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COURSE SYLLABUS

2nd Semester, AY 2018-2019

Course Information Faculty Information


Course Code: CHE 426N Name: Engr. May V. Tampus
Course Title: Introduction to Biotechnology Office: Department of Chemical Engineering
Credit Units: 2 Email: mvtampus@usc.edu.ph
Pre-requisites: CHEM 31 Organic Chemistry II Phone: (032)3446783
Schedule: 5:00 – 6:00 PM TTH (LBCH1TC) Consultation See posted schedule on department
Time: bulletin board.
Course Description
This course will provide you a brief treatment of the foundations of biotechnology and some of its present and future
uses. This will also give you the fundamental science behind molecules of life. Attention will be given on the chemistry
and biology of cells, metabolism, and enzymes. Also, the course will briefly introduce cell and enzyme kinetics and
bioreactors.

COURSE OUTCOMES (CO)


By the end of the semester, you should be able to: Alignment to Program Outcomes
CO1: explain the structure, organization, function, The course is enabling to your achievement of:
genetics and metabolism of living matter in molecular [PO1] ability to apply knowledge of mathematics and
terms; science to the general practice of chemical engineering
CO2: define the role of living cells (and the substances and in at least one specialized field of application; and
derived from them) in some biochemical reactions [PO5] ability to identify, formulate, and solve chemical
occurring in nature; engineering problems.
CO3: critique current methods/techniques for the
production of commercially important biochemical The course is introductory to your achievement of:
products; and
[PO9] Ability to engage in life-long learning and to update
CO4: apply the principles governing cell and enzyme oneself continuously with the current trends and
kinetics in solving bioreaction problems. development in a chosen field of specialization; and
[PO10] Understanding of the broad economic,
environmental, societal and global impacts of chemical
engineering solutions.

ASSESSMENT OF OUTCOMES
Your level of achievement of the outcomes shall be evidenced by the quality of your outputs and your performance
in tests and exams.
Formative Summative (Rubric-Based)
For CO1 – CO4: Seatworks & Assignments (SA) For CO1: Molecules of Life Picture Album (PA)
For CO2: Role Play on Metabolism (RP)
For CO3: Paper Critique (PC)
For CO4: Final Examination- Cell & Enzyme Kinetics and
Bioreactors (FE)
Specific guidelines for the preparation and submission of each summative output will be provided in class.

Assessment & Evaluation Rubrics (See Annex)

Output/Performance Rubric Number and Title


Molecules of Life Picture Album Report (PA) [CHE426N-1] Picture Album Report Rubric
Paper Critique (PC) [CHE426N-2] Paper Critique Rubric
Role Play on Metabolism (RP) [CHE426N-3] Role Playing Rubric
Final Examination- Cell & Enzyme Kinetics and Bioreactors [CHE426N-4] Answering Numerical Problems Rubric
(FE)

© Department of Chemical Engineering, University of San Carlos, Cebu City, Philippines Page 1
Portfolio of Seatworks & Assignments (AS)

Grading System
Your grade for the course is computed based on both formative and summative assessment data. The computation
is detailed below.
Grade Component Weight Computation
AS Grade (10%) AS Grade x 0.10
FE Grade (40%) FE Grade x 0.40
PA Grade (15%) PA Grade x 0.15
PC Grade (20%) PC Grade x 0.20
RP Grade (15%) RP Grade x 0.15
Total Grade
Passing Grade: 3.0
Condition for Passing: FE Grades must be 3.0 or better.

LEARNING PLAN
Course
Topics Week Learning Activities
Outcome
Introduction to the Course  Open forum re Course Syllabus
--- 1
 Interactive Discussion
Chemistry and Biology of Cells  Interactive Discussion
 History of Biotechnology  Exercises: Issues on the risk and
 Cellular basis of life new technology
 Organization of cells  Picture Search
CO1
 Biomolecules 2–5
CO2
 Chemical Forces Important to
Biomolecules
 The Structure of DNA
 The Flow of Biological Information
Cellular Metabolism  Interactive Discussion
CO1  Carbohydrate Metabolism  Exercises: Issues on the risk and
6–8
CO2  Protein Metabolism new technology
 Fat Metabolism  Role Playing
MIDTERM EXAM WEEK 9  Submission of Picture Album
Enzyme and Enzyme Kinetics  Interactive Discussion
 Introduction  Calculation Workshop
 Simple Enzyme Kinetics  Reading and Paper Critique: Roles of
CO2  Inhibition of Enzyme Reactions Enzyme and the
CO3  Factors Influencing Enzyme Activity 10 - 13 Methods/Techniques of
CO4  Industrial Application of Enzymes Commercially Important Biochemical
Products
 Final Examination on Enzyme and
Enzyme Kinetics
Cell Kinetics and Bioreactors  Interactive Discussion
 Introduction and Definition of Terms  Calculation Workshop
CO2
 Growth Cycle for Batch Cultivation  Final Examination on Cell Kinetics
CO3 14 - 17
 Laboratory and Industrial Bioreactors and Bioreactors
CO4
 Industrial Application of Cells

FINAL TERM EXAM WEEK 18  Submission of Paper Critique

© Department of Chemical Engineering, University of San Carlos, Cebu City, Philippines Page 2
Learning Resources
Books
1. Bourgaize D, Jewel TR and Buiser RG. Biotechnology (Demystifying the Concepts). Addison Wesley Longman,
INC. 2000.
2. Shuler ML and Kargi F. Bioprocess Engineering Basic Concepts. Prentice-Hall, Inc. NJ, 2002.
3. Lee J. Biochemical Engineering. John Wiley and Sons, USA, 1995.
Note: Numerous books dealing on biotechnology can be found at the Learning Resource Center. Ask the help of our
librarian.
Course Policies
Molecules of Life Picture and Paper Critique Team
You are to form a project team of up to three members to work on presenting a picture album on the molecular
structure of different types of cells and its components. The groups are to submit a written report containing the said
picture collection during the midterm week. Compilation of the said picture album can be softbound or fastened in a
short folder.
For the paper critique report, this will be on the second half of the semester. The teams are allowed up to Week 9 to
decide what specific topic/product they will work with. By Week 10, you must already inform the instructor of the final
topic. The content should focus on the roles of cells and the substances (e.g. enzymes) derived from them and the
new methods/techniques used for the commercial production of biochemicals. At least 15 published research papers
will serve as references. Written report should be submitted during the final week in a softbound copy.
Aside from the hardcopy for the two course requirements, please submit a softcopy (in CD) to the instructor.
Attendance and Tardiness
You are required to attend all classes. The policies in the USC Student Manual (Current Edition) shall be followed.
Coming to class on time is also required. If you are more than 15 minutes late, do not anymore enter the classroom.
You are only allowed three instances of up to 15-minute tardiness for the entire semester. Once you have reached
that allowed number, you will no longer be allowed to come inside the classroom late, even if you are only 1-minute
tardy.
Tests and Examinations
No make-up will be given for missed long tests as these tests are only formative in nature. If you are not able to take
any of the two final examinations on the scheduled date, you can make a formal written request to take a make-up
examination but only in cases when you missed an examination due to serious medical condition or personal
emergency. Pertinent supporting documents must be attached to your letter of request. Any request stands both
chances of getting granted or denied. The instructor shall be the one to set the date and time of the make-up exam.
Timely Submission of Required Outputs
Indicated in the learning plan above are the weeks when the two required outputs (PA and PC) are respectively due.
The exact date and time of the submission deadline will be announced a week before. Outputs submitted beyond the
deadline will not be accepted and will automatically lead to an INC rating for the course. To complete the INC, new
equivalent tasks will be required.
Communication
All course-related communications outside of class should be done through the course email mvtampus@usc.edu.ph.
Supplementary learning materials, announcements, instructions and the like will be through such email. Make sure
that you regularly check your inbox.
Use of Gadgets in Class
Gadgets should only be used in class in aid of learning. It may be allowed that you go online in the classroom if you
want to find out more about the topic being taken up. In no way that you are allowed to use your gadgets in class to
do social networking, games, or other activities that have no direct bearing on the ongoing class activity. At all times,
set your gadgets on silent mode.

© Department of Chemical Engineering, University of San Carlos, Cebu City, Philippines Page 3
Prepared by : _____Engr. May V. Tampus_______________
(Name in print & signature of Faculty Member)

Approved by : _____Engr. Luis K. Cabatingan ________


(Name in print & signature of Department Chair)

Date Approved: ____________________________________

Annex
(CHE 426N: Introduction to Biotechnology)

[ChE 426N-1] Picture Album Report


Partially Meets Does Not Meet
Exceeds Expectations Meets Expectations
Expectations Expectations
1.0-1.3 2.0 3.0 4.0
Picture Collection & Presentation (40%)
It is very obvious what the It is fairly obvious what It requires some time to It is unclear what the
picture collection features; the picture collection identify what the picture picture collection features;
the collection shows clearly features; the collection collection features; the the collection does not
the structure, organization, shows the structure, collection vaguely show show the structure,
function, genetics and organization, function, the structure, organization, organization, function,
metabolism of living matter; genetics and metabolism of function, genetics and genetics and metabolism of
labels are effectively used; living matter; labels are metabolism of living matter; living matter; labels do not
all sources are properly used; all sources are labels are used but can be aid understanding of the
credited. properly credited. better done; some sources picture; sources are not
are not properly credited. credited.
Picture Descriptions (60%)
The accompanying text The accompanying text The accompanying text The accompanying text
describes in concise full describes some detail gives a sketchy general does not describe any
detail the underlying about the underlying remark about an underlying underlying principle or idea
principle or innovative idea principle or innovative idea principle or innovative idea about the design of the
(behind the design of the behind the design of the behind the design of the equipment, equipment part
equipment, equipment part equipment, equipment part equipment, equipment part or material shown in the
or material) as captured in or material; there are a few or material; however, the pictures.
the pictures. mismatches with the description does not show
description and what the a good match with the
pictures are able to show. pictures presented.

© Department of Chemical Engineering, University of San Carlos, Cebu City, Philippines Page 4
[ChE 426N-2] Paper Critique Rubric
Partially Meets Does Not Meet
Exceeds Expectations Meets Expectations
Expectations Expectations
1.0-1.3 2.0 3.0 4.0
Summary (20%)
Well-written summary of Well-written summary of Summary of the article that Not providing a summary of
the article that provides a the article that provides a is either not clear or leaves the article’s contents.
clear description of the clear description of the several questions as to the
article leaving no question article but leaves some contents.
of the contents. questions as to the
contents.
Criticism (70%)
Writing shows a deep Writing shows an average Writing shows a below Writing shows a poor
understanding of the understanding of the average understanding of understanding of the
concepts behind the role of concepts behind the role of the concepts behind the concepts behind the role of
the microorganisms the microorganisms role of the microorganisms the microorganisms
(and/or the substances (and/or the substances (and/or the substances (and/or the substances
derived from them) as derived from them) as derived from them) as derived from them) as
presented in the article. presented in the article. presented in the article. presented in the article.

Interpreted, analyzed, and Interpreted and analyzedInterpretation is either Interpretation is clearly


described new insight(s), new insight(s), methods or
incorrect or not supported incorrect or you have
methods or techniques for techniques for the
by appropriate arguments made no attempt to think
the production of production of commercially
with regards to the new deeply about the concepts
commercially important important biochemical
insight(s), methods or presented in the article.
biochemical products not products in a fairly clear
techniques for the
considered before in a and coherent manner. production of commercially Described the content of
clear and coherent important biochemical the article and have not
manner. Connected most the products. thought deeply about it.
contents of the articles to
Thoroughly connected the other concepts learned. Connected most the
contents of the articles to contents of the articles to
other concepts learned. other concepts learned.
Grammar and Spelling (10%)
Writing is excellent. Writing clear enough to Errors detract somewhat, Errors make reading
support a clear but there seems to be difficult, if not impossible to
No errors. understanding of the general understanding of comprehend.
paper’s content. the paper’s content.
More than five errors.
One or two errors. More than two errors but
less than six.

[ChE 426N-2] Presentation Rubric

Criteria Exceeds Expectations Meets Expectations Partially Meets Did Not Meet
(1.0-1.3) (2.0) Expectations Expectations
(3.0) (4.0)
Knowledge/ Knowledge of topic is Issue is accurately Issue is explained with Issue requires more
Understanding exceptionally accurate and explained and uses many some accuracy but need accurate information and
is explained clearly and details and various sources more details and more details or examples;
effectively during in presentation with some variety in sources and less Heavy reliance on notes
explanation using details of reliance on notes. reliance on notes. during presentation.
the fundamental principles,
relevant theories and
concepts;
There is little reliance on
notes
Delivery & Very clear & concise flow of Clear flow of ideas; Most ideas flow but focus is Hard to follow the flow of
Enthusiasm ideas Demonstrates interest in lost at times; ideas;
topic & engagement with the Lack of enthusiasm &
class interest

© Department of Chemical Engineering, University of San Carlos, Cebu City, Philippines Page 5
Demonstrates passionate Clear enunciation & rate of Limited evidence of interest Many blunders in
interest in the topic & speed is appropriate most of in & engagement with the enunciation & rate of
engagement with the class; the time; topic speed is either too fast or
Very clear enunciation & Speaker sometimes makes Sometimes clear too slow;
rate of speed is appropriate; eye contact with the enunciation & rate of speed Very little or no eye
Speaker makes eye contact audience; is appropriate some of the contact is made with the
with everyone and has no Mildly distracting nervous time; audience;
nervous habits; habits are present but do Speaker makes eye Speaker is reading the
Speaker has excellent not override the content contact with only a selected presentation;
posture few; Nervous habits distract
Nervous habits sometime the audience
distract the audience
Visuals Visuals augment and Use of visuals related to the Limited use of visuals No use of visuals
extend comprehension of material loosely related to the
the issues in unique ways material

[ChE 426N-4] Answering a Numerical Problem Exam Rubric


1.0-1.3 2.0 3.0 4.0
Criteria
Outstanding Competent Marginal Not Acceptable

 All givens  All givens  All givens  Givens are listed


necessary for necessary for necessary for but incomplete;
solving the problem solving the problem solving the problem irrelevant givens are
are stated along are stated along are stated along listed, or givens are
with correct units; with correct units; with units; irrelevant stated without
givens noted in the some irrelevant givens are also accompanying
problem statement givens are also listed. Givens are correct units.
but not necessary listed. Some givens confused with Givens are
for solving the are confused with assumption. confused with
problem are assumption. assumption.
eliminated.

 Problem statement
 Problem statement  Problem statement is ambiguous and/or
is clear and is clear but some  Problem statement misses to indicate
Given and thorough with all requisite variables is clear but critical unknowns
Assumptions variables required for solving the important variables required.
for solving the problem is not for solving the
problem clearly indicated. problem are not
indicated. indicated.

 Assumptions are  Most assumptions


completely listed, are missing.
Assumptions listed
valid, justified.  Assumption  Some assumptions are mostly valid but
completely listed are missing or not justified or
and valid. In some confused with simply implied in the
cases not clearly givens. calculation section.
justified but are Assumptions are
clearly implied in the valid although in
calculation section. some cases not
clearly justified, but
implied in the
calculation section.
 A complete and  Relevant schematic  Relevant schematic  The provided
clear schematic of is provided but is provided but schematic is either
the system being some information important ambiguous or
Interpretation of described is (state and condition) information (state incomplete,
provided and and labels and condition) and hindering the
the problem and
properly labeled. (dimensions and labels (dimensions assessment of the
schematic diagram variables) as and variables) as system described in
described in the described in the the problem.
(If appropriate) problem are problem are not
missing, but would provided, hindering
not hinder the the assessment of
assessment of the the system
system described.

© Department of Chemical Engineering, University of San Carlos, Cebu City, Philippines Page 6
described in the
problem.

 All relevant  All key equations  Some key equations  Most key equations
governing equations are provided are are missing, are missing or
are given in full form mostly in reduced erroneous or erroneous.
form. reduced form of
governing equations
are given.

 Some errors exist in


 Equations are
the reduction and
properly reduced
according to  Equations are mathematical
mathematically manipulation.
assumptions and
manipulated  Many errors exist in
mathematically
correctly to solve for the reduction and
manipulated
unknown on the left mathematical
correctly to solve for
in terms of known manipulation.
unknown on the left
in terms of known on the right (if
Analysis and on the right (if possible).
Solution possible).

 Steps in the  Solution is difficult


analysis are easy to to follow.
follow.
 Steps in the
analysis are easy to
 Unit conversions
follow.
 Unit conversions are correct but not
are explicit and clearly shown
correct.
 Unit conversions
are explicit and  Solution is messy
correct. and not possible to
follow

 Error in the
conversion of units.
 Results are clearly  Results are clearly  Results are given  Results are
indicated, error-free indicated, correct but not clearly incomplete, wrong
and thorough. and thorough. highlighted, or some or difficult to
key results are identify.
missing, or some
are erroneous.
Results and
Interpretations  Correctness of
 Correctness of  Correctness of result is judged.
(When necessary) Validity of answers  Erroneous results
result is judged. result is judged.
Validity of answers Validity of answers in terms of are improperly
in terms of in terms of assumptions is judged to be
assumptions is assumptions is discussed. reasonable, or
discussed. “What if” discussed. assumptions not
scenarios are reflected upon.
considered.

© Department of Chemical Engineering, University of San Carlos, Cebu City, Philippines Page 7

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