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EVEROLIMUS EVERTOR 10MG - ANTICANCER DRUGS |

BIOCON | MHP

EVERTOR

DESCRIPTION

Evertor 10mg tablet consist of an active ingredient known as Everolimus which is intrude with
growth of cancer cell and process is slows down.Evertor 10mg tablet is not a curable medication,
which is helps to slow their spreading in to the body.

EVERTOR PRESCRIBING INFORMATION

Primarily Evertor 10mg tablet indicated for the treatment kidney carcinoma Breast carcinoma
Brain carcinoma Everolimus is also indicated in various advanced stage cancer in stomach,
intestines or pancreas.

EVERTOR MECHANISM

Everolimus is an inhibitor of mTOR, joins at high compatibility to FK506 binding protein 12, via
producing drug complex that inhibits the productive of mTOR. This inhibition reduce the activity
of effectors downstream, which may leads to stoppage of cell progression from G1 into S phase,
Finally causes cell growth arrest and apoptosis

ADME PROCESS

ABSORPTION

The maximium plasma concentration time of Everolimus reaches within 1 to 2 hours.

DISTRIBUTION

Albumin human plasma protein bound of 74%.

METABOLISM

In hepatic Everolimus metabolism is occurred, which is a substrate of CYP3A4. The metabolites


of Everolimus in 3 process; Three monohydroxylated metabolite, Two hydrolytic rings opened
products, Phosphatidylcholine conjugate of Everolimus.

ELIMINATION
half life period of Everolimus is 30 hours The elimination primarily via 5% in urine; the parent
compound has been detected in urine or feces.

EVERTOR 10Mg

PRODUCT DETAILS:

Brand : Evertor
Ingredients : Everolimus
Strength : 10mg
Manufactured : Biocon
Package : 10 Tablets in a strip

DOSAGE REGIMEN

In breast cancer, renal cell cancer, pancreatic cancer, Neuro endocrine cancer: The prescribed
dosage is 10mg should be taken as a single dose. In Brain or intracranial cancer: The prescribed
dosage of Evertoras 10mg a single dose. is 4.5mg/m2 given orally In pediatric: The pediatric
dosage of Evertor as a single dose in brain or intracranial tumor is 4.5mg/m2 should be given
orally.

OVER DOSAGE

The over dosage of Everolimus is limited, If over dosage occurs patient must be provide with
supportive measures. And monitor evidence of toxicity in Everolimus over dosage

WHEN TO TAKE THE DRUG EVERTOR

Evertor 10mg tablets should be given with or without food.


EVERTOR CAUSED SIDE EFFECTS

Hypersensitivity reactions Lymphomas & other malignancy Serious infections Kidney graft
thrombosis Hepatic artery thrombosis Nephrotoxicity Hyperlipemia Angioedema Interstitial lung
disease Thrombocytopenia Male infertility Proteinuria New commencement of diabetes

SAFETY PRECAUTIONS

LYMPHOMAS

Developed hazard of skin cancers, patient may protect from UV light

SERIOUS INFECTIONS

Patients getting Evertor 10mg have severe risk of achieve various infections related to bacteria,
virus, and fungi

HEPATIC ARTERY THROMBOSIS

Evertor 10ng tablet therapy should not be recommended in In liver transplant patients,

EMBRYO FETAL TOXICITY

using Evertor 10mg in pregnancy condition Causes fetal damage

ANGIOEDEMA

While patients receiving concomitantly Evertorwith Angiotensin converting enzyme agents will
cause angiodema

NEPHROTOXICITY

While using Evertor 10mg tablet in renal impaired patients Renal function should be monitored
frequently; drug use with caution

INTERSTITIAL LUNG DISEASE

In Evertor 10mg therapy interstitial lung disease occur Blood glucose level should be monitored

HEREDITARY DISORDERS
while using evetor 10mg tablet the conditions occurs like galactose intolerance, glucose-
galactose malabsorption, Evertor 10mg should not be used may results in diarrhea &
malabsorption.

GRAPE JUICE INTERACTION

avoid these concomitant use with grape juice Causes increasing blood levels of Everolimus

DRUG INTERACTION

Evertor 10mg tablet interaction with strong inhibitor of CYP3A4, or P-gp, cause reducing the
efflux of Everolimus and high plasma concentration of Everolimus. Interaction of Evertor with
strong CYP3A4 inducers, will increasing the disclosure of Everolimus. Combination ofEvertor
with cyclosporine will increasing the AUC level of Everolimus frequently.

Combination ketaconazole with Evertor 10mg tablet or other CYP3A4 inhibitors will increase
the plasma concentration and AUC of Everolimus. Concomitant use of Evertor with verapamil
leads to increasing the plasma concentration of Everolimus.

Concomitant use of Evertor 10mg with Atorvastatin or pravastatin leads to rhabdomyolysis, due
to increasing concentration of lipid lowering agents. Evertor interaction with rifampicin will
decreasing the AUC of Everolimus

PREGNANCY & LACTATION

Pregnancy category of Everolimus C In patients Evertor is used only after knowing the benefits
to the mother exceed the risk to fetus. Breast feeding should not be suggested

CONTRAINDICATION

If patients are contraindicated to the components present in the Evertor 10mg tablet. Some
anaphylactic reaction occurs.

STORAGE

Evertor 10mg tablet store at 25°C Store the medicine away from moisture, heat and light

MISSED DOSE

If the dose is missed, consult with healthcare practitioner and follow the instructions given by
them. Thereby missed dose should be avoid and follow the regular dosing schedule.

CONTACT US:
MOBILE NO: +91-9940472902

E-MAIL: millionhealthpharmaceuticals@gmail.com

WEBSITE URL: https://millionpharma.com/evertor.php