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Focal

Points
Clinical Practice

Perspectives VO LU ME X X XV
N U MB ER 5
MAY 2 01 7

Surgical Management of Ptosis and


Brow Ptosis
Richard C. Allen, MD, PhD, FACS Clinicians’ Corner Consultants
Eric A. Cole, MD, FACS
Allan E. Wulc, MD, FACS
Focal Points Contents
Editorial Review Board
Eric P. Purdy, MD, Bluffton, IN
Editor-in-Chief; Oculoplastic, Lacrimal, and Orbital Surgery Introduction 1
Lisa B. Arbisser, MD, Sarasota, FL
Cataract Surgery Dermatochalasis 1
Deeba Husain, MD, Boston, MA
Brow Ptosis 2
Retina and Vitreous
Katherine A. Lee, MD, PhD, Boise, ID Ptosis 7
Pediatric Ophthalmology and Strabismus
W. Barry Lee, MD, FACS, Atlanta, GA Congenital Ptosis 7
Refractive Surgery; Optics and Refraction
P. Kumar Rao, MD, St. Louis, MO
Ptosis in the Adult 10
Ocular Inflammation and Tumors
Conclusion 13
Sarwat Salim, MD, FACS, Milwaukee, WI
Glaucoma Podcast Discussions 13
Elmer Y. Tu, MD, Chicago, IL
Cornea and External Disease Clinicians’ Corner 14
Billi S. Wallace, MD, Smithville, MO
Neuro-Ophthalmology Suggested Reading 19

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Reviewers and Contributing Editor


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designates this enduring material for a maximum of 2 The following contributors state that they have Copyright ©2017 American Academy of
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aao.org/cme. Click on “Claim CME Credit” to take a Lisa B. Arbisser, MD; Stephen R. Klapper, MD;
Learning Objectives concerns (eg, difficulty applying eyelid and eyelash
makeup). Dermatochalasis is usually symmetric and has a
gradual onset over several years. An onset over months or
Upon completion of this module, the
significant asymmetry should raise clinical suspicion and
reader should be able to:
prompt further evaluation, particularly for any condition
1 
Name the steps in the evaluation of a that causes periorbital edema, such as thyroid eye disease.
patient with dermatochalasis, ptosis, Significant dermatochalasis typically presents after the fifth
and/or brow ptosis. decade. Earlier age of onset, especially with cyclic relapsing
and remitting episodes of periorbital edema, should raise
2 
Describe the surgical options available the suspicion of blepharochalasis syndrome, a rare familial
for the treatment of brow ptosis. variant of angioneurotic edema.
3 
Describe the surgical options available Examination of the patient with upper eyelid dermato-
for the treatment of ptosis. chalasis centers on the identification of the amount and type
of redundant tissue. The brow position should be determined
4 
Identify the surgical complications of (see “Brow Ptosis”), and a ptotic brow, if present, should be
upper blepharoplasty, ptosis, and brow manually normalized to help determine the actual severity of
ptosis procedures. dermatochalasis. The distance from the upper eyelid margin
to the corneal light reflex—or margin–reflex distance 1
(MRD1)—should be documented to identify underlying
ptosis and to determine whether it is primary ptosis or
Introduction secondary to dermatochalasis or brow ptosis. The orbicularis
Management of “droopy lids” constitutes a large part of strength, eyelid closure, and status of the cornea and tear
most oculoplastic surgeons’ practices. However, as straight- film should be evaluated. Any patient with compromised
forward as the concept may seem, “droopy lids” encompass eyelid closure, severely dry eyes, or corneal disease should
a large spectrum of possible etiologies and treatment be counseled about the possibility of a surgical procedure
options. The goal of this module is to assist the oculoplastic causing or worsening dry eye symptoms. Functional versus
surgeon and the comprehensive ophthalmologist in cosmetic concerns should be documented. Preauthorization
understanding the relationships connecting blepharoptosis criteria for insurance are satisfied by preoperative examina-
(ptosis), dermatochalasis, and brow ptosis, and in choosing tion, visual field testing, and photographs.
the most appropriate intervention for the patient.
Overall, the most common etiology of “droopy lids” Upper Eyelid Blepharoplasty
is age related: involutional changes encompass most issues Upper eyelid blepharoplasty is commonly used to correct
noted in brow ptosis, ptosis, and dermatochalasis. These dermatochalasis, whether for cosmetic or functional
findings may coexist, and the treating physician needs to purposes. The surgical procedure has evolved over the
recognize the relative contribution of each condition and years. Currently, there is a trend toward excising skin only
address the distinct anatomical findings in view of the and leaving underlying orbicularis (especially in younger
patient’s goals. Frequently, the contribution of one or more patients or patients predisposed to dry eye). Many surgeons
of these conditions does not require surgical correction, will excise the lateral orbicularis to aid in brow elevation,
especially if one is much more severe than the other. similar to applying botulinum toxin to this area. There
However, the physician must discuss with the patient the is also a trend toward conserving preaponeurotic fat and
main complaints and goals so that a satisfactory outcome excising the medial fat pad. Any lacrimal gland prolapse
can be obtained. In addition, one must also be cognizant should be identified preoperatively, so that the gland can be
of less common conditions that may require specific repositioned intraoperatively.
treatment plans. The procedure has many possible complications. Early
postoperative hemorrhage can be potentially blinding;
this is most common in patients with iatrogenic or innate
Dermatochalasis coagulation abnormalities and cases where there was fat
Dermatochalasis refers to redundant skin and subcutane- manipulation. Other potential complications include over-
ous tissue in and around the eyelids, frequently the correction, undercorrection, eyelid or crease asymmetry,
upper eyelids. (Lower eyelid dermatochalasis is not a unsightly scar, dry eye, and infection. These are potential
subject of this module.) The evaluation of upper eyelid complications of any of the surgical procedures discussed
dermatochalasis assesses the medial fat pad, preaponeurotic
fat, lacrimal gland, and associated structures, including
the eyelashes and eyebrows. Patients often note difficulty Richard C. Allen, MD, PhD, FACS, is a professor, Department
with peripheral vision, skin draping onto the eyelashes, of Head and Neck Surgery, Section of Ophthalmology, at MD
“puffiness” or “swelling” of the upper eyelids, and cosmetic Anderson Cancer Center, in Houston, Texas.

Focal Points Module 5, 2017 1


in this module. One frequently overlooked complication of eyelashes and the inferior eyebrow cilia. This can sometimes
upper blepharoplasty is brow depression; if skin is removed be difficult to identify in patients who manicure their
below the brow, the brow will descend (Figure 1). This brows, and the junction between thin eyelid skin and thick
descent may be ever so slight, but potentially noticeable. eyebrow skin can be used in place of the inferior brow cilia.
This highlights the importance of recognizing brow ptosis The cutting instrument of the surgeon’s choice can be used,
preoperatively and addressing brow malposition at the time including but not limited to a blade, monopolar cautery,
of blepharoplasty surgery. Video 1 demonstrates upper laser, and thermal cautery. Sutures and methods of closure
blepharoplasty. vary. Many surgeons prefer a running 6-0 monofilament
suture that is removed at a 1-week postoperative visit.

1. Upper Blepharoplasty
VIDEO
Brow Ptosis
Brow ptosis refers to a depression of the eyebrows, most
commonly from involutional changes. Brows are very
important: by looking only at someone’s brows, one can
TECHNIQUE. Upper eyelid blepharoplasty involves mark- often determine the person’s gender, age, and mood.
ing the eyelid crease (or the proposed eyelid crease) and then Typically, female brows are arched in contour, peaked more
marking the amount of excess skin to be excised. A main laterally, and usually rest above the superior orbital rim.
goal is symmetry—patients will notice asymmetry more Male brows tend to be flatter and often at or below the level
than they will undercorrection. For the beginning surgeon, of the superior orbital rim. With age, the brows descend
it is wise to tend toward being conservative. In general, one due to gravity, involutional changes in the underlying
should not necessarily excise the same amount of skin on supportive structure, and loss of deep tissue volume. Often
each side, as much as leave the same amount postoperatively, the temporal portion of the brow is the first area to descend,
because it is common for patients to start with some because the frontalis muscle does not extend lateral to the
asymmetry. A general rule for preparing a woman patient temporal fusion line. Brow height can also be understood
for surgery is to mark an eyelid crease somewhere around by looking at the interplay between the brow elevators and
8–10 mm above the eyelid margin, and, for a man, 6–8 mm the brow depressors. The main brow elevator is the frontalis
above the margin. There should be adequate skin for closure, muscle. Brow depressors include the corrugator, procerus,
and a general rule is to leave 20 mm of skin between the depressor supraciliaris, and orbicularis muscles. The
strength and tension of these muscles should be determined
when examining the height and contour of the brows.
The diagnosis of brow ptosis can be challenging in
that brow heights vary between individuals. Even though
there are discussions on ideal brow height, some brows are
naturally higher in some individuals and lower in others;
examination of previous photos or photos of younger rela-
tives is often helpful (Figure 2), as familial characteristics play
an important role in an individual’s baseline brow position.
The most common cause of brow ptosis is age related.
However, a compromised seventh cranial nerve (CN VII)
a can result in varying degrees of brow ptosis, depending
on the severity of the palsy. Usually a CN VII palsy will be
unilateral; however, there are rare causes of bilateral CN VII
nerve palsies that can be difficult to diagnose, due to the
symmetry. Bilateral CN VII nerve palsies are associated
with other facial muscle weakness, so the evaluation of
brow ptosis should also include assessment of the facial
musculature. Other causes of bilateral brow ptosis include
progressive supranuclear palsy and various muscular
dystrophies. It is important to be aware of the concomitant
b presence of lagophthalmos in many of these patients, as
any upper eyelid or brow elevation surgery can worsen the
Figure 1 ​Dermatochalasis. a. Preoperative ocular exposure.
evaluation shows dermatochalasis with brow
As with dermatochalasis, one should be vigilant of
descent. b. After upper blepharoplasty,
additional brow descent is noted.
dry eye preoperatively. A brow elevation procedure may
temporarily worsen existing eye dryness. When choosing

2 Focal Points Module 5, 2017


a

a b

Figure 2 ​Dermatochalasis. a. 65-year-old


woman shows upper eyelid dermatochalasis
and possible brow descent. b. Patient’s 32-year-
old daughter exhibits that the brow height
is normally low. This panel demonstrates
the usefulness of examining younger family
members to determine the normal anatomical b
position of the brow. Much of what is seen in
Figure 3 ​Patient before (a) and after (b) a direct
part a is also related to deflation.
browplasty and upper blepharoplasty.

the appropriate procedure, the surgeon should have multiple corresponding to the amount of ptosis needing to be cor-
options, and treatment should be individualized to the patient. rected. In general, it is uncommon to take much less than
10 mm and more than 15 mm, unless it is associated with a
Direct Browplasty
CN VII palsy. The marking is incised with a #15 blade, and
Direct browplasty (supraciliary browlift) delivers predict- the skin and subcutaneous fat are resected. Care should be
able results. This procedure is best for older patients who taken to avoid dissection around the supraorbital nerve. The
have significant brow ptosis that is mostly temporal. In defect is then closed with deep interrupted 4-0 polyglactin
addition, it is good for patients who want a simpler surgical sutures, followed by a running 5-0 polyethylene suture.
procedure and will be less bothered if the scar is noticeable Closure techniques and suture choices vary among surgeons.
(Figure 3). In this procedure, an incision is made just above
the cilia of the brow, or above the brow in an advantageous Browpexy
forehead crease. Extending the incision medially is difficult, A browpexy procedure “pushes” the brow superiorly. While
so this lift is best for temporal brow ptosis. Some believe it a browplasty lifts though the excision of tissue above the
is best for women, since an arched contour is attained with brow (“pulling” the brow superiorly), a browpexy is usually
the temporal incision, but men do well with the procedure, performed though a blepharoplasty incision, with dissection
and the resulting scar is easier to conceal due to the denser to release the attachments of the brow and various manipu-
hairs of the male brow. Although this is not thought to be lations to alter the position of the brow. The popularity of
a cosmetic lift, the incisions may heal surprisingly well. browpexy procedures waxes and wanes. The advent of the
Video 2 demonstrates direct browplasty. transblepharoplasty Endotine device (Endotine TransBleph,
Advantech Surgical; Torquay, Devon, England) in the
early 2000s resulted in renewed interest in the procedure;
2. Direct Browplasty however, long-term results showed unimpressive amounts
VIDEO
of sustained brow elevation. The lack of standardization
and quantification, and the postoperative pain that patients
often noted associated with the device, was also discourag-
ing. The procedure seemed to be best suited for men who
TECHNIQUE. A marking is made above the brow or in had a smooth forehead, a high hairline, and an insignificant
a good crease or furrow above it. The amount of brow amount of ptosis. Most surgeons appreciated the procedure
ptosis is determined by lifting the portion of the brow that as a brow stabilizer, without significant lift. The introduc-
appears ptotic. The amount of needed brow elevation is tion of the Ultratine TransBleph has lessened some of the
measured and a marking is made above the initial marking, concerns regarding postoperative pain.

Focal Points Module 5, 2017 3


Several years ago, the external browpexy was intro- TECHNIQUE. Dissection is carried out along the surface of
duced with some early enthusiasm. Some surgeons found the orbital septum to the superior orbital rim, then carried
it difficult to pass the suture from an external incision out in a preperiosteal fashion above the superior orbital rim
and were unimpressed with the results. It was perceived for 15–20 mm. This dissection is lateral to the supraorbital
that significant subcutaneous dissection was needed, as neurovascular bundle and extends laterally to the lateral
well as elevation of the brow fat. The quantitated internal orbital rim. A 4-0 polyglactin suture is used to engage the
suture browpexy, or a “chicken brassiere” technique, was periosteum 12–15 mm superior to the superior orbital
then developed. A “brassiere” suture attaches the superior rim at the level of the peak of the brow. This suture then
blepharoplasty incision to the periosteum of the superior engages the soft tissue (usually the brow fat) superior to
orbital rim. Some surgeons were reluctant to perform the superior edge of the blepharoplasty incision, the same
this procedure, due to fears of lagophthalmos. A safer amount as was measured from the superior orbital rim to
modification of the internal browpexy suspends the deep the preperiosteal pass. This essentially places the superior
brow soft tissue (superior to the orbicularis oculi) to the edge of the blepharoplasty incision near the superior orbital
superior orbital rim periosteum in a controllable fashion, rim. After the internal browpexy has been completed, the
allowing assessment and adjustment intraoperatively. This blepharoplasty incision is closed in a typical fashion.
can be performed with nonabsorbable suture (such as
polypropylene) in 1 or 2 broad mattress sutures to provide Indirect Browplasty/Mid-Forehead Lift
more sustained brow stabilization. The indirect browplasty (mid-forehead lift) is an option
This procedure seems to function well as a brow for some patients with significant medial brow ptosis and
stabilizer. Its use has decreased the number of endoscopic a deep furrow in the forehead that is replaced with a less
browlifts in the hands of some surgeons. The ideal patient noticeable scar. At present, the procedure is less frequently
for this procedure has minimal brow ptosis and will performed, but some patients are good candidates. The
undergo a concurrent blepharoplasty (Figure 4). Video 3 patient must realize that there may be a noticeable scar
demonstrates an internal suture browpexy. across the middle of the forehead.
The procedure is predictable, can lift the entire brow,
and can be performed under minimal anesthesia. Patients
3. Internal Suture Browpexy should have significant furrows in which the scar can be
VIDEO
hidden. This procedure should usually be reserved for men,
as many women will not accept the forehead scar. Wearing
bangs across the forehead can help mask the scar. Video 4
demonstrates the procedure.

4. Mid-Forehead Browplasty
VIDEO

TECHNIQUE. The amount of lift that is needed is


determined medially and laterally. The supraorbital and
supratrochlear nerves are marked. A good forehead crease
a should be identified and marked. Sometimes it is better and
less noticeable to use different creases on each side of the
forehead that do not connect centrally. This breaks up the
scar and may make it less noticeable. Ideally, an additional
parallel crease above the first one that is marked can be
used for the second marking. This then turns 2 creases into
1 scar. The area is anesthetized, and incisions are made with
a blade along the markings. Extending the incision deeper
than the subcutaneous fat may result in paralysis of por-
tions of the frontalis muscle. Dissection should be avoided
laterally in the normal anatomical location of CN VII or
b
medially around the supraorbital nerve. There may be
Figure 4 ​Patient before (a) and after (b) a loss of some sensation above the incisions; however, this
transblepharoplasty internal suture browpexy typically is recovered over 6 months. The resulting defect is
and upper blepharoplasty. then closed with deep 4-0 polyglactin sutures, followed by
5-0 polypropylene sutures in the skin.

4 Focal Points Module 5, 2017


Pretrichial Browplasty orbital rim and expose the supraorbital neurovascular
The pretrichial browlift is a very effective procedure that bundle. Lateral to the temporal fusion line, dissection
can elevate the entire brow. It is best reserved for women is carried out along the surface of the deep temporalis
who have elevated hairlines, wear bangs, and will not be fascia. The temporal fusion line is then lysed between the
bothered by loss of sensation above the incision. Hypes- medial and lateral dissections. This results in the forehead
thesia is temporary in most patients and scalp sensation being completely mobile. The brows are elevated, and the
typically returns in 4–6 months, but may be permanent in overlapping soft tissue at the incision is marked. This will
some patients. This lift is in between a mid-forehead lift and usually measure at least 15 mm but not much more than
a coronal lift. An incision is made at the hairline, following 20 mm. The soft tissue is then excised, and the resulting
its contour. defect is closed with deep interrupted 4-0 polyglactin
The scar of the pretrichial incision will heal well with sutures, followed by interrupted 5-0 polyethylene sutures
time (Figure 5). It will not be optimal for the first month in a vertical mattress fashion. A dressing is placed around
or so, but it is almost imperceptible later. Patients should the head using a gauze bandage roll followed by an elastic
be counseled that they will need to cover the scar with self-adhering dressing. This dressing should not be too
their bangs or with makeup. This procedure will lower the tight, as there have been reports of scalp necrosis due to
hairline. Video 5 demonstrates pretrichial browplasty. overzealous dressings.

Endoscopic Small-Incision Browplasty


5. Pretrichial Browplasty The endoscopic small-incision browplasty was developed
VIDEO to give a result like a coronal lift, but without the excision
extending ear-to-ear across the top of the head. It is
currently the most popular cosmetic lift. Because it is not
as strong as the coronal lift, it should be considered a less
TECHNIQUE. A marking is made at the hairline, extending effective and somewhat temporary solution.
laterally beyond the temporal fusion line. An incision is This lift works best on women with a thin scalp. The
made along the marking in a saw-tooth manner to hide a thicker the forehead and scalp, the less the effect from
linear scar. Dissection is then carried out in the subgaleal/ this lift. A direct, pretrichial, or coronal browplasty would
preperiosteal plane medial to the temporal fusion line to usually best serve a patient with more severe brow ptosis.
a level 2 cm above the superior orbital rim. Below this The advantages of this lift are that the incisions are small
level, the dissection continues subperiosteal to the superior and the patients heal quickly. The disadvantages are that it
orbital rim to release the attachments of the brow to the will raise the hairline and is not as effective as the incisional

a b
Figure 5 ​Patient before
(a) and 8 months after
(b) a pretrichial browplasty
with upper eyelid
blepharoplasty and ptosis
repair (Müller muscle–
conjunctival resection).
c, d. Appearance of the scar
1 month and 8 months after
c d surgery.

Focal Points Module 5, 2017 5


techniques. However, for women with thin skin and mild deep temporalis fascia to the lateral orbital rim. This
brow ptosis, it works well along with a blepharoplasty dissection needs to be beneath the superficial temporal
(Figure 6). Potential complications include damage to the fascia, where the frontal branch of the facial nerve lies.
sensory (V-1) and motor (facial) nerves. With experience, The dissections on either side of the temporal fusion line
this procedure can also be performed without the aid of an are then connected by lysing the conjoint tendon. This
endoscope. Video 6 demonstrates the procedure. is done with long Metzenbaum scissors, with or without
the endoscope. This is a similar dissection as with a
coronal incision, but without the direct visualization. The
6. Small-Incision Browplasty endoscope is used to avoid injury to the supraorbital nerve
VIDEO
and the facial nerve.
After all attachments are released, then the forehead
needs to be lifted, a task that involves a multitude of fixa-
tion devices and procedural details. An Endotine forehead
TECHNIQUE. Four small incisions are made in the device is easy to use and has a broad fixation. The device is
hair-bearing scalp: 2 vertical incisions are placed at the placed through each of the vertical incisions and popped
level of the peak of the brow, 1 or 2 cm above the hairline, into the bone into holes that have been drilled. The entire
2 cm in length; 2 horizontal incisions are made to straddle forehead is then elevated and suspended from the barbs on
the temporal fusion line, approximately 2 cm above the the device. It is difficult to overcorrect in this procedure.
hairline temporally. These incisions should be perpendicu- The incisions straddling the temporal fusion line are then
lar to an imaginary line extending from the ala of the nose used to lift temporally. This can be done with superficial
to the lateral canthus. The main purpose of the endoscopic temporalis plication or excision of scalp. Other methods of
browplasty is to create a subperiosteal dissection plane fixation include bone tunnels with suture fixation or a long
medial to the temporal fusion lines to the superior orbital 14 mm screw from which the scalp can be secured (lifted
rim. The endoscope is used mainly around the supraor- firmly and staples placed to hold it).
bital neurovascular bundle to make sure this is not injured.
This dissection plane is performed through the 2 vertical Coronal Browplasty
incisions. An additional dissection plane is performed The coronal browplasty was once considered the cosmetic
lateral to the temporal fusion line, on the surface of the lift to which all others are compared. It is a strong lift and
can address the entire extent of the brow. However, it is a
more extensive surgery than the other procedures discussed
here, with greater dissection and a larger incision. The
advantages of this lift are that it is strong, long lasting, and
can lift along the entire extent of the brow. The disadvan-
tages include longer operative time, elevation of the hairline,
extensive dissection, permanent scalp numbness, alopecia,
and the scar along the top of the head, which can sometimes
be noticeable, especially if it affects the way the hair parts.
Overcorrection is more common with coronal browlifting
than with the other brow elevation procedures.
TECHNIQUE. An incision is made across the top of the
a head from ear to ear. Dissection can then be performed in
a subgaleal or subperiosteal plane medial to the temporal
fusion line. Lateral to the temporal fusion line, dissection is
performed along the surface of the deep temporalis fascia.
This dissection is performed down to the superior orbital
rim and lateral orbital rim. The supraorbital nerves are
identified and preserved. This allows mobilization of the
entire forehead. The desired amount of lift is determined,
and the corresponding amount of scalp is excised. Closure
can then be performed with deep 3-0 polyglactin sutures,
followed by staples.
b
Weakening of Brow Protractors
Figure 6 ​Patient before (a) and after (b) an Since the position of the brow is partially dependent on
endoscopic browplasty with upper blepharoplasty. an interplay between brow depressor and brow elevator
muscles, one way to aid in brow elevation is to weaken the

6 Focal Points Module 5, 2017


Eyelid measurements are generally considered as the
“vital signs” of the eyelids. Palpebral fissure height (PF) is
the distance between the peak of the upper eyelid margin
X X and the lower eyelid margin with the eyes in primary gaze
X X
X position. MRD1 is the distance between the upper eyelid
X X margin and the corneal light reflex with the eyes in primary
gaze position. MRD2 is the distance between the lower
eyelid margin and the corneal light reflex with the eyes in
primary gaze position. Thus, MRD1 + MRD2 = PF.
Lagophthalmos is present when space exists between
the upper eyelid margin and lower eyelid margin when the
Figure 7 ​Diagram showing the location for patient is attempting eyelid closure. Levator function (LF)
injection of botulinum toxin for weakening the is the excursion of the upper eyelid margin from downgaze
brow protractors (corrugator, procerus, and
to upgaze with the brows fixed and head immobilized. Lid
lateral orbicularis). (Courtesy of ForeverLee/
crease (LC) is the distance from the upper eyelid margin
Shutterstock.com.)
to the eyelid crease. The LF and LC measurements are
important when evaluating a patient with ptosis.
The measurements are made with a millimeter ruler,
depressors (protractors). This would include the orbicularis, with the patient looking straight ahead, usually at the
procerus, and corrugator muscles. Surgically, one can do light of a Finhoff transilluminator. An MRD1 of 2 mm or
this through the blepharoplasty incision or the endoscopic, less is thought to represent clinically significant ptosis. In
pretrichial, or coronal incision. As noted earlier, it is often patients with dermatochalasis, the MRD1 could be normal,
reasonable to be a bit more aggressive in excising lateral but extra skin may hang down over the eyelid margin.
orbicularis during the blepharoplasty to help in elevation of The distance between the edge of the extra skin (rather
the lateral brow. than the eyelid margin) and the corneal light reflex should
Realistically, the easiest and most predictable way to also be measured. Surgeons have used various ways to
weaken the brow protractors is with injection of botulinum represent this—using “MRD (skin)” or “pseudo MRD” can
toxin into the lateral orbicularis under the temporal brow. help delineate the difference between this and the MRD1
Injection of 2.5 units botulinum toxin A on each side is a measurement. Many patients have both ptosis and dermato-
good starting point. One should not inject more medial chalasis and will therefore have abnormal MRD1 and MRD
than the lateral orbital rim. The most common risk with (skin) measurements.
this injection is causing ptosis, due to diffusion of the In categorizing ptosis patients, it is important to
toxin into the levator muscle. It is best to start low with differentiate congenital ptosis from adult-onset ptosis (see
the toxin dose and stay lateral. Regarding the procerus and “Ptosis in the Adult”).
corrugator muscles, complications are less likely—usually
5.0–7.5 units of botulinum toxin A injected into each cor-
rugator and 5 units into the procerus will suffice (Figure 7). Congenital Ptosis
Volume Restoration for Brow Elevation Congenital ptosis is present from birth. In rare cases, birth
trauma may be the cause, but most of these birth trauma–
Aging is a process of deflation and descent. Sometimes
related cases rarely present to the surgeon because they
deflation plays a major role in brow descent. This aspect of
resolve spontaneously. Congenital ptosis has historically
brow descent has been gaining a lot of attention recently.
been considered a myogenic form of ptosis, but now there is
The area to reinflate is the brow fat inferior to the temporal
evidence that the levator muscle is not innervated correctly
portion of the brow. Loss of volume in this area results
during development in many of these patients. Many
in loss of support for the brow. Inflating this area has an
ophthalmologists now favor the term congenital cranial
elevating effect on the brow. This can be performed with a
dysinnervation disorder (CCDD) to generally categorize
dermal filler or autologous fat injection.
any child who has a dysinnervation of one or more cranial
nerves.
Several factors need to be considered when a child has
Ptosis congenital ptosis: bilateral or unilateral ptosis; severity; any
Ptosis (blepharoptosis) refers to the upper eyelid margin variation with jaw movement, eating, or nursing; amblyopia;
being low. This can be difficult to define—eyelid position in strength of the levator muscle; and associated conditions.
one person might be too high; in another person, it might Bilateral and unilateral congenital ptosis are distinctly dif-
constitute ptosis. The MRD is the primary measurement ferent clinical problems. Although it seems counterintuitive,
used to define the height of the upper eyelid in relation to bilateral congenital ptosis is easier to treat than a unilateral
the center of the pupil. case. Usually, there will be no ocular preference in bilateral

Focal Points Module 5, 2017 7


symmetric ptosis, so surgery will not be performed early brow cilia and upper eyelid margin. Three markings
unless the ptosis is amblyogenic or causing an abnormal are then made above each brow: 1 medial, 1 lateral, and
head position (usually a backward head tilt). In that case, 1 halfway between these 2, approximately 1 cm above them,
then it will usually be significant enough to require a fronta- preferably in an advantageous wrinkle. These areas are
lis sling, which works better bilaterally than unilaterally. infiltrated with local anesthesia.
A pediatric ophthalmologist should evaluate every A #15 blade is used to make a stab incision in each brow
child with congenital ptosis not simply to evaluate the marking. A hemostat is used to bluntly dissect each of these
patient for amblyopia, but also to ensure there is no incisions. An incision is then made along the blepharoplasty
strabismus or motility issue and to check for any significant marking, and a flap of skin and orbicularis is removed.
refractive error. The strength of the levator muscle can The orbital septum is opened, and the levator aponeu-
be difficult to determine in a young child. In general, the rosis is exposed. The levator aponeurosis is dissected from
amount of ptosis is inversely correlated with the strength the anterior surface of the tarsus. The silicone frontalis
of the levator muscle in a child. Also, a more distinct eyelid sling is then sutured to the anterior surface of the tarsus
crease is reflective of a stronger levator muscle. 1 or 2 mm inferior to the superior border of the tarsus with
In bilateral ptosis, the surgery preference rests upon 3 interrupted 5-0 polyester fiber sutures placed partially
the amount of ptosis and the strength of the levator muscle. through the anterior surface of the tarsus. The ends of
In general, the more severe the ptosis and the weaker the the silicone sling are then placed posterior to the orbital
levator muscle, the more likely the patient would be best septum to exit out the medial and lateral brow incisions.
served with a frontalis sling. In addition, if the patient lifts Each end of the sling is then placed to exit out the central
the brows to see, that is also an indication that a frontalis brow incision. The sleeve that comes with the sling (or a
sling will likely succeed. 270 Watzke sleeve) is cut in half, and each half is placed
In unilateral ptosis, there is a recent trend toward push- over the slings.
ing a levator advancement or resection to its limits rather The patient is placed in a sitting position, and the sling
than using a primary frontalis sling. The main issue is that it is tightened to attain an appropriate height and contour. The
is sometimes difficult to get children with unilateral ptosis patient is then placed in the supine position. A 5-0 polyester
to use their brow to elevate the sling. Part of the issue is fiber suture is then placed around the sling inferior to the
that the side with the ptosis will usually not be the patient’s most inferior sleeve. A second 5-0 polyester fiber suture
dominant eye, or there may be amblyopia. If the child raises is then placed around the most superior half of the sleeve.
the brow on the side of the ptosis preoperatively, it is a good The redundant portion of the frontalis sling is cut, and the
sign that a frontalis sling may work. If a unilateral sling is sling is placed under the subcutaneous tissue through the
performed, the parents will need to patch the contralateral superior incision.
eye at least part-time until the age of 9 to make the child The brow incisions are then closed with 5-0 fast-
want to use the sling. The goal of a levator resection is to absorbing gut suture placed in a vertical mattress fashion.
raise the eyelid not necessarily to symmetry, but out of the The eyelid incisions are then closed with the same suture,
amblyogenic range. Later in life, the height of the eyelid can which engages a skin edge, followed by the disinserted end
be refined. of the levator aponeurosis, followed by the other skin edge.

Frontalis Sling Procedures Levator Resection and Advancement


There are many choices with respect to frontalis sling For mild-to-moderate congenital ptosis, Table 1 is useful for
materials. For very young children, a nylon monofilament determining how much levator should be excised. Table 2
suture is useful. For children older than 1 year of age, many presents the intraoperative eyelid height desired, depending
surgeons prefer donor fascia or a silicone rod. Recently, on the preoperative upper eyelid excursion. In general,
more surgeons are leaning toward use of a silicone rod at it is uncommon to overcorrect pediatric patients with
earlier ages. After the age of 4 or so, autogenous fascia can congenital ptosis, especially if they have 3 mm or more of
be harvested, which is still the gold standard. ptosis. With reoperations, overcorrection is more of a risk,
Surgery is performed under general anesthesia for a probably due to increased internal fibrosis and adhesions.
frontalis sling in children. A single rhomboid configuration
EXTERNAL LEVATOR ADVANCEMENT. An incision
has gained in popularity, regardless of the sling material.
is made at the level of the eyelid crease or the proposed
Five principles are important to follow for optimal results:
eyelid crease, keeping in mind that the measured lid crease
tarsal fixation of the sling, retroseptal placement of the
will often rise after the surgery. Dissection is carried out
sling, no fat excision, minimal (if any) skin incision, and
through the orbicularis muscle to the orbital septum.
incorporation of the levator aponeurosis into the skin
The orbital septum is then opened and the underly-
incision.
ing preaponeurotic fat is identified and dissected from
FRONTALIS SUSPENSION/SLING. The upper eyelid the underlying levator aponeurosis/muscle. The levator
crease is marked along with a conservative blepharoplasty, aponeurosis is then dissected from the anterior surface of
so that at least 18 mm of skin remains between the inferior the tarsus and dissection is then carried out between the

8 Focal Points Module 5, 2017


Table 1. Estimation of Levator Resectiona
AMOUNT OF PTOSIS UPPER EYELID EXCURSION AMOUNT OF RESECTION
2 mm (mild) 0–5 mm (poor) 22–27 mm
6–11 mm (fair) 16–21 mm
12 or more (good) 10–15 mm
3 mm (moderate) 0–5 mm (poor) Maximum (30 mm)
6–11 mm (fair) 22–27 mm
12 or more (good) 16–21 mm
4 mm or more (severe) 0–5 mm (poor) Maximum (30 mm)
6–11 mm (fair) 25–30 mm
12 or more (good) 25–30 mm
a
Recommended resection amount of the levator muscle for patients with congenital ptosis, dependent on the amount of ptosis and the strength of the levator muscle
(levator function/excursion). From Beard C. Congenital ptosis. Ptosis. 1976;91–115.

general, one should be wary of using an MMCR to address


Table 2. Intraoperative Eyelid Heighta
more than 2 mm of ptosis. Part of the issue is that the
UPPER EYELID SUPERIOR CORNEAL levator muscle is weak. If an MMCR is actually an internal
EXCURSION COVERAGE BY UPPER EYELID
levator advancement, then an 8.5 mm resection would
0–5 mm (poor) 0 mm (eyelid margin at
superior limbus)
do very little in a patient with subnormal levator strength
(12 mm or less). If the patient has convincingly excellent
6–11 (fair) 2 mm
levator strength (eg, levator function of ≥15 mm) and at
12 or more (good) 4 mm most 2 mm of ptosis, then an MMCR may be appropriate,
a
Berke’s method of desired intraoperative eyelid height during a levator resec- as in a congenital Horner syndrome.
tion surgery in patients with congenital ptosis, based on the preoperative upper
eyelid excursion (levator function).
MÜLLER MUSCLE–CONJUNCTIVAL RESECTION.
The amount to be resected is determined preoperatively,
depending on the patient’s response to the instillation
levator aponeurosis and the underlying Müller muscle. A of phenylephrine 2.5% drops. A 4-0 silk suture is placed
double-armed 5-0 nylon suture on a spatula needle is then through the upper eyelid margin, and the eyelid is everted
placed partially through the anterior surface of the tarsus, over a Desmarres retractor. Additional local anesthetic can
approximately 2 mm inferior to the superior border of the be placed at this point. Two marks are made with cautery
tarsus just nasal to the center of the pupil. Each arm of the or a marking pen, corresponding to the middle third of the
suture is then placed through the underside of the levator tarsus. Calipers are placed on half the proposed resection
aponeurosis, and a temporary tie is performed. amount, and marks are made corresponding to this
The patient is placed in the sitting position and the amount superior to the previously placed marks. A toothed
height and contour of the eyelid are inspected. The patient forceps is used to grasp the conjunctiva and presumed
is then placed supine, and any appropriate adjustments Müller muscle and placed on traction. A Putterman clamp
of the suture on the tarsus are made to alter the contour. is used and placed at the superior border of the tarsus. A
Eyelid height can be adjusted by altering the placement of 6-0 chromic suture is then placed in a mattress fashion
the suture in the levator aponeurosis. The patient is again along the edge of the Putterman clamp. A #15 blade then
placed in the sitting position. If the appropriate height and excises along the clamp (“metal on metal”). The suture is
contour of the eyelid has been attained, the patient is placed tied. A bandage contact lens is placed on the eye, followed
supine, and the temporary tie is converted into a permanent by antibiotic drops.
tie. The redundant portion of the levator aponeurosis can be
excised, and the incision is closed with placement of sutures Conditions Associated With
that incorporate a portion of the levator aponeurosis to Congenital Ptosis
create an eyelid crease. Sutures used can be a nonabsorbable A final issue to consider in congenital ptosis is whether
or an absorbable monofilament material; many surgeons there is any association with other abnormalities. Associ-
prefer a 6-0 polyethylene suture. ated forms of congenital ptosis include blepharophimosis,
ptosis, epicanthus inversus syndrome (BPES), Marcus Gunn
Posterior-Approach Ptosis Surgery jaw-winking ptosis, congenital fibrosis of the extraocular
Success has been reported using a Müller muscle-con- muscles, and congenital myasthenic syndromes. Treating
junctival resection (MMCR) for congenital ptosis cases. In these conditions is beyond the scope of this module.

Focal Points Module 5, 2017 9


In the United Kingdom, surgeons have had success in that the reoperation rate in ptosis patients can be as high as
convincing parents to have surgery done on both sides (Beard 10%. Video 7 demonstrates external levator advancement.
procedure) for unilateral congenital ptosis, and typically for There are several “pearls” for performing levator-based
Marcus Gunn jaw-winking ptosis. In this situation, the leva- surgery. Limiting the volume of local anesthetic avoids
tor on the normal side is extirpated so that ptosis is induced introducing mechanical issues from the anesthetic. Using
on that side as well, and then treated with a bilateral frontalis epinephrine in the local anesthetic to decrease bleeding
sling. This allows the child to raise both brows to elevate both is helpful, but the eyelid should be slightly overcorrected
eyelids, rather than depending on them to raise one brow. intraoperatively due to the temporary elevating effect of
Many surgeons in the United States have difficulty convinc- the epinephrine on the Müller muscle. Identification of the
ing parents to approve this more aggressive procedure. preaponeurotic fat is critical, because dissecting it from the
underlying levator aponeurosis ensures that one is in the
correct dissection plane. The suture should be placed on the
Ptosis in the Adult tarsus just medial to the pupil to place the peak of the eyelid
Adult-onset ptosis is categorized into one or more of the in the appropriate position. The beginning surgeon should
following categories: aponeurotic, myogenic, neurogenic, be aware that levator-based surgery takes considerable
and mechanical (Bartley Frueh classification). Aponeurotic practice. Even in experienced hands, achieving consistent
ptosis refers to a dehiscence, atrophic thinning, stretching, results can be challenging.
or disinsertion of the levator aponeurosis. The aponeurosis
is the tendon portion of the levator and inserts into the
anterior surface of the tarsus 1 or 2 mm below the superior 7. External Levator
border of the tarsus in Caucasians. With age, the aponeu- Advancement
VIDEO
rosis is thought to stretch, dehisce, or disinsert, resulting in
ptosis (there is some controversy as to the true etiology of
involutional ptosis). In this type of ptosis, the levator should
be of normal strength (LF >12–15 mm), the eyelid crease POSTERIOR-APPROACH PTOSIS SURGERY. This
should be high, and the ptosis will be worse with downgaze. procedure refers to incisions on the inside of the upper
These patients will sometimes report that the ptosis eyelid to elevate the eyelid. There are basically 2 posterior-
bothers them most as they try to read, due to their looking approach options: the Fasanella–Servat procedure and
down during this activity. Other common risk factors for Müller muscle–conjunctival resection (MMCR). The
aponeurotic ptosis include long-term contact lens wear, Fasanella-Servat procedure excises some of the tarsus at
previous ocular surgery, chronic manipulation or rubbing of the time of the surgery. This particular type of posterior-
the eyelid (as observed in chronic allergic ocular disorders), approach ptosis surgery has lost popularity for numerous
and corticosteroid injection around the area. reasons. Shortening the tarsus vertically compromises the
meibomian glands. Also, shortening the tarsus results in
Levator-Based Surgery a very unstable tarsus if one must reoperate later with a
If the aponeurosis is stretched, then the appropriate proce- levator-based procedure or a frontalis sling. In addition,
dure would be to shorten the aponeurosis. This is generally the shortened, unstable upper eyelid tarsus can later lead to
referred to as levator-based surgery. There are a few different upper eyelid entropion in some patients.
levator-based surgeries. A levator advancement refers to However, MMCR (Video 8) has regained popularity
disinsertion of the levator aponeurosis from the anterior in addressing less than or equal to 2.5 mm of ptosis. The
surface of the tarsus, dissecting between the aponeurosis surgery was popular in the 1970s and fell out of favor in the
and the underlying Müller muscle, and resuturing the 1980s and 1990s. Lately surgeons have again embraced this
aponeurosis to the tarsus to advance it. Another surgery is a surgery as a predictable, easy surgery in appropriate situa-
levator resection; in this surgery, the dissection is performed tions: 2.5 mm or less of ptosis, good levator function, and a
under the Müller muscle, and then both the levator and good response to phenylephrine drops. During the ptosis
Müller muscle are shortened and advanced to the tarsus. evaluation, a drop of 2.5% phenylephrine is placed in the eye
Finally, a levator plication is performed by not disinserting on the side of the ptosis. A second drop is given 10 seconds
the aponeurosis, but rather placing sutures through the later. After 5 minutes, the position of the eyelid is checked.
tarsus followed by sutures into the aponeurosis so that the If it attains a normal position from the drop, an 8.5 mm
levator aponeurosis is folded over itself. resection would be appropriate. If the eyelid is higher or
The determination as to what procedure to perform lower than what would be desired, then less or more of a
is the surgeon’s preference. In each of these surgeries in an resection would be performed (Figure 8). In general, not
adult, the patient is placed in the sitting position intraopera- much less than 6 mm (for about 1 mm of ptosis) nor more
tively to determine if the eyelid is in the appropriate position. than 9.5 mm (for a response from the phenylephrine drop
An appropriate eyelid position is determined by the height that is 1 mm less than would be desired) is resected.
and contour of the eyelid margin. This is the most challeng- The advantages of MMCR are that it is weak relative
ing part of the management of ptosis. Studies have shown to external levator surgery, will not produce a significant

10 Focal Points Module 5, 2017


dystrophy. Otherwise, it is sometimes related to congenital
ptosis that was not previously treated. Congenital ptosis
in an adult patient should be a relatively stable condition
and can be treated per the amount of ptosis and levator
muscle strength. CPEO, OPMD, and myotonic dystrophy
are progressive forms of ptosis (secondary to a dystrophy
of the levator muscle) and are best treated with silicone
frontalis suspension. The issue with these progressive
a
forms of myogenic ptosis is that levator-based procedures
eventually fail, and then the more surgery that is done on
these eyelids, the more the eyelid closure is compromised.
Some surgeons advocate an aggressive blepharoplasty as a
treatment, but eliminating the excess skin also eliminates
the chance of producing an eyelid crease, thus leading to
a poor cosmetic result. A silicone sling works very well on
these patients and has the advantage of the elasticity of the
b material enabling closure and the ability to adjust the sling
later (Figure 9). Video 9 demonstrates a bilateral silicone
frontalis sling procedure.

9. Bilateral Silicone
Frontalis Sling
VIDEO

Figure 8 ​Müller muscle–conjunctival resection Ptosis Due to Myasthenia Gravis


(MMCR). a. Patient with left upper eyelid ptosis.
b. After instillation of phenylephrine. c. Four Ptosis from a problem at the neuromuscular junction is
months after left 8.5 mm MMCR. due to myasthenia gravis. Myasthenia should be suspected
in any patient with acquired ptosis, especially if he or
she has a subnormal levator function, acute or subacute
onset, diplopia, significant variability in eyelid position,
overcorrection, and will maintain a normal contour. As to
orbicularis oculi muscle weakness, other symptoms of
contraindications for MMCR surgery, the relative weakness
generalized muscle weakness, or a history of thyroid eye
of the procedure should be respected, so it should not
disease. Most patients with ptosis report worsening of
be used for more significant ptosis. Realistically, it should be
their eyelid malposition at the end of the day; however,
reserved for aponeurotic ptosis or a Horner syndrome with
myasthenic patients may experience variation in the ptosis
2.5 mm or less of ptosis. Although success has been reported
during the day. Uniquely, patients with myasthenia may
in patients with a compromised ocular surface (including
give a history of episodes of complete ptosis, which is
patients with previous penetrating keratoplasty and glaucoma
rarely observed in other causes of ptosis. Eliciting fatigue
filtering blebs), many surgeons believe that the resection of
in the clinic is very helpful. Having the patient fixate on a
conjunctiva with the mucus-producing goblet cells places
superior target and observing if one or both eyelids descend
patients at increased risk for significant ocular irritation,
will test for fatigability. Additional diagnostic tests and
ocular surface disease, and exacerbation of dry eye syndrome.
signs for myasthenia gravis include the identification of a
Cogan eyelid twitch, the ice test, the sleep test, and various
8. Müller Muscle–Conjunctival serological investigations.
A Cogan eyelid twitch refers to the situation in which
Resection
VIDEO the patient looks down for 3–5 seconds followed by
refixation to primary position. In doing this, the upper
eyelid will show a transient retraction (or twitch) during the
period of refixation before returning to its ptotic position.
Myogenic Ptosis In the ice test, the palpebral fissure is measured and
Adult-onset myogenic ptosis is associated with chronic a bag with ice is placed over the eyelids for 2 minutes.
progressive external ophthalmoplegia (CPEO), oculo- After the ice is removed, the palpebral fissure should be
pharyngeal muscular dystrophy (OPMD), or myotonic remeasured within 10 seconds. Patients without myasthenia

Focal Points Module 5, 2017 11


Figure 9 ​Patient with
chronic progressive external
ophthalmoplegia who
underwent previous levator a b
advancement procedure
2 years ago. a. She now
has recurrent ptosis.
b. Same patient 6 months
after silicone frontalis
suspension. c. Patient with
oculopharyngeal muscular
dystrophy before silicone
frontalis suspension. d. Four
months after. c d

will have no change in the palpebral fissure height. Patients Horner syndrome is very effectively treated with MMCR.
with myasthenia respond to the ice test with an increase in For mild unilateral ptosis, attention should be paid to the
palpebral fissure height of 2 mm with an 80% sensitivity pupils. The patient should be asked about previous neck
and 100% specificity. surgery, and checked for pulmonary symptoms and Horner
The sleep test refers to having patients gently close their syndrome. The latter is easily missed. Any unexplained
eyes for 10 minutes followed by opening of the eyes. In some Horner syndrome needs to be fully evaluated for the
patients with myasthenia gravis the ptosis will temporarily underlying etiology.
improve.
Lastly, testing for antibodies to the acetylcholine receptor Mechanical Ptosis
can be useful; these antibodies are present in 80%–90% of Mechanical ptosis refers to a ptotic lid due to a mass or
patients with generalized myasthenia gravis and 50%–75% chronic edema. This can be caused by a tumor, a foreign
of patients with ocular myasthenia gravis. body (traumatic or iatrogenic), or inflammation. It is very
If myasthenia is diagnosed, the patient needs to know important to look for a mechanical etiology in children,
that this is a potentially fatal condition, and they need ex- especially if there is a temporal drooping of the upper
amination and treatment by a neurologist. Once maximum eyelid. It is easy to assume that a patient has congenital
improvement is achieved with medical therapy, surgery ptosis when the problem is a mass, such as a plexiform
can be considered for residual ptosis. Levator advancement neurofibroma in the lateral upper eyelid and anterior
surgery may be effective for mild-to-moderate ptosis. More orbit. Usually, capillary hemangiomas are more obvious.
advanced cases may require combined levator–Müller In adults, a mass is also usually obvious. Amyloid on the
muscle advancement or a silicone frontalis sling procedure. conjunctival surface of the upper eyelid is easy to miss—
so it is important to evert the upper eyelid in all patients,
Neurogenic Ptosis but especially those with ptosis. Also, superior orbital
The most common neurogenic causes of ptosis include lymphomas often cause ptosis in adult patients.
third cranial nerve palsy and Horner syndrome. The main
issue with third nerve palsy is the strabismus. Some third Pseudoptosis
nerve palsies are secondary to trauma and should be Pseudoptosis refers to the situation in which an upper
given 6 months to recover before surgery is considered. eyelid is low relative to the contralateral upper eyelid, but
In nontraumatic cases of third nerve palsy, neuroimaging the patient has other factors, such as strabismus, orbital
studies are important, especially if pupillary involvement disorders, or contralateral eyelid problems, that are causing
is present, to rule out an intracranial aneurysm or tumor. an eyelid to be low relative to the contralateral upper eyelid.
Close collaboration with a strabismus surgeon is helpful Hypertropia may result in an eye that is supraducted rela-
to determine if it will be possible to provide good ocular tive to the eyelid, but when the eye is forced into primary
alignment. Otherwise, it is sometimes acceptable to allow position, the eyelid position becomes normal. Also, a large
the ptosis to provide occlusion to prevent diplopia. Usually hypotropia can cause pseudoptosis, because the eyelid is
a frontalis sling will be necessary (silicone rods are the following the hypotropic eye downward in its infraducted
preferred choice). position.

12 Focal Points Module 5, 2017


Enophthalmos may also result in the appearance of but they may not wish to undergo the additional time or
ptosis. It is very important to pay attention to the axial expense of multiple surgical procedures or a potentially
position of the eye and perform Hertel measurements. longer recovery. Regarding compliance, it is always good
Finally, a retracted contralateral upper eyelid may to decide whether the patient will be able to follow the
result in the appearance of ptosis. This is often observed in postoperative instructions that are necessary for a successful
early thyroid eye disease, in which a patient presents with surgical result. Surgeon experience may be a factor in
“ptosis” of a single upper eyelid, but actually has retraction choosing the surgical procedure for the patient, but should
of the other upper eyelid. This can be very difficult to not put the patient through a procedure that is not in his or
determine, and sometimes an apparent retraction can be her best interest.
caused by a contralateral ptosis. In this situation, the ptotic
eyelid is usually on the side of the patient’s dominant eye,
resulting in raising the ptotic eyelid, which in turn results Podcast Discussions
in contraction of the contralateral lid, as stated in Hering’s
You are invited to hear author Richard C. Allen, MD, PhD,
law. In situations of trying to determine true ptosis versus
FACS, and Eric P. Purdy, MD, editor-in-chief and editor for
contralateral retraction, it is useful to instill phenylephrine
Oculoplastic, Lacrimal, and Orbital Surgery, discuss key
on the ptotic side to see if the contralateral side then relaxes.
topics of this module. To tune in, simply scan the QR codes
Holding the relatively ptotic lid up manually while examin-
with a QR app on your digital device.
ing the position of both upper eyelids can also demonstrate
this phenomenon.

Preoperative Topics

Conclusion
PODCAST

In general, the conditions of dermatochalasis, brow


ptosis, and ptosis are seen in combination in patients with Patients Who Need
Combined Procedures
an involutional etiology. As the treatment choices for PODCAST
dermatochalasis are limited, the choice of ptosis and brow
ptosis repair will depend on the patient’s goals and compli-
Findings in Older Patients
ance with postoperative instructions, and the surgeon’s Regarding Tissue Laxity
experience and skill with various surgical techniques. Some PODCAST
patients may be better served by more extensive surgery,

Focal Points Module 5, 2017 13


Clinicians’ Corner
Eric A. Cole, MD, FACS, and Allan E. Wulc, MD, FACS, weigh in with

their clinical perspectives on “Surgical Management of Ptosis and

Brow Ptosis.” Clinicians’ Corner consultants respond to questions

without reading the module or each other’s responses.

1. How do you approach the patient with dry Dr. Wulc: While dry eye is not a contraindication to
eyes and blepharoptosis? ptosis repair, patients with a diagnosis of dry eye should
be approached conservatively. All our patients fill out the
Dr. Cole: A patient with pre-existing dry eye syndrome ocular surface disease index questionnaire (OSDI), and
is at significant risk for potential complications after approximately 10% of patients in our practice present with
blepharoptosis surgery. Examples include keratopathy, due mild to moderate dry eye as defined by the OSDI score.
primarily to increased tear evaporative loss, and risk of Preoperatively, the ocular surface should be optimized.
lagophthalmos and corneal exposure. Patients with mild Management might include treatment of pre-existing
dry eye and minimal symptoms typically tolerate ptosis blepharitis and use of artificial tears, gels, oral supplements,
surgery well. In patients with moderate-to-severe dry eye, I punctal plugs, and/or Restasis. In our area, several special-
attempt to diagnose the cause or causes of the patient’s dry ists interested primarily in dry eye have access to diagnostic
eye and optimize its treatment prior to performing ptosis tools and additional treatments, and we often refer patients
surgery. Patients with aqueous tear deficiency benefit from with severe dry eye for treatment prior to surgery.
interventions such as use of preservative-free artificial If the patient has symptomatic severe dry eye, including
tears, cyclosporine ophthlamic emulsion (Restasis), and blurred vision and/or photophobia, and exhibits signs
punctal plugs prior to surgery. Patients with significant such as corneal staining, then consideration to perform
meibomian gland dysfunction benefit from therapies such conservative surgery, or to avoid surgery, must be made in
as warm compresses, artificial tears, eyelid scrubs, and conjunction with the patient, making him or her fully aware
topical agents with anti-inflammatory properties. In my of the risks.
area, patients frequently suffer from ocular rosacea, and If lower eyelid retraction in the dry eye patient
they also benefit from low-dose doxycycline medications. accompanies ptosis, the lower eyelid may be elevated
I have not found treatments of the meibomian glands with simultaneously with the upper ptosis repair, thus maintain-
intense pulse light therapy (IPL) or LipoFlow (TearScience, ing palpebral fissure width as the area of functional vision
Morrisville, NC) to be significantly more effective than is translocated, minimizing additional postoperative surface
warm compresses alone. exposure.
Once tear function has been optimized, we discuss We prefer an external repair approach for ptosis in dry
the pros and cons of correction of their visually significant eye patients because of the theoretic possibility of interfer-
ptosis and their need for a long-term commitment to ing with accessory lacrimal gland function, and because of
continue these therapies after surgery. In patients who elect the ease of postoperative adjustment of aponeurotic repair
to undergo surgery, I often employ the internal levator when necessary. We attempt to avoid overcorrection and
advancement procedure for ptosis, as I have found that often settle for undercorrection. If simultaneous upper
this procedure minimizes risks of overcorrection and
lagophthalmos. In patients who are not candidates for
this procedure or are also in need of a blepharoplasty, I
perform an orbicularis-sparing external levator advance- Eric A. Cole, MD, FACS, is a fellowship-trained oculofacial
plastic and reconstructive surgeon at Cole Aesthetic Center in
ment procedure with intraoperative adjustment and try Silverdale, Washington.
to undercorrect the postoperative margin–reflex distance
1 (MRD1) slightly. Older patients with lower eyelid laxity Allan E. Wulc, MD, FACS, is an oculofacial cosmetic surgeon
with a practice in Plymouth Meeting, Pennsylvania. Dr. Wulc
or inferior scleral show often benefit from a horizontal is an associate clinical professor of ophthalmology at the
tightening procedure simultaneously to improve their tear University of Pennsylvania, and an adjunct clinical associate
pump mechanism. professor of otolaryngology at Temple University.

14 Focal Points Module 5, 2017


Clinicians’ Corner
eyelid blepharoplasty is performed along with the ptosis In the presence of dermatochalasis and steatoblepha-
repair, less than the expected amount of skin is resected and ron, if an eyelid crease anomaly needs to be addressed and
no orbicularis muscle is removed, to attempt to maintain if there is an intention of dealing with these issues, I will
normal eyelid closure. employ an external approach. If the patient has had a prior
Postoperatively, patients with dry eye must be treated internal approach, has a cicatrizing conjunctival disorder,
with aggressive topical therapy and observed carefully for or has had glaucoma surgery or is being considered for
worsening of dry eye signs and symptoms. In the rare case glaucoma surgery, I will also employ an external approach.
where the dry eye patient becomes more symptomatic after When performing an internal approach, my preference
ptosis repair, and after exhausting additional dry eye treat- is to perform an MMCR. I believe that this procedure spares
ment methods, an external levator advancement ptosis repair the meibomian glands, which are inevitably transected
has the advantage of being reversed as a minor procedure. with the Fasanella–Servat procedure. Furthermore, if a
future external approach is necessary, because of the lack
of success of the internal approach due to persistent ptosis
2. How do you decide whether to perform or recurrent ptosis, it is much more difficult to perform an
an internal or an external approach to external repair when the tarsus has been vertically chal-
involutional ptosis repair? If you perform a lenged with a previous Fasanella–Servat procedure. Eyelid
transconjunctival procedure, do you prefer the abnormalities, such as peaks or unnatural upper eyelid
Fasanella–Servat technique or a Müller muscle– contours, are common in this group of patients, and I have
often found it necessary to add additional tissue (dermis or
conjunctival resection (MMCR)? Which ptosis
contralateral tarsus when available) to support the elevation
clamp do you find most useful? and to maintain a natural eyelid shape.
Dr. Cole: I decide whether to perform an internal versus My preferred ptosis clamp with the internal procedure
external ptosis procedure based upon the patient’s response is the 6-pin titanium Putterman clamp.
to testing using 2.5% phenylephrine. In patients with a good
response (MRD-1 of 3 mm or greater after phenylephrine), 3. How do you counsel the patient with brow
I usually perform an internal ptosis repair. I have found that ptosis who is only aware of and referred for
neither the type of ptosis (acquired versus congenital) nor
management of eyelid malposition?
the severity of the ptosis is important in this decision. If the
patient responds favorably to phenylephrine testing, he or Dr. Cole: I am frequently referred patients for manage-
she is usually a good candidate for internal ptosis repair. I ment of eyelid malposition who actually suffer from
use the procedure described by Dr. Allen Putterman and eyebrow ptosis either as an isolated condition or concur-
favor his style of clamp. I find the procedure quick, easy, rently with eyelid ptosis. I carefully explain to patients, as
and extremely predictable. I am not a proponent of the they look into a mirror in primary gaze, what the effect of
Fasanella–Servat procedure, as it involves partial excision each of the separate procedures would accomplish both
of the tarsal plate. Excision of a portion of the tarsal plate, functionally and aesthetically. Once I am sure that patients
while effective in elevation of the ptotic eyelid, can result understand the interrelationship of the eyelid–eyebrow
in eyelid instability if future ptosis procedures, such as an complex and have a reasonable expectation of the potential
external levator resection, become necessary for the patient. aesthetic and functional outcomes, I let them make an
In patients who do not favorably respond to phenylephrine educated decision as to which procedures or combinations
or need a simultaneous blepharoplasty, I use the external of procedures they feel would be of the most benefit. In
approach to ptosis repair, with levator aponeurosis advance- my practice, most women with eyebrow ptosis or temporal
ment or resection. eyebrow hooding elect to have their eyebrows repositioned
surgically to improve their functional and/or aesthetic
Dr. Wulc: The phenylephrine test is a maneuver used
outcome. Correction of the eyebrow ptosis can occur in
in routine ptosis evaluation. Originally described with
conjunction with eyelid surgery or as an isolated surgical
10% phenylephrine instilled into the affected eye, I use a
procedure, depending upon the patient’s needs and
2.5% solution and assess the eyelid position at 10 minutes.
aesthetic expectations. In general, most men in my practice
A phenylephrine-responsive patient will often benefit
choose not to proceed with eyebrow repositioning surgery
from an internal approach, such as an MMCR, and can
unless functionally necessary, due primarily to potential
obtain predictable results. The phenylephrine test is also
complications such as facial feminization or poor scar
clinically useful if an external repair is contemplated. In the
camouflage due to male pattern hair loss.
patient undergoing an external approach, local anesthetic
with epinephrine injected in a phenylephrine-responsive Dr. Wulc: The patient who is referred and unaware of his
patient will produce intraoperative elevation of the eyelids, or her brow malposition is a daily visitor to my practice.
interfering with intraoperative assessment. In these patients, The patient who comes in for an eyelid lift often pulls the
a compensatory overcorrection of the ptosis should be brow upward, stating that vision is improved with this
performed (by approximately 1.5 mm).

Focal Points Module 5, 2017 15


Clinicians’ Corner
maneuver. The patient thinks that this maneuver mimics with which the silicone sling can be adjusted in the office with
the effects of eyelid surgery. I quickly point out that this is local anesthesia, if symptomatic dry eye or lagophthalmos
not the procedure that he or she will be undergoing if eyelid develops in an adult patient. Children are more able to
surgery alone is performed: they are mimicking the effects tolerate lagophthalmos and do not develop keratopathy as
of a brow lift. readily, when compared to adult patients. I do not harvest
Many patients with brow ptosis inevitably believe autogenous fascia in children, as this leaves an unsightly
that the removal of excess skin from the eyelids will both scar on the lateral aspect of the thigh and has no proven
improve their appearance and relieve the hooding that benefit regarding the longevity of the sling. Because I
exists because of ptosis of the tail of the brows. In fact, have had a higher incidence of inflammatory reactions to
ptosis repair and/or blepharoplasty may accentuate or even products made of Gore-Tex, requiring secondary interven-
worsen the brow ptosis, because the demand for frontalis tions, I have discontinued use of this material for frontalis
action may diminish after the eyelid issues are addressed. sling procedures.
I often counsel these patients that they may be dissatisfied
with the aesthetic aspects of their surgery if a browlift is Dr. Wulc: When performing autologous fascia repair, I
not performed. Postoperatively, this group of patients often often use temporalis fascia. It is easily harvested, proximate
thinks that not enough skin was removed with the original to the operative field, abundant, regenerates, and can be
procedure, and the patients think they need a secondary reharvested if necessary. I employ a modification of the
blepharoplasty to remove more skin. suspension approach described by Dailey, Wilson, and
In our office, we have an album of pre- and postopera- Wobig. I have no experience with banked fascia, but many
tive photos of patients who have undergone blepharoplasty of my colleagues use it and are satisfied with it. For exog-
and/or ptosis repair, with and without brow surgery, to enous slings in adults, I use the Seiff silicone suspension set
allow the patient to better understand this management (Beaver-Visitec, Waltham, MA). These are most helpful in
conundrum. This album also includes examples of patients cases of myopathic or neuromyopathic ptosis, especially in
with brow and eyelid ptosis who elected to have eyelid the presence of concomitant ophthalmoparesis, as the repair
surgery alone, and then who underwent brow ptosis surgery. can be adjusted at any point postoperatively to address an
This way the patient can see the aesthetic transition as each undercorrection or an overcorrection.
element was individually addressed. Often—but not always—
there is an “aha” moment where the patient understands how
the brow is intimately involved in eyelid aesthetics. 5. What are the primary advantages and
Most patients with upper eyelid ptosis and brow ptosis disadvantages of different methods of fixation
who are referred because of visual symptoms, such as in endoscopic forehead lifting?
altitudinal field loss, are improved from a visual standpoint
without brow lift surgery. A subgroup of these patients, Dr. Cole: I have used many of the products commercially
however, will be unhappy with their appearance after available for brow fixation in endoscopic brow and
functional upper eyelid surgery. While it is easy to diagnose forehead lifting, including sterile self-tapping dissolvable
these 2 conditions when they occur simultaneously, it is screws and anchors, removable self-tapping screws,
difficult to predict the individual patient’s level of postop- and Endotine devices (Advantech Surgical; Torquay,
erative satisfaction. Devon, England). I believe that if the eyebrow, forehead,
If, after counseling these patients, I am convinced a and posterior scalp are properly released during the
browlift will be necessary from an aesthetic standpoint endoscopic browlift, the type of fixation used is of minimal
and if the patient declines a browlift, I ask for a signed importance, as all these devices are extremely effective. The
informed consent stating that a browlift was advised. This major issue is the product cost, which can be significant,
maneuver has helped me remind the dissatisfied patient in especially if you are performing the surgery for functional
the postoperative period that the interrelationship between purposes in a private ambulatory surgery center. Years
brow and upper eyelid aesthetics was discussed. ago, I switched to the bone bridge device developed by
Dr. Sykes at the University of California Davis. This
product is reusable, easy to use, low cost, and extremely
4. Which materials do you use for frontalis effective, requiring only suture for fixation. The use of this
sling procedures? device also limits potential foreign body reactions and
patient dissatisfaction due to the temporary palpability of
Dr. Cole: In general, I perform frontalis sling procedures most implants.
only in patients with severe congenital ptosis who have a
Berke levator function less than 4 mm. In patients with Dr. Wulc: It is impossible to achieve fixation of the
4–8 mm of levator function, I prefer procedures such as the forehead unless a complete periosteal release is performed
“supermaximal” external levator resection. Typically, I will at the supraorbital rim, and a lateral release is performed
use a silicone frontalis sling for adult patents and a banked beyond the inferotemporal crest ligament at least to the
fascia product for children. I base this choice on the ease level of the sentinel veins. The release is more important

16 Focal Points Module 5, 2017


Clinicians’ Corner
than the means of fixation. Excessive traction in the absence procedure that I greeted with great enthusiasm because
of release can result in alopecia that often can go beyond the of the ease and elegance of addressing the brow through
area of the incisions. an eyelid incision. In 1994, I compiled my results with
Over the years, I have tried several approaches, such this technique and presented them at an International
as nonfixation after full periosteal release, externalized Aesthetic Congress, and, unfortunately, found that my
screws, permanent and nonresorbable anchors, which are long-term results with this procedure were disappointing.
sutured to frontalis, and sutureless resorbable tines, which The medial brow could not be elevated with this technique.
penetrate the soft tissues of the forehead. Patients who had the internal approach often complained
Currently, obtain fixation by suturing the frontalis of palpability of the sutures and tenderness long after the
muscle directly to the frontal bone in my 2 paramedian procedure, whether absorbable or nonabsorbable sutures
incisions areas, made approximately 4.5 cm from the were employed. Recurrence of lateral brow ptosis also was a
midline and posterior to the hairline. I use a 5 mm, guarded problem in my patients.
J-latch bit to create 2 adjoining drill holes in the anterior Recently, Massry described a mini-external browpexy
table, through which I pass 2-0 absorbable sutures that performed at the time of eyelid surgery—a direct browlift
secure the frontalis to bone in buried mattress fashion. Fixa- with a single suture performed through a small incision—
tion of the temporal aspect of the temporoparietal fascia to and I have tried this procedure in a limited number of
the temporalis can be accomplished with a 3-0 absorbable patients with success. Postoperatively, patients may com-
suture, but I have not found this maneuver particularly plain about pain related to the suture, and, while healing,
useful, as temporal brow ptosis recurs unless a complete prominence of the suprabrow scar.
release is achieved.
The tines can clip, and they can be painful if they are
placed close to sensory nerves. They have been associated 7. What is your approach to the male patient
with granulomatous reactions. Anchors, if not seated with marked alopecia, absence of forehead
properly, can be palpable until they resorb and can be furrows, and a thin eyebrow, but with
annoying to the patient. Both these means of securing the significant brow ptosis and temporal
forehead add substantially to the cost of the procedure. hooding?

Dr. Cole: Male patients with marked alopecia, absent


6. What is the role for the browplasty forehead furrows, and thin eyebrow hairs are excellent
procedure performed concomitantly with candidates for an endoscopic brow- and forehead lifting.
upper eyelid blepharoplasty and/or ptosis The 2 central incisions can be 1–1.5 cm vertical lines and
surgery? the temporal incisions need to only be approximately
1.5–2 cm in length. With meticulous closure of these
Dr. Cole: I commonly perform browlifting procedures incisions and great care with tissue manipulation, these
in combination with blepharoplasty or ptosis surgery. The incisions are nearly invisible several months after surgery.
combination of these procedures can safely be performed Patient satisfaction with this procedure is extremely high.
for either cosmetic or functional indications. Patients who Internal eyebrow-pexy through an eyelid-crease incision is
have truly visually significant brow ptosis as well as visually also in option in these patients, although I have not been
significant blepharoptosis benefit tremendously by the able to personally achieve the degree of eyebrow eleva-
combination. Patients who desire aesthetic improvement, tion or patient satisfaction with this procedure as I have
most commonly due to mild-to-moderate temporal brow achieved with endoscopic browlifting.
hooding or medial brow descent, are also typically very
happy with this combination of procedures. The surgeon Dr. Wulc: Bald or balding patients represent a manage-
must be very careful not to over lift the eyebrow, as this ment dilemma because of the theoretic risk of creating a
can result in significant lagophthalmos. The risk of this visible scar in someone who may already be self-conscious
complication can be minimized by simultaneously perform- about hair loss. However, I have had excellent results with
ing the “pinch test” of the upper eyelid dermatochalasis to endoscopic forehead lifting in patients who are completely
determine the amount of excess skin to be resected, while bald, where there is no possibility of concealing a scar. Scars
having your assistant manually lift the eyebrow to the in this location are usually inconspicuous and heal well.
desired postoperative height. The patient is then marked Forehead incisions can be hidden in horizontal forehead
in this position to determine the maximum safe potential rhytids, or made in slightly irregular patterns to avoid
eyebrow height that can be achieved, while ensuring the drawing attention to a linear scar. If a scar were to become
eyelids will still freely close after the procedure. apparent postoperatively, it could be treated postoperatively
with fractional laser resurfacing or radiofrequency micro­
Dr. Wulc: Transpalpebral internal browpexy, originally needling. Fortunately, I have not found additional treat-
described by McCord and Doxanas in 1990, was a ments of this sort to be necessary.

Focal Points Module 5, 2017 17


Clinicians’ Corner
8. What role do botulinum toxin (eg, Botox, can be quite different in each patient. I ask patients to
Dysport, or Xeomin) injections have in return when they feel the effects have worn off and they
the management of brow ptosis? What is desire re-treatment.
your preferred technique and frequency of Dr. Wulc: Botulinum toxin is a useful adjunct for elevating
injections? the brow and can be used in instances of mild-to-moderate
brow ptosis. Chemical browlifting with botulinum toxin is
Dr. Cole: Botulinum toxin injections have a role in unpredictable—patients should be advised that the results
mild-to-moderate brow ptosis in patients who are not ready are not as precise as those that can be obtained with surgery.
to undergo eyebrow surgery or are not currently candidates Contour abnormalities and undercorrections are common.
for surgical intervention. To my knowledge, none of the A trial of botulinum toxin to elevate the brows can be
insurance carriers in my area consider botulinum treatment performed to decide whether it is useful for the patient who
for eyebrow ptosis a “covered” expense, which severely is not interested in a surgical browlift.
limits its use in functional patients. I use approximately The most recent technical contribution to the
20 units of Botox (60 units of Dysport) to maximally “microdroplet” botulinum toxin injections as described by
weaken the eyebrow/forehead depressors (corrugators Steinsapir. This innovative technique produces a uniform
and procerus muscles) of the glabella. I also weaken the and natural elevation of the brows. Botulinum toxin is
lateral orbital orbicularis, which has a secondary function administered to the depressor supracilii, the procerus,
of pulling the eyebrows down and inward. To get maximal the corrugator supracilii, and the orbital portion of the
browlifting with botulinum toxin injections, one should orbicularis in small concentrations.
not treat the frontalis muscle too aggressively. The goal Chemical browlifting with botulinum toxin needs to
is to allow it to elevate the eyebrows upward without the be repeated at approximately 3-month intervals. Over time,
oppositional downward force of the weakened glabellar this approach may become more expensive than a cosmetic
muscles. I do not have set periods for patients to return for endoscopic browlift.
treatment, as I find the effective duration of the treatment

18 Focal Points Module 5, 2017


Suggested Reading Collin JRO. A Manual of Systematic Eyelid Surgery. 2nd ed. London: Churchill
Livingstone; 1989.
Allen RC, Saylor MA, Nerad JA. The current state of ptosis repair: a
comparison of internal and external approaches. Curr Opin Ophthalmol. Cruz AA, Akaishi PM, Mendonça AK, Bernardini F, Devoto M, Garcia DM.
2011;22(5):394–9. Supramaximal levator resection for unilateral congenital ptosis: cosmetic
and functional results. Ophthal Plast Reconstr Surg. 2014;30(5):366–71.
Allen RC, Zimmerman MB, Watterberg EA, Morrison LA, Carter KD.
Primary bilateral silicone frontalis suspension for good levator function Dailey RA, Wilson DJ, Wobig JL. Transconjunctival frontalis suspension
ptosis in oculopharyngeal muscular dystrophy. Br J Ophthalmol. 2012; (TCFS). Ophthal Plast Reconstr Surg. 1991:7(4):289–97.
96(6):841–5. Frueh BR. The mechanistic classification of ptosis. Ophthalmology. 1980;
Anderson RL. Predictable ptosis procedures: do not go to the dark side. 87(10):1019–21.
Ophthal Plast Reconstr Surg. 2012;28(4):239–41. Georgescu, Anderson RL, McCann JD. Brow ptosis correction: a compari-
Anderson RL, Dixon RS. Aponeurotic ptosis surgery. Arch Ophthalmol. son of five techniques. Facial Plast Surg. 2010;26(3):186–92.
1979;97(6):1123–8. Kikkawa DO, Miller SR, Batra MK, Lee AC. Small incision nonendoscopic
Baker MS, Shams PN, Allen RC. The quantitated internal suture browpexy: browlift. Ophthal Plast Reconstr Surg. 2000;16(1):28–33.
comparison of two brow-lifting techniques in patients undergoing upper Lemke BN, Stasior OG. The anatomy of eyebrow ptosis. Arch Ophthalmol.
blepharoplasty. Ophthal Plast Reconstr Surg. 2016;32(3):204–6. 1982:100(6):981–6.
Ben Simon GJ, Lee S, Schwarcz RM, McCann JD, Goldberg RA. External Massry GG. The external browpexy. Ophthal Plast Reconstr Surg. 2012;
levator advancement vs Müller’s muscle–conjunctival resection for correc- 28(2):90–5.
tion of upper eyelid involutional ptosis. Am J Ophthalmol. 2005;140(3):
McCord CD, Doxanas MT. Browplasty and browpexy: an adjunct to
426–32.
blepharoplasty. Plast Reconstr Surg. 1990;86(2):248–54.
Berke R. Results of resection of the levator muscle through a skin incision
McCulley TJ, Kersten RC, Kulwin DR, Feuer WJ. Outcome and influencing
in congenital ptosis. Arch Ophthalmol. 1959;61(2):177–201.
factors of external levator palpebrae superioris aponeurosis advancement
Berke, R. The surgical treatment of congenital ptosis. Trans Pa Acad Ophthal- for blepharoptosis. Ophthal Plast Reconstr Surg. 2003;19(5):388–93.
mol Otolaryngol. 1961;14:57–61.
Nerad JA. Oculoplastic Surgery: The Requisites in Ophthalmology. St Louis:
Bernardini F, Cetinkaya A, Zambelli A. Treatment of unilateral congenital Mosby; 2001.
ptosis: putting the debate to rest. Curr Opin Ophthalmol. 2013;24(5):484–7.
Steinsapir KD, Rootman D, Wulc A, Hwang C. Cosmetic microdroplet
Callahan MA, Beard C. Beard’s Ptosis. 4th ed. Birmingham, AL: Aesculapius botulinum toxin A forehead lift: a new treatment paradigm. Ophthal Plast
Publishing Co; 1990. Reconstr Surg. 2015;31(4):263–8.

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Focal Points Cumulative Index 1983–2016
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