PMID- 31369649

OWN - NLM
STAT- In-Data-Review
LR - 20190801
IS - 1553-7374 (Electronic)
IS - 1553-7366 (Linking)
VI - 15
IP - 8
DP - 2019 Aug
TI - Primary infection with dengue or Zika virus does not affect the severity of
heterologous secondary infection in macaques.
PG - e1007766
LID - 10.1371/journal.ppat.1007766 [doi]
AB - Zika virus (ZIKV) and dengue virus (DENV) are genetically and antigenically
related flaviviruses that now co-circulate in much of the tropical and
subtropical world. The rapid emergence of ZIKV in the Americas in 2015 and
2016,
and its recent associations with Guillain-Barre syndrome, birth defects, and
fetal loss have led to the hypothesis that DENV infection induces cross-
reactive
antibodies that influence the severity of secondary ZIKV infections. It has
also
been proposed that pre-existing ZIKV immunity could affect DENV pathogenesis.
We
examined outcomes of secondary ZIKV infections in three rhesus and fifteen
cynomolgus macaques, as well as secondary DENV-2 infections in three
additional
rhesus macaques up to a year post-primary ZIKV infection. Although cross-
binding
antibodies were detected prior to secondary infection for all animals and
cross-neutralizing antibodies were detected for some animals, previous DENV
or
ZIKV infection had no apparent effect on the clinical course of heterotypic
secondary infections in these animals. All animals had asymptomatic
infections
and, when compared to controls, did not have significantly perturbed
hematological parameters. Rhesus macaques infected with DENV-2 approximately
one
year after primary ZIKV infection had higher vRNA loads in plasma when
compared
with serum vRNA loads from ZIKV-naive animals infected with DENV-2, but a
differential effect of sample type could not be ruled out. In cynomolgus
macaques, the serotype of primary DENV infection did not affect the outcome
of
secondary ZIKV infection.
FAU - Breitbach, Meghan E
AU - Breitbach ME
AUID- ORCID: http://orcid.org/0000-0001-5974-8353
AD - Department of Pathology and Laboratory Medicine, School of Medicine and
Public
Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of
America.
FAU - Newman, Christina M
AU - Newman CM
AD - Department of Pathology and Laboratory Medicine, School of Medicine and
Public
Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of
America.
FAU - Dudley, Dawn M
AU - Dudley DM
AUID- ORCID: http://orcid.org/0000-0003-0934-2042
AD - Department of Pathology and Laboratory Medicine, School of Medicine and
Public
Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of
America.
FAU - Stewart, Laurel M
AU - Stewart LM
AD - Department of Pathology and Laboratory Medicine, School of Medicine and
Public
Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of
America.
FAU - Aliota, Matthew T
AU - Aliota MT
AUID- ORCID: http://orcid.org/0000-0002-6902-9149
AD - Department of Veterinary and Biomedical Sciences, College of Veterinary
Medicine,
University of Minnesota, Minneapolis, Minnesota, United States of America.
FAU - Koenig, Michelle R
AU - Koenig MR
AUID- ORCID: http://orcid.org/0000-0003-3825-9600
AD - Department of Pathology and Laboratory Medicine, School of Medicine and
Public
Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of
America.
FAU - Shepherd, Phoenix M
AU - Shepherd PM
AD - Department of Pathology and Laboratory Medicine, School of Medicine and
Public
Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of
America.
FAU - Yamamoto, Keisuke
AU - Yamamoto K
AD - Department of Pathology and Laboratory Medicine, School of Medicine and
Public
Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of
America.
FAU - Crooks, Chelsea M
AU - Crooks CM
AUID- ORCID: http://orcid.org/0000-0003-3874-4577
AD - Department of Pathobiological Sciences, School of Veterinary Medicine,
University
of Wisconsin-Madison, Madison, Wisconsin, United States of America.
FAU - Young, Ginger
AU - Young G
AD - Takeda Vaccines, Inc., Madison, Wisconsin, United States of America.
FAU - Semler, Matthew R
AU - Semler MR
AD - Department of Pathology and Laboratory Medicine, School of Medicine and
Public
Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of
America.
FAU - Weiler, Andrea M
AU - Weiler AM
AD - Wisconsin National Primate Research Center, Madison, Wisconsin, United States
of
America.
FAU - Barry, Gabrielle L
AU - Barry GL
AD - Department of Pathobiological Sciences, School of Veterinary Medicine,
University
of Wisconsin-Madison, Madison, Wisconsin, United States of America.
FAU - Heimsath, Holly
AU - Heimsath H
AD - Department of Pediatrics, School of Medicine, Duke University, Durham, North
Carolina, United States of America.
FAU - Mohr, Emma L
AU - Mohr EL
AD - Department of Pediatrics, School of Medicine and Public Health, University of
Wisconsin-Madison, Madison, Wisconsin, United States of America.
FAU - Eichkoff, Jens
AU - Eichkoff J
AD - Department of Biostatistics & Medical Informatics, School of Medicine and
Public
Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of
America.
FAU - Newton, Wendy
AU - Newton W
AUID- ORCID: http://orcid.org/0000-0003-2206-2061
AD - Wisconsin National Primate Research Center, Madison, Wisconsin, United States
of
America.
FAU - Peterson, Eric
AU - Peterson E
AD - Wisconsin National Primate Research Center, Madison, Wisconsin, United States
of
America.
FAU - Schultz-Darken, Nancy
AU - Schultz-Darken N
AUID- ORCID: http://orcid.org/0000-0002-8436-2820
AD - Wisconsin National Primate Research Center, Madison, Wisconsin, United States
of
America.
FAU - Permar, Sallie R
AU - Permar SR
AD - Department of Pediatrics, School of Medicine, Duke University, Durham, North
Carolina, United States of America.
FAU - Dean, Hansi
AU - Dean H
AD - Takeda Vaccines, Inc., Madison, Wisconsin, United States of America.
FAU - Capuano, Saverio 3rd
AU - Capuano S 3rd
AD - Wisconsin National Primate Research Center, Madison, Wisconsin, United States
of
America.
FAU - Osorio, Jorge E
AU - Osorio JE
AD - Department of Pathobiological Sciences, School of Veterinary Medicine,
University
of Wisconsin-Madison, Madison, Wisconsin, United States of America.
FAU - Friedrich, Thomas C
AU - Friedrich TC
AUID- ORCID: http://orcid.org/0000-0001-9831-6895
AD - Department of Pathobiological Sciences, School of Veterinary Medicine,
University
of Wisconsin-Madison, Madison, Wisconsin, United States of America.
FAU - O'Connor, David H
AU - O'Connor DH
AUID- ORCID: http://orcid.org/0000-0003-2139-470X
AD - Department of Pathology and Laboratory Medicine, School of Medicine and
Public
Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of
America.
LA - eng
PT - Journal Article
DEP - 20190801
PL - United States
TA - PLoS Pathog
JT - PLoS pathogens
JID - 101238921
SB - IM
COIS- I have read the journal's policy and the authors of this manuscript have the
following competing interests: G. Young and H. Dean are employees of Takeda
Vaccines, Inc. All other authors declare no conflicts of financial or
personal
interests.
CRDT- 2019/08/02 06:00
PHST- 2019/04/12 00:00 [received]
PHST- 2019/06/26 00:00 [accepted]
PHST- 2019/08/02 06:00 [entrez]
AID - 10.1371/journal.ppat.1007766 [doi]
AID - PPATHOGENS-D-19-00665 [pii]
PST - epublish
SO - PLoS Pathog. 2019 Aug 1;15(8):e1007766. doi: 10.1371/journal.ppat.1007766.
eCollection 2019 Aug.