, CCRP,
Kirsten Childs, RN, BSN, Abhik Das, PhD, Rosemary D. Higgins, MD, Waldemar A. Carlo, MD, Pablo J. Sánchez, MD,
David P. Carlton, MD, Lara Pavageau, MD, William F. Malcolm, MD, Carl T. D’Angio, MD, Robin K. Ohls, MD,
Brenda B. Poindexter, MD, MS, Gregory M. Sokol, MD, Krisa P. Van Meurs, MD, Tarah T. Colaizy, MD, MPH,
Ayman Khmour, MD, Karen M. Puopolo, MD, PhD, Meena Garg, MD, and Michele C. Walsh, MD, MS, for the
Eunice Kennedy Shriver National Institute of Child Health, and Human Development Neonatal Research Network............................... 96
Birth Hospitalization Costs and Days of Care for Mothers and Neonates in California, 2009-2011 e
Ciaran S. Phibbs, PhD, Susan K. Schmitt, PhD, Matthew Cooper, PhD, MBA, Jeffrey B. Gould, MD, Henry C. Lee, MD, MS,
Jochen Profit, MD, MPH, and Scott A. Lorch, MD, MSCE............................................................................................................................... 118
50 Years Ago in The Journal of Pediatrics – Radiologic Findings in the Lungs of Premature Infants
Meredith Laguna, MD, MPH, Benjamin Laguna, MD, and Michael D. Cabana, MD, MPH.................................................................. 133
Racial and Ethnic Disparities in the Use of Mother’s Milk Feeding for Very Low Birth Weight Infants
in Massachusetts e
Margaret G. Parker, MD, MPH, Munish Gupta, MD, MMSc, Patrice Melvin, MPH, Laura A. Burnham, MPH,
Adriana M. Lopera, MPH, James M. Moses, MD, MPH, Jonathan S. Litt, MD, MPH, ScD, and Mandy B. Belfort, MD, MPH............... 134
Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive
and Language Performance in Children Born Extremely Preterm e
Andrea F. Duncan, MD, MSClinRes, Carla M. Bann, PhD, Allison Dempsey, PhD, Myriam Peralta-Carcelen, MD, MPH, and
Susan Hintz, MD, MSepi, for the Eunice Kennedy Shriver National Institute of Child Health and Development Neonatal
Research Network................................................................................................................................................................................................. 148
50 Years Ago in The Journal Of Pediatrics – Cytogenetics in Mentally Defective Children with
Anomalies: A Controlled Study
Jennifer L. Heithaus, MD................................................................................................................................................................................ 161
Risk of Serious Infections Associated with Biologic Agents in Juvenile Idiopathic Arthritis:
A Systematic Review and Meta-Analyses e
Florence A. Aeschlimann, MD, MPH, Shu-Ling Chong, MD, MPH, Todd W. Lyons, MD, MPH, Beate C. Beinvogl, MD, MPH,
Lina Maria Góez-Mogollón, MD, MPH, Sally Tan, MD, MPH, and Ronald M. Laxer, MD.......................................................................... 162
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The Journal of Pediatrics • www.jpeds.com
Factors Associated with Adverse Outcomes among Febrile Young Infants with Invasive
Bacterial Infections e
Christopher M. Pruitt, MD, Mark I. Neuman, MD, MPH, Samir S. Shah, MD, MSCE, Veronika Shabanova, PhD,
Christopher Woll, MD, Marie E. Wang, MD, MPH, Elizabeth R. Alpern, MD, MSCE, Derek J. Williams, MD, MPH,
Laura Sartori, MD, Sanyukta Desai, MD, Rianna C. Leazer, MD, Richard D. Marble, MD, Russell J. McCulloh, MD,
Adrienne G. DePorre, MD, Sahar N. Rooholamini, MD, MPH, Catherine E. Lumb, BS, Fran Balamuth, MD, PhD, MSCE,
Sarah Shin, BS, and Paul L. Aronson, MD, on behalf of the Febrile Young Infant Research Collaborative................................................. 177
Variation in Use of Tympanostomy Tubes: Impact of Privately Owned Ambulatory Surgery Centers e
Jennifer N. Cooper, PhD, and Charles A. Elmaraghy, MD................................................................................................................................ 183
Risk of Serious Bacterial Infection in Infants Aged ≤60 Days Presenting to Emergency Departments
with a History of Fever Only
Sriram Ramgopal, MD, Stephen Janofsky, MD, Noel S. Zuckerbraun, MD, MPH, Octavio Ramilo, MD,
Prashant Mahajan, MD, MPH, MBA, Nathan Kuppermann, MD, MPH, and Melissa A. Vitale, MD......................................................... 191
Composite Health Outcomes in Pediatric and Young Adult Kidney Transplant Recipients
Veronica A. Taylor, MD, Cassie L. Kirby, BA, Edward J. Nehus, MD, MS, Jens Goebel, MD, and David K. Hooper, MD, MS.................. 196
Major Depressive Disorder Screening Remains Low Even Among Privately Insured Adolescents
Deepa L. Sekhar, MD, MSc, Djibril M. Ba, MPH, Guodong Liu, PhD, and Jennifer L. Kraschnewski, MD, MPH..................................... 203
Detecting 22q11.2 Deletion Syndrome in Newborns with Low T Cell Receptor Excision Circles from
Severe Combined Immunodeficiency Screening e
Hsuan-Chieh Liao, PhD, Chien-Hui Liao, MS, Shu-Min Kao, BS, Chuan-Chi Chiang, PhD, and Yann-Jang Chen, MD, PhD................ 219
Health-Related Quality of Life in Children and Young Adults with Marfan Syndrome e
Jill C. Handisides, RN, Danielle Hollenbeck-Pringle, MPH, Karen Uzark, PhD, NP, Felicia L. Trachtenberg, PhD,
Victoria L. Pemberton, RNC, MS, CCRC, Teresa W. Atz, PhD, RN, Timothy J. Bradley, MBChB, Elizabeth Cappella, APN, NP,
Sylvia De Nobele, MSc, RN, Georgeann Keh-Teng Groh, MD, Michelle S. Hamstra, MS, Rosalind Korsin, RN,
Jami C. Levine, MD, Bergen Lindauer, MS, Aimee Liou, MD, Meghan K. Mac Neal, MS, CGC, MPH, Larry W. Markham, MD,
Tonia Morrison, MSM, CCRC, Kathleen A. Mussatto, PhD, RN, Aaron K. Olson, MD, Mary Ella M. Pierpont, MD, PhD,
Reed E. Pyeritz, MD, PhD, Elizabeth A. Radojewski, RN, Mary J. Roman, MD, Mingfen Xu, MSN, and Ronald V. Lacro, MD, for
the Pediatric Heart Network Investigators......................................................................................................................................................... 250
Daily Intake of Soft Drinks and Moderate-to-Severe Acne Vulgaris in Chinese Adolescents e
Xiaoyan Huang, MD, Jianglin Zhang, MD, PhD, Jie Li, MD, PhD, Shuang Zhao, MD, PhD, Yi Xiao, MD, MPH,
Yuzhou Huang, MD, Danrong Jing, MD, Liping Chen, MD, Xingyu Zhang, MPH, Juan Su, MD, PhD,
Yehong Kuang, MD, PhD, Wu Zhu, MD, PhD, Mingliang Chen, MD, PhD, Xiang Chen, MD, PhD, and
Minxue Shen, MD, PhD....................................................................................................................................................................................... 256
Familial Mediterranean Fever Is Commonly Diagnosed in Children in Israel with Periodic Fever
Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome
Yonatan Butbul Aviel, MD, Liora Harel, MD, Maryam Abu Rumi, MD, Riva Brik, MD, Nofar Hezkelo, MD,
Orli Ohana, BSc, and Gil Amarilyo, MD............................................................................................................................................................ 270
Commentary
Sedative and Anesthetic Neurotoxicity in Infants and Young Children: Not Just an Operating
Room Concern
Pradip P. Kamat, MD, MBA, FCCM, Sapna R. Kudchadkar, MD, PhD, and Harold K. Simon, MD, MBA................................................. 285
Grand Rounds
The Importance of Delabeling β-Lactam Allergy in Children e
Elissa M. Abrams, MD, FRCPC, Adelle R. Atkinson, MD, FRCPC, Tiffany Wong, MD, FRCPC, and
Moshe Ben-Shoshan, MD, MSc, FRCPC............................................................................................................................................................. 291
Pulse Oximeter Saturation Targeting and Oximeter Changes in the Benefits of Oxygen Saturation
Targeting (BOOST)-II Australia and BOOST-II UK Oxygen Trials e
Benjamin J. Stenson, MD, Mark Donoghoe, PhD, Peter Brocklehurst, MB, ChB, Peter G. Davis, MD,
Edmund Juszczak, MSc, Ian C. Marschner, PhD, John Simes, MD, and William O. Tarnow-Mordi, MB, ChB......................................... 301
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The Journal of Pediatrics • www.jpeds.com
Workshop/Symposium Summary
Evidence-Based Consensus and Systematic Review on Reducing the Time to Diagnosis of Duchenne
Muscular Dystrophy e
Annemieke Aartsma-Rus, PhD, Madhuri Hegde, PhD, FACMG, Tawfeg Ben-Omran, MD, FRCPS, FCCMG, FACMG,
Filippo Buccella, PharmD, Alessandra Ferlini, MD, PhD, Pia Gallano, PhD, R. Rodney Howell, MD, France Leturcq, PharmD,
Ann S. Martin, MS, CGC, Anna Potulska-Chromik, MD, PhD, Jonas A. Saute, MD, PhD, Wolfgang M. Schmidt, PhD,
Thomas Sejersen, MD, PhD, Sylvie Tuffery-Giraud, PhD, Zehra Oya Uyguner, PhD, Luci A. Witcomb, PhD, Shu Yau, PhD, FRCPath,
and Stanley F. Nelson, MD................................................................................................................................................................................... 305
Reply
Donald L. Gilbert, MD, MS, FAAP, FAAN, Jonathan W. Mink, MD, PhD, FAAN, FANA, FAAP,
Frederick A. Horner, MD, and Harvey S. Singer, MD....................................................................................................................................... 324
Reply
Donald L. Gilbert, MD, MS, FAAP, FAAN, Jonathan W. Mink, MD, PhD, FAAN, FANA, FAAP, and Harvey S. Singer, MD.................. 326
Reply
Elissa M. Abrams, MD, Allan B. Becker, MD, and Stanley J. Szefler, MD....................................................................................................... 328
Reader Services
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