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Bandung, ..............
Ketua Kelompok Keahlian Dekan …………..
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NIP. ……….......…………….. NIP. ………………….....…..
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II. EXECUTIVE SUMMARY
1. TITLE : Porous Architecture and Permeability Evaluation of Silk
Fibroin Scaffold from Direct Dissolution Salt Leaching Method
2. HEAD OF TEAM : Dr. Ir Hermawan Judawisastra
3. TEAM MEMBERS : Dr. Ir. Arif Basuki
Dr. Ekavianty Prajatelistia
4. OFFICIAL ADDRESS :
Metallurgical and Material Engineering Laboratory, Faculty of Mechanical and Aerospace
Engineering, ITB
Email: hermawan.judawisastra@material.itb.ac.id
5. EXTENDED ABSTRACT :
Tissue engineering scaffold is used as a template to facilitate and support the attachment,
growth, proliferation, and differentiation of cells or tissues. The fabricating of silk fibroin
scaffold with the direct dissolution salt leaching method has been successfully developed to
produce biocompatible and biodegradable scaffolds that support cell growth, and
significantly reduce processing time and temperature compared to conventional methods.
The scaffold architecture has a direct impact on attachment, growth, and migration of cells
through the scaffold. Permeability affects the diffusion of nutrients, oxygen, waste, and cell
migration into the scaffold. In this study evaluation of pore architecture and permeability of
scaffolds, which is the result direct dissolution salt leaching method. The evaluated scaffold
architecture are pore size, scaffold porosity, wall thickness scaffold, pore interconnectivity,
and the scaffold specific surface area. The varied process parameters are NaCl particle size
(158 ± 47 μm, 250 ± 58 μm, 378 ± 42 μm, 503 ± 31 μm), and silk fibroin concentration (6%
w / v, 8% w / v, 10% w / v, 12% w / v). The evaluation of scaffold architecture using
microcomputed tomography (micro-CT) method. The scaffold permeability measured using
falling head method. The 3D evaluation of micro-CT can be used to evaluate scaffold
architecture, see Figure 1. The increasing of NaCl particle size generates increasing of pore
size, scaffold porosity, scaffold wall thickness, pore interconnectivity, and the scaffold
specific permeability, while the scaffold specific surface area was decrease, see Figure 2. The
increasing of silk fibroin concentration doesn’t result in significant changes in scaffold
architecture and scaffold permeability. The larger of pore size, the larger of scaffold porosity,
wall thickness scaffold, the pore interconnectivity was result, but the smaller of scaffold
specific surface area, see Figure 2. The higher of the scaffold porosity, and the scaffold pore
interconnectivity, while the lower scaffold specific surface area, results in higher specific
scaffold permeability, see Figure 3 and Figure 4.
Figure 1. 3D model of silk fibroin scaffolds with different NaCl particle sizes: (a) 158 μm, (b)
250 μm, (c) 378 μm, (d) 503 μm.
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Figure 2. Scaffold architecture measurement results: (a) Mean pore size, (b) Scaffold
porosity, (c) Scaffold wall thickness, (d) Pore interconnectivity, and (e) The scaffold specific
surface area, also (f) The scaffold specific permeability.
Figure 3. The increase of scaffold specific permeability along with scaffold porosity and pore
interconnectivity resulting from the use of larger NaCl particle size.
Figure 4. Correlation of the scaffold specific surface area and the scaffold specific
permeability at different NaCl particle size.
RE 2. SCAFFOLD ARCHITECTURE MEAS UREMENT RES ULTS (A) MEAN PORE SIZE, (B) SCAFFOLD PO ROSITY, (C) SC AFFOLD WALL THICKNESS, (D) PO RE INTE RCONNECTI VITY, AND (E) THE SCAFFOLD SPECIFIC S URFACE AREA.
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III. EVALUASI DIRI
a. Topik Penelitian : 100% anggaran
4
b. Topik Pengabdian kepada masyarakat: …. % anggaran
*) Rincian Capaian luaran mohon diisikan pada tabel luaran di bawah ini.
**) Panduan TKT dapat dilihat di website LPIK
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Tabel Isian Luaran Kegiatan Penelitian
1. Publikasi di Jurnal
Nama Nama File PDF
Jenis Nama P- E- Halaman Nama Seluruh NIP Penulis
Tahun Judul Artikel Vol Nomor URL Penulis Co-Author Artikel**
Jurnal* Jurnal ISSN ISSN (… sd…. ) Author Dosen
Dosen (dilampirkan)
Porous
Architecture and
Permeability
Hermawan
Evaluation of
Judawisastra, Febri Dr. Ir
Internasio Silk Fibroin 19700403206
2018 Ramdani Nugraha, Hermawan
nal Scaffold from 041010
Untung Ari Judawisastra
Direct
Wibowo
Dissolution Salt
Leaching
Method
*Jenis Jurnal: Jurnal Internasional;;Jurnal Nasional Terakreditasi;Jurnal Nasional Tidak Terakreditasi (Mempunyai ISSN)
**Bukti: Scan/PDF halaman pertama artikel yang memuat nama jurnal, volume, tahun, judul artikel, nama penulis, dan abstrak
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Waktu Pelaksanaan Tempat
Nama Kegiatan Unit Pelaksana Mitra/Sponsorship Skala Forum Ilmiah*
(…… s.d. ……) Pelaksanaan
*Jenis HKI: Paten;Paten Sederhana;Hak Cipta;Merek Dagang;Rahasia Dagang;Desain Produk Industri;Indikasi Geografis;Perlindungan Varietas Tanaman;Perlindungan Topografi Sirkuit Terpadu
*Status Pendaftaran: Terdaftar;Granted
**Bukti: Halaman pertama Surat Keterangan Pendaftaran HKI atau Surat Keputusan Granted
6. Luaran Lainnya
Nama File Dokumen Pendukung
NIP Dosen Nama Peneliti Dosen Tahun Kegiatan Jenis Luaran* Nama Luaran Deskripsi Singkat
(dilampirkan)**
*Jenis Luaran: Teknologi Tepat Guna; Model; Purwarpa (Prototype); Karya Seni/Desain Kriya/Bangunan dan Arsitektur; Rekayasa Sosial
**Bukti: Berupa foto (jika ada) beserta spesifikasi teknis dari luaran
7. Buku
Nama File Dokumen
NIP Dosen Nama Penulis Dosen Tahun Penerbitan Jenis Buku* Judul Buku ISBN Jumlah Halaman Penerbit Pendukung
(dilampirkan)**
*Jenis Buku: Buku Ajar;Buku Teks;Modul;Panduan Praktis;Buku Profil Daerah;Buku Profil Usaha;Katalog Kegiatan Seni;Novel;Kumpulan Puisi atau Cerpen;Buku Saku;Kamus;Monograf;Biografi;Tafsir;Atas;Ensiklopedia;Lain-Lain
**Bukti: Scan cover buku
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Tabel Isian Luaran Kegiatan Pengabdian kepada Masyarakat
1. Publikasi di Jurnal
Jenis Nama Nama Nama File Dokumen
Tahun Judul Nama P- Halaman NIP Penulis
Publikasi E-ISSN Volume Nomor URL Seluruh Penulis Co-Author Pendukung
Penerbitan Artikel Jurnal ISSN (… s.d. …) Dosen
Jurnal* Author Dosen (dilampirkan)**
*Jenis Jurnal: Jurnal Internasional;;Jurnal Nasional Terakreditasi;Jurnal Nasional Tidak Terakreditasi (Mempunyai ISSN)
**Bukti: Scan/PDF halaman pertama artikel yang memuat nama jurnal, volume, tahun, judul artikel, nama penulis, dan abstrak
*Jenis HKI: Paten;Paten Sederhana;Hak Cipta;Merek Dagang;Rahasia Dagang;Desain Produk Industri;Indikasi Geografis;Perlindungan Varietas Tanaman;Perlindungan Topografi Sirkuit Terpadu
*Status Pendaftaran: Terdaftar;Granted
**Bukti: Halaman pertama Surat Keterangan Pendaftaran HKI atau Surat Keputusan Granted
5. Produk Terstandarisasi
Nama File Dokumen Pendukung
Nama Dosen Tahun Perolehan Nama Produk Lembaga Standarisasi No. Sertifikat
(dilampirkan)**
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6. Produk Tersertifikasi
Nama File Dokumen Pendukung
Nama Dosen Tahun Perolehan Nama Produk Lembaga Sertifikasi No. Sertifikat
(dilampirkan)**
8. Buku
Nama File Dokumen
NIP Dosen Nama Penulis Dosen Tahun Penerbitan Jenis Buku* Judul Buku ISBN Jumlah Halaman Penerbit Pendukung
(dilampirkan)**
*Jenis Buku: Buku Ajar;Buku Teks;Modul;Panduan Praktis;Buku Profil Daerah;Buku Profil Usaha;Katalog Kegiatan Seni;Novel;Kumpulan Puisi atau Cerpen;Buku Saku;Kamus;Monograf;Biografi;Tafsir;Atas;Ensiklopedia;Lain-Lain
**Bukti: Scan cover buku
*Jenis Luaran: Teknologi Tepat Guna; Model; Purwarpa (Prototype); Karya Seni/Desain Kriya/Bangunan dan Arsitektur; Rekayasa Sosial
**Bukti: Berupa foto (jika ada) beserta spesifikasi teknis dari luaran
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