Diagnostics

Your doctor will base a diagnosis on the following:

Medical history.
 Your doctor will ask about your signs and symptoms and review your medical history.

Blood tests.
 A sample of your blood is analyzed to see whether you have elevated gastrin levels. While
elevated gastrin may indicate tumors in your pancreas or duodenum, it also can be caused by
other conditions. For example, gastrin may also be elevated if your stomach isn't making acid,
or you're taking acid-reducing medications, such as proton pump inhibitors.

 You need to fast before this test and may need to stop taking any acid-reducing medications to
get the most accurate measure of your gastrin levels. Because gastrin levels can fluctuate, this
test may be repeated a few times.

 Your doctor may also perform a secretin stimulation test. For this test, your doctor first
measures your gastrin levels, gives you an injection of the hormone secretin and measures
gastrin levels again. If you have Zollinger-Ellison, your gastrin levels will increase even more.

 Upper gastrointestinal endoscopy. After you're sedated, your doctor inserts a thin, flexible
instrument with a light and video camera (endoscope) down your throat and into your stomach
and duodenum to look for ulcers. Through the endoscope, your doctor may remove a tissue
sample (biopsy) from your duodenum to help detect the presence of gastrin-producing tumors.
Your doctor will ask you not to eat anything after midnight the night before the test.

 Endoscopic ultrasound. In this procedure, your doctor examines your stomach, duodenum and
pancreas with an endoscope fitted with an ultrasound probe. The probe allows for closer
inspection, making it easier to spot tumors.

It's also possible to remove a tissue sample through the endoscope. You'll need to fast after midnight
the night before this test, and you'll be sedated during the test.

 Imaging tests. We can use imaging techniques such as a nuclear scan called somatostatin
receptor scintigraphy. This test uses radioactive tracers to help locate tumors. Other helpful
imaging tests include ultrasound, computerized tomography (CT) and magnetic resonance
imaging (MRI).

Treatment
Treatment of tumors

 An operation to remove the tumors that occur in Zollinger-Ellison requires a skilled surgeon
because the tumors are often small and difficult to locate. If you have just one tumor, your
doctor may be able to remove it surgically, but surgery may not be an option if you have
multiple tumors or tumors that have spread to your liver. On the other hand, even if you have
multiple tumors, your doctor still may recommend removing a single large tumor.
Other treatments to control tumor growth are the following:

 Removing as much of a liver tumor as possible (debulking)

 Attempting to destroy the tumor by cutting off the blood supply (embolization) or by using heat
to destroy cancer cells (radiofrequency ablation)
 Injecting drugs into the tumor to relieve cancer symptoms
 Using chemotherapy to try to slow tumor growth
 Having a liver transplant
 Treatment of excess acid

 Medications known as proton pump inhibitors are the first line of treatment. These are effective
medications for decreasing acid production in Zollinger-Ellison syndrome.

 Proton pump inhibitors are powerful drugs that reduce acid by blocking the action of the tiny
"pumps" within acid-secreting cells. Commonly prescribed medications include lansoprazole
(Prevacid), omeprazole (Prilosec, Zegerid), pantoprazole (Protonix), rabeprazole (Aciphex) and
esomeprazole (Nexium).

 Long-term use of prescription proton pump inhibitors, especially in people age 50 and older, has
been associated with an increased risk of fractures of the hip, wrist and spine, according to the
Food and Drug Administration. This risk is small and should be weighed against the acid-blocking
benefits of these medications.

 Octreotide (Sandostatin), a medication similar to the hormone somatostatin, may counteract

the effects of gastrin and be helpful for some people