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CNU0010.1177/1474515118786677European Journal of Cardiovascular NursingDanielis et al.

Original Article

European Journal of Cardiovascular Nursing

A five-year retrospective study of


1­–8
© The European Society of Cardiology 2018
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DOI: 10.1177/1474515118786677
https://doi.org/10.1177/1474515118786677

north-east Italian urban area journals.sagepub.com/home/cnu

Matteo Danielis1, Martina Chittaro2, Amato De Monte1,


Giulio Trillò1 and Davide Durì1

Abstract
Background: The reporting and analysing of data of out-of-hospital cardiac arrests encourages the quality improvement
of the emergency medical services. For this reason, the establishment of a sufficiently large patient database is intended
to allow analysis of resuscitation treatments for out-of-hospital cardiac arrests and performances of different emergency
medical services.
Aims: The aim of this study was to describe the demographics, characteristics, outcomes and determinant factors of
survival for patients who suffered an out-of-hospital cardiac arrest.
Methods: this was a retrospective study including all out-of-hospital cardiac arrest cases treated by the emergency
medical service in the district of Udine (Italy) from 1 January 2010–31 December 2014.
Results: A total of 1105 out-of-hospital cardiac arrest patients were attended by the emergency medical service. Of
these, 489 (44.2%) underwent cardiopulmonary resuscitation, and return of spontaneous circulation was achieved in
142 patients (29%). There was a male predominance overall, and the main age was 72.6 years (standard deviation 17.9).
Cardiopulmonary resuscitation before emergency medical service arrival was performed on 62 cases (44%) in the return
of spontaneous circulation group, and on 115 cases (33%) in the no return of spontaneous circulation group (p<0.024).
Among the 142 cases of return of spontaneous circulation, 29 (5.9%) survived to hospital discharge. There was a smaller
likelihood of return of spontaneous circulation when patients were female (odds ratio 0.61, 0.40–0.93). Patients who had
an out-of-hospital cardiac arrest with an initial shockable rhythm (odds ratio 6.33, 3.86–10.39) or an age <60 years (odds
ratio 2.91, 1.86–4.57) had a greater likelihood of return of spontaneous circulation. In addition, bystander cardiopulmonary
resuscitation (odds ratio 1.56, 1.04–2.33) was associated with an increased chance of return of spontaneous circulation.
Conclusion: The incidence of out-of-hospital cardiac arrest and survival rate lies within the known range. A wider
database is necessary to achieve a better knowledge of out-of-hospital cardiac arrest and to drive future investments in
the healthcare system.

Keywords
Out-of-hospital cardiac arrest, outcome, emergency medical service, cardiopulmonary resuscitation, survival.

Date received: 28 September 2017; revised: 13 June 2018; accepted: 13 June 2018

Introduction
1Department of Anaesthesia and Intensive Care, Azienda Sanitaria
Out-of-hospital cardiac arrest (OHCA) is one of the lead-
Universitaria Integrata di Udine, Italy
ing causes of death in Europe, with an incidence of 2Pneumology and Respiratory Physiopathology, Azienda Sanitaria
350,000–700,000 cases/year.1,2 In 2014, the European Universitaria Integrata di Udine, Italy
Registry of Cardiac arrest (EuReCa One) recorded 10,682
Corresponding author:
events in one month in a population of about 174 m citi-
Matteo Danielis, Department of Anaesthesia and Intensive Care,
zens in 27 European countries; of these, 773 events Azienda Sanitaria Universitaria Integrata di Udine, Via Pozzuolo, 330 –
occurred in Italy among a study population of 8 m citi- 33100 Udine, Italy.
zens.3 The Friuli Venezia Giulia Arrest Cooperative Study Email: danielis.matteo@gmail.com
2 European Journal of Cardiovascular Nursing 00(0)

(FACS) in 1998 accounted an incidence of 0.95/1000 of the Azienda Sanitaria Universitaria Integrata di
inhabitants events with a survival rate of 6.7%.4 Recently, Udine, Italy.
a retrospective cohort study based on the District of Trieste The EMS medical director extracted the pertinent data
(Friuli Venezia Giulia, Italy), reported an incidence of of all patients who suffered an OHCA which was con-
OHCAs of 287/100,000 with a survival rate of 8.5%.5 firmed and attended by EMS. The researchers of this study
Sudden cardiac death accounts for 78.5% of cases of maintained the anonymity and confidentiality of the data
OHCA,4 in the majority of cases due to acute coronary collected in strict accordance with the Italian law.
syndrome though other causes such as congenital cardi- Furthermore, data collection and study design were carried
opathy or arrhythmias may contribute.6 Initially, the out according to the Helsinki Declaration.
rhythm is ventricular fibrillation (VF) in 25–30% of cases Data were collected and reported using the Utstein
followed by ventricular tachycardia (VT).7 Asystole and style, a method developed for uniform reporting of data
pulseless electrical activity (PEA) are less frequent and from OHCAs and to solve a major problem in resuscita-
may be the result of a delayed monitoring of the arrest.8,9 tion research.13 Following this reporting style, we included
Early cardiopulmonary resuscitation (CPR) and the a flow chart with cardiac arrests and outcome variables.
availability of an automated external defibrillator (AED) The cardiac arrest variables were the aetiology (chest
are associated with significantly higher long-term survival pain, chronic kidney disease, lost of consciousness, neu-
of OHCA victims.10 It has been reported that bystander rological problem, trauma, hypoglycaemia, tentamen,
CPR and short intervention time are associated with unknown or other cause), causes of not carrying out resus-
increased survival post-cardiac arrest.11,12 citation (time criteria, serious injuries, dead body, termi-
Reporting and analysing data from OHCAs may encour- nal illness or other), number of CPRs performed, initial
age the quality improvement of the emergency medical ser- rhythm detected (VF, VT, PEA and asystole), and inci-
vice (EMS). Therefore, establishing a sufficiently large dence of return of spontaneous circulation (ROSC).
patient database is the main goal for identification of the best The outcome variables included 30-day, one-month and
treatment methods for OHCAs and organization of services. one-year survival, and the neurological status of survivors
The aim of this study was to investigate OHCA events according to the cerebral performance category (CPC) at
in the district of Udine (Friuli Venezia Giulia, Italy) in discharge. The CPC scale is composed of five categories:
terms of incidence, features and outcomes. a CPC score of one or two represented a favourable neuro-
logical outcome, while a CPC score of 3–5 was considered
as an unfavourable neurological outcome (score=1: good
Methods cerebral performance; 2: moderate cerebral disability; 3:
Design severe cerebral disability; 4: coma or vegetative state; and
5: brain death).14
A retrospective and cohort study was adopted, including The EMS time was defined as the interval in minutes
all OHCA cases treated by the EMS in the district of Udine from call to arrival at the scene of event.
between 1 January 2010–31 December 2014.

Study outcomes
Setting and population
The primary outcome was the incidence of ROSC in OHCA.
The Udine district is part of Friuli Venezia Giulia, a region Secondary outcomes included survival, neurological status
in the north-east of Italy. The EMS system targets 180,000 among those patients who survived to discharge as deter-
citizens. In Italy, 112 (emergency telephone number) calls mined by CPC score, determinant factors of ROSC, such as
are filtered through an Emergency Call Centre, and are EMS intervention time, minutes of CPR, CPR started by lay-
processed by trained nurses that assign a priority colour person/bystander, initial cardiac rhythm and defibrillations.
code: red (emergency), yellow (urgency), green (deferra-
ble), and white (not critical). Subsequently, they dispatch
Statistical analysis
the most appropriate team for each case. Nurses and vol-
unteers (non-healthcare qualified professionals) in the Collected data were entered into a Microsoft Excel work-
ambulance often become first responders in the local EMS; sheet and all statistical analysis was performed using R
in addition, vehicles staffed by emergency physicians can Statistical Software (version 3.4.1, Foundation for Statistical
support selected cases. All the OHCA intervention proto- Computing, Vienna, Austria). Continuous variables (age,
cols are based on the recommendations of the International time intervals) are displayed as mean, first, second, third
Liaison Committee on Resuscitation (ILCOR). quartile and standard deviation (SD). Nominal variables
(gender, CPR, ROSC, sending dispatch code, initial rhythm,
aetiology and outcome) are displayed as absolute number
Data collection and percentage. Student’s unpaired t-test was used to ana-
Study data were obtained from the database of the EMS lyse comparisons between means and categorical variables
that was hosted by the Udine University Hospital, part were analysed using chi-squared test for independence.
Danielis et al. 3

Figure 1.  Main data of out-of-hospital cardiac arrests (OHCAs) reported with Utstein style.
Missing data for cases not resuscitated (n=5) and aetiology (n=4). CKD: chronic kidney disease; CPC: cerebral performance category; CPR: car-
diopulmonary resuscitation; LoC: loss of consciousness; PEA: pulseless electrical activity; ROSC: return of spontaneous circulation; VF: ventricular
fibrillation; VT: ventricular tachycardia.

Logistic regression was performed to determine the an incidence of 123/100,000 inhabitants/year. Most of the
predictors of the main outcome (ROSC) for the patient OHCAs (742, 67%) occurred during daytime (from
submitted to CPR. Each potential variable was considered 08:00–20:00). We specified that EMS providers did not
separately to obtain odds ratio (ORs) for the individual witness the cardiac arrests, and confirmed OHCAs at the
effect of each predictor on the main outcome. All predictor time of their arrival.
variables used in the univariate analysis were used in the Figure 1 shows the Utstein data elements characterising
multivariable analysis to obtain adjusted ORs. A p value of OHCAs. Four hundred and three (37%) were immediately
<0.05 was considered significant for all tests. coded as OHCAs by dispatch nurses, whereas the remain-
ing 702 cases were classified under different dispatch rea-
sons: loss of consciousness (231, 21%), acute respiratory
Results failure (169, 15%), unknown problems (74, 7%), trauma
The EMS dealt with a total of 1105 OHCAs in the district (59, 5%), chest pain (30, 3%), neurological problems (35,
of Udine from 1 January 2010–31 December 2014, with 3%), tentamen (suicide attempt, 33, 3%), hypoglycaemia
4 European Journal of Cardiovascular Nursing 00(0)

Table 1.  Characteristics of patients submitted to cardiopulmonary resuscitation (CPR).

Variable ROSC (n=142) No ROSC (n=347) p


Age (mean, SD) 67.5±18.1 74.8±18.2 <0.001
Sex, F (n, %) 41 (29%) 137 (40%) 0.028
M (n, %) 100 (71%) 207 (60%)  
Sending dispatch code (n, %)  
White 3 (2%) 3 (1%)  
Green 7 (5%) 15 (4%)  
Yellow 44 (31%) 141 (41%) 0.583
Red 87 (62%) 188 (54%)  
EMS intervention time (min) 8’ 53’’ 9’ 18’’ 0.031
(mean, I, II, III quartile) 5/8/10 6/8/12
Minutes of CPR (min) 28.6 31.4 0.062
(mean, I, II, III quartile) 18.5/26/36 20/29/40
CPR started by layperson/bystander (n, %) 62 (44%) 115 (33%) 0.024
Initial rhythm  
VT/VF (n, %) 55 (39%) 9 (3%) <0.001
Asystole/PEA/not reported (n, %) 87 (61%) 338 (97%)
Defibrillation (n, %) 59 (42%) 48 (14%) <0.001

EMS: emergency medical service; PEA: pulseless electrical activity; ROSC: return of spontaneous circulation; SD: standard deviation; VF: ventricular
fibrillation; VT: ventricular tachycardia.
Missing data for gender (n=4) and sending dispatch code (n=1).

Table 2.  Distribution of out-of-hospital cardiac arrests over the five years.

Event 2010 2011 2012 2013 2014 p


(n=200) (n=166) (n=246) (n=245) (n=248)
CPR (n, %) 83 (42%) 81 (49%) 112 (46%) 111 (45%) 102 (41%) 0.55
ROSC (n,%) 24 (12%) 26 (16%) 28 (12%) 33 (14%) 31 (12%) 0.781
Alive (n, %) 3 (2%) 4 (2%) 6 (2%) 9 (4%) 7 (3%) 0.497

CPR: cardiopulmonary resuscitation; ROSC: return of spontaneous circulation.

(5, <1%), and others (i.e. haemorrhages, intoxications, yellow, and in 275 (56%) red, with no difference between
abdominal pain, psychiatric disorders, electrocution). the two groups.
Resuscitation was withheld in 616 cases (55.8%): Table 2 shows that the incidence of CPR, ROSC and
262 (43%) of those cases showed signs unequivocally survivors remained constant over the five years of obser-
associated with death; 162 (26%) cases were found in vation. Considering all OHCAs, patients undergoing CPR
cardiac arrest too late and resuscitation was withheld for ranged from 41–49%; of these, ROSC occurred in cases
time criteria, 46 (8%) had a serious injury, 141 (23%) which ranged from 12–16%, and survival rate ranged from
were terminally ill. A total of 489 patients (44.2%) 2–4%. Similarly, the interval in minutes from dispatch to
underwent CPR. There was an overall male predomi- arrival at site of collapse over the time remained the same
nance, and the mean age was 72.6 years (SD 17.9). VF (Figure 2). Specifically, in 2010, 2012 and 2013 the median
and pulseless VT are the shockable rhythms that EMS intervention time was eight minutes (SD=5), in 2011
appeared in the monitor of 87 patients (18%). Of the was eight (SD=4) and in 2014 was nine (SD=6; p=0.21).
489 patients, ROSC was achieved in 142 patients (29%). Nurse-assisted telephone bystander CPR instructions are
Among the 142 cases of ROSC, 77 died in the first 24 h, used in Italy. CPR started by layperson/bystander before
26 within 30 days, five in one year, and five after one EMS arrival was performed on 177 cases (16%), over a
year, 29 of them (5.9% of those receiving CPR) sur- period of five years (Table 3).
vived to hospital discharge. The association of potential predictor variables with the
Pre-EMS arrival, CPR was performed on 62 cases (44%) outcome ROSC is summarised in Table 4. In the univariate
in the ROSC group, and on 115 cases (33%) in the no ROSC analysis, patients with a ROSC were less likely to be
group (p<0.024). The median EMS intervention time was female (OR 0.61, 0.40–0.93) compared to non-survivors.
eight minutes in the two groups (Table 1). In six cases (1%), Patients who had an OHCA with an initial shockable
the dispatch code was white, in 22 (5%) green, in 185 (38%) rhythm (OR 6.33, 3.86–10.39) or an age <60 years (OR
Danielis et al. 5

2.91, 1.86–4.57) had a greater likelihood of ROSC. In treated by the Vienna Ambulance Service.16 This means
addition, bystander CPR (OR 1.56, 1.04–2.33) was associ- that the OHCA phenomenon must be linked to the demo-
ated with an increased chance of ROSC. graphic and clinical characteristics of the study population.
Furthermore, geographical features (urban vs rural) and
type of EMS are determinants when performing an epide-
Discussion miological analysis.
The incidence of OHCAs in our setting was 123/100,000 Historically, it’s well known that a shockable rhythm
inhabitants/year. Previously, other studies in our region (VF/VT) is correlated with a higher survival rate.8 We
investigated epidemiology and survival rate of OHCAs. found that an initial shockable rhythm had higher chance
The FACS study reported 150 cases of cardiac arrest due to of ROSC in patients with a cardiac arrest (OR 5.89, 3.49–
cardiac aetiology based on a population of 157,098 in one 9.95, p<0.0001). Non-shockable arrest rhythms (PEA and
year. Incidence was 95/100,000 inhabitants/year, with an asystole) represented an increasing proportion of reported
overall survival rate on resuscitation attempts of 6.7%.4 cases of OHCA. Studies of non-shockable rhythms are
More recently, Sanson et al., in 2016, registered a total of becoming gradually more important because of the larger
678 OHCAs due to different aetiology in a one-year retro- numbers of arrests with those rhythms as well as their sig-
spective study, with an incidence of 287/100,000 inhabit- nificantly worse outcomes.17,18 The goal is the conversion
ants/year and a survival rate of 8.5% of those receiving from non-shockable to shockable rhythms during the
CPR.5 Data reported in the international literature varies course of resuscitation.
greatly around the world. A prospective multi-centre Our results confirm a trend of poor survival rate, with a
observational study of all OHCAs from 2006–2007, high incidence of OHCAs. However, 18 survivors (62%)
reported an incidence ranging from 72–59 inhabitants/year showed a good neurological recovery with a CPC value of
in 11 North American sites, with a rate of survival to dis- one. A population-based cohort study in the Netherlands
charge ranging from 7.7–39.4%.15 Other data suggested an reported that the proportion of surviving patients that had
OHCA incidence of 207/100,000 inhabitants/year, as a favourable neurological outcome at discharge remained
reported in a cohort of patients with OHCAs who were high throughout the study period of seven years (89.9–
95.1%).19 Previous studies have shown that time to defi-
brillation decreased and survival increased with the
implementation of AED and CPR programmes.20,21 In our
study, CPR started by a bystander before EMS arrival was
performed in only 177 cases (16%), without an increase
over the study period. In 2015, Hasselqvist-Ax et al. ana-
lysed a total of 30,381 OHCAs in Sweden in a 10-year
period. CPR was performed before the arrival of EMS in
15,512 cases (51.1%) and this result was associated with
an increased 30-day survival rate (OR 2.15; 95% confi-
dence interval (CI), 1.88–2.45).22 In our country, across the
Province of Brescia, development of a programme based
on diffuse deployment of AEDs operated by trained volun-
teers was associated with an increase of survival rate from
0.9% in the historical cohort to 3% in the study population
(p=0.0015).10 In the future, the goal will be to increase
bystander CPR and AED use, to improve long-term sur-
vival and the other outcomes from cardiac arrests.
In our study, EMS response time was similar to other
research studies.5,23,24 Literature analysis confirms that the
Figure 2.  Interval in minutes from dispatch to arrival at the most suitable time of emergency response in OHCA is still
site of collapse over the five years. 0: 2010; 1: 2011; 2=2012; unknown, as well as the intensity and duration of treatment
3= 2013; 4=2014. by the EMS. However, EMS response time, including the

Table 3.  Cardiopulmonary resuscitation (CPR) started by layperson/bystander over the five years.

2010 2011 2012 2013 2014 Total p


(n=200) (n=166) (n=246) (n=245) (n=248) (n=1105)
CPR started by layperson/bystander (n, %) 33 (16%) 26 (16%) 42 (17%) 37 (15%) 39 (16%) 177 (16%) 0.975
6 European Journal of Cardiovascular Nursing 00(0)

Table 4.  Logistic regression analysis was performed to investigate the influence of different variables on chance of return of
spontaneous circulation (ROSC).

Univariate analysis Multivariate analysis


Characteristics OR (95% CI) p OR (95% CI) p
Sex (female) 0.61 (0.40–0.93) 0.023 0.74 (0.46–1.18) 0.207
Age<60 years 2.91 (1.86–4.57) <0.0001 2.51 (1.53–4.13) 0.0003
Cardiac aetiology 1.19 (0.80–1.78) 0.377 0.90 (0.57–1.44) 0.687
CPR duration>20 min 1.42 (0.93–2.16) 0.102 1.57 (0.98–2.51) 0.059
EMS response time>8 min 0.77 (0.52–1.15) 0.211 0.85 (0.54–1.31) 0.468
Shockable initial rhythm 6.33 (3.86–10.39) <0.0001 5.89 (3.49–9.95) <0.0001
CPR started by layperson/bystander 1.56 (1.04–2.33) 0.028 1.21 (0.75–1.94) 0.416

CI: confidence interval; CPR: cardiopulmonary resuscitation; EMS: emergency medical service; OR: odds ratio.

time used to access the EMS dispatch centre and for per- available except for survival. Secondly, all the data came
forming call processing and dispatch of the rescue from a single metropolitan area served by a dedicated
resources, should be as short as possible. It is well known emergency central, a model since discontinued with the
that rapid resuscitation performed within the first four recent adoption of a single dispatch centre covering the
minutes after OHCA shows a favourable prognostic factor whole Friuli Venezia Giulia Region.
for higher survival.24
Our study reported six (1%) cases of white (not criti-
Implications for practice and the
cal) and 22 (5%) cases of green (not very critical) dis-
patch runs, that were subsequently identified as OHCAs nursing perspective
upon arrival of the ambulance. This may highlight a lack Although survival rates for OHCA are disappointing,
of effort in education of the whole population on proper rapid and effective basic and advanced life support
EMS activation. A previous study in Danish and Swedish (ALS) are crucial to improve survival, prevent neuro-
countries, aimed to analyse and compare the accuracy of logical deficit and improve the quality of life of patients
OHCA recognition by medical dispatchers.25 Data from suffering from cardiac arrest.10 Nurses play a key role in
cardiac arrest databases were merged with audio record- the management of OHCAs; in Italian EMS they are
ings of emergency call data, and showed that the sensi- often the first on the scene of an OHCA. This translates
tivities for recognition of cardiac arrest (calculated with to the need for all nursing staff to be currently CPR and
data from electronically registered data) were only defibrillator-certified and further trained to the level of
40.9% in Denmark and 78.4% in Sweden (p<0.001). ALS. However, the certificate alone is not enough;
When adding data from the audio recordings, the sensi- refresher training in a simulated environment with
tivities were 80.7% and 86.0% for the two regions emphasis on quality is crucial.26
respectively (p=0.06). ‘Unclear problem’ was the most In an out-of-hospital environment, emergency nurses
frequent dispatch code for audited non-recognised need to keep their skills updated including both technical
OHCA. In conclusion, for EMS nurses, prehospital tri- skills, such as managing defibrillation, airway and ventila-
age of patients with cardiac arrest is a difficult task, and tion, lines, drugs and tubes, and non-technical skills, such
the recognition of cardiac arrest by citizens seems to be as communication, decision making, teamwork and lead-
challenging in the prehospital setting.25 A high compli- ership.27 Furthermore, the starting point is the continuous
ance to the follow the priority tool and mandatory ques- improvement of the education of nursing students, in order
tions is important and facilitates the assignment to to improve self-efficacy and critical thinking skills in
recognise OHCA and dispatch correct resources with the emergency cardiac arrest situations.
right priority. Further studies to identify the causes Secondly, emergency nurses should be involved in
underlying (or related to) underestimation of red codes, community training programmes and guide citizens to
like OHCA, should be implemented and are strongly improve the skills of CPR and early defibrillation use.
recommended. Some strategies to improve CPR training may be adopted
into civic, work or school activities; 30-minute training
sessions, whether with video self-instruction or group
Limitations training, can achieve good post-training CPR knowl-
This study shows some limitations due to its retrospective edge.28 In our study, the majority of OHCAs were cor-
nature. First of all the lack of data. No variables on previ- rectly identified by dispatchers, but a better knowledge of
ous history of the patients or the intra-hospital events were the phenomenon amongst the population through CPR
Danielis et al. 7

courses is desirable, to improve the ability to recognise on the phenomenon and to asses areas of future interven-
an OHCA followed by prompt activation of the EMS. tions to improve outcomes.
Very few studies have investigated the outcomes related
to OHCA, considering that the dispatching code (in terms
Implications for practice
of priority) is merely based on telephone calls. It is fun-
damental, indeed, that the bystander who is making the •• Nurses should continue to expand their resus-
call explains the situation clearly, helping the staff trained citation skills and tasks.
to receive emergency calls to recognise cardiac arrest- •• Educational and advisory services for citizens
related symptoms promptly.29 Therefore, education and should be implemented.
awareness among the population remain important steps •• There is a need for recognition of the impor-
in reducing the impact of this event, in order to prevent tance of end of life and unnecessary treatments.
cardiac arrest and identify all risk factors as early as pos- •• Epidemiological analyses are necessary to
sible. In addition, several studies have aimed to identify guide decision-making on public health.
public locations and houses where cardiac arrests are
most likely to occur. Studies have reported data showing Conflict of interest
that many public access defibrillation (PAD) programmes The authors declare that there is no conflict of interest.
have been implemented worldwide and have demon-
strated improved cardiac arrest outcomes.2,30,31 Current Funding
and future research should also explore the potential of
This research received no specific grant from any funding agency
digital resources and public knowledge through mobile
in the public, commercial, or not-for-profit sectors.
media and social media.32
Thirdly, in our study we highlight incidence data from
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