OBESITY, ADIPOKINES AND OXIDATIVE STRESS: THE EFFECT OF BODY WEIGHT REDUCTION

Authors: Milica Bošković, assit. prof. dr Milena Velojić Golubović

Introduction: Increased oxidative stress is one of the main characteristic of obesity and it is known to be related with
comorbidities [1]. With weight reduction there were increase in the antioxidant defense system and reduction of oxidative
markers [2].
The aim: Aim of the study was to investigate the correlation between anthropometric parameters, adiponectin and leptin with
parameters of oxidative stress, and to determine the effect of weight reduction (TT) and changes in the level of adipokines on
the parameters of oxidative stress.
Material and Methods: This study included 60 obese women with a body mass index (BMI) of 36.46 ± 5.32, waist circumference
(WC) of 103.18 ± 14.42 and waist/hip ratio (WC/HC) of 0.89 ± 0.09. After a low-calorie diet was applied, over a six-month
period, weight reduction was greater than 5%. In all subjects, before and after the weight reduction, levels of leptin,
adiponectin, xanthine oxidase (XO), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were
determined.
Results: The average weight loss was 8.64 ± 1.99 kg or 8.55 ± 1.97℅ (p <0.001), resulting in a statistically significant reduction in
anthropometric parameters (BMI, WC, WC/HC) with a statistically significant reduction in the level of leptin and increase in the
level of adiponectin (p <0.001). Achieved TT reduction resulted in a statistically significant increase in the parameters of
antioxidant protection (GPx, SOD, CAT) and the decline in XO values (p <0.001). Significant correlation between the
anthropometric parameters and the parameters of oxidative stress was not established. Leptin statistically significant negative
correlates with GPx, SOD and CAT. The correlation of adipokines with anthropometric parameters was positive and statistically
significant only with SOD.
Conclusion: Achieved weight reduction led to statistically significant changes in the parameters of oxidative stress in terms of
reduction of the oxidative stress levels. There was positive correlation between adipokines and antioxidant protection
parameters, with statistically significantly influence of leptin.

References:

1. Klisic A, Kocic G, Kavaric N, Jovanovic M, Stanisic V et al.. Body mass index is independently associated with xanthine oxidase
activity in overweight/obese population. Eat Weight Disord 2018.
2. Bigornia SJ, Hess DT, Apovian CM, McDonnell ME, Duess MA et al.. Long-term successful weight loss improves vascular
endothelial function in severely obese individuals. Obesity 2010; 18: 754–759.