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Desirable Biological Variation Database specifications

Updated for 2014! Desirable Specifications for imprecision, inaccuracy, and total allowable
error, calculated from data on within-subject and between-subject biologic variation. This
database is updated and compiled by Dr. Carmen Ricos and colleagues. We are honored to be
able to host this database.

Desirable Specifications for Total Error, Imprecision, and Bias, derived from intra- and inter-
individual biologic variation

This most recent and extensive listing of biologic goals has been provided by Ricos C, Alvarez
V, Cava F, Garcia-Lario JV, Hernandez A, Jimenez CV, Minchinela J, Perich C, Simon M.
"Current databases on biologic variation: pros, cons and progress." Scand J Clin Lab Invest
1999;59:491-500. This database was most recently updated in 2014.

Annex I, Part I: Within-subject and between-subject CV values of analytes and Desirable

Analytical Quality Specifications for imprecision, bias and total error

Note on abbreviations:
CVI = within-subject biologic variation
CVG = between-subject biologic variation
I = desirable specification for imprecision
B = desirable specification for inaccuracy
TE = desirable specification for allowable total error

Nr. Number Biological Desirable

crt Analyte of Variation specification
Papers CVI CVg I(%) B(%) TE(%)
1. Activated partial
P- thromboplastine 3 2.7 8.6 1.4 2.3 4.5
time
2. Alanine
S- aminotransferase 9 19.40 41.6 9.7 11.48 27.48
(ALT)
3. Alkaline
S- 22 6.45 26.1 3.23 6.72 12.04
phosphatase
4. Alkaline
S- phosphatase, 4 6.2 37.4 3.1 9.5 14.6
bone
5. Alkaline
S- phosphatase, 1 10.0 27.0 5.0 7.2 15.4
liver
Nr. Number Biological Desirable
crt Analyte of Variation specification
Papers CVI CVg I(%) B(%) TE(%)
6. Alkaline
S- phosphatase, 1 19.1 --- 9.6 --- ---
placental
7. Aspartate
S- aminotransferase 13 12.3 23.1 6.15 6.54 16.69
(AST)
8. S- Bilirubin total 11 21.8 28.4 10.90 8.95 26.94
9. Bilirubin
S- 2 36.8 43.2 18.4 14.2 44.5
conjugated
10. S- C3 Complement 2 5.2 15.6 2.6 4.1 8.4
11. S- C4 Complement 2 8.9 33.4 4.5 8.6 16.0
12. S- Calcium 24 2.1 2.5 1.05 0.82 2.55
13. S- Calcium, ionized 2 1.7 1.9 0.9 0.6 2.0
14. S- Cholesterol 46 5.95 15.3 2.98 4.1 9.01
15. P- Cortisol 1 21.7 46.2 10.85 12.76 30.66
16. S- Cortisol 3 15.2 38.1 7.6 10.26 22.8
17. S- Creatinine 28 5.95 14.7 2.98 3.96 8.87
18. Creatinine,
U- concentration, 8 24.0 24.5 12.0 8.6 28.4
24h
19. Creatinine,
U- concentration, 8 23.2 25.7 11.6 8.7 27.8
first morning
20. Creatinine,
U- concentration, 8 36.3 32.4 18.2 12.2 42.1
random
21. Creatinine,
U- 8 11.0 23.0 5.5 6.4 15.4
output, 24h
22. Erythrocytes,
B- 7 3.2 6.3 1.6 1.7 4.4
count
23. Erythrocyte
B- 3.5 5.7 1.8 1.7 4.6
distribution wide
24. U- Estradiol 1 30.4 --- 15.2 --- ---
25. S- Estradiol 5 22.5 24.4 11.25 8.3 26.86
26. Factor V
P- 1 3.6 --- 1.8 --- ---
coagulation
27. Factor VII
P- 2 6.8 19.4 3.4 5.1 10.7
coagulation
28. Factor VIII
P- 2 4.8 19.1 2.4 4.9 8.9
coagulation
29. Factor X
P- 1 5.9 --- 3.0 --- ---
coagulation
Nr. Number Biological Desirable
crt Analyte of Variation specification
Papers CVI CVg I(%) B(%) TE(%)
30. P- Fibrinogen 5 10.7 15.8 5.4 4.8 13.6
31. P- -Fibrinogen 1 14.1 27.25 7.05 7.67 19.3
32. P- Glucose 1 4.5 5.8 2.3 1.8 5.5
33. S- Glucose 15 5.6 7.5 2.8 2.34 6.96
34. S- HDL cholesterol 25 7.3 21.2 3.65 5.61 11.63
35. B- Hematocrit 11 2.7 6.41 1.35 1.74 3.97
36. B- Hemoglobin 13 2.85 6.8 1.43 1.84 4.19
37. Immunoglobulin
S- 7 5.4 35.9 2.7 9.1 13.5
A
38. Immunoglobulin
S- 6 4.5 16.5 2.3 4.3 8.0
G
39. Immunoglobulin
S- 5 5.9 47.3 3.0 11.9 16.8
M
40. S- Iron 11 26.5 23.2 13.3 8.8 30.7
41. S- LDL Cholesterol 6 7.8 20.4 3.9 5.46 11.9
42. Leukocytes
B- 8 11.4 21.3 5.73 6.05 15.49
count
43. Lymphocytes,
B- 1 10.2 35.3 5.1 9.19 17.6
count
44. (B)Erythr- Magnesium 2 5.6 11.3 2.8 3.2 7.8
45. (B)Leuc- Magnesium 1 18.5 12.4 9.25 5.57 20.83
46. (B)Mon - Magnesium 1 18.1 20.3 9.1 6.8 21.7
47. S- Magnesium 9 3.6 6.4 1.8 1.8 4.8
48. Magnesium,
U- 1 1.9 5.1 1.0 1.4 2.9
ionized
49. Magnesium,
U- 2 38.3 37.6 19.2 13.4 45.0
output, 24h
50. Mean
corpuscular
(B)Erythr- 4 1.4 5.2 0.7 1.35 2.5
hemoglobin
(MCH)
51. Mean
corpuscular
(B)Erythr- hemoglobin 5 1.06 1.2 0.53 0.4 1.27
concentration
(MCHC)
52. Mean
(B)Erythr- corpuscular 7 1.4 4.85 0.7 1.26 2.42
volume (MCV)
53. Mean platelet
(B)Plat- 3 4.3 8.1 2.15 2.29 5.84
volume (MPV)
54. B- Monocytes, 3 17.8 49.8 8.9 13.2 27.9
Nr. Number Biological Desirable
crt Analyte of Variation specification
Papers CVI CVg I(%) B(%) TE(%)
count
55. B- Platelets, count 7 9.1 21.9 4.6 5.9 13.4
56. Platelet
B- 2 2.8 --- 1.4 --- ---
distribution wide
57. B- Plateletcrit 2 11.9 --- 6.0 --- ---
58. P- Prolactin 1 39.2 65.1 19.6 19.0 51.34
59. S- Prolactin 4 23.0 35.0 11.5 10.5 29.4
60. Prostatic
S- specific antigen 3 18.1 72.4 9.1 18.7 33.6
(PSA)
61. Prothrombin
P- 2 4.0 6.8 2.0 2.0 5.3
time
62. Red cell
B- distribution wide 4 3.5 5.7 1.8 1.7 4.6
(RDW)
63. Thyroid
P- stimulating 1 29.30 48.4 14.65 14.14 38.2
hormone (TSH)
64. Thyroid
S- stimulating 9 19.3 24.6 9.7 7.8 23.7
hormone (TSH)
65. Thyroxine, free
P- 1 7.1 9.1 3.55 2.89 8.74
(FT4)
66. Thyroxine, free
S- 5 5.7 12.1 2.9 3.3 8.0
(FT4)
67. S- Triglyceride 31 19.9 32.7 9.95 9.57 25.99
68. S- Urea 20 12.1 18.7 6.05 5.57 15.55