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3.A.3.5.2
Cu+-, Ag+-ATPase (efflux)

Accession Number: P05425

Protein Name: CopB
Length: 745
Molecular Weight: 81523.00
Species: Enterococcus hirae [1354]
Number of TMSs: 8
Location1 / Topology2 /
Cell membrane1 / Multi-pass membrane protein2
Orientation3:

Cross database links:

Pfam: PF00122 PF00702

Gene Ontology

GO:0016021 C:integral to membrane

GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0004008 F:copper-exporting ATPase activity
GO:0046872 F:metal ion binding
GO:0006754 P:ATP biosynthetic process
GO:0006825 P:copper ion transport

References (4)

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[1] “Primary structure of two P-type ATPases involved in copper homeostasis in

Enterococcus hirae.” Odermatt A.et.al. 8048974
[2] “Cloning of the K+-ATPase of Streptococcus faecalis. Structural and
evolutionary implications of its homology to the KdpB-protein of Escherichia
coli.” Solioz M.et.al. 2953719
[3] “Induction of the putative copper ATPases, CopA and CopB, of Enterococcus
hirae by Ag+ and Cu2+, and Ag+ extrusion by CopB.” Odermatt A.et.al.
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8037745
[4] “Copper and silver transport by CopB-ATPase in membrane vesicles of
Enterococcus hirae.” Solioz M.et.al. 7721839

External Searches:

Search: nr DB with NCBI Protein BLAST

BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
CDD Search (Conserved Domain Database)
Search COGs (Clusters of Orthologous Groups of proteins)
2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)

Window Size: 19 Angle: 100 Alpha

Plot Hydropathy & Amphipathicity

FASTA formatted
sequence
1: MNNGIDPENE TNKKGAIGKN PEEKITVEQT NTKNNLQEHG KMENMDQHHT HGHMERHQQM
61: DHGHMSGMDH SHMDHEDMSG MNHSHMGHEN MSGMDHSMHM GNFKQKFWLS LILAIPIILF
121: SPMMGMSFPF QVTFPGSNWV VLVLATILFI YGGQPFLSGA KMELKQKSPA MMTLIAMGIT
181: VAYVYSVYSF IANLINPHTH VMDFFWELAT LIVIMLLGHW IEMNAVSNAS DALQKLAELL
241: PESVKRLKKD GTEETVSLKE VHEGDRLIVR AGDKMPTDGT IDKGHTIVDE SAVTGESKGV
301: KKQVGDSVIG GSINGDGTIE ITVTGTGENG YLAKVMEMVR KAQGEKSKLE FLSDKVAKWL
361: FYVALVVGII AFIAWLFLAN LPDALERMVT VFIIACPHAL GLAIPLVVAR STSIAAKNGL
421: LLKNRNAMEQ ANDLDVIMLD KTGTLTQGKF TVTGIEILDE AYQEEEILKY IGALEAHANH
481: PLAIGIMNYL KEKKITPYQA QEQKNLAGVG LEATVEDKDV KIINEKEAKR LGLKIDPERL
541: KNYEAQGNTV SFLVVSDKLV AVIALGDVIK PEAKEFIQAI KEKNIIPVML TGDNPKAAQA
601: VAEYLGINEY YGGLLPDDKE AIVQRYLDQG KKVIMVGDGI NDAPSLARAT IGMAIGAGTD
661: IAIDSADVVL TNSDPKDILH FLELAKETRR KMIQNLWWGA GYNIIAIPLA AGILAPIGLI
721: LSPAVGAVLM SLSTVVVALN ALTLK

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