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PREDISPOSING FACTORS PRECIPITATING FACTORS

 Age  Hyperparathyroidism
 Gender  Cancers
 Genetics (Familial Hypocalciuric Hypercalcemia  Medications (Thiazide Diuretics)

Parathyroid gland
inactivating
hyperactive in
mutation of the Thiazide Diuretics Mutation
producing PTH
calcium-sensing inactivates tumor
receptor gene suppressor gene
Calcium blood Chemotherapy
Excess PTH
tests; >10.2 Loss of water and
released in Pamidronate
mg/dl underexcretion of Ca
bloodstream
inappropriate regulation of Gallium Nitrate Cell proliferation
Serum
passive paracellular calcium and inactivation of
creatinine
absorption in the loop of Henle Surgical Resection DNA-repair gene
Increase stimulation of test; elevated
bones to release >0.6 mg/dl Osmotic diuresis
Calcium
Failure of kidney to excrete Metastasis in the
calcium body
Calcium retained in MRI Scan; presence
blood of tumors
Excess Calcium in the Polyuria
kidneys
Dehydration Calcium release
from breakdown

Calcitonin

Surgical Neck Exploration/


Hypercalcemia
Removal

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