Bioanalytical Services

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Proteins, or polypeptides, are organic compounds composed of amino acids.

They are arranged in a linear chain and folded into globular form or other forms.
Proteins are essential components of organisms and they participate in
virtually every process within a cell. Many proteins are enzymes that catalyze
biochemical reactions and are vital to metabolism. Not only are proteins a
major structural component of living systems, they can also be effector
molecules whose states determine downstream activities. Therefore, studying
the protein characterization can reveal the mechanisms behind many of the
cell’s responses to its environment. Given the vast number of applications for
protein analysis, several tools and methods for its study exist; determining the
correct method for your application is paramount to success.

Proteins differ from each other according to the type, number and sequence of
amino acids that make up the polypeptide backbone. Hence, they have
different molecular structures and physiochemical properties. Protein analysis
technologies are used to understand the unique and complex relationships
between proteins. They are utilized in various applications including
biomolecular interactions, enzyme kinetics, heterogeneity applications,
immunogenicity testing and affinity characterization. These applications are
useful in the pharmaceutical, research and quality control industries. Some
features to consider in selecting a protein analysis method are sample size
and type, automation, ease of use, integrated software, binding parameters,
data quality assessment and assay portability. Some protein analysis methods
might be better suited for particular applications so be sure to inquire to
guarantee the best fit for your project.

A workflow example for protein analysis

Profacgen provides bioanalytical services for proteins using the most

cutting-edge technology and experienced experts. Our services are fully
flexible to your needs, and can be used as stand-alone tests or as a
comprehensive package that could include:

Biosimilar testing services

For analytical and bioanalytical comparability of the biosimilar product
Immunogenecity Assay
 For detection and confirmation of anti-drug antibodies (ADAs) and neutralizing antibodies
(NAbs) supporting nonclinical and clinical studies
Stability Analysis
To detect, monitor and characterize proteins during formulation development
Biopharmaceutical Process and Product Related Impurities Analysis
To support bioprocessing validation and biologic product release in line with ICH Q6B

We offer a full package of protein analysis to GLP/cGMP standards and is the

perfect partner for customers looking to outsource your pharmaceutical and
biologic product characterization services. We customize the service
according to the specific requirements from the customers. Please do not
hesitate to contact us for more details about our membrane protein modeling
service.

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