Phthalic Anhydride

Safety Data Sheet

according to Regulation (EC) No. 453/2010
Revision date: 02/02/2011 Supersedes: Version: 10.0

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1. Product identifier
Chemical type : Substance
Substance name : Phthalic Anhydride
EC index no : 607-009-00-4
EC no : 201-607-5
CAS No. : 85-44-9
REACH registration No. : 01-2119457017-41-0024
IUPAC name : 2-benzofuran-1,3-dione
Chemical name : C8H4O3
Synonyms : Anhydride of Phthalic Acid / Anhydride of Acid 1,2 Benzene Di-Carboxilic
1.2. Relevant identified uses of the substance or mixture and uses advised against
1.2.1. Relevant identified uses
Main use category : Industrial use
Use of the substance/preparation : Intermediate
monomer
Laboratory chemicals
Production of chemicals.
Formulation of preparations (mixtures).

See Annex for Exposure Scenarios.

1.2.2. Uses advised against
None
1.3. Details of the supplier of the safety data sheet
Supplier (Only Representative):
ITS Testing Services (UK) Ltd
Intertek Expert Services
Caleb Brett House
734 London Road
RM20 3NL
West Thurrock, Grays
United Kingdom
Phone: +44 (0)1708 680 200
e-mail: ies10.reach@intertek.com

Manufacturer:
Elekeiroz S.A. (Várzea Paulista-SP Plant)
Rua Dr. Edgardo de Azevedo Soares, 392
CEP 13224-030
Phone:
(00-55-11) 4596-8880
(00-55-11) 4596-8788
(00-55-11) 4596-8907 (business hours).
Fax:
(00-55-11) 4596-8881
E-mail (customer service):
elisabete.moskalenko@elekeiroz.com.br
carlos.villani@elekeiroz.com.br
1.4. Emergency telephone number
Emergency number : +44 (0)1708 680 200,(business hours)

SECTION 2: Hazards identification

2.1. Classification of the substance or mixture
Classification according to Regulation (EC) No. 1272/2008 [CLP]
Acute Tox. 4 (Oral) H302
Skin Irrit. 2 H315
Eye Dam. 1 H318
Resp. Sens. 1 H334
Skin Sens. 1 H317
STOT SE 3 H335
Full text of H-phrases: see section 16.
Classification according to Directive 67/548/EEC or 1999/45/EC
Xn; R22
Xn; R42
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Phthalic Anhydride
Safety Data Sheet
according to Regulation (EC) No. 453/2010

Xi; R41
Xi; R37/38
Xi; R43
Full text of R-phrases: see section 16.

Adverse physicochemical, human health and environmental effects

No reliable data available.
2.2. Label elements
Labelling according to Regulation (EC) No. 1272/2008 [CLP]
Hazard pictograms (CLP) :

GHS05 GHS07 GHS08

Signal word (CLP) : Danger
Hazard statements (CLP) : H302 - Harmful if swallowed
H315 - Causes skin irritation
H317 - May cause an allergic skin reaction
H318 - Causes serious eye damage
H334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335 - May cause respiratory irritation
Precautionary statements (CLP) : P261 - Avoid breathing fume.
P280 - Wear protective gloves, protective clothing, eye protection, face protection.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water
P304+P340 - IF INHALED: Remove to fresh air and keep at rest in a position comfortable for
breathing
P305+P351+P338 - IF IN EYES: Rinse cautiously with water for several minuts. Remove contact
lenses, if present and easy to do. Continue rinsing
P312 - Call a POISON CENTER/doctor/physician if you feel unwell

2.3. Other hazards

other hazards which do not result in : None known.
classification

SECTION 3: Composition/information on ingredients

3.1. Substances
Name Product identifier % Classification according to
Directive 67/548/EEC
Phthalic anhydride (CAS No.) 85-44-9 > 99.5 Xn; R22
(EC no) 201-607-5 Xi; R37/38-41
(EC index no) 607-009-00-4 R42/43
Name Product identifier % Classification according to
Regulation (EC) No.
1272/2008 [CLP]
Phthalic anhydride (CAS No.) 85-44-9 > 99.5 Eye Dam. 1, H318
(EC no) 201-607-5 Resp. Sens. 1, H334
(EC index no) 607-009-00-4 Acute Tox. 4 (Oral), H302
Skin Irrit. 2, H315
STOT SE 3, H335
Skin Sens. 1, H317
Full text of R-, H- and EUH-phrases: see section 16.
3.2. Mixtures
Not applicable

SECTION 4: First aid measures

4.1. Description of first aid measures
First-aid measures after inhalation
: Solid. Remove casualty to fresh air and keep warm and at rest. In case of hazardous fumes,
wear autonomous breathing apparatus. In case of irregular breathing or respiratory arrest
provide artificial respiration. If not breathing, give artificial respiration. No mouth-to-mouth or
mouth-to-nose resuscitation.Use respiratory bag or oxygen resuscitation apparatus. Seek
medical advice. If unconscious, place in the recovery position and seek medical advice. Liquid.
Move victim out of danger zone. Move to fresh air. In case of breathing difficulties administer
oxygen. Put victim at rest, cover with a blanket and keep warm.

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Phthalic Anhydride
Safety Data Sheet
according to Regulation (EC) No. 453/2010

First-aid measures after skin contact : Solid. After contact with skin, wash immediately with plenty of water. Remove contaminated
clothing and shoes. Wash contaminated clothing before reuse. Liquid. After contact with skin,
take off immediately all contaminated clothing, and wash immediately with plenty of water and
soap. Seek medical advice. Do not try to remove product crusts from affected parts of the skin by
force or by using solvents. Seek medical attention immediately. Rinse thoroughly with plenty of
water for at least 20 minutes and take medical advice. Thoroughly clean shoes before re-using.
After contact with the molten product, cool rapidly with cold water.
First-aid measures after eye contact : Solid. Seek medical attention immediately. Remove contact lenses, if present and easy to do.
Continue rinsing. Liquid. Rinse immediately and thoroughly, pulling the eyelids well away from
the eye (15 minutes minimum). Rinse immediately with plenty of water for 15 minutes. Keep eye
wide open while rinsing. Seek immediate medical advice.
First-aid measures after ingestion : Solid. If swallowed, rinse mouth with water (only if the person is conscious). Remove casualty to
fresh air and keep warm and at rest. Give water to drink if victim completely conscious/alert. If
swallowed, do not induce vomiting: seek medical advice immediately and show this container
label. Caution if victim vomits: Risk of aspiration!. Never give anything by mouth to an
unconscious person. In case of unconsciousness place in unconscious position and seek
medical advice. Liquid. Seek medical advice. Unconscious: maintain adequate airway and
respiration. If the person is fully conscious, make him/her drink water. Never give an unconscious
person anything to drink.
4.2. Most important symptoms and effects, both acute and delayed
No reliable data available.
4.3. Indication of any immediate medical attention and special treatment needed
Avoid any direct contact with the product. Keep victim warm and rested. Symptomatic treatment should include, above all, measured of support as
correction of hydro electrolytic and metabolic disturbances and respiratory failure.

SECTION 5: Firefighting measures

5.1. Extinguishing media
Suitable extinguishing media: : Water spray. carbon dioxide (CO2), dry chemical powder, foam.
5.2. Special hazards arising from the substance or mixture
Fire hazard : Combustible if heated.
Explosion hazard : Dust may form explosive mixture in air. Explosive vapour/air mixtures may be formed.
5.3. Advice for firefighters
Protective equipment for firefighters : In case of fire: Wear self-contained breathing apparatus. Complete protective clothing. Refer to
section 8.

SECTION 6: Accidental release measures

6.1. Personal precautions, protective equipment and emergency procedures
6.1.1. For non-emergency personnel
Protective equipment : Refer to section 8.
Emergency procedures : Remove all sources of ignition. Wear suitable protective clothing. Avoid contact with skin and
eyes.

6.1.2. For emergency responders

Protective equipment : Refer to section 8.
Emergency procedures : Remove all sources of ignition. Wear suitable protective clothing. Avoid contact with skin and
eyes.
6.2. Environmental precautions
Prevent entry to sewers and public waters.
6.3. Methods and material for containment and cleaning up
For containment : If melted: allow liquid to solidify before taking it up. Solid spill: shovel into dry and closing drums.
Methods for cleaning up : Dispose of this material and its container to hazardous or special waste collection point. Ensure
waste is collected and contained. Dispose in a safe manner in accordance with local/national
regulations. Do not empty into drains or the aquatic environment.
6.4. Reference to other sections
refer to section 8. For disposal of residues refer to section 13 : Disposal considerations.

SECTION 7: Handling and storage

7.1. Precautions for safe handling
Precautions for safe handling
: Avoid inhalation of product. Avoid contact with skin and eyes. Keep away from oxidising agents
and strongly alkaline and strongly acidic materials. Copper oxide (II). Nitric acid. Sulfuric acid.
Sodium nitrite. Use personal protective equipment as required. Refer to section 8. Wash hands
thoroughly after handling. When using do not eat, drink or smoke. Take off contaminated clothing
and wash before reuse.

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Phthalic Anhydride
Safety Data Sheet
according to Regulation (EC) No. 453/2010

7.2. Conditions for safe storage, including any incompatibilities

Technical measures: : Keep/Store only in original container. Store in dry, cool, well-ventilated area. Keep away from
food, drink and animal feedingstuffs. Keep locked up and out of the reach of children. Proper
grounding procedures to avoid static electricity should be followed. Keep away from sources of
ignition. Liquid.
Storage condition(s) : Solid. Keep container tightly closed and dry. Protect from sunlight. Store in a well-ventilated
place. storage temperature: Store under inert atmosphere. Keep contents under nitrogen. store
in adequate storage tanks placed in containment basin to retain product in case of leakage.
Incompatible products : Keep away from oxidising agents and strongly alkaline and strongly acidic materials. Copper
oxide (II). Nitric acid. Sulfuric acid. Sodium nitrite.
Packaging materials : Solid. Liquid.
7.3. Specific end use(s)
See Annex for Exposure Scenarios.

SECTION 8: Exposure controls/personal protection

8.1. Control parameters

Phthalic anhydride (85-44-9)

Austria MAK (mg/m³) 1 mg/m³
Austria MAK Short time value (mg/m³) 2 mg/m³
Austria Remark (AT) inhalable aerosol
Belgium Limit value (mg/m³) 6.2 mg/m³
Belgium Limit value (ppm) 1 ppm
France VLE (mg/m³) 6 mg/m³
Italy - Portugal - USA ACGIH ACGIH TWA (mg/m³) 6.1 mg/m³
Italy - Portugal - USA ACGIH ACGIH TWA (ppm) 1 ppm
Spain VLA-ED (mg/m³) 6 mg/m³
Spain VLA-ED (ppm) 1 ppm
Switzerland VLE (mg/m³) 1 mg/m³
Switzerland VME (mg/m³) 1 mg/m³
Switzerland Remark (CH) inhalable aerosol
Canada (Québec) VEMP (mg/m³) 6.1 mg/m³
Canada (Québec) VEMP (ppm) 1 ppm
DNEL : 32.2 mg/m³ Workers/Inhalation (Long-term, systematic effects)
: 10 mg/kg bw/day Workers/Dermal (Long-term, systematic effects)
: 8.6 mg/m³ Consumers/Inhalation (Long-term, systematic effects)
: 5 mg/kg bw/day Consumers/Dermal (Long-term, systematic effects)
: 5 mg/kg bw/day Consumers/Oral (Long-term, systematic effects)
PNEC : 1 mg/l Fresh water
: 0.1 mg/l Marine water
: 5.6 mg/l Intermittent releases
: 3.80 mg/kg d.w. Sediment (freshwater)
: 0.38 mg/kg d.w. Sediment (marine water)
: 0.173 mg/kg d.w. Soil
: 10 mg/l Sewage treatment

8.2. Exposure controls

Appropriate engineering controls : Emergency eye wash fountains and safety showers should be available in the immediate vicinity
of any potential exposure. Local exhaust is needed at source of vapours. In case of inadequate
ventilation wear respiratory protection.
Personal protective equipment : Safety glasses. Protective clothing. Gloves.

Eye protection : safety goggles. Don`t wear contact lenses.

Skin and body protection : Solid. Liquid. Full protective suit. chemical resistant PVC gloves (to European standard EN 374
or equivalent). Wear protective gloves/protective clothing/eye protection/face protection.
Respiratory protection : respiratory protection helmet/breathing hood.

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Phthalic Anhydride
Safety Data Sheet
according to Regulation (EC) No. 453/2010

Environmental exposure controls : Avoid release to the environment. Do not allow into drains or water courses or dispose of where
ground or surface waters may be affected. Prevent spreading over great surfaces (e.g. by
damming or installing oil booms). Relevant water authorities should be notified of any large
spillage to water course or drain.

SECTION 9: Physical and chemical properties

9.1. Information on basic physical and chemical properties
Physical state : solid
Appearance : crystalline.
Molecular mass : 148.1156
Colour : colourless.
Odour : No data available
Odour threshold : No data available
pH : No data available
Melting point : 131.6 °C
Solidification point : 131.6 °C liquid
Boiling point : 284.5 °C standard pressure (101,3 kPa)
Flash point : 152 °C Closed cup
Relat. evapor. rate comp. to butylacetate : No data available
Flammability (solid, gas) : Not flammable.
Explosive limits : 1.7-10.85 vol %
0.015 g/m³ Powder
Vapour pressure : 0.0006 hPa (at 26.6 °C)
Relative vapour density at 20 °C : 5.1
Relative density : 1.527 g/cm³ (at 20 °C)
Solubility : soluble in most organic solvents. Soluble in carbon disulfide. soluble in formic acid (470 g/L at
20°C).
Water: 6000-16400 mg/l According to literature
Log Pow : 1.6 measured
Self ignition temperature : 580 °C
Decomposition temperature : No data available
Viscosity, kinematic : No data available
Viscosity, dynamic : 1.19 mPa.s (at 132 °C)
Explosive properties : No data available
Oxidising properties : No data available
9.2. Other information
No reliable data available.

SECTION 10: Stability and reactivity

10.1. Reactivity
No reliable data available.
10.2. Chemical stability
Stable in use and storage conditions as recommended in item 7. No polymerization .
10.3. Possibility of hazardous reactions
No reliable data available.
10.4. Conditions to avoid
No reliable data available.
10.5. Incompatible materials
Keep away from oxidising agents and strongly alkaline and strongly acidic materials. Copper oxide (II). Nitric acid. Sulfuric acid. Sodium nitrite.
10.6. Hazardous decomposition products
carbon dioxide (CO2). Carbon monoxide.

SECTION 11: Toxicological information

11.1. Information on toxicological effects
Acute toxicity : Harmful if swallowed.
Phthalic Anhydride (85-44-9)
LD50 oral rat 1530 mg/kg
LD50 dermal rabbit > 3160 mg/kg

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Phthalic Anhydride
Safety Data Sheet
according to Regulation (EC) No. 453/2010

Phthalic Anhydride (85-44-9)

LC50 inhalation rat (mg/l) > 2.14 mg/l/4h
Skin corrosion/irritation : Causes skin irritation.
Serious eye damage/irritation : Causes serious eye damage.
Respiratory or skin sensitisation : May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic
skin reaction.
Germ cell mutagenicity : Not classified
Carcinogenicity : Not classified
Reproductive toxicity : Not classified
Specific target organ toxicity (single exposure) : May cause respiratory irritation.
Specific target organ toxicity (repeated : Not classified
exposure)
Aspiration hazard : Not classified
Potential Adverse human health effects and : Irritating to the respiratory system, may cause throat pain and cough. Abdominal pain, nausea.
symptoms Burning sensation. pulmonary oedema.
Other information : Phthalic anhydride is metabolized in humans to phthalic acid. Repeated dose toxicity (oral),
NOAEL: 500 mg/kg bw/day. Mutagenicity (in vitro) : negative. Did not show carcinogenic effects
in animal experiments. NOAEL: 1000 mg/kg bw/day. No indications of human reproductive
toxicity exist. Toxicity for reproduction: NOAEL: 1000 mg/kg bw/day. Developmental toxicity,
maternal toxicity: NOAEL: 1000 mg/kg bw/day. Developmental toxicity, teratogenicity: NOAEL =
1700 mg/kg bw/day.

SECTION 12: Ecological information

12.1. Toxicity
Ecology - general : This substance may be hazardous to the environment.
Ecology - water : Phthalic anhydride reacts rapidly with water, forming phthalic acid.
Phthalic Anhydride (85-44-9)
LC50 fishes 1 560 mg/l
EC50 Daphnia 1 > 640 mg/l 48 h
EC50 other aquatic organisms 1 731 mg/l Terrestrial Plants (3d)
EC50 other aquatic organisms 2 > 1000 mg/l
NOEC (acute) 10 mg/l fishes (60d)
NOEC (chronic) 16 mg/l Daphnia (21d)

12.2. Persistence and degradability

Phthalic Anhydride (85-44-9)
Persistence and degradability Rapidly degradable. low persistence.
Biodegradation in water readily biodegradable and inherent biodegradable
Degradation rate in water Hydrolysis - 30.5 seconds at pH 7.24 at 25°C
Photolysis - 3.9 to 9.6 hours
Phototransformation in air Atmospheric half-life of 21.4 d for phthalic anhydride
Atmospheric half-life of 13 d for phthalic acid
Adsorption/desorption Koc < 31
Volatilisation Henry’s law constant: 2.21 x 10-7 Pa m³/mol

12.3. Bioaccumulative potential

Phthalic Anhydride (85-44-9)
BCF terrestial organisms - seeds 0.0046
BCF terrestial organisms - plants 0.0013
BCF other aquatic organisms 1 3.4 calculated
Log Pow 1.6 measured
Bioaccumulative Potential The product presents low bioaccumulative potential in aquatic organisms.

12.4. Mobility in soil

Phthalic Anhydride (85-44-9)
Mobility in soil High
Ecology - soil Direct and indirect exposure to soil is unlikely.

12.5. Results of PBT and vPvB assessment

Phthalic Anhydride (85-44-9)
Results of PBT assessment This substance does not meet the criteria for classification as PBT or vPvB.

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Phthalic Anhydride
Safety Data Sheet
according to Regulation (EC) No. 453/2010

12.6. Other adverse effects

No reliable data available.

SECTION 13: Disposal considerations

13.1. Waste treatment methods
Additional information : Dispose in a safe manner in accordance with local/national regulations. Empty container retains
product residue.

SECTION 14: Transport information

In accordance with ADR / RID / ADNR / IMDG / ICAO / IATA
14.1. UN number
Solid : Not a hazardous material with respect to transportation regulations.
Liquid UN-No. : 3256
14.2. UN proper shipping name
Solid : Not a hazardous material with respect to transportation regulations.
Liquid
Proper shipping name : ELEVATED TEMPERATURE LIQUID, FLAMMABLE, N.O.S.
Transport document description : UN 3256 ELEVATED TEMPERATURE LIQUID, FLAMMABLE, N.O.S., 3, III, (D/E)
14.3. Transport hazard class(es)
14.3.1. Overland transport
Solid : Not a hazardous material with respect to transportation regulations.
Liquid
Class (ADR) : 3 - Flammable liquids
Danger labels (ADR) : 3 - Flammable liquid

14.3.2. Transport by sea

Solid : Not a hazardous material with respect to transportation regulations.

14.3.3. Air transport

Solid : Not a hazardous material with respect to transportation regulations.
14.4. Packing group
Packing group (ADR) : III
14.5. Environmental hazards
Other information : No supplementary information available.
14.6. Special precautions for user
14.6.1. Overland transport
No reliable data available.
14.6.2. Transport by sea
No reliable data available.
14.6.3. Air transport
No reliable data available.
14.7. Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable

SECTION 15: Regulatory information

15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture
15.1.1. EU-Regulations
Compliance with following regulations:
- Regulation (EC) 1907/2006 as amended
- Regulation (EC) 1272/2008 as amended
- Directive 67/548/EEC as amended
- Directive 1999/45/EC as amended

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Phthalic Anhydride
Safety Data Sheet
according to Regulation (EC) No. 453/2010

15.1.2. National regulations

No data available. For further information contact our Product Safety Office.

15.2. Chemical safety assessment

Chemical Safety Assessment has been completed. See Annex for Exposure Scenarios.

SECTION 16: Other information

Sources of Key data : SDS. CSR: Chemical Safety Report.
Abbreviations and acronyms : ASTM - American Society for Testing and Materials . CLP - Classification, Labelling and
Packaging. CSR: Chemical Safety Report. EC - European Community. EEC: European
Economic Community. GHS - Globally Harmonised System. Overland transport (ADR). PVC
(Polyvinyl chloride). REACH - Registration, Evaluation, Authorisation and Restriction of
Chemicals. SDS - Safety Data Sheet.
Full text of R-, H- and EUH-phrases:
------ Acute Tox. 4 (Oral) Acute toxicity (Oral) Category 4
------ Eye Dam. 1 Serious Eye Damage/Irritation Category 1
------ Resp. Sens. 1 Respiratory sensitization Category 1
------ Skin Irrit. 2 skin corrosion/irritation Category 2
------ Skin Sens. 1 Skin sensitization Category 1
------ STOT SE 3 Specific target organ toxicity (single exposure) Category 3
------ H302 Harmful if swallowed
------ H315 Causes skin irritation
------ H317 May cause an allergic skin reaction
------ H318 Causes serious eye damage
------ H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
------ H335 May cause respiratory irritation
------ R22 Harmful if swallowed.
------ R37/38 Irritating to respiratory system and skin.
------ R41 Risk of serious damage to eyes.
------ R42 May cause sensitization by inhalation.
------ R42/43 May cause sensitization by inhalation and skin contact.
------ R43 May cause sensitisation by skin contact.

This information is based on our current knowledge and is intended to describe the product for the purposes of health, safety and environmental requirements only. It should not therefore be
construed as guaranteeing any specific property of the product.

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