Escolar Documentos
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Cultura Documentos
Author:
John H Pemberton, MD
Section Editor:
Martin Weiser, MD
Deputy Editor:
Wenliang Chen, MD, PhD
Contributor Disclosures
All topics are updated as new evidence becomes available and our peer review
process is complete.
Literature review current through: May 2017. | This topic last updated: Mar 27,
2017.
The indications for surgery, the choice of procedures in different clinical scenarios, the
surgical techniques, and the perioperative considerations are discussed here. The
diagnosis and medical management of acute diverticulitis are discussed separately.
(See "Clinical manifestations and diagnosis of acute diverticulitis in adults" and "Acute
colonic diverticulitis: Medical management".)
INDICATIONS FOR SURGERY — Since most patients with diverticulitis are treated
medically, surgery is only indicated when diverticular disease is either not amenable or
refractory to medical therapy (algorithm 1) [5,7-9].
Indication for emergency surgery — Acute diverticulitis with frank (free) perforation
is a life-threatening condition that mandates emergency surgery [5,9-11].
(See 'Resection' below.)
Indications for urgent surgery — Urgent surgery (in which an operation is generally
required during the same hospitalization) should be performed in patients with one of
the indications discussed below.
Failure of medical treatment — Patients who deteriorate or fail to improve after three
to five days of inpatient intravenous antibiotics may require urgent surgery, as further
medical therapy is unlikely to resolve their diverticulitis. (See "Acute colonic
diverticulitis: Medical management", section on 'Failure of inpatient medical treatment'.)
Colonic obstruction due to diverticular disease is rarely complete, which allows bowel
preparation to be attempted. Alternatively, on-table lavage can be used to clean out the
fecal load, which may also permit a primary anastomosis.
Endoluminal stenting may not be helpful for colonic obstruction caused by diverticulitis.
In a systematic review, treating benign colorectal obstructions (most due to
diverticulitis) with self-expanding stents resulted in more cases of perforation (12
versus 4 percent), stent migration (20 versus 10 percent), and recurrent obstruction (14
versus 7 percent) than stenting malignant colorectal obstructions [12]. When stenting
was used as a bridging therapy to surgery, only 43 percent of patients with diverticulitis
successfully avoided a stoma. (See "Enteral stents for the management of malignant
colorectal obstruction".)
Indications for elective surgery — Patients may require elective colon surgery
because of persistent symptoms from conditions such as diverticular fistula or chronic
smoldering diverticulitis. In addition, asymptomatic patients with a history of acute
diverticulitis may be offered elective surgery based upon their risk of developing
serious complications or dying from a recurrent diverticulitis attack.
Fistula — As a result of diverticulitis, a fistula can develop between the colon and
another pelvic organ, such as the bladder, vagina, uterus, small bowel, or the
abdominal wall. Diverticular fistulas rarely close spontaneously, and therefore require
surgical correction. The management of diverticular fistula is discussed separately.
(See "Acute diverticulitis complicated by fistula formation".)
Patients with prior complicated attack — Elective surgery is indicated for patients
with one prior episode of complicated diverticulitis, such as a microperforation that
was treated with antibiotics, or an abscess that was treated with percutaneous
drainage and/or antibiotics. Studies show that such patients are at a greater risk of
developing complications or dying from a recurrent attack, and therefore would benefit
from early elective surgery [13,14]. (See "Acute colonic diverticulitis: Medical
management", section on 'Complicated first attack'.)
Resection — The primary goal of surgery is to remove the diseased colonic segment,
the feasibility of which is predicated upon a patient's hemodynamic stability.
SURGICAL TECHNIQUES
Laparoscopic surgery for diverticular disease can be performed with the standard
multiport technique or with a technique called single-incision laparoscopic colectomy
(SILC). Studies showed that SILC is feasible and safe when performed by experienced
surgeons [39,40]. In a prospective study of 330 patients with diverticular disease,
patients who underwent SILC had lower peak pain scores compared with patients who
underwent a standard laparoscopic procedure (4.9 versus 5.6) [39]. The techniques of
single-incision laparoscopic surgery are discussed elsewhere. (See "Abdominal access
techniques used in laparoscopic surgery", section on 'Single-incision ports and
placement'.)
Because creating a mucous fistula by bringing the distal end of the transected bowel
through the abdominal wall is often not possible after resecting the entire sigmoid
colon, many surgeons mark the rectal stump with a long nonabsorbable suture and
tack it to the anterior abdominal wall or sacral promontory to help identify the rectal
stump at the second-stage operation.
This approach is most commonly used in Hinchey I or II diverticulitis when there are
relative contraindications to primary anastomosis (eg,
excessive contamination/inflammation of surrounding tissue) but the bowel is not
edematous. It is the preferred approach in this setting because a protective stoma is
easier to close than an end colostomy with a rectal stump [45,46]. (See 'Localized
contamination (Hinchey I or II)' above.)
Although a primary anastomosis is generally not performed for perforated (Hinchey III
or IV) diverticulitis, a primary anastomosis protected by a diverting ileostomy has been
attempted in such patients. In a randomized trial of 62 patients with left-sided colonic
perforation due to Hinchey III or IV diverticulitis, patients treated with a primary
anastomosis with diverting ileostomy, compared with patients treated with a
Hartmann's procedure, had similar mortality (9 versus 13 percent) and morbidity rates
(75 versus 67 percent) after the first operation [47]. However, a greater percentage of
patients treated with a primary anastomosis with diverting ileostomy underwent stoma
reversal (90 versus 57 percent); and reversal of the diverting ileostomy in those
patients required less operative time (73 versus 183 minutes), length of hospital stay (6
versus 9 days), and resulted in fewer serious complications (0 versus 20 percent),
compared with colostomy reversals in patients treated with a Hartmann's procedure.
Further studies are required before this approach can be recommended for general use
in all patients with Hinchey III or IV diverticulitis.
Although a 2010 systematic review of retrospective studies found a low mortality rate of
2 percent and avoidance of a permanent stoma in the majority of patients who
underwent laparoscopic lavage [52], subsequent randomized trials reported conflicting
results:
●In one trial (SCANDIV), 199 patients suspected of having perforated diverticulitis
based upon detection of free air by abdominal computed tomography scan were
randomly assigned to undergo emergency surgery with laparoscopic lavage or
sigmoidectomy [53]. Compared with sigmoidectomy, laparoscopic lavage
achieved similar mortality (13.9 versus 11.5 percent) and severe morbidity rates
(30.7 versus 26 percent) at 90 days. However, patients who were treated with
laparoscopic lavage were more likely to require reoperation (20.3 versus 5.7
percent) for complications such as secondary peritonitis (6 versus 0 patients) or
missed sigmoid cancer (4 versus 0 patients).
●Another randomized trial (LOLA) including 90 patients with purulent perforated
diverticulitis showed that laparoscopic lavage produced a higher combined major
morbidity and mortality rate within 30 days compared with sigmoidectomy (39
versus 19 percent) [54]. At 12 months, the rates were comparable between the
two groups (65 percent for lavage versus 63 percent for sigmoidectomy).
●Another trial (DILALA) randomly assigned 83 patients to laparoscopic lavage or
Hartmann's procedure after a laparoscopic diagnosis of purulent perforated
diverticulitis [55,56]. The mortality rates were similar at both 90 days (8 versus 11
percent) and one year (14 versus 15 percent); the major morbidity rates were
similar at 30 (13 versus 18 percent) and 90 days (21 versus 25 percent). The
reoperation rates were similar at 30 days (13 versus 17 percent). At one year,
however, fewer patients required reoperation after laparoscopic lavage (28 versus
63 percent). In addition, laparoscopic lavage resulted in shorter operative time (1
versus 2.5 hours) and hospital stay (6 versus 9 days for index admission; 8 versus
14 days at one year).
In all three trials, the major morbidity and mortality rates were similar between the two
groups. The trials, however, reported different reoperation rates, which affected their
conclusions (table 1). DILALA was the only trial that favored laparoscopic lavage,
largely due to lower reoperation rates.
However, reoperation rates can be affected by how they are calculated (table 1). All
patients in DILALA assigned to sigmoidectomy underwent colostomy, and colostomy
reversals were counted as reoperations. Thus, the reoperation rate in this trial of 63
percent at one year after sigmoidectomy was almost entirely accounted for by
colostomy reversals. In contrast, only approximately one-half of patients assigned to
sigmoidectomy in LOLA underwent initial colostomy, and colostomy reversals
were not counted as reoperations, resulting in a reoperation rate of just 19 percent.
SCANDIV only reported 90-day reoperation rates, which would not have been affected
by colostomy reversals, as reversals typically occur three to six months after the initial
surgery.
Patients who are candidates for laparoscopic lavage should be advised that a
reoperation (usually sigmoidectomy) may be necessary if laparoscopic lavage fails to
control the sepsis or a sigmoid carcinoma is later found. The reoperation rate is likely to
increase further with longer follow-up; LOLA reported that 20 percent of patients
treated with laparoscopic lavage developed recurrent diverticulitis within just the first
year [54].
Drainage and diversion — A classic procedure for colonic perforation includes three
stages: the first stage involves drainage but not resection of the diseased segment and
construction of a proximal diverting stoma; the second stage involves resection of the
diseased segment with a primary anastomosis under the protection of the proximal
stoma; the third stage closes the proximal stoma.
This classic procedure has been largely replaced by other procedures (eg, the
Hartmann's procedure) because of a higher postoperative mortality rate with the three-
stage procedure (26 versus 7 percent) [57,58]. In contemporary practice, the three-
stage procedure is only performed when inflammation precludes safe pelvic dissection
of the colon from critical sidewall structures (eg, iliac vessels and ureters), or when the
patient is unstable. Drainage and fecal diversion in these situations can serve as a
temporizing measure to allow treatment of infection and inflammation before further
surgery or transfer to a more experienced center. (See "Overview of mechanical
colorectal obstruction", section on 'Three-stage'.)
PERIOPERATIVE CONSIDERATIONS
OUTCOMES
The mortality rates after colon surgery for diverticular disease range from 1.3 to 5
percent depending upon the severity of illness and the presence of comorbidities
[17,60]. Emergency surgery for acute perforated diverticulitis has been associated with
a mortality rate of 15 to 25 percent, and a morbidity rate of up to 50 percent [17-
20,58,61]. Specific complications of colon surgery are discussed elsewhere.
(See "Management of anastomotic complications of colorectal
surgery" and "Management of intra-abdominal, pelvic, and genitourinary complications
of colorectal surgery".)
Patients are typically cured of their diverticular disease after surgery. However, 15
percent will develop new diverticula in the remaining colon, and 2 to 11 percent will
require repeat surgery [24,62,63]. After surgery, up to 27 percent of patients may
complain of persistent abdominal pain in the same location as their prior diverticular
disease. Such patients require further evaluation by gastroenterologists, as these
symptoms are more attributable to coexisting functional intestinal disorders (eg, irritable
bowel syndrome) rather than recurrent diverticulitis. (See "Clinical manifestations and
diagnosis of irritable bowel syndrome in adults" and "Treatment of irritable bowel
syndrome in adults".)
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