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COLLEGE OF MEDICINE AND HEALTH SCIENCES

SCHOOL OF MEDICINE AND PHARMACY


Department of Pharmacy / YEAR 4: 2018-2019

FORENSIC TOXICOLOGY MCQs

1. According to the history of forensic toxicology, the following are correct except
a. Orfila is the father of forensic toxicology
b. Publication of the first complete work on the subject of poisons
and legal medicine in 1813
c. James M. Marsh developed a test for the presence of arsenic in
tissue in 1836
d. James M. Marsh successfully identify arsenic extracted from
human tissues in 1839

2. The following explain the forensic toxicology except


a. Integrate the analytical chemistry and toxicology
b. It is conducted for the medico-legal purpose
c. applies published and widely accepted scientific methods and practices,
for both detection of poisons and interpretation of results
d. none

3. The following are the sources of the poison except


a. Domestic
b. Agricultural and horticultural
c. Industrial and Commercial
d. Drugs and medicines
e. Food and drink
f. No other possible sources

4. The following sample specimen is crucial for postmortem in identification of


times elapsed from the incidence take place
a. Blood and kidney
b. Urine and vitreous humor
c. Lung and hair
d. Answer b is partially correct (50%)

BY MT-EINSTEIN
MINANI
COLLEGE OF MEDICINE AND HEALTH SCIENCES
SCHOOL OF MEDICINE AND PHARMACY
Department of Pharmacy / YEAR 4: 2018-2019

5. The following specimen is the most important in substance investigation in the


human body
a. Kidney
b. Lung
c. Liver
d. Blood
e. All are most crucial

6. For the suicidal death investigation cause by water , liver , lac etc,… the
following organs is the best indicator to access the truth
a. Blood
b. Gastric content
c. Liver
d. lung

7. The most important sample for forensic pathologist is:


a. Blood
b. Urine
c. Bile
d. Liver
e. Stomach content

8. Subjective effects of alcohol are due to its subjective effects on:


a. Brain (frontal)
b. Stomach
c. Liver
d. Heart
e. Prostate

9. Most common pathology due to alcoholism involves:


a. Liver
b. Lung
c. Kidney
d. Brain

BY MT-EINSTEIN
MINANI
COLLEGE OF MEDICINE AND HEALTH SCIENCES
SCHOOL OF MEDICINE AND PHARMACY
Department of Pharmacy / YEAR 4: 2018-2019

10. What is the most effective sample for detection of substance abuse?
a. Plasma
b. Whole blood
c. Urine
d. Gastric content

11. The following specimen are used for the heroin detection
a. Bile
b. Gastric content
c. Hair
d. Kidney

12. The following is the best sample for heroin detection


a. Hair
b. Gastric content
c. Urine
d. Bile

13. The following are the major scope of forensic toxicology except
a. Death Investigation Toxicology (Postmortem Toxicology)
b. Human Performance Toxicology
c. Doping Control
d. Forensic Workplace Drug Testing
e. None

14. Regarding the postmortem toxicology , the following are correct except
a. It is The dose make that makes poisons which vary interindividually
b. F.T deals with the analysis of a variety of fluids and tissue samples for
the detection of drug or poisons
c. Evidence will be collected by any pathology specialist or and sent to a
toxicologist for analysis
d. The chain of custody should be thoroughly respected
e. None

BY MT-EINSTEIN
MINANI
COLLEGE OF MEDICINE AND HEALTH SCIENCES
SCHOOL OF MEDICINE AND PHARMACY
Department of Pharmacy / YEAR 4: 2018-2019

15. Regarding the death investigation, the following are correct except
a. There are numerous possible specimens
b. The history and preference may narrow the fluid specimen to collect
c. In recent death, blood, vitreous humor, liver and the gastric contents are
commonly collected.
d. The bone is the only good specimen for the severely decomposed death

16. The following are correct EXCEPT


a. The blood is the first choice of specimen to be collected by forensic
pathologist
b. The syringe with large gauge needle is used due to the small clot appear
in the blood
c. Urine is not useful for detecting substance abuse
d. urine is only available in about 50% of deaths, as it is fairly common for
the bladder to be voided during the dying process
e. Many drugs are metabolized so extensively that the parent drug is not
detected in urine, or is present only at a relatively low concentration
f. The extreme poor correlation urine drug and concentration

17. The following are essential and critical reasons for Proper collection and
preservation of postmortem specimens are correct except
a. In forensic toxicology , there are need to perform many experiment
b. There are no opportunity to go back collecting the new specimen
c. The body should be buried or hidden
d. None is incorrect

18. The following is the primary specimen applied in postmortem toxicology


a. Urine
b. Gastric content
c. Bile
d. Liver
e. None

BY MT-EINSTEIN
MINANI
COLLEGE OF MEDICINE AND HEALTH SCIENCES
SCHOOL OF MEDICINE AND PHARMACY
Department of Pharmacy / YEAR 4: 2018-2019

19. The following are most important and primary specimen to use in postmortem
toxicology respectively
a. Blood and Liver
b. Kidney and bile
c. Gastric content and hair
d. No right answer

20. The following is the best specimen for analysis of substances undergo
postmortem redistribution
a. Brain
b. Liver
c. Lung
d. Bile

21. The following are correct except


a. The liver is highly fatty this need the stage of cleanup for reducing matrix
effect for well specimen analysis
b. drug concentrations in the stomach may be quite high, even after the
majority of the drug has passed into the small intestine
c. the concentration of sbces in the leaver is relatively stable before death
d. it take long detection window for analyzing sbces in hair specimen

22. The following specimens is specific for the substances which are extensively
metabolized and extensive distribution is
a. Lung
b. Gastric content
c. Kidney
d. Urine
e. All

BY MT-EINSTEIN
MINANI
COLLEGE OF MEDICINE AND HEALTH SCIENCES
SCHOOL OF MEDICINE AND PHARMACY
Department of Pharmacy / YEAR 4: 2018-2019

23. Which of the drug can be identified by the smell


a. Parathion
b. Alcohol
c. Hashish
d. All of the above
e. None of the above

24. The following drugs can be detected via the hair specimens except
a. Cannabis
b. Heroin
c. Cocaine
d. Alcohol
e. Amphetamine

25. It take one week for the hair to reach at the scalp T/F
26. The hair to tested in laboratory is 3.9cm from the root T/F
27. The hair growth at speed of 1.3cm/month T/F

28. The following specimens is suitable for analyzing substances containing


conjugate metabolite

a. Liver
b. Kidney
c. Bile
d. Gastric content
e. Spleen

29. They are poor correlational of substances concentration in the following


specimens
a. Bile and spleen
b. Kidney and liver
c. Brain and spleen
d. Urine and bile
e. All are correct

BY MT-EINSTEIN
MINANI
COLLEGE OF MEDICINE AND HEALTH SCIENCES
SCHOOL OF MEDICINE AND PHARMACY
Department of Pharmacy / YEAR 4: 2018-2019

30. The following specimen is secondary suitable for detection of heavy metals
a. Bile
b. Spleen
c. Kidney
d. Brain

31. The concentration of drug/poison is like in the brain part T/F

32. The following is secondary suitable organs for detection of carbon monoxide
and cyanide
a. Liver
b. Blood
c. Spleen
d. Kidney

33. The following are correct except


a. The drug/ poison is distributed in the brain at different concentration in
the different brain part
b. The spleen specimen is used in the detection of the heavy metal
c. Kidney has been used as a secondary specimen for toxins, such as carbon
monoxide and cyanide, which bind to hemoglobin.
d. Subcutaneous injection sites offer a better chance of detection, since
absorption is considerably slower.
e. B and c are incorrect

34. The following drug can be detected in nasal swabs


a. Heroin
b. Cocaine
c. Alcohol
d. Antidepressant
e. All

BY MT-EINSTEIN
MINANI
COLLEGE OF MEDICINE AND HEALTH SCIENCES
SCHOOL OF MEDICINE AND PHARMACY
Department of Pharmacy / YEAR 4: 2018-2019

35. Cadaveric spasm is common in:


a. Homicidal and violent deaths.
b. Ante-mortem stress.
c. Suicidal and accidental deaths.
d. Excessive activity.
e. Convulsive deaths.

36. perforated nasal septum is found in addicts of:


A) opium
B) cocaine
C) hashish
D) alcohol
E) heroin

37. The following are correct except


a. residues of partially dissolved medications found in a drinking glass at a
scene of death can be a strong indicator of suicidal intent
b. Other containers used to mix poisons prior to suicidal consumption (or
homicidal administration) can also be useful to the toxicologist.
c. Most of pesticides are not detected readily in blood using routine screening
procedures, but can be detected much more easily in the concentrated
residue in a container.
d. Ante mortem specimen are those taken before the patient die and are
essential for since some are almost impossible to be seen after death

38. The following is the recommended specimens due to motor vehicles accidents
except
a. Blood
b. Urine
c. vitreous humor
d. liver
e. kidney

BY MT-EINSTEIN
MINANI
COLLEGE OF MEDICINE AND HEALTH SCIENCES
SCHOOL OF MEDICINE AND PHARMACY
Department of Pharmacy / YEAR 4: 2018-2019

39. The following is the recommended specimens due homicide and drug related
accidents except
a. Blood and Urine
b. vitreous humor and gastric contents
c. bile ,liver and hair
d. none of the above

40. The common ante mortem specimen need to the hospital is


a. Urine
b. Gastric content
c. Blood
d. Liver
e. All

41. The following drugs could not be more harmful when exposed without
synergist
a. Cocaine
b. Marijuana
c. Benzodiazepine
d. Antidepressant

42. The following is the reasons of postmortem toxicology of analgesics


a. They all target mainly liver
b. They are accessible by people easily (OTC)
c. They have small therapeutic window
d. They have unknown mechanisms

BY MT-EINSTEIN
MINANI
COLLEGE OF MEDICINE AND HEALTH SCIENCES
SCHOOL OF MEDICINE AND PHARMACY
Department of Pharmacy / YEAR 4: 2018-2019

43. Regarding the human performance toxicology , the following are false except
a. Human performance toxicology involves the determination of the
absence of drugs/alcohol in an appropriate sample and how they modify
human behavior and performance.
b. The use of alcohol and drug is implicated in various death investigations
such us homicides, sexual assault and impaired driving, resulting in
serious medico-legal repercussions.
c. The most frequently analyzed specimens are blood and urine, providing a
strong basis for interpreting the effects of exposure, using ancient
analytical techniques
d. Positive results from a hair sample can be used to determine time of use
as the drug may deposit in hair for prolonged period of time
e. None

44. Regarding the human performance toxicology , the following are true except
a. Forensic pathologist are required to reveal the extent and time of
impairment caused by the ingested drugs or alcohol
b. It is important that toxicologist interpret the result and be aware of the
medicine synergistic mechanism
c. The anabolic steroid are prohibited to the sportive like athletics
d. Biological samples have different windows for detection such as heroin
and cocaine may be detected in urine or saliva for week period while
marijuana may be detected for a month.

45. Regarding the performance toxicology investigation , the following are correct
except:
a. Samples are obtained from living humans and there is no any impact of
postmortem drug redistribution.
b. Samples are collected for different purposes such as presence, use, or
abuse of substance.
c. The identification process is usually further examined with quantification
of the drug in the body or of the amount that may have been ingested.
d. Testing for some commonly abused drugs such as methadone, fentanyl
and other synthetic opioids may need separate order

BY MT-EINSTEIN
MINANI
COLLEGE OF MEDICINE AND HEALTH SCIENCES
SCHOOL OF MEDICINE AND PHARMACY
Department of Pharmacy / YEAR 4: 2018-2019

46. Regarding the doping control , the following are correct


“According to the World-Anti Doping Code, for a substance to be prohibited it
must meet at least two of the following criteria”:
a. Represents only actual health risks
b. Enhances, or potentially enhances, sport performance
c. Against the spirit of the sport
d. b and c are correct

47. Regarding the clenbuterol use , the following are correct except
a. Increase metabolism
b. Reduce fat
c. Increase muscle mass
d. All are correct

48. Preservation of nasal swab may be useful in:


a. Immersion
b. Cocaine poisoning
c. Cyanide poisoning
d. Asphyxia
e. CO poisoning

49. The hair specimen are advantages for substance abuse investigation for the
following reasons except
a. Less embarrassment during sample collection
b. Non-invasive
c. Longer detection period
d. None

50. Regarding doping control choose the incorrect “Though, techniques to analyse
hair samples for doping control are available, the lack of information in the
following areas makes result interpretation difficult”
a. Influence of external contamination
b. Genetic differences
c. Influence of cosmetic treatment
d. Reference data

BY MT-EINSTEIN
MINANI
COLLEGE OF MEDICINE AND HEALTH SCIENCES
SCHOOL OF MEDICINE AND PHARMACY
Department of Pharmacy / YEAR 4: 2018-2019

e. Influence of hair color


f. Quality of drug used and metabolites in hair

51. Regarding the Forensic Workplace Drug Testing “ the following are not
correct”
a. Alcohol and drugs are used in society and is reflected in the workplace
b. Alcohol and drug misuse during working hours before or after work,
always poses a problem to both the employer and employees
c. Drug abuse effects and symptoms are much better known compared to
those of alcohol use
d. The drug testing programme in a workplace should be legally, ethically
and scientifically accepted
e. B and c are not correct

52. Regarding the Forensic Workplace Drug Testing, choose the incorrect
a. Documentation of sample collection in chain-of-custody record help in
avoiding error and keeping sample integrity
b. immunoassay technology screening test that enables only the preliminary
detection of possible drug abuse with as results “non-negative” means
there is no presence of substance under detection.
c. For the negative result by immunino essay technology screening test
imply that there is no other further confirmatory test require
d. For the non-negative result make the person not entered in sensitive area
e. all are incorrect

53. Regarding the Forensic Workplace Drug Testing, choose the correct answers
a. mere repetition of the analysis by a second preliminary assay is a
confirmation and can be used in a medico-legal setting
b. For the non-negative preliminary result and the result to be deemed
“positive” a confirmation test is required.
c. The most suitable matrix for drug testing in workplace is hair
d. alcohol testing, breath is the ideal matrix since it mimics blood alcohol
concentration
e. For cannabis, saliva is ideal matrix for workplace drug testing

BY MT-EINSTEIN
MINANI
COLLEGE OF MEDICINE AND HEALTH SCIENCES
SCHOOL OF MEDICINE AND PHARMACY
Department of Pharmacy / YEAR 4: 2018-2019

54. Regarding Investigation of Toxicity-related death/injury, choose the right


answers
a. Basic phases in investigation of toxicity related death are Collection of
information and specimens, Toxicological analysis and Data
interpretation.
b. What was the route of administration, What was administered dose?, Is
concentration enough to have caused death or injury or altered the
victim’s behavior enough to cause death or injury? “are the primary
questions to ask when conducting autopsy”
c. Many different body fluids and organs should be subjects to collection
since xenobiotic have different affinities for body tissues and therefore
multiple extractions (for specific analyses) may be needed.
d. Specimen collection should be carried out after applying processes that
may destroy evidence

55. The following specimen is available for the burned or buried cadaver for
detection of antibiotics, antipsychotics, and drugs of abuse except
a. Blood
b. Muscle
c. Bone marrow
d. Vitreous humor and hair

56. The following specimen is available for the burned or buried cadaver for
detection of barbiturates, benzodiazepines, phenothiazine, morphine, and
Malathion.
a. Blood
b. Muscle
c. Bone marrow
d. Maggots

BY MT-EINSTEIN
MINANI
COLLEGE OF MEDICINE AND HEALTH SCIENCES
SCHOOL OF MEDICINE AND PHARMACY
Department of Pharmacy / YEAR 4: 2018-2019

57. The following are false except


a. addition of potassium fluoride to a tissue specimen can for example
preservative
b. sodium fluoride inhibit the production of bacterial ethanol that give false
positive result for the presence of ingested ethanol
c. It is critically only to realize the labeling and documentation of data/
specimen at the analysis stage
d. At every stage from the sampling to interpretation , the address of analyst
have to be indicated and time the result obtained
e. B and d are good choice

58. For the specimen with the drug in smallest amount , the suitable method have
to be
a. Accurate
b. Specific
c. Precise
d. Sensitive

59. While conducting the toxicological analyse remember to value


a. The suitability of method of choice
b. Nature of toxicant under the test
c. mount of specimen available
d. all of the above

60. The following is the specific methods for toxicological analysis except
a. Thermal desorption (residual volatile agents)
b. Thin-layer chromatography (TLC)
c. Enzymatic immunoassay
d. Gas chromatography (GC)

BY MT-EINSTEIN
MINANI
COLLEGE OF MEDICINE AND HEALTH SCIENCES
SCHOOL OF MEDICINE AND PHARMACY
Department of Pharmacy / YEAR 4: 2018-2019

61. Mr. manzi has been in the bar , he drink a lot of the alcohol , later he become
dependent to the alcohol that was finally lead to his hiver cirrhosis and failure,
while she was walking was talkative and move with disequilibrium, what
should be the right choice for mr manzi
a. Alcohol is a cause of Manzi’s death
b. alcohol Contribute to Manzi’s death
c. alcohol Cause Manzi’s liver impairment
d. alcohol Explain Manzi’s behavior
e. c and d are correct

62. this drug are common investigated in criminal case except


a. cannabis
b. heroin and cocaine only
c. ethanol
d. opioid
e. Caffeine

63. The following is common known the substances drug abuse for the musicians
a. Heroin
b. Cocaine
c. Cannabis
d. Opioid

64. The following is common known as substances drug abuse for the football
players
a. Opioid
b. Heroin
c. Cannabis
d. Cocaine

65. The following is common knowns substance drug abuse for the athletics
a. Anabolic steroid drug
b. Heroin
c. Cannabis
d. Cocaine

BY MT-EINSTEIN
MINANI
COLLEGE OF MEDICINE AND HEALTH SCIENCES
SCHOOL OF MEDICINE AND PHARMACY
Department of Pharmacy / YEAR 4: 2018-2019

66. Regarding the alcohol / ethanol ,choose the wrong answer


a. Ethanol is eliminated by first order kinetic elimination by oxidation and
excretion
b. Ethanol is a CNS stimulant affecting particularly the brain
c. Analysis of alcohol exemplifies the primary objective of forensic toxicology
d. Alcohol appears in the blood within minutes after it has been taken by mouth
e. A and B are the right choice

67. Choose the wrong statement


a. Elimination of alcohol throughout the body is accomplished through
oxidation and excretion.
b. The blood and breath are used to estimate quantity of alcohol in blood
c. Oxidation takes place less in the liver than in the kidney
d. Alcohol is excreted unchanged in the breath, urine, and perspiration.
e. A ,b and d are wrong statement

68. Regarding the alcohol testing , all are correct except


a. Many types of breath testers are designed to analyze a set volume of breath
b. The captured breath is exposed to UV- light
c. degree of the interaction of the light with alcohol in the captured breath
sample that allows the instrument to measure a blood alcohol concentration
in breath and
d. Some breath testing devices also use fuel cells

69. Regarding the alcohol testing , choose the right answer


a. Capillary electrophoresis is suitable for detecting alcohol in blood
b. retrograde extrapolation help to know amount of alcohol at the
moment of the incident
c. Capillary electrophoresis sample blood into its components, while
the MS represents a unique “fingerprint” pattern that can be used
for identification
d. Only A and C are the correct statement

BY MT-EINSTEIN
MINANI
COLLEGE OF MEDICINE AND HEALTH SCIENCES
SCHOOL OF MEDICINE AND PHARMACY
Department of Pharmacy / YEAR 4: 2018-2019

70. The following countries has zero tolerance of criminal action of alcohol
drinking while planning driving
a. USA
b. Rwanda
c. Russia
d. Uganda

71. Regarding endocannabinoid synaptic Transmission, choose the wrong


a. Excitatory transmission of the neurotransmitter glutamate causes an
influx of Ca++ into the post-synaptic neuron
b. The presence of Ca++ post-synaptically causes the production of
anandamide in the post-synaptic neuron
c. Chocolate cause mild euphoria due to the presence of anandamide and
anandamide digesting enzymes inhibitors
d. The endocannabinoid is then released into the synaptic cleft that later
binds to the Cannabinoid Receptor of the pre-synaptic neuron
e. Pre-Synaptic Neuron to Post-Synaptic Neuron impulse direction occur

72. Many cannabinoid receptors are found in the parts of the brain that affect
a. Pleasure and Memory
b. Thought and Concentration
c. Sensory and Time Perception
d. Coordinated Movement
e. All are the right options

73. According to Merck Index (12th Edition) has indicated an LD50 value for THC
as determined using rats, the following are correct except
a. Male Rats were determined to have an LD50 of 1270 mg/kg
b. Female Rats were determined to have and LD 50 of 730 mg/kg
c. Doing a direct scale up of this is 50g (female) and 86g (male)
d. The estimation show that it is a 68kg (150lbs) person.
e. Conclusively said there is direct correlation of result with human toxicity

BY MT-EINSTEIN
MINANI
COLLEGE OF MEDICINE AND HEALTH SCIENCES
SCHOOL OF MEDICINE AND PHARMACY
Department of Pharmacy / YEAR 4: 2018-2019

74. In general, which of the following factors is the most important regarding the
expected severity of a case of poisoning?
a. Dose of the poison.
b. Age of the person.
c. Sex of the person.
d. Form of the substance.
e. Route of exposure

75. Select the wrong statement


a. Toxicology is the science of poisons
b. Forensic toxicology deals with the identification of legal aspects of
poisoning
c. The poison is the substance that causes harmful effects to the living
organism
d. All poisons are toxins

76. The following are the negative short term effect of using cannabis except
a. Memory and Learning
b. Distorted Perception
c. Difficulty in Thinking and Problem Solving
d. Loss of Coordination and Increased Heart Rate
e. An increase in activation of the stress-response system

77. Regarding marijuana use, the following is wrong


a. Short term effects can lead to Changes in activity of nerve cells
containing dopamine
b. Risk of heart attack more than triple in first hour after smoking marijuana
c. Similar respiratory problems to tobacco smokers
d. Double or triple the risk of developing head and or neck cancer
e. None

BY MT-EINSTEIN
MINANI
COLLEGE OF MEDICINE AND HEALTH SCIENCES
SCHOOL OF MEDICINE AND PHARMACY
Department of Pharmacy / YEAR 4: 2018-2019

78. Regarding marijuana use, the following is wrong


a. Marijuana smoke contains 50 to 70 percent more carcinogenic
hydrocarbons than does tobacco smoke.
b. Marijuana users usually inhale more deeply and hold their breath longer
than tobacco smokers do
c. Marijuana strengthen the immunity as involves in possible tumor and
bacterial infections reduction
d. Research has shown that marijuana abusers remain impaired for a week
after quitting, but could return to normal within 4 weeks
e. None

79. Regarding marijuana use, the following is wrong


a. Aid in Cancer or AIDS treatment
b. Aid in Glaucoma by increasing blood pressure in the eye
c. Can relieve spasms (multiple sclerosis)
d. Mother compound Can reduce nervous tics and urges(Tourette syndrom)
e. Activation of CB1 receptors may facilitate neurogeneration and
neuroprotection which involve normalizing the problem of Alzheimer ,
Parkinson and multiple sclerosis

80. High dose of the cocaine intake involve in disturbing neurotransmitter by


a. Increasing re-uptake of noradrenaline
b. Increasing re-uptake of dopamine
c. Decrease re-uptake of noradrenaline and dopamine
d. Decrease re-uptake of serotonin
e. Only c and d are right answers

81. Cocaine is known as general anesthetic agent T/F

82. Hypertension is the common presentation in the poisoning


a. Morphine
b. Cocaine
c. Barbiturate
d. Tricyclic anti-depressant

BY MT-EINSTEIN
MINANI
COLLEGE OF MEDICINE AND HEALTH SCIENCES
SCHOOL OF MEDICINE AND PHARMACY
Department of Pharmacy / YEAR 4: 2018-2019

83. Hypothermia may cause death in poisoning with


a. Morphine
b. Opioids
c. Cocaine
d. TCA
e. Strychnine

84. Hyperthermia may cause death in poisoning with


a. Morphine
b. Opioids
c. Cocaine
d. TCA
e. Strychnine

85. A classic example of a poison that can give both systemic and local effects is
a. Oxalic acid.
b. Sulfuric acid.
c. Alkali
d. All of the above

THE END

BY MT-EINSTEIN
MINANI