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Perspectives VO LU ME X X XV
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Learning Objectives concerns (eg, difficulty applying eyelid and eyelash
makeup). Dermatochalasis is usually symmetric and has a
gradual onset over several years. An onset over months or
Upon completion of this module, the
significant asymmetry should raise clinical suspicion and
reader should be able to:
prompt further evaluation, particularly for any condition
1
Name the steps in the evaluation of a that causes periorbital edema, such as thyroid eye disease.
patient with dermatochalasis, ptosis, Significant dermatochalasis typically presents after the fifth
and/or brow ptosis. decade. Earlier age of onset, especially with cyclic relapsing
and remitting episodes of periorbital edema, should raise
2
Describe the surgical options available the suspicion of blepharochalasis syndrome, a rare familial
for the treatment of brow ptosis. variant of angioneurotic edema.
3
Describe the surgical options available Examination of the patient with upper eyelid dermato-
for the treatment of ptosis. chalasis centers on the identification of the amount and type
of redundant tissue. The brow position should be determined
4
Identify the surgical complications of (see “Brow Ptosis”), and a ptotic brow, if present, should be
upper blepharoplasty, ptosis, and brow manually normalized to help determine the actual severity of
ptosis procedures. dermatochalasis. The distance from the upper eyelid margin
to the corneal light reflex—or margin–reflex distance 1
(MRD1)—should be documented to identify underlying
ptosis and to determine whether it is primary ptosis or
Introduction secondary to dermatochalasis or brow ptosis. The orbicularis
Management of “droopy lids” constitutes a large part of strength, eyelid closure, and status of the cornea and tear
most oculoplastic surgeons’ practices. However, as straight- film should be evaluated. Any patient with compromised
forward as the concept may seem, “droopy lids” encompass eyelid closure, severely dry eyes, or corneal disease should
a large spectrum of possible etiologies and treatment be counseled about the possibility of a surgical procedure
options. The goal of this module is to assist the oculoplastic causing or worsening dry eye symptoms. Functional versus
surgeon and the comprehensive ophthalmologist in cosmetic concerns should be documented. Preauthorization
understanding the relationships connecting blepharoptosis criteria for insurance are satisfied by preoperative examina-
(ptosis), dermatochalasis, and brow ptosis, and in choosing tion, visual field testing, and photographs.
the most appropriate intervention for the patient.
Overall, the most common etiology of “droopy lids” Upper Eyelid Blepharoplasty
is age related: involutional changes encompass most issues Upper eyelid blepharoplasty is commonly used to correct
noted in brow ptosis, ptosis, and dermatochalasis. These dermatochalasis, whether for cosmetic or functional
findings may coexist, and the treating physician needs to purposes. The surgical procedure has evolved over the
recognize the relative contribution of each condition and years. Currently, there is a trend toward excising skin only
address the distinct anatomical findings in view of the and leaving underlying orbicularis (especially in younger
patient’s goals. Frequently, the contribution of one or more patients or patients predisposed to dry eye). Many surgeons
of these conditions does not require surgical correction, will excise the lateral orbicularis to aid in brow elevation,
especially if one is much more severe than the other. similar to applying botulinum toxin to this area. There
However, the physician must discuss with the patient the is also a trend toward conserving preaponeurotic fat and
main complaints and goals so that a satisfactory outcome excising the medial fat pad. Any lacrimal gland prolapse
can be obtained. In addition, one must also be cognizant should be identified preoperatively, so that the gland can be
of less common conditions that may require specific repositioned intraoperatively.
treatment plans. The procedure has many possible complications. Early
postoperative hemorrhage can be potentially blinding;
this is most common in patients with iatrogenic or innate
Dermatochalasis coagulation abnormalities and cases where there was fat
Dermatochalasis refers to redundant skin and subcutane- manipulation. Other potential complications include over-
ous tissue in and around the eyelids, frequently the correction, undercorrection, eyelid or crease asymmetry,
upper eyelids. (Lower eyelid dermatochalasis is not a unsightly scar, dry eye, and infection. These are potential
subject of this module.) The evaluation of upper eyelid complications of any of the surgical procedures discussed
dermatochalasis assesses the medial fat pad, preaponeurotic
fat, lacrimal gland, and associated structures, including
the eyelashes and eyebrows. Patients often note difficulty Richard C. Allen, MD, PhD, FACS, is a professor, Department
with peripheral vision, skin draping onto the eyelashes, of Head and Neck Surgery, Section of Ophthalmology, at MD
“puffiness” or “swelling” of the upper eyelids, and cosmetic Anderson Cancer Center, in Houston, Texas.
1. Upper Blepharoplasty
VIDEO
Brow Ptosis
Brow ptosis refers to a depression of the eyebrows, most
commonly from involutional changes. Brows are very
important: by looking only at someone’s brows, one can
TECHNIQUE. Upper eyelid blepharoplasty involves mark- often determine the person’s gender, age, and mood.
ing the eyelid crease (or the proposed eyelid crease) and then Typically, female brows are arched in contour, peaked more
marking the amount of excess skin to be excised. A main laterally, and usually rest above the superior orbital rim.
goal is symmetry—patients will notice asymmetry more Male brows tend to be flatter and often at or below the level
than they will undercorrection. For the beginning surgeon, of the superior orbital rim. With age, the brows descend
it is wise to tend toward being conservative. In general, one due to gravity, involutional changes in the underlying
should not necessarily excise the same amount of skin on supportive structure, and loss of deep tissue volume. Often
each side, as much as leave the same amount postoperatively, the temporal portion of the brow is the first area to descend,
because it is common for patients to start with some because the frontalis muscle does not extend lateral to the
asymmetry. A general rule for preparing a woman patient temporal fusion line. Brow height can also be understood
for surgery is to mark an eyelid crease somewhere around by looking at the interplay between the brow elevators and
8–10 mm above the eyelid margin, and, for a man, 6–8 mm the brow depressors. The main brow elevator is the frontalis
above the margin. There should be adequate skin for closure, muscle. Brow depressors include the corrugator, procerus,
and a general rule is to leave 20 mm of skin between the depressor supraciliaris, and orbicularis muscles. The
strength and tension of these muscles should be determined
when examining the height and contour of the brows.
The diagnosis of brow ptosis can be challenging in
that brow heights vary between individuals. Even though
there are discussions on ideal brow height, some brows are
naturally higher in some individuals and lower in others;
examination of previous photos or photos of younger rela-
tives is often helpful (Figure 2), as familial characteristics play
an important role in an individual’s baseline brow position.
The most common cause of brow ptosis is age related.
However, a compromised seventh cranial nerve (CN VII)
a can result in varying degrees of brow ptosis, depending
on the severity of the palsy. Usually a CN VII palsy will be
unilateral; however, there are rare causes of bilateral CN VII
nerve palsies that can be difficult to diagnose, due to the
symmetry. Bilateral CN VII nerve palsies are associated
with other facial muscle weakness, so the evaluation of
brow ptosis should also include assessment of the facial
musculature. Other causes of bilateral brow ptosis include
progressive supranuclear palsy and various muscular
dystrophies. It is important to be aware of the concomitant
b presence of lagophthalmos in many of these patients, as
any upper eyelid or brow elevation surgery can worsen the
Figure 1 Dermatochalasis. a. Preoperative ocular exposure.
evaluation shows dermatochalasis with brow
As with dermatochalasis, one should be vigilant of
descent. b. After upper blepharoplasty,
additional brow descent is noted.
dry eye preoperatively. A brow elevation procedure may
temporarily worsen existing eye dryness. When choosing
a b
the appropriate procedure, the surgeon should have multiple corresponding to the amount of ptosis needing to be cor-
options, and treatment should be individualized to the patient. rected. In general, it is uncommon to take much less than
10 mm and more than 15 mm, unless it is associated with a
Direct Browplasty
CN VII palsy. The marking is incised with a #15 blade, and
Direct browplasty (supraciliary browlift) delivers predict- the skin and subcutaneous fat are resected. Care should be
able results. This procedure is best for older patients who taken to avoid dissection around the supraorbital nerve. The
have significant brow ptosis that is mostly temporal. In defect is then closed with deep interrupted 4-0 polyglactin
addition, it is good for patients who want a simpler surgical sutures, followed by a running 5-0 polyethylene suture.
procedure and will be less bothered if the scar is noticeable Closure techniques and suture choices vary among surgeons.
(Figure 3). In this procedure, an incision is made just above
the cilia of the brow, or above the brow in an advantageous Browpexy
forehead crease. Extending the incision medially is difficult, A browpexy procedure “pushes” the brow superiorly. While
so this lift is best for temporal brow ptosis. Some believe it a browplasty lifts though the excision of tissue above the
is best for women, since an arched contour is attained with brow (“pulling” the brow superiorly), a browpexy is usually
the temporal incision, but men do well with the procedure, performed though a blepharoplasty incision, with dissection
and the resulting scar is easier to conceal due to the denser to release the attachments of the brow and various manipu-
hairs of the male brow. Although this is not thought to be lations to alter the position of the brow. The popularity of
a cosmetic lift, the incisions may heal surprisingly well. browpexy procedures waxes and wanes. The advent of the
Video 2 demonstrates direct browplasty. transblepharoplasty Endotine device (Endotine TransBleph,
Advantech Surgical; Torquay, Devon, England) in the
early 2000s resulted in renewed interest in the procedure;
2. Direct Browplasty however, long-term results showed unimpressive amounts
VIDEO
of sustained brow elevation. The lack of standardization
and quantification, and the postoperative pain that patients
often noted associated with the device, was also discourag-
ing. The procedure seemed to be best suited for men who
TECHNIQUE. A marking is made above the brow or in had a smooth forehead, a high hairline, and an insignificant
a good crease or furrow above it. The amount of brow amount of ptosis. Most surgeons appreciated the procedure
ptosis is determined by lifting the portion of the brow that as a brow stabilizer, without significant lift. The introduc-
appears ptotic. The amount of needed brow elevation is tion of the Ultratine TransBleph has lessened some of the
measured and a marking is made above the initial marking, concerns regarding postoperative pain.
4. Mid-Forehead Browplasty
VIDEO
a b
Figure 5 Patient before
(a) and 8 months after
(b) a pretrichial browplasty
with upper eyelid
blepharoplasty and ptosis
repair (Müller muscle–
conjunctival resection).
c, d. Appearance of the scar
1 month and 8 months after
c d surgery.
9. Bilateral Silicone
Frontalis Sling
VIDEO
will have no change in the palpebral fissure height. Patients Horner syndrome is very effectively treated with MMCR.
with myasthenia respond to the ice test with an increase in For mild unilateral ptosis, attention should be paid to the
palpebral fissure height of 2 mm with an 80% sensitivity pupils. The patient should be asked about previous neck
and 100% specificity. surgery, and checked for pulmonary symptoms and Horner
The sleep test refers to having patients gently close their syndrome. The latter is easily missed. Any unexplained
eyes for 10 minutes followed by opening of the eyes. In some Horner syndrome needs to be fully evaluated for the
patients with myasthenia gravis the ptosis will temporarily underlying etiology.
improve.
Lastly, testing for antibodies to the acetylcholine receptor Mechanical Ptosis
can be useful; these antibodies are present in 80%–90% of Mechanical ptosis refers to a ptotic lid due to a mass or
patients with generalized myasthenia gravis and 50%–75% chronic edema. This can be caused by a tumor, a foreign
of patients with ocular myasthenia gravis. body (traumatic or iatrogenic), or inflammation. It is very
If myasthenia is diagnosed, the patient needs to know important to look for a mechanical etiology in children,
that this is a potentially fatal condition, and they need ex- especially if there is a temporal drooping of the upper
amination and treatment by a neurologist. Once maximum eyelid. It is easy to assume that a patient has congenital
improvement is achieved with medical therapy, surgery ptosis when the problem is a mass, such as a plexiform
can be considered for residual ptosis. Levator advancement neurofibroma in the lateral upper eyelid and anterior
surgery may be effective for mild-to-moderate ptosis. More orbit. Usually, capillary hemangiomas are more obvious.
advanced cases may require combined levator–Müller In adults, a mass is also usually obvious. Amyloid on the
muscle advancement or a silicone frontalis sling procedure. conjunctival surface of the upper eyelid is easy to miss—
so it is important to evert the upper eyelid in all patients,
Neurogenic Ptosis but especially those with ptosis. Also, superior orbital
The most common neurogenic causes of ptosis include lymphomas often cause ptosis in adult patients.
third cranial nerve palsy and Horner syndrome. The main
issue with third nerve palsy is the strabismus. Some third Pseudoptosis
nerve palsies are secondary to trauma and should be Pseudoptosis refers to the situation in which an upper
given 6 months to recover before surgery is considered. eyelid is low relative to the contralateral upper eyelid, but
In nontraumatic cases of third nerve palsy, neuroimaging the patient has other factors, such as strabismus, orbital
studies are important, especially if pupillary involvement disorders, or contralateral eyelid problems, that are causing
is present, to rule out an intracranial aneurysm or tumor. an eyelid to be low relative to the contralateral upper eyelid.
Close collaboration with a strabismus surgeon is helpful Hypertropia may result in an eye that is supraducted rela-
to determine if it will be possible to provide good ocular tive to the eyelid, but when the eye is forced into primary
alignment. Otherwise, it is sometimes acceptable to allow position, the eyelid position becomes normal. Also, a large
the ptosis to provide occlusion to prevent diplopia. Usually hypotropia can cause pseudoptosis, because the eyelid is
a frontalis sling will be necessary (silicone rods are the following the hypotropic eye downward in its infraducted
preferred choice). position.
Preoperative Topics
Conclusion
PODCAST
1. How do you approach the patient with dry Dr. Wulc: While dry eye is not a contraindication to
eyes and blepharoptosis? ptosis repair, patients with a diagnosis of dry eye should
be approached conservatively. All our patients fill out the
Dr. Cole: A patient with pre-existing dry eye syndrome ocular surface disease index questionnaire (OSDI), and
is at significant risk for potential complications after approximately 10% of patients in our practice present with
blepharoptosis surgery. Examples include keratopathy, due mild to moderate dry eye as defined by the OSDI score.
primarily to increased tear evaporative loss, and risk of Preoperatively, the ocular surface should be optimized.
lagophthalmos and corneal exposure. Patients with mild Management might include treatment of pre-existing
dry eye and minimal symptoms typically tolerate ptosis blepharitis and use of artificial tears, gels, oral supplements,
surgery well. In patients with moderate-to-severe dry eye, I punctal plugs, and/or Restasis. In our area, several special-
attempt to diagnose the cause or causes of the patient’s dry ists interested primarily in dry eye have access to diagnostic
eye and optimize its treatment prior to performing ptosis tools and additional treatments, and we often refer patients
surgery. Patients with aqueous tear deficiency benefit from with severe dry eye for treatment prior to surgery.
interventions such as use of preservative-free artificial If the patient has symptomatic severe dry eye, including
tears, cyclosporine ophthlamic emulsion (Restasis), and blurred vision and/or photophobia, and exhibits signs
punctal plugs prior to surgery. Patients with significant such as corneal staining, then consideration to perform
meibomian gland dysfunction benefit from therapies such conservative surgery, or to avoid surgery, must be made in
as warm compresses, artificial tears, eyelid scrubs, and conjunction with the patient, making him or her fully aware
topical agents with anti-inflammatory properties. In my of the risks.
area, patients frequently suffer from ocular rosacea, and If lower eyelid retraction in the dry eye patient
they also benefit from low-dose doxycycline medications. accompanies ptosis, the lower eyelid may be elevated
I have not found treatments of the meibomian glands with simultaneously with the upper ptosis repair, thus maintain-
intense pulse light therapy (IPL) or LipoFlow (TearScience, ing palpebral fissure width as the area of functional vision
Morrisville, NC) to be significantly more effective than is translocated, minimizing additional postoperative surface
warm compresses alone. exposure.
Once tear function has been optimized, we discuss We prefer an external repair approach for ptosis in dry
the pros and cons of correction of their visually significant eye patients because of the theoretic possibility of interfer-
ptosis and their need for a long-term commitment to ing with accessory lacrimal gland function, and because of
continue these therapies after surgery. In patients who elect the ease of postoperative adjustment of aponeurotic repair
to undergo surgery, I often employ the internal levator when necessary. We attempt to avoid overcorrection and
advancement procedure for ptosis, as I have found that often settle for undercorrection. If simultaneous upper
this procedure minimizes risks of overcorrection and
lagophthalmos. In patients who are not candidates for
this procedure or are also in need of a blepharoplasty, I
perform an orbicularis-sparing external levator advance- Eric A. Cole, MD, FACS, is a fellowship-trained oculofacial
plastic and reconstructive surgeon at Cole Aesthetic Center in
ment procedure with intraoperative adjustment and try Silverdale, Washington.
to undercorrect the postoperative margin–reflex distance
1 (MRD1) slightly. Older patients with lower eyelid laxity Allan E. Wulc, MD, FACS, is an oculofacial cosmetic surgeon
with a practice in Plymouth Meeting, Pennsylvania. Dr. Wulc
or inferior scleral show often benefit from a horizontal is an associate clinical professor of ophthalmology at the
tightening procedure simultaneously to improve their tear University of Pennsylvania, and an adjunct clinical associate
pump mechanism. professor of otolaryngology at Temple University.
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