8/16/2017 Evaluation of antidiabetic potential of oyster mushroom (Pleurotus ostreatus) in alloxan-induced diabetic mice: Immunopharmacology and I…

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Immunopharmacology and Immunotoxicology 

Volume 35, 2013 - Issue 1

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Research Article

Evaluation of antidiabetic potential of oyster mushroom

(Pleurotus ostreatus) in alloxan-induced diabetic mice
Bindhu Ravi, R. Emilin Renitta , M. Lakshmi Prabha, Reya Issac & Shanti Naidu
Pages 101-109 | Received 21 Apr 2012, Accepted 06 Jul 2012, Published online: 07 Aug 2012

 Download citation  http://dx.doi.org/10.3109/08923973.2012.710635

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Abstract

Objectives: To study the antidiabetic activity of Pleurotus ostreatus in normal and alloxan-induced diabetic mice.

Materials and methods: Ethanolic extract of fruiting bodies of P. ostreatus was tested for their antidiabetic activity. BALB/C mice
(25–30 g) were divided into four groups of six animals each normal control mice, diabetic control mice, diabetic mice
posttreated with standard drug glibenclamide and diabetic mice treated with P. ostreatus ethanolic extract. Blood glucose
level, biochemical parameters such as serum total cholesterol, LDL, HDL, VLDL, triglyceride creatinine, urea, and Serum
glutamate oxaloacetate transaminase and Serum glutamate pyruvate transaminase were studied in alloxan-induced diabetic
mice after 15 days of treatment.

Results: Animals treated with the ethanolic extract of P. ostreatus showed a signi cant decrease in serum glucose level (p <
0.01). The posttreatment with P. ostreatus extract reduced serum cholesterol, triglyceride and LDL-cholesterol. The serum HDL
cholesterol was signi cantly increased in posttreated groups. The serum creatinine, urea levels were signi cantly reduced in
posttreated group, whereas the decrease in the body weight was arrested by administration of P. ostreatus extract to the
animals.

Discussion and conclusion: The consumption of P. ostreatus produced a signi cant hypoglycemic e ect in diabetic mice and it is
capable of improving hyperlipidemia and the impaired kidney functions in alloxan-induced diabetic mice. Thus, indicating that
the ethanolic extract of P. ostreatus could be added in the list of medicinal preparations bene cial in diabetes mellitus.

Keywords:: Pleurotus ostreatus, glibenclamide, hyperlipidemia, hypoglycemic, alloxan

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