1. If 1 gm atropine sulfate produces 14.75 ml of isotonic solution.

This solution is used to prepare

30 ml of 1% atropine sulfate. How much atropine sulfate should be added to make up to 30 ml
isotonic solution.
1% atropine solution 1 100 ml
xg 30 ml thus x = 0.3 g atropine
Since 1g 14.75
0.3 g x ml x = 4.4 ml isotonic soln.
Thus to make up to 30 ml isotonic solution = 30 – 4.4 = 25.6 ml.
2. Provided with a stock solution of ventoline of 1 : 5000. How many ml of this solution is needed
to prepare 500 ml of 0.25 mg / 100 ml.
1 : 5000 solution = 0.02 g %
0.25 mg % = 0.25 / 1000 g %
0.02 X V = 0.25/1000 X 500
V = 6.25 ml
Another solution:
0.25 100 ml
x 500 ml x = 1.25 mg
1g 5000 ml
1.25/1000 x ml x = 6.25 ml
3. A ventoline solution is used to prepare 21 ml of 1 : 6 conc. How many ml of saline should be
added.
1g 6 ml
xg 21 ml x = 3.5
Amount of saline to be added = 21 – 3.5 = 17.5 ml
4. A preservative solution contains 21.3% w/v benzalkonium chloride. What volume of this
solution is required to produce 2 quarts of 1 : 10,000 solution.
1 : 10,000 solution = 0.01%
Since 1 quart = 2 pints, 1 pint = 16 fl oz, 1 fl oz = 29.57 ml, thus,
2 quarts = 2 X 2 X 16 X 29.57 = 1892 ml
Since C1 X V1 = C2 X V2
21.3 X V1 = 1892 X 0.01
V1 = 0.888 ml.
5. To prepare 6 g of fluconide 0.01% from 0.02% stock, how much cream base is added?
0.2 0.01
0.01
0 0.19
Total parts = 0.20
Amount of base = 6 X 0.19 / 0.2 = 5.7 g
Another solution:
C1 X V1 = C2 X V2
0.01 X 6 = 0.2 X V2
V2 = 0.3 g
Amount of base to be added = 6 – 0.3 = 5.7 g
6. A pharmacist receives a Rx for 30 g of 3% amo. Hg ointment. He has only 5% conc. stock. How
many gm of white petrolatum is needed to make the correct conc.?
5 3
3
0 2
Amount of base = 30 X 2/5 = 12 g
Amount of 5% stock = 30 X 3/5 = 15 g
7. You want to prepare 10 g oint. 2.5%. You have 20% stock. How much base & oint 20% you
need?
20 2.5 parts
2.5
0 17.5 parts
Amount of base = 10 X 17.5/20 = 8.75 g
Amount of 20% stock = 10 X 2.5/20 = 11.25 g
8. You are requested to prepare 120 g of 10% ointment; provided with 20% oint. Stock, what
amount of base is needed?
20 10
10
0 10
Amount of base = 120 X 10/20 = 60 g
Amount of 20% stock = 120 X 10/20 = 60 g
9. We need to prepare 20% urea cream. We have 120 g of 15% urea cream. What amount of urea
should be added?
100 5
20
15 80  120 g
gm of urea = 120 X 5 / 80 = 7.5 g
10. We need to prepare 20% coal tar oint. We have 120 g of 5% oint. What amount of coal tar
should be added?
100 15
20
5 80  120 g
gm of coal tar = 120 X 15 / 80 = 22 .5 g

Q5

1. A 1g Ampicillin vial reconstitutes with 3.5ml SWFI to 250 mg/mL. How much SWFI is
required to reconstitute to 100mg/mL?
a. 1.25mL
b. 4.90mL
c. 8.90mL
d. 9.50mL
e. 10.00mL
2. The daily dose of pyrantel pamoate is 11mg/kg for 3 consecutive days. How many mLs of
pyrantel pamoate suspension containing 50mg/mL should be given to a patient weighing
100lbs ?
a. 10mL
b. 22mL
c. 30mL
d. 50mL
e. 66mL
 3. The label on a bottle of 5g dry powder Pen V Potassium instructs the Pharmacist to add
sufficient water to make 120mL of solution. How much antibiotic is in 10mL of reconstituted
solution ?
a. 0.25mg d. 12.5mg
b. 25mg e. 125mg
c. 250mg
4. A prescription is for 120g of 15% urea cream. The pharmacist has 20% urea cream to be
mixed with an appropriate base. How much base is needed to compound this prescription ?
a. 30g
b. 45g
c. 60g
d. 95g
e. 105g
5. For benzocaine ointment, prepare 10g of 2.5%. In stock you have 20% benzocaine ointment.
How much benzocaine and ointment base do you need?
6. How many grams of KCl (MW 74.5g) is required to prepare 2L of solution containing 5mEq
of K+ per mL?
Qual
31. A physician wants to switch a terminally-ill patient from slow release morphine sulphate tablets,
15 mg twice daily, to a liquid morphine sulphate dosage form because the patient has difficulty in
swallowing tablets. If a morphine sulphate solution containing 5 mg per mL is prescribed q4h, what
volume should be dispensed for a 20 day supply to provide the same pain relief as the tablet
regimen?
a. 20 mL d. 100 mL
b. 60 mL e. 120 mL
c. 80 mL
Answer: E Competency: 5.1
34. A patient is currently taking 220 mg of anhydrous zinc sulphate. To receive the equivalent amount
of elemental zinc, how many milligrams of zinc sulphate heptahydrate (A7 H20) would the patient
have to take? Molecular weights: zinc 65, ZnSO4 161, H2O 18.
a. 123 mg d. 392 mg
b. 220 mg e. 545 mg
c. 300 mg
Answer: D Competency: 5.1
35. A physician has prescribed 60 g of 0.01% fluocinolone acetonide cream. You have available the
commercially prepared cream containing 0.2% fluocinolone acetonide (Synalar®) & cream base
(Dermabase®) for dilution. To prepare the Rx would require:
a. 1.2 g Synalar® and 58.8 g Dermabase®.
b. 3 g Synalar® and 60 g Dermabase®.
c. 0.3 g Synalar® and 59.7 g Dermabase®.
d. 3 g Synalar® and 57 g Dermabase®.
e. 12 g Synalar® and 48 g Dermabase®.
Answer: D Competency: 5.1
36. In the International System of Units (SI), most drug levels are to be reported in the units of
micromoles/litre (µmol/L). The therapeutic concentration range for theophylline (molecular weight
180) is 10-20 µg/mL. The SI equivalent would be:
a. 0.055 - 0.11 µmol/L d. 110 - 220 µmol/L.
b. 27 - 55µmol/L e. 180 - 360 µmol/L
c. 55 - 110 µmol/L.
Answer: C Competency: 5.1
Q9
72- A baby was given 100 mg phenytoin for his seizures the blood level was 5/ml but the seizures
did not stop, so the dosage was increased to 200 mg and this time the blood level was 40/ml. If the
elimination was first order what sould be the blood level after increasing dosage
a. 5/ml b. 10/ml c. 20/ml d. 40/ml
82- 20 g NaCl (95% pure) is dissolved in 2.5 lit water. What is the amount of Na mmol/lit
95- Solution contains 5,000,000 U of antibiotic diluted by 8 mls of dist. water to make 500,000 u/ml.
how many ml of dis. water to be added to get a concentration of 125 000/0.5 ml. (30 ml ??) (10 ml)
147- An Rx calls for 1mg/1ml aldactazide 6mg/day total dose 300 mg. you have aldactazide 25 mg
in stock. How many tablets would you dispense
Q 21 – 22

38- 500mL of a 5% glucose solution ontaining 15mEq K. 20mEq Na. If NaCl and KCl is used what
is the chloride concentration ?
a-15 mEq/L b-30 mEq/L
c-35mEq/L d-40mEq/L
e-70mEq/L
56 & 57 are questions regarding TPN calculations, be aware of converstion of mmols 10meq to mg
66- 10 year old child on aminophylline
weight of child = 30kg
theophylline rate = 0.8 mg/kg/hr
equivalent of aminophylline =0.8
equivalent of oxtriphyline =0.6
calculate the rate of infusion have on hand 500 mg aminophylline toad to 1 litre of DSW 
60 ml/hr (1 ml /min)
67-what will be the Css  10 mg / L
68- what would be the appropriate oral dose for oxtriphylline ? 225 mg Q6 hr
3- Formula: glycerin 10 g (SG = 1.25) in 200 g of ointment How much glycerin is needed for 10 kg
of ointment. (400 ml)
5- 220 mg of Zn SO4; how much of ZnSO4 H2O will give the same amount of elemental zinc? (all
molecular weights were given) (Same question appeared on previous exams).
41- A child weighing 20kg is given a presctlption for amplicillin for 10 days the dose is 50mg /kg/
day in 4 equally divided doses : the suspension is 250mg/5ml what is the volume required?
a- 20 mL b- 100 mL c-150 mL d- 200 mL e- 250 mL
43- A patient is 53 pounds, prescription for megacillin 50 mg / kg / day for 7 days to be given qid.
How may mLs are needed perdose? (megacillin available as 300mg / 5mL)  5 ml
49- To make 100 grams of an ointoment you need 60g mineral oil (SG 0.9). How many mls of
mineral oil are required to make 480 g of oint.  320 ml
51- Need KMnO4 5% 500mL. How many grams of KMnO are needed ?  25 g
82- How long would you infuse a phenytoin dose of 20mg/kg in a 33 pound child at a rate or 0.5
mg/kg/ min?
a- 4 b- 40 c- 83 d- 126
87-You have on hand 5mL ampoules of isoproternol 1: 5000 solution. How much of this solution
would be needed to give 500mL of 0.25 mg/100mL of this solution ?
a- 6.25 b-62.5
109- How much KCl (Mwt 74.5) is needed to make 5 mEq/mL of 2L solution?  745 g
2-How much KMnO4 would be needed to preared 225 mL of 8mg % concentration?
a- 18g b- 18mg c- 1.8mg
10- What was the original concentration of a solution if you took 5mL of the solution and got at a 1 :
25 000 solution?  0.02%
11- How many ampoules are needed of morphine for a daily dose if the infusion is running at 15
mg/h? The ampoules on hand are 10 mg / mL of morphine  36 amp
17- You want to make a 10% urea cream and need to dispense 60g. You have on hand a 20% cream.
How much base do you need to add ?
a- 2g b- 57g c- 60g d- 30g
26-How much CaCl2 is needed to make a solution of calcium 1 mmol/mL
a- 1.47 g b- 14.7g
27- Know the specifics about making an ophthalmic solution isotonic using NaCl, including the
calculations
29- Phenobarb 0.6g
Belladona tincture 12mL
Peppermint water. qs 120m L
Sig 5 ml tid.
How much phenobarb per day is used ?  25 mg / dose, 75 mg/day
37- How many grams of a solution made up to 18mL will give a 1: 250 solution when 15 mL are
diluted to 150mL  1.44 gm
43- A patient weighing 176 lbs needs amphotericin B. 0.25mg/kg. How much of a 50mg/20mL
solution of amphoteriein B is needed ?  8 ml
58- This question involved cefoperazone and calculation conversions of w/v % to w/w %
59- This question was related to question 121 and involved calculating the amount of sodium in an
injection diluted with 0.9 saline.
Questions 60 to 63 pertain to the following scenario.
P.J. is a 35 year old female who is placed on Lithium therapy. The suggested dose is 600mg q8h of
lithium carbonate. The total body elearance of lithium is 0.44mL/s or 1.621 L/h. The biogical half
life is 18 hours. The molecular weight of lithium carbonate is 74.
60- The number of mmol the patients will receive per dose of lithium carbonate (Li) will be :
a- 8 b- 16 c- 24 d- 32 e- 48
61-The number of mEq per dose the patient will receive is :
a- 8 b- 16 c- 24 d- 32 e- 48
62-how long will it take to reach 94 % of steady state ?
a- 18 hours b- 1 day c- 3days d- 5 days
63-The lithium does is now changed to 300mg q8h. How long will it take lithium to reach 94% of
steady state?
a-immediately b- 1 day
c- 1.5 days d- 3 days e- 5 days
Q 17
7. 2L contains of 0.9% NaCl contains how many meq  308 meq
8. 10 gm NaCl in 1L how many meq  170 meq
15. problem on mEq 10 g/L NaCl how many meq of Na & Cl ?
16. pt taking slow k tab 8 meq/tab (2 tab bid), is shifting to a liquid form (bid), know that
each 5 ml has 2 g , calculate 3 of mls /dose
17. 120 lb girl is taking oral Fe 5 mg /kg/day, to be shifted to another form (feSO4) 50 mg/5 ml,so
how many mls needed/day ?

Yasser Q 2

14. ng = log -g

Mesc 3
3. Make 120 ml solution with how many gms of a substance of which 1 ml gives 2 ppm conc if
dissolved in 150 ml ….. 3 gm
15. TPN we have to make 60 mmol/L of Na+ & 40 mmol/L of K+. We have 4 mEq/L of Na & 3
mEq/L of K+ so how many ml of NaCl & KCl is needed for 1 L solution.
32. How many gm of coal tar should be added to 120 gm of 5% coal tar to give 20% coal tar?
a. 15 c. 18.9
b. 22.5 d. 28.6
39. In 500 ml of TPN, 15 mmol Na+, 20 mmol K+, so how many mmol of Cl are present (Na= 23,
K= 20, Cl = 35.5)
a. 35 b. 40 c. 70 (answer b or c???)

Mesc 4

1. Atropine 1% 7.5 ml is already isotonic, water add to 15 ml

15 – 7.5 = 7.5 ml water
100 ml 0.9 gm NaCl
7.5 ml X gm NaCl
X = 7.5 X 0.9 / 100 = 0.0675 gm NaCl must be added to isotonise the solution
 2. Cefazolin dose is 1.5 gm / day. We have 2 gm vials so we add 19 ml of water inorder to get
20 ml solution. We need doses from this solution every 3 hrs. How many ml soln we need for
every dose?
3. How many ml NaCl 23.4% we need to prepare a solution of NaCl 0.45%, 500ml.
23.4% 0%
0.45%
0.45x 22.95x
0.45 x + 22.95x = 500 (total solution)
23.4x = 500
x = 500 / 23.4 = 21.36
The quantity of NaCl 23.4% = 0.45 X 21.36 = 9.61 ml
Q 19

95. Problem on stock soln

96. Problem on dilution
97. Problem calc. dose morphine liq. ( mL / day) Given oral dose,
98. mEg of KCl, calc Mg
99. Biaxin Sup 210 ml for 14 days and it will not be effective after 10 days Therefore give 150 ml
(mixed) and then 100 ml in special bottle
100. NaC1 equivalence
101. Given benzocaine 1% Vaseline base, 1:2 mitte 150 gm, calc the amount of benzocaine
102. p.p.m  120 mL must be prepared such that 1 ml of it when diluted to 150 ml 2 p.p.m
1. Problem on Ampicillin? (A: = 9.5)
2. Problem on Inventory? (A: = 8)
3. Problem? (A: 17.9)
4. Problem of Urea Cream (A: = 30)
Notes: mole = wt. gm /m wt.
m-mole = wt. mgm / m wt.
 mole = wt. gm / m wt.
51. Captopril paper 5 mg (same repeated problem)
Milte 90 - - -
18 gm (powder)
52.  18 tab captopril
53. 15.7 gm powder of lactose
69. A patient come with Rx for an antibiotic suspension for a boy for 14 days and it’s stable for 10
days if refrigerated and he should be given 5cc TID, the most economic and convenient way to
dispense this Rx is to give:
- 300 ml (mixed)
- 150 ml (mixed) and make a refill
- 150 ml (mixed) and 100 ml powder + suitable diluent
29. Dr. wants to switch from slow release 15 mg BID to liquid preparation how many ml of drug
(5 mg/ml) g 4 tt you have to prepare ???????

30. ng = log -9
-g
ng = log
12. The package insert enclosed with a vial containing 1 g of ampicillin sodium powder specifies
that when 3.5 mL of sterile water is added to the powder the resulting concentration is 250 mg per
mL. Using this information what volume of sterile water should be added to make a solution
containing 125 mg per mL? (Problem)
a. 3.5 mL b. 5.0 mL
c. 7.0 mL d. 7.5 mL
e. 10.0mL
Answer: D
6- There was a problem on how to prepare a solution of certain dilution from another solution of a
more concentrated solution of KMnO4
1. A Child needs Captopril 5 mg TID
Rx Captopril 5mg powder paper
Mitte 90 powder paper
In the pharmacy their is Captopril 25 mg tab
Maximum or each powder paper = 200 mg
Weight or each 2 tab. = 260 mg
How many Component tab. 25 mg are needed?  18 tabs.
2. How many gm of total powder paper is prepared? 18 gm
3. What is the amount of lactose needed as filler to prepare 90 sachets?  15.70 gm
4. Calculations on Amphotericin
 5. Calculation of cats weight
6. Calculate total number of tablets given to a gp of students traveling given different signatures
7. Calculation of isotonicity

1. A problem on how to calculate the number of capsules of Rifampcin that are used for
prophylaxis of different populations. (Used as 1 dose BID * 2 days).
2. A problem on isotonicity (refer to Comprehensive Pharmacy Review, Pharmaceutical
Calculations)
3. You have to make 100 gm of a mixture of Betamethasone Cream and Betamethasone Ointment
in a ratio of 2:1. What are the weights of cream and ointment used?
2. In 500 ml of TPN 15 mmol Na+, 20 mmol K+, so how many mmols of chloride is
present (Na 23, K , Cl 35.5)
1. 35
2. 40
3. 70
3. There was a problem on how to prepare a solution of certain dilution from another solution of a
more concentrated solution of KMnO4
4. A problem in which prednisone tablets are used, given final conc. and stength of the tablet,
calculate how many tablet to use,
1. Should be dispensed in amber glass
2. 50 tablets are used
3. solubility in isopropyl alc

1. A child needs Captopril 5 mg (PROBLEM) if we have in the pharmacy 25 mg captopril Tab

max. wt of each cachet powder paper is 200 mg, and prepare 90 sachets. How many gm of
total powder is prepared
gm of total powder paper = 90 * 200 = 18,000 mg = 18 gm
How many capoten tab 25 mg needed = 90/5 = 18, Therefore 18 tab.
What is the amount of lactose needed to prepare the 90 sachets
wt of 2 tablets = 260 mg (given)
wt of one tab = 130 mg
18* 130 /1000 = 2.34 gm
wt of 90 sachets = 18 gm - 2.34 = 15 .66 gm = 15.7 gm
 2. A physician has prescribed 60 gm of 0.01 % cortisone cream. You have the commercial
available 0.2% and cream base for dilution. How many base cream used to prepare 60 gm of
0.1%
a. 3 gm
3. Ampicillin vial reconstitution needs 3.5 ml SWFI to make 250 mg/ml and  total 4 ml, How
many ml of SWFI are needed to reconstitute 100 mg/ml
Vol of Ampicillin = 4 - 3.5 = 0.5 ml
for 100 mg  1 ml
1000 mg  x ml
x = 10ml
SWFI needed = 10 – 0.5 = 9.5 ml
My Quest 24 (answers available in 3 sheets)

1. 1 g of penicillin powder when we add 3.5 ml of dist H2O the concentration yield is 250/ml. How
much H2O should be added to prepare 100/ml.
a. 8.75 ml
b. 9.5 ml
2. 10g\L NaCl. How much is the mEq of Na+ and Cl? {MWT Cl=35.5 & Na+ = 23 & NaCl=58.8}
a. 0.709 and 0.709
b. 709.9 and 709.9
3. How much clindamycin {MWT= } should be used to prepare the following prescription?
Clindamycin 2% 250ml
a. 5 g
b. 2.2 g
c. 10 g
d. 15 g
e. 25 g
4. Phenol 2% calculation
5. You want to prepare an ointment contains 5% ----- & 2% sulfur in steroid 1%. You want to use
60 g of the steroid cream. How much you need from ----- & sulfur
a. 1.2 g and 3 g
 1. Prednisone 1 mg
H2O 10 ml
Tuti-Fruiti flavor 250 ml
Prednisone is a white odourless powder with bitter taste. Does not dissolve in water. It
dissolves in alc with ratio 1 : 192 needs protection from light. What should you do to prepare
this prescription?
b. Change H2O with Isopropy1 alcohol
c. You need 50 tablets to prepare it
d. Put it in amber glass
6. A child needs Captopril 5 mg TID
Rx Captopril 5 mg
Mitte 90 mg
The pharmacist has Captopril 25 mg
The maximum batch powder is 200 mg
Weight or each 2 tablets 260 mg
How many Captopril tablet is needed?
a. 18 Tab.
7. How many gm of total powder is prepared?
a. 18 mg
8. What is the amount of Lactose as filtered is needed to prepare 90 sachets?
a. 15.7 mg
9. Wt of Li 600 mg, m wt = 74.5 so mmoles = 8
10. Css = 4 t ½ = 3 days (4 X 18 hrs) (Li)
11. Another change in …. Still the Css = 4 t ½ = 3 days = 4 X 18 hrs
12. Rifampicin ; 600 mg X 2 X BID
10 mg / kg X 2 X 2 (32 caps)
4 adults
10  10 kg
6  20 kg
10  30 kg
available 300 mg caps (adult)
50 mg /5 ml (child)  146 caps
 13. Morphine 30 mg BID, change the dosage form to sol (5 mg /ml) how much in each dose (ml)
14. Streptoterecin vial 0.25mg/ml (Xkg) = 50 mg/20ml
15. E value, NaCl equivalent
79- You have a stock solution of liquified phenol 89% w/w (SG 1.071). You want 60g of a 2%
solution of phenol in HC 0.5 % w/w. How many mLs of liquefied phenol is needed?  12.5 ml
Q. In a total parentral nutrition TPN, we have to make 60 mmol/L of Na+ and 40 mmol/L of K+.
If we have 4 meq/L of Na+ & 3 mEq /L K+, so how many ml of NaCl & of KCl are needed for
Key Equation wt = meq * molec wt mole= wt / mol wt