Paracetamol 500 mg oral

Kadar(mg/ml)
No. Jam(t) Cp Terminal Cp Residual Cp Distribusi
X
1 0.00 0.00 4.066 -4.066 12.323
2 0.25 9.593 3.872 5.721 11.028
3 0.50 12.122 3.688 8.434 9.870
4 0.75 12.951 3.512 9.439 8.833
5 1.00 11.342 3.345 7.997
6 1.50 9.215 3.035 6.180
7 2.00 7.881 2.753 5.128
8 3.00 5.398 2.265 3.133
9 4.00 3.872 1.864 2.008
10 5.00 2.439 1.534 0.905
11 6.00 1.692 1.262 0.430
12 8.00 0.848 0.854 -0.006
13 10.00 0.58 0.578 0.002
14 12.00 0.388 0.392 -0.004

Persamaan Farmakokinetika Oral

y= (12.648e-0.463x) + (4.065e-0.195x) + (16.887e-4.87x)

Eleminasi
Disstribusi 1
10.000 f(x) = 4.0656392502 exp( - 0.195468824 x )
R² = 0.999732066
f(x) = 12.3225418379 exp( - 0.4442414362 x )
R² = 0.9915507257

0.1
7.50 8.00 8.50 9.00 9.50 10.00 10.50 11.00 11.50 12.00 12.50

1.000
0.80 1.00 1.20 1.40 1.60 1.80 2.00 2.20
Kompartemen Dua
Col umn D
14.00
12.00
10.00
8.00
6.00
4.00
2.00
0.00
0.00 2.00 4.00 6.00 8.00 10.00 12.00 14.00
8.00
6.00
4.00
2.00
0.00
0.00 2.00 4.00 6.00 8.00 10.00 12.00 14.00
 C2 Residual AUC

16.389 1.199
5.307 2.714
1.436 3.134
3.037
5.139
4.274
6.640
4.635
3.156
2.066
2.540 Ke 0.195
1.428 Ka 4.87
0.968 Kd 0.444
1.990
AUC Total 42.919

Eleminasi Absorpsi
100.000
2502 exp( - 0.195468824 x )
66
10.000 f(x) = 16.8879066233 exp( - 4.8700127093 x )
R² = 0.9981804061

1.000
0.00 0.10 0.20 0.30 0.40 0.50 0.60

.50 10.00 10.50 11.00 11.50 12.00 12.50

12.00 14.00
12.00 14.00
 Kadar (mg/ml)
No. t(jam) Cp Terminal Cp Residual Cp Distribusi
X
1 0.00 0.00 2.128 -2.13 7.644
2 0.25 4.115 2.038 2.08 6.725
3 0.50 5.156 1.951 3.21 5.917
4 0.75 5.640 1.868 3.77 5.206
5 1.00 5.519 1.788 3.73 4.581
6 1.50 5.152 1.639 3.51 3.546
7 2.00 4.290 1.503 2.79 2.745
8 3.00 2.901 1.263 1.64 1.645
9 4.00 2.044 1.061 0.98 0.986
10 5.00 1.356 0.892 0.46 0.591
11 6.00 0.912 0.749 0.16 0.354
12 8.00 0.530 0.529 0.00 0.127
13 10.00 0.370 0.374 0.00 0.046
14 12.00 0.264 0.264 0.00 0.016

Eleminasi
1.000

f(x) = 2.1283368461 exp( - 0.1742319758 x )

R² = 0.9996733561

0.100
50 .00 .50 .00 .50 .00 .50 .00 .50 .00 .50
7. 8 8 9 9 10 10 11 11 12 12

Distribusi
Kompartemen Dua 10.00
Persamaan Farmakokinetik Oral
6.00
5.00 Y = (7.6435e-0.512x) + (2.1283e-0.174x) + (9.3734e-2.51
f(x) = 7.6435173997 exp( - 0.5117798142 x )
4.00 R² = 0.9988947791
3.00
2.00 1.00
1.40 1.60 1.80 2.00 2.20 2.40 2.60 2.80 3.00 3.20
1.00
0.00
0.00 2.00 4.00 6.00 8.00 10.00 12.00 14.00
 C2 Residual AUC

9.772 0.514
4.648 1.159
2.712 1.350
1.434 1.395
2.668
2.361
3.596
2.473
1.700
1.134 Ka 2.564
1.442 Ke 0.178
0.900 Kd 0.512
0.634
1.483
AUC Total 22.807

si Adsorpsi
10.000
f(x) = 9.4444894154 exp( - 2.5635416134 x )
R² = 0.9915934235

+ (2.1283e-0.174x) + (9.3734e-2.518x)
0.5117798142 x )

1.000
40 2.60 2.80 3.00 3.20 0.00 0.10 0.20 0.30 0.40 0.50 0.60
 Kadar (mg/ml)
No. t(jam) Cp Terminal Cp Residual Cp Distribusi C2 Residual
X
1 0.00 0.00 0.123 -0.123 0.813 0.936
2 0.25 0.069 0.120 -0.051 0.689 0.740
3 0.50 0.164 0.118 0.046 0.584 0.537
4 0.75 0.224 0.115 0.109 0.495 0.386
5 1.00 0.267 0.113 0.154 0.419
6 1.50 0.302 0.108 0.194 0.301
7 2.00 0.290 0.103 0.187 0.216
8 3.00 0.200 0.094 0.106 0.112
9 4.00 0.150 0.086 0.064 0.058
10 5.00 0.107 0.079 0.028 0.030
11 6.00 0.077 0.072 0.005 0.015
12 8.00 0.060 0.060 0.000 0.004
13 10.00 0.051 0.051 0.000 0.001
14 12.00 0.042 0.042 0.000 0.000
AUC Total

Eleminasi
1.000
1.000
f(x) = 0.9
R² = 0.99

0.100
f(x) = 0.1230963396 exp( - 0.089168736 x )
R² = 0.9973842936
0.010
7.50 8.00 8.50 9.00 9.50 10.0010.5011.0011.5012.0012.50
0.100
0.00 0.

Kompartemen Dua
0.35 Distribusi
0.30 y = 0.8127e-0.662x + 0.1231e
1.000
0.25
0.20
0.15
0.10 0.100
f(x) = 0.8127132259 exp( - 0.662375026 x )
0.05 R² = 0.9816975911
0.00
0.00 2.00 4.00 6.00 8.00 10.00 12.00 14.00
0.010
2.50 3.00 3.50 4.00 4.50 5.00 5.50
 AUC

0.009
0.029
0.049
0.061
0.142
0.148
0.245
0.175
0.129
0.092
0.137
0.111
0.093 0.089
0.472
1.891

Adsorpsi
1.000
f(x) = 0.9492236786 exp( - 1.1092158699 x )
R² = 0.9921481901

0.100
0.00 0.10 0.20 0.30 0.40 0.50 0.60

8127e-0.662x + 0.1231e-0.089 - 0.949e-1.115x

00 5.50
 Kadar (mg/ml)
No. t(jam) Cp Terminal Cp Residual Cp Distribusi
X
1 0.00 0.00 0.073 -0.073 0.591
2 0.25 0.041 0.071 -0.030 0.491
3 0.50 0.070 0.070 0.000 0.408
4 0.75 0.105 0.069 0.036 0.339
5 1.00 0.130 0.068 0.062 0.281
6 1.50 0.165 0.066 0.099 0.194
7 2.00 0.153 0.063 0.090 0.134
8 3.00 0.118 0.059 0.059 0.064
9 4.00 0.091 0.055 0.036 0.030
10 5.00 0.065 0.052 0.013 0.014
11 6.00 0.055 0.048 0.007 0.007
12 8.00 0.042 0.042 0.000 0.002
13 10.00 0.037 0.037 0.000 0.000
14 12.00 0.032 0.032 0.000 0.000

Kompartemen Dua
0.18
0.16
0.14
0.12
0.10
0.08
0.06
0.04
0.02
0.00
0.00 2.00 4.00 6.00 8.00 10.00 12.00 14.00

Eleminasi
1.000

0.100

f(x) = 0.0725741477 exp( - 0.0679834289 x )

R² = 0.9984711912
0.010
7.50 8.00 8.50 9.00 9.50 10.00 10.50 11.00 11.50 12.00 12.50

Adsorpsi
1.000

f(x) = 0.6639185519 exp( - 0.972915278 x )

R² = 0.9999798337
 Adsorpsi
1.000

f(x) = 0.6639185519 exp( - 0.972915278 x )

R² = 0.9999798337

0.100
0.00 0.10 0.20 0.30 0.40 0.50 0.60
 C2 Residual AUC

0.664 0.005125
0.521 0.013875
0.408 0.021875
0.303 0.029375
0.07375
0.0795
0.1355
0.1045
0.078 ka 0.973
0.06 ke 0.068
0.097 kd 0.742
0.079
0.069
0.470588
AUC Total 1.317088
AUC Tak hingga 19.83953
Cl

Distribusi
1.000

0.100

f(x) = 0.5909417807 exp( - 0.7422102969 x )

R² = 0.9655117719

0.010
2.50 3.00 3.50 4.00 4.50 5.00 5.50
y = (0.5909e-0.742X) + (0.0726e-0.068X) - (0.6639e-0.973)
Obat Ke eleminasi ke distribusi ka (jam-1) T1/2(jam)
Parasetamol tunggal 0.195 0.444 4.87 3.554601
Parasetamol kombinasi 0.174 0.512 2.564 3.983604
Fenilpropanolamin tunggal 0.089 0.662 1.109 7.788171
Fenilpropanolamin kombinasi 0.068 0.742 0.973 10.19334

t1/2 distribusi 1.561142

y = (12.323e-0.444x) + (4.065

y = (0.5909e-0.742X) + (0.0726e-0.068X) - (0.6639e-0.973)

0.512 2.564 3.983604

 Tmax Cmax AUC Oral F Penurunan F Cl AUC Iv Vd
0.541126 12.13871 42.90974 0.9 47% 10487.13 47.67748889 53780.15
0.785087 5.708196 22.84112 0.47908 10487.23 60271.42
1.154247 0.225698 1.891285 0.9 30% 23793.35 2.101427778 267341
1.173311 0.102462 1.310338 0.62676 23915.97 351705.4

y = (12.323e-0.444x) + (4.0656e-0.195x) – (16.888e-4.87x)

0.785087 11.81564 22.84112 0.47908 10487.23 47.67704767 60271.42 10487.23 10487.23