Senior High School Department

Experiment:
Acid Base Titration: Determining the Efficiency of Antacid Tablet

LABORATORY REPORT
Mapili, Fernan Gerald
Marcelino, Andrea Nicole
Mepania, Charles Windsor
Mercado, John Allen
Mesa, Nicole KC
Morales, Ian
Naval, David
Nayve, Andrei
Ocampo, Karen Nicole
Octaviano, Cheska

ABSTRACT
The experiment about acid-base titration is to learn the technique of acid-base
titrations and to compare the efficiency of commercially available antacids by looking at
their wt. of HCl/wt. of antacid values. In the experiment, the antacid tablet was crushed in
mortar and pestle. After crushing, the student got 0.2grams of antacid using the digital
weighing scale. The grounded antacid is then transferred in to a 250mL Erlenmeyer flask
and 50.0 mL of 0.1 M HCl was added to the antacid and was dissolved as much as
possible. Three drops of phenolphthalein indicator is added into the mixture and was
mixed thoroughly. The antacid mixture with 0.1 M NaOH was then titrated until the
solution turns to a faint pink color. The volume of the Sodium Hydroxide consumed by the
reaction was then measured and measured at 11.0ml. The weight of HCl/gram antacid
tablet is equal to 0.7 which shows the effectiveness of the medicine in the body is
somewhat low because the medicine that was used is generic.

Key words: acid-base titration, efficiency of antacid, antacid

OBJECTIVES:
- To familiarize the students to Acid Base Titration technique
- To determine the efficiency of an Antacid Tablet determining the amount of
hydrochloric acid they can neutralize.
 Senior High School Department

INTRODUCTION:
Digestion in the stomach results from the action of gastric fluid, which includes
secretions of digestive enzymes, mucous, and hydrochloric acid. The acidic environment
of the stomach makes it possible for inactive forms of digestive enzymes to be converted
into active forms, and acid is also needed to dissolve minerals and kill bacteria that may
enter the stomach along with food. However, excessive acid production (hyperacidity)
results in the unpleasant symptoms of heartburn and may contribute to ulcer formation in
the stomach lining. Antacids are weak bases (most commonly bicarbonates, hydroxides,
and carbonates) that neutralize excess stomach acid and thus alleviate symptoms of
heartburn.

Different brands of antacids contain a diverse range of active ingredients but all
have the purpose of neutralizing excess stomach acid (HCl) by acting as a base. A
chemical technique called a ‘titration’ can be used to see how much acid an antacid tablet
can neutralize. When a base is added to an acid, water and salt are formed. This is called
neutralization. When a known amount of acid is added to an unknown amount of base, a
measurable amount of the acid is neutralized. By measuring the amount of acid
neutralized, the initial amount of base can be determined. The stronger the antacid, the
more acid can be neutralized.

PROCEDURE:
1. Prepare one liter of approximately HCl solution by diluting 10 ml of the
concentrated acid for one liter. Also prepare a NaOH solution.
2. Prepare the 0.2g of antacid tablets by grounding in a mortar and pestle and weigh
it using the digital weighing scale.
3. Put the 0.2g antacid in an Erlenmeyer flask and dissolve it in 50ml HCl acid
solution.
4. Add three drops of phenolphthalein to serve as an indicator.
5. Fill the burette with Sodium Hydroxide (NaOH) solution until it reaches the 0 mark.
6. Titrate this solution against the standardized NaOH solution, till a permanent
pinkish tinge is obtained.
7. Measure the initial and final volume of the Sodium Hydroxide solution
8. Solve for the HCl/wt of the antacid.
 Senior High School Department

RESULTS AND DISCUSSIONS

Mass of Volume of Drops of Initial Final Total
Kremil-S HCl Solution Indicator Volume of Volume of Volume of
NaOH NaOH NaOH
0.2 grams 50mL 3 drops 0mL 11.0mL 11.0mL
Table 1: Determination in Volume of Base used to Neutralize Acid with Kremil-S by Titration Method

This table showed the volume used for sodium hydroxide in order to neutralize
hydrochloric acid with the help of an antacid (Kremil-S).
Calculation for the moles of HCl neutralized by antacid
The weight of HCl neutralized by the antacid can be calculated with this equation:
WeightHCl = MolweightHCl (MHCl◦VHCl - MNaOH◦VNaOH)
WeightHCl = 36g/mol [(0.1mol/L)0.05L – (0.1mol/L)0.011L]
WeightHCl = 0.1404g
𝑊𝑒𝑖𝑔ℎ𝑡𝐻𝐶𝑙 0.1404𝑔
= = 𝟎. 𝟕
𝑔 𝑡𝑎𝑏𝑙𝑒𝑡 0.2𝑔

CONCLUSION

Results showed that the antacid activity of Kremil-S as a neutralizing agent to an

acid was better that a single base. This indicated that Kremil-S is a good treatment when
having hyperacidity because it neutralized more acid in the stomach directly. Thus, two
or more bases were needed to neutralize effectively stomach hyperacidity.

REFERENCE:

Acid–base titration. (2018, December 20). Retrieved from https://en.wikipedia.org/wiki/Acid–base_titration

Ana Margarita, B. L., & Rochelle, E. P. (2017). Analysis of Stomach Antacid Tablet. University of Science
and Technology of Southern Philippines.