PHARMACOLOGY (FINALS) 15TERIPARATIDE – recombinant form og PTH

16STRONTIUM RANELATE – reduces osteoblast activity

DRUG AFFECTING BONE & CALCIUM 17NaF – strengthen teeth, and prevents tooth decay

BONE REMODELING:
A, DEMINERALIZATIONB. MINERALIZATIONSTIMULI: ANTICOAGULANTS & ANTIPLATELETS

FIBRINOLYTIC & PROTHROMBOTIC DRUGS

DECREASE calcium level in the bloodSTIMULI: INCRASE
- inhibits coagulation and thrombosis formation
calcium level in bloodACTION:
ANTICOAGULANTS
OSTEOCLAST – bone RESORBING cells 1WARFARIN
2: PT- INR – 2 to 3 vit. K > antidote
RESORPTION: calcium GOES OUT from the bone to 3:>2 to 3 = bleeding/ haemorrhaging
INCREASE calcium level in the bloodACTION: 4:<2 to 3 = coagulation
5HEPARIN
6: APTT prothamine sulfate (antidote for overdose)
OSTEOBLAST – bone FORMING cells 7ENOXAPARIN
8DALTEPARIN
: calcium ENTERS the bone from the blood to DECREASE 9TINZAPARIN
calcium levels in the blood 10FAXIPARINDARAPROID
11FONDAPARIMAX
12HIRUDIN
CALCIUM: 13LEPIRUDIN
-normal function of the nerves 14BIRAMIDIN
-gland secretion 15AGATRUBAN
-blood coagulation 16DABIGATRAN
-enzymatic reaction 17RIVAROXABAN

ANTIPLATELET
HORMONAL REGULATION OF THE ABSORPTION & -inhibit platelet aggregation
SECRETION OF CALCIUM -myocardial infarction
A. VITAMIN D 1ASPIRIN
-fat soluble 2PROSUGREL
-increase gastrointestinal absorption of Ca2+ 3TICLODIPINE
B. PARATOID HORMONE 4CLOPIDOGREL
-increase plasma calcium levels by: 5TICAGREDOR
a. stimulates resorption of Ca++ in renal tubules 6DYPRIMADOLE
b. decrease resorption of PO4 by renal tubules 7CILOSTAZOL
= increase urinary excretion of PO4
c. hydroxylization of VIT. D to CALCITRIOL(active FIBRINOLYTICS
form of vit. D) in the kidney -Lyse fibrin
d. increase bone resorption by stimulating osteoclast
activity 1STREPTOKINASE
C. CALCITONIN 2ALTEPLASE
-decrease calcium levels in the blood by inhibiting bone 3TENECTEPLASE
resorption or osteoclast activity.
PROTHROMBIN DRUGS
BONE DISORDERS -Facilitates coagulation
ñOSTEOPOROSIS – post menopausal women -to speed up healing
ñPAGET DISEASE OF THE BONE 1TRANEXAMIC ACID
ñOSTEOMALARIA - adults
ñRICKETS – children
ñ

DRUGS
1CALCIUM SUPPLEMENTATION – calcium carbonate
2VIT. D SUPPLEMENTATION
3BIPHOSPHONATES -bone cancer, osteoporosis
4MOA: inhibits osteoclast activity
5- etidronate
6- aledronate
7- pamidronate
8- ibandronate
9- zoledronic acid
10ESTROGEN – reduces action and formation of osteoclast
11RALOXXIFENE – mimics the effect of estrogen
12CALCITONIN - hypercalemia
13DENOSUMAB
14MOA: inactivation of gene transcription required for osteoclast
activity and function