Natural Sciences (/academics/areas-of-study/natural%20sciences)

Chemistry
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CHM 201

An introductory course. Principles of chemistry;

General Chemistry I understanding the world around us; structure
and reactions of atoms and molecules;
Professor/Instructor
laboratory manipulations, preparations, and
Michael H. Hecht, Robert Paul L’Esperance,
analysis. Fulfills medical school entrance
Sonja Angelique Francis
requirements in general chemistry and
qualitative analysis. Three lectures, one class,
one three-hour laboratory. Open to those
whose mathematics preparation is insufficient
to qualify them for 203.

CHM 202

Continuation of 201. Principles of chemistry;

General Chemistry II
Professor/Instructor
Andrew Bruce Bocarsly, Robert Paul
L’Esperance, Sonja Angelique Francis
introduction to chemical bonding and solid
state structure; chemical kinetics, nuclear
chemistry; descriptive inorganic chemistry;
laboratory manipulations, preparations, and
analysis. Fulfills medical school entrance
 requirements in general chemistry and
qualitative analysis. Three lectures, one class,
one three-hour laboratory.

CHM 203

The fundamental principles of chemistry;

Advanced General descriptive chemistry, molecular structure, and
Chemistry I bonding. Lectures and demonstrations.
Laboratory includes qualitative and
Professor/Instructor quantitative methods in chemical analysis, as
well as selected experiments in general
chemistry. Fulfills medical school entrance
requirements in general chemistry and
qualitative analysis. Three lectures, one class,
one three-hour laboratory.

CHM 204

Continuation of 203. Topics in chemistry

Advanced General selected to illustrate fundamental principles;
Chemistry II electrochemistry, chemical kinetics, bonding,
and descriptive chemistry focusing on
Professor/Instructor inorganic chemistry. Lectures and
demonstrations. Laboratory includes
qualitative and quantitative methods in
chemical analysis, as well as selected
experiments in general chemistry. Fulfills
medical school entrance requirements in
general chemistry and qualitative analysis.
Three lectures, one class, one three-hour
laboratory.

CHM 207

Introduction to the basic concepts of

Advanced General chemistry: stoichiometry, types of reactions,
Chemistry: Materials thermodynamics, quantum mechanics, and
chemical bonding. Introduction to the
Chemistry structure, chemistry, and properties of
technologically important materials: metals,
Professor/Instructor semiconductors, ceramics, and polymers.
Robert Paul L’Esperance, Haw Yang, Bruce
E. Koel Fulfills medical school requirements in general
chemistry and qualitative analysis. Three
lecture hours, one class, one three-hour
laboratory.

CHM 215

An intensive study of fundamental theoretical

Advanced General and experimental principles. Topics are drawn
Chemistry: Honors from physical, organic, and inorganic
chemistry. For students with excellent
Course preparation who are considering scientific
careers. Fulfills medical school entrance
Professor/Instructor requirements in general chemistry and
Paul J. Chirik, Robert Paul L’Esperance qualitative analysis. Completion of 215
qualifies the student for 300-level courses and
some 400-level courses after consultation with
the instructor of the upper-level course. Three
lectures, one class, one three-hour laboratory.

ISC 231 / CHM 231 / COS 231 / MOL 231 /

PHY 231
An integrated, mathematically and
computationally sophisticated introduction to
An Integrated, physics, chemistry, molecular biology, and
Quantitative computer science. Alternative to the
combination of PHY 103-104, CHM 201-202,
Introduction to the MOL 214-215 and COS126. Students must
enroll in ISC231 and ISC232 in the fall and
Natural Sciences I ISC233 and ISC234 in the spring.
Prerequisites: familiarity with calculus at the
Professor/Instructor
level of MAT103/104 or Advanced Placement
Curtis Gove Callan Jr., Joshua William
Calculus BC, solid high school physics and
Shaevitz, Peter Andolfatto
chemistry courses. Five lectures, one three-
hour laboratory, one three-hour computational
laboratory, one evening problem session.

ISC 232 / CHM 232 / COS 232 / MOL 232 /

PHY 232
An integrated, mathematically and
computationally sophisticated introduction to
physics, chemistry, molecular biology, and
 computer science. Alternative to the
An Integrated, combination of PHY 103-104, CHM 201-202,
MOL 214-215 and COS126. Students must
Quantitative enroll in ISC231 and ISC232 in the fall and
ISC233 and ISC234 in the spring.
Introduction to the Prerequisites: familiarity with the calculus at
Natural Sciences I the level of MAT 103-104 or Advanced
Placement Calculus BC, solid high school
Professor/Instructor physics and chemistry courses. Five lectures,
Peter Andolfatto, Curtis Gove Callan Jr., one three-hour laboratory, one three-hour
Joshua William Shaevitz computational laboratory, one evening
problem session.

ISC 233 / CHM 233 / COS 233 / MOL 233 /

PHY 233
An integrated, mathematically and
computationally sophisticated introduction to
An Integrated, physics and chemistry, drawing on examples
Quantitative from biological systems. Alternative to the
combination of PHY 103-104, CHM 201-202,
Introduction to the MOL 214-215, and COS126. Students must
enroll in ISC231 and ISC232 in the fall and
Natural Sciences II ISC233 and ISC234 in the spring.
Prerequisites: familiarity with the calculus at
Professor/Instructor
the level of MAT 103-104 or Advanced
Joshua William Shaevitz, Olga G.
Placement Calculus BC, solid high school
Troyanskaya, Haw Yang
physics and chemistry courses. Five lectures,
one three-hour laboratory, one three-hour
computational laboratory, one evening
problem session.

ISC 234 / CHM 234 / COS 234 / MOL 234 /

PHY 234
An integrated, mathematically and
computationally sophisticated introduction to
An Integrated, physics and chemistry, drawing on examples
Quantitative from biological systems. Alternative to the
combination of PHY 103-104, CHM 201-202,
Introduction to the MOL 214-215 and COS126. Students must
enroll in ISC231 and ISC232 in the fall and
Natural Sciences II ISC233 and ISC234 in the spring.
Prerequisites: familiarity with the calculus at
Professor/Instructor
the level of MAT 103-104 or Advanced
Joshua William Shaevitz, Olga G.
Placement Calculus BC, solid high school
Troyanskaya, Haw Yang
 physics and chemistry courses. Five lectures,
one three-hour laboratory, one three-hour
computational laboratory, one evening
problem session.

GEO 255B / AST 255 / EEB 255 / CHM 255

Introduces students to Astrobiology, a new

Life in the Universe field where scientists trained in biology,
chemistry, astrophysics and geosciences
Professor/Instructor
combine their skills to unravel life’s origins and
Tullis C. Onstott, Christopher F. Chyba, A.
to search for extraterrestrial life. Topics
James Link
include: the astrophysical prerequisites for life,
the RNA world, the evolution of metabolism
and photosynthesis, microbes in extreme
environments, and the search for life within
our solar system and in nearby solar systems.
Two 90 minute lectures and field training in
Yellowstone National Park over Fall break is
required. Prerequisite: one geoscience,
chemistry, biology or astronomy class or
instructors’ permission.

GEO 255A / AST 255 / EEB 255 / CHM 255

Introduces students to Astrobiology, a new

Life in the Universe field where scientists trained in biology,
chemistry, astrophysics and geosciences
Professor/Instructor
combine their skills to unravel life’s origins and
Tullis C. Onstott, Christopher F. Chyba, A.
to search for extraterrestrial life. Topics
James Link
include: the astrophysical prerequisites for life,
the RNA world, the evolution of metabolism
and photosynthesis, microbes in extreme
environments, and the search for life within
our solar system and in nearby solar systems.
Two 90 minute lectures. Track A will be
required to take a mid-term exam during Fall
break. Prerequisite: one geoscience,
chemistry, biology or astronomy class or
instructors’ permission.

CHM 301
 An introductory course that covers the
Organic Chemistry I structures, properties, spectroscopy, and
reactivity of organic compounds. Students will
Professor/Instructor
learn the mechanisms of organic chemistry
and general principles through a combination
of lectures and problemsolving in small
groups. The course may be followed by 302 or
304. This course is appropriate for students in
chemistry, biology, and premedical programs.
Prerequisite: 201 and 202; or 203 (or 207)
and 204; or 215; or a score of 5 on the AP
Chemistry Exam. Three lectures, one three-
hour laboratory.

CHM 302

Continuation of 301. The principles introduced

Organic Chemistry II in 301 are extended to the structures and
reactions of more complex, often
Professor/Instructor
polyfunctional molecules. Small-group
problemsolving is emphasized. This course is
appropriate for students in chemistry, biology,
and premedical programs. Prerequisite: 301.
Three classes, one three-hour laboratory.

CHM 303

Introductory course devoted to the concepts of

Organic Chemistry I: organic chemistry, including the structures,
Biological Emphasis properties, and reactivity of simpler organic
compounds. Emphasis on the mechanisms of
Professor/Instructor organic chemistry; examples from biology
Martin F. Semmelhack, Henry Lee Gingrich, when appropriate to illustrate the principles.
Susan Killian VanderKam The course should be followed by 304 in
spring. Appropriate for students in biology or
premedical programs. Prerequisite: 201 and
202; or 203 (or 207) and 204; or 215; or a
score of 5 on the AP Chemistry Exam. Three
lectures, one preceptorial, one three-hour
laboratory.

CHM 304
 Continuation of 303 (or 301). The concepts
Organic Chemistry II: introduced in CHM 303 will be extended to the
Foundations of structures and reactions of more complex
molecules, with an emphasis on how organic
Chemical Reactivity chemistry provides the framework for
understanding molecular processes in biology.
and Synthesis The fundamental concepts of organic
chemistry will be illustrated, as often as
Professor/Instructor
possible, with examples drawn from biological
Erik J. Sorensen, Bradley Patrick Carrow,
systems. Prerequisite: 301 or 303. Three
Martin F. Semmelhack
lectures, one preceptorial, one three-hour
laboratory.

CHM 305

Introduction to quantum mechanics, surveying

The Quantum World applications in chemistry, physics, molecular
biology, and molecular imaging. Computer-
Professor/Instructor
based tools will be emphasized. Prerequisites:
Gregory D. Scholes
CHM 202 or 204 or 215; MAT 102 or 104;
PHY 101 or 102 or AP Physics. Three lectures,
one preceptorial.

CHM 306

Introduction to chemical thermodynamics,

Physical Chemistry: statistical mechanics, and kinetics. Special
Chemical emphasis on biological problems, including
nerve conduction, muscle contraction, ion
Thermodynamics and transport, enzyme mechanisms, and
macromolecular properties in solutions. Three
Kinetics lectures. Prerequisites: 201 and 202, or 203
(or 207) and 204, or 215; MAT 104; PHY 101
Professor/Instructor
and 102, or PHY 103 and 104; or instructor’s
Michael T. Kelly
permission.

CEE 311 / CHM 311 / GEO 311 / ENE 311

The chemical and physical processes involved

Global Air Pollution in the transformation, transport, sources, and
sinks of air pollutants on local to global scales.
Professor/Instructor
Topics include photochemical smog,
Mark Andrew Zondlo

GEO 363 / CHM 331 / ENV 331
Environmental
Geochemistry:
Chemistry of the
Natural Systems
Professor/Instructor
Satish Chandra Babu Myneni
CHM 333 / ENV 333 / GEO 333
Oil to Ozone:
Chemistry of the
Environment
Professor/Instructor
MOL 345 / CHM 345
particulate matter, greenhouse gases, and
stratospheric ozone depletion. Students will
have the unique opportunity to analyze
chemical and physical data acquired in real-
time from the NSF Gulfstream-V research
aircraft as it probes the atmosphere from the
Earth’s surface to the lower stratosphere over
a latitudinal range from the Arctic to the
Antarctic. A wide range of environments will be
studied, from very clean, remote portions of
the globe to urban megacities.
Covers topics including origin of elements;
formation of the Earth; evolution of the
atmosphere and oceans; atomic theory and
chemical bonding; crystal chemistry and ionic
substitution in crystals; reaction equilibria and
kinetics in aqueous and biological systems;
chemistry of high-temperature melts and
crystallization process; and chemistry of the
atmosphere, soil, marine, and riverine
environments. The biogeochemistry of
contaminants and their influence on the
environment will also be discussed. Two 90-
minute lectures. Prerequisite: one term of
college chemistry or instructor’s permission.
The chemistry behind environmental issues,
including energy consumption, atmospheric
change, water consumption and pollution, food
production and toxic chemicals. The course
includes discussion of questions and
problems, guest lectures, and a group project
to construct an informational Web page.
Prerequisites: a 200-level chemistry course or
permission of instructor.

Biochemistry
Professor/Instructor
GEO 364 / CHM 364
Earth Chemistry: The
Major Realms of the
Planet
Professor/Instructor
Daniel Mikhail Sigman
CHM 371
Experimental
Chemistry
Professor/Instructor
Michael T. Kelly, Chia-Ying Wang
Fundamental concepts of biomolecular
structure and function will be discussed, with
an emphasis on principles of thermodynamics,
binding and catalysis. A major portion of the
course will focus on metabolism and its logic
and regulation. Prerequisites: MOL 214/215
and either CHM 304/304B or ISC 335. CHM
304/304B may be taken concurrently with
MOL 345.
The chemical composition of the major realms
of the planet: core, mantle, continents, ocean,
atmosphere, and biosphere. Topics include the
synthesis of the chemical elements in stars,
the origin of the solar system and Earth, and
the chemical differentiation of Earth’s core,
mantle, crust, ocean, atmosphere, and
biosphere. Also explores the global cycles of
carbon, nitrogen, and other biologically
important elements, their interactions with the
geosphere, and their evolution through time.
Prerequisites: CHM 201, or equivalent; MAT
103, or equivalent. Three lectures.
Discusses the principles of experimental
design, data acquisition, analysis and
interpretation, and the presentation of
experimental results. Students are exposed to
a broad range of quantitative laboratory
methods in preparation for thesis work in
chemistry. Typical laboratory exercises include
synthesis, physical characterization,
spectroscopy, kinetics, thermodynamics,
electronics ,and instrument design. Lectures
on experimental design, data analysis,
interpretation, and presentation. Two lectures,
two three-hour laboratories.
CHM 403

A selection of advanced topics in organic

Advanced Organic chemistry. Topics include reaction
Chemistry mechanisms, synthetic chemistry, chemistry of
biologically important molecules. Selected
Professor/Instructor biosynthetic pathways are compared and
John Taylor Groves, Paul Joseph Reider contrasted to synthetic approaches. Three
lectures. Prerequisites: 301 and 302 (or 304);
or, 303 and 304.

CHM 405

Introduction to quantum theory, atomic and

Advanced Physical molecular structure, and spectroscopy. This
Chemistry: Quantum course will emphasize the development of
fundamental underlying principles and
Mechanics illustrative examples. Prerequisites: 202, 204,
or 215; MAT 201 or 203 (required); MAT 202
Professor/Instructor or 204 (very helpful, even if taken
concurrently); PHY 103 (may be taken
concurrently) or AP Physics. Three lectures,
one preceptorial.

CHM 406

Statistical thermodynamics, kinetics, and

Advanced Physical molecular reaction dynamics. Three lectures.
Chemistry: Chemical Prerequisites: background in thermodynamics
as developed in 202, 204, or 215; MAT 201 or
Dynamics and equivalent.

Thermodynamics
Professor/Instructor
Chia-Ying Wang

CHM 407

Structural principles and bonding theories are

Inorganic Chemistry: discussed for the various classes of inorganic
Structure and Bonding and organometallic compounds. Includes an
introduction to the electronic structure of
Professor/Instructor transition elements and ligand field theory.
Susan Killian VanderKam Prerequisites: 201 and 202, or 207 and 202,
or 215, or advanced placement. Three
lectures.

CHM 408

Synthetic and mechanistic aspects of

Inorganic Chemistry: inorganic chemistry are presented; modern
Reactions and problems in inorganic chemistry are
emphasized. Prerequisites: 201 and 202, or
Mechanisms 207 and 202, or 215, or advanced placement.
Three lectures.
Professor/Instructor
Jeffrey Schwartz, Susan Killian VanderKam

CBE 415 / CHM 415 / MSE 425

Broad introduction to polymer science and

Polymers technology, including polymer chemistry (major
synthetic routes to polymers), polymer physics
Professor/Instructor
(solution and melt behavior, solid-state
Richard Alan Register
morphology and properties), and polymer
engineering (overview of reaction engineering
and melt processing methods). Three lectures.
Prerequisites: CHM 301 or 303, which may be
taken concurrently, and MAT 104, or
permission of the instructor.

GEO 418 / CHM 418

Application of quantitative chemical principles

Environmental to the study of natural waters. Includes
Aqueous equilibrium computations, weathering and
diagenetic processes, precipitation of chemical
Geochemistry sediments, and pollution of natural waters.
Two lectures. Prerequisite: one year of college
Professor/Instructor chemistry. Previous or concurrent enrollment
François Morel in CHM 306 recommended.

CBE 421 / CHM 421 / ENE 421

Catalytic Chemistry Concepts of heterogeneous catalysis applied
to chemical processes. Major industrial
Professor/Instructor processes based on heterogeneous catalysis,
Jay Burton Benziger including ammonia synthesis, partial oxidation,
petroleum refining, and environmental control.
The major classes of heterogeneous catalysts,
such as solid acids and transition metals, and
the classes of chemical reactions catalyzed by
these materials. Processing conditions and
reactor design are considered. Fundamentals
of surface reactivity will be explored. Two
lectures. Prerequisite: CHM 303 organic
chemistry.

GEO 470 / CHM 470

Focuses on the inorganic and organic

Environmental constituents of aqueous, solid, and gaseous
Chemistry of Soils phases of soils, and fundamental chemical
principles and processes governing the
Professor/Instructor reactions between different constituents. The
Satish Chandra Babu Myneni role of soil chemical processes in the major
and trace element cycles, and the
biogeochemical transformation of different soil
contaminants will be discussed in the later
parts of the course. Prerequisites:
GEO363/CHM331/ENV331, or any other basic
chemistry course. Two 90-minute lectures.

CHM 501

Basic development of quantum theory and the

Basic Principles of Schroedinger equation. Single-particle
Quantum Mechanics potential problems, an introduction to angular
momentum theory, and operator concepts and
Professor/Instructor electron structure.
Herschel Albert Rabitz

CHM 502
Advanced Quantum Typical topics covered include advanced
aspects of angular momentum theory,
Chemistry scattering, time dependent processes, and
interaction of radiation with matter. Specialized
Professor/Instructor topics are included at the discretion of the
Annabella Selloni, Denys Ivanovych Bondar instructor.

CHM 503 / CBE 524 / MSE 514

Statistical mechanics provides the basis for

Introduction to understanding the equilibrium and
Statistical Mechanics nonequilibrium properties of matter in terms of
the microscopic details of molecular
Professor/Instructor interactions and structure. The course aims to
Salvatore Torquato, Roberto Car provide students with working knowledge of
the fundamentals and applications of
statistical mechanics.

CHM 504

This course will cover selected topics in

Molecular molecular spectroscopy with an emphasis on
Spectroscopy the basic principles. An additional focus will be
placed on strong radiation field interactions
Professor/Instructor with molecules going into a regime where the
Chia-Ying Wang, Gregory D. Scholes spectra and dynamics of the molecules are
influenced by the radiation.

CHM 509

Topics covered vary from year to year and are

Topics in Physical selected from the following: state-selected
Chemistry chemical processes; high-resolution
spectroscopy; energy transfer and
Professor/Instructor redistribution; laser-induced chemistry;
Roberto Car surface chemistry; electronic properties of
conjugated polymers; nonlinear optical
materials; physical electrochemistry;
heterogeneous reaction dynamics;
spectroscopy and dynamics of clusters; and
chaotic systems.
CHM 510 / PHY 544
Topics in Physical
Chemistry
Professor/Instructor
Salvatore Torquato, Roberto Car
MSE 513 / CHM 511 / MAE 516
Introduction to
Nanotechnology
Professor/Instructor
Michael C. McAlpine
CHM 512
Chemical Kinetics
Professor/Instructor
Steven L. Bernasek
CHM 513
Electronic Structure
Theory
Professor/Instructor
Topics covered vary from year to year and are
selected from the following: state-selected
chemical processes; high-resolution
spectroscopy; energy transfer and
redistribution; laser-induced chemistry;
surface chemistry; electronic properties of
conjugated polymers; nonlinear optical
materials; physical electrochemistry;
heterogeneous reaction dynamics;
spectroscopy and dynamics of clusters; and
chaotic systems.
The first part of the course contains
fundamental chemical concepts and basic
ideas needed to calculate the difference
between the bulk properties of matter and the
properties of aggregates. The second part
describes the tools needed to probe matter at
the nanoscale level. The third part discusses
examples of nanoscale materials (clusters,
monolayers, fullerenes, biomolecules) and
their applications.
Discussion of reaction rate theory, molecular
dynamics and experimental techniques.
An introduction to the basic aspects of the
electronic structure theory of molecules and
materials in the context of simple model
Hamiltonians. Topics include: molecules,
crystallline solids, clusters and
 nanostructures, defects, surfaces and
disordered materials, optical properties,
simple models of electron-phonon and
electron-electron interaction. Basic knowledge
of quantum mechanics at the single particle
level required.

CHM 515

Broad introduction to major contemporary

Biophysical Chemistry
I functions, and interactions of biological
Professor/Instructor
Nozomi Ando, Joshua D. Rabinowitz
techniques used to study structures,
macromolecules. Emphasis on applications,
practical aspects, and experimental design
rather than theory, and on strengths and
limitations of individual methods and
complementarities among them. Intended to
convey to students with diverse backgrounds
and interests the utility of each method for
solving molecular problems.

CHM 516

Comprehensive introduction to major

Biophysical Chemistry contemporary techniques used to study the
II structures, functions, and interactions of
biological macromolecules, with an emphasis
Professor/Instructor on applications rather than theory. Particular
Jannette Carey, Nozomi Ando, Joshua D. stress is laid on the strengths and limitations
Rabinowitz of individual methods and the
complimentarities among them. Methods
covered include spectroscopies (UV,
florescense, CD, and NMR), X-ray diffraction,
hydrodynamic and transport methods
(sedimentation and diffusion), and
miscellaneous methods.

CHM 521

Familiarizes the student with basic principles

Organometallic of structural reactivity of transition metal
Chemistry organometallic chemistry.
Professor/Instructor
Abigail Gutmann Doyle

CHM 522 / MSE 592

Advanced topics in inorganic chemistry,

Advanced Inorganic including solid-state and bioinorganic
Chemistry chemistry, band theory, and reaction
mechanisms.
Professor/Instructor
Paul J. Chirik, Leslie Mareike Schoop

CHM 523

Chemistry of transition metal complexes and

Coordination ligand field and molecular orbital theory.
Chemistry
Professor/Instructor
Andrew Bruce Bocarsly

CHM 524

Topics covered vary from year to year and are

Topics in Inorganic selected from the following: inorganic
Chemistry spectroscopy and applications to chemical
bonding in transition metal complexes;
Professor/Instructor homogeneous catalysis based on transition
Andrew Bruce Bocarsly, Susan Killian metal systems; noninnocent ligand and
VanderKam fluxional processes; organic synthesis via
organometallic reagents and the mechanisms
of these reactions; metal clusters;
stereochemistry of inorganic reactions; and
bioinorganic chemistry.

GEO 568 / CHM 528

This course focuses on selected topics in

Advanced Aqueous aqueous chemistry of the natural systems,
Chemistry including: chemistry of inorganic and organic
species in aqueous solutions- hydration,
Professor/Instructor hydrolysis, coordination chemistry of metal-
Satish Chandra Babu Myneni ligand complexes, chemical equilibria in fresh
 and saline water; mineral dissolution and
alteration, recrystallization and evolution of
secondary phases, dissolution kinetics;
nucleation and precipitation of minerals,
biological control in mineral precipitation,
precipitation kinetics; electron transfer in
aquatic systems, redox equilibria and kinetics;
chemistry of water-solid/air interfaces.

CHM 529

Topics covered vary from year to year. The

Topics in Inorganic subject matter will be selected from among
Chemistry the following, related to the inorganic
chemistry of solids: point group and space
Professor/Instructor group symmetry, irreproducible
Robert Joseph Cava, Annabella Selloni, representations, structure-property relations,
Andrew Bruce Bocarsly crystallography, methods in X-ray, neutron and
electron diffraction science, the structures of
solids and molecules, the electronic structure
of molecular and non-molecular solids, the
optical, electronic and magnetic properties of
molecular and non-molecular solids and their
relation to crystal structure.

CHM 530

Methods for introduction and modification of

Synthetic Organic functional groups, formation and cleavage of
Chemistry bonds; selection and employment of protecting
groups; control of stereochemistry;
Professor/Instructor manipulation of polyfunctional molecules;
Todd K. Hyster, Erik J. Sorensen design and use of selective reagents; and
multistage syntheses are studied. These areas
of study are illustrated with examples of
outstanding achievements in the total
synthesis of complex molecules.

CHM 532
Mechanistic and The ways in which molecules are changed into
other molecules are studied. Some topics
Physical Organic include mechanisms of acid and base
catalyzed reactions, nucleophilic and
Chemistry electrophilic displacements and substitutions,
addition and elimination reactions,
Professor/Instructor
condensations, inter- and intramolecular
Bradley Patrick Carrow, Robert Randolph
rearrangements, electrocyclic ring openings
Knowles
and closings, and sigmatropic shifts.

CHM 534

A mechanism-based course on modern

Modern Methods for synthetic methodologies for beginning
Organic Synthesis graduate students and advanced
undergraduates. The class will discuss various
Professor/Instructor types of organic reactions, their mechanisms,
Erik J. Sorensen, David W.C. MacMillan the reactive intermediates involved in these
transformations, and the scope and limitations
of each method. The initial goal is to become
fluent in the language of organic chemistry; the
broader objective is to understand
fundamental principles underlying each
transformation. The course is expected to
provide sufficient foundation to comprehend
and use the research literature in chemical
synthesis.

CHM 536

Topics covered vary from year to year and are

Topics in Organic selected from the following: structure,
Chemistry synthesis, reactions, stereochemistry, and
biosynthesis of naturally occurring substances,
Professor/Instructor including polyketides, alkaloids, terpenoids,
Todd K. Hyster, Robert Randolph Knowles and antibiotics; and the structure and
reactivity of reaction intermediates such as
carbonium ions, carbanions, radicals,
carbenes, and excited states.

CHM 538
 The chemical mechanisms of enzyme-
Topics in Biological catalyzed reactions are studied. The nature
Chemistry and sequence of events at enzyme active
sites, emphasizing the participation of
Professor/Instructor prosthetic groups and amino acid side chains
Ralph Elliot Kleiner, Tom Muir in catalysis are also studied. Topics discussed
include the use of kinetic, spectroscopic, and
structural data as well as substrate analog
and isotopic substitution studies for analysis
of enzyme mechanisms.

CHM 539

The operation and application of

Introduction to instrumentation used in modern chemical
Chemical research is covered. Emphasis is on proton
and carbon NMR. Pulsed-Fourier transform
Instrumentation and 2D-NMR techniques are described. The
course also has a laboratory section in which
Professor/Instructor the students get hands-on exposure to FT-NMR
Istvan Pelczer and other spectrometers.

CHM 541 / QCB 541

A chemically and quantitatively rigorous

Chemical Biology II treatment of metabolism and protein
synthesis, with a focus on modern advances
Professor/Instructor
and techniques. Topics include metabolic
Mohammad R. Seyedsayamdost, Ralph Elliot
pathways and their regulation; metabolite and
Kleiner
flux measurement; mathematical modeling of
metabolism; amino acid, peptide and protein
chemistry; protein engineering and selected
applications thereof.

CHM 542 / MOL 542

Structures and properties of biological

Principles of macromolecules. The forces and interactions
Macromolecular that direct biological polymers to adapt
particular 3-dimensional structures are
Structure: Protein discussed from both a structural and a
thermodynamic perspective. Special emphasis
 is placed on recent experimental work probing
Folding, Structure and the folding and stability of proteins as well as
Design on the design of novel proteins.

Professor/Instructor
Michael H. Hecht

CHM 544 / ENV 544

A course in inorganic physiology and

Metals in Biology: biochemistry, presenting the chemical
From Stardust to principles adopted by nature to perform
biological functions. Topics include metal ion
DNA function in protein and nucleic acid structure,
metalloenzyme mechanisms, metal regulation
Professor/Instructor of gene expression, biological energy
John Taylor Groves conversion via ion pumping, storage and
mobilization of the elements, and
biomineralization.

MSE 504 / CHM 560 / PHY 512 / CBE 520

This course examines methods for simulating

Monte Carlo and matter at the molecular and electronic scale.
Molecular Dynamics Molecular dynamics, Monte Carlo and
electronic structure methods will be covered
Simulation in with emphasis on hands-on experience in
writing and/or exercising simulation codes for
Statistical Physics & atomistic and electronic structure simulation.
Materials Science
Professor/Instructor
Roberto Car

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