a
Antimicrobial activity
“the methanolic extract of B. hirta was active against Shigella spp. vsing the Vero coll Yine. The
net was found to be non-cytotoxieand a9 Be ive antibacterial agent (Vijaya 995).
Increased platelet count
‘The aqueous and methanolic extracts WO administered orally to albino Wistar ais. Platelet
Count, bleeding time, and clotting time were Nietermined before and at different me intervals
gfter administration of the extracts. "Admninistration of the aqueous extract 60 min significantly
Teduced the bleeding time by 54% ompared to 49.5% for the methanolic extract. Similarly,
Meetgg and 42.5% secuctions in clotting me WEE ‘achieved with the agueous and methanolic
extracts, respectively, while platelet count me getions with the aqueous and methanone extracts
lore 19-29% and 36.1% respectively. Thee: WA however, o significant correlation between, the
‘Jose and activities of the extracts. These findings validate the claim that E hirta arests bleeding
sot modulates hemostasis COmeje 2007)
‘sedative and ansciolytic properties
Tyopbilized aqueous extracts OFF, Hirka wee evaluated for behavioral effects nmice, The extract
Ged not induce any toxic effect when it wat eTmninistered intraperitoneally and orally. Sedative
properties could be confirmed ‘with high doses, by a decrease vorbehavioral parameters measured
jn non-familiar environment tests. ‘aieonflct effects appeared at lower doses by an enhance-
in nevf behavioral parameters measared s% the staiease test and in the Tight/dark choice situa
tion test (Lanhers 1990).
c. Recommendations
ihe efficacy of B. hirta in the management of dengue ot dengue
hemorrhagic fevers lacking (Natural ‘Medicines Comprehensive Database 2013). The wse of
F. havea for the treatment of dengue has not yet been established. However the Philippine Depart-
ment of Health is not against the use of &. hirta to treat dengue but stressed that this should be
aecompanied by proper medical ‘consultation (PCHRD 2013).
Safe use of E, hirta during pregnancy and lactation has not been established. It has been
reported to cause ‘oth contraction and relaxation of the smooth muscles, In view of the lack of
mney and lactationis
pharmacological and toxicity date, he 1 Of. hirta especially during pregne
phate not recommended (Natural Medicines ‘Comprehensive Database 2013, Hiermann and
Bucar 1994).
‘Ovallyy E.hirea was reported t0 case nanere and vorniting. The sap contains latex that 8
toxic when ingested and which is highly «stating externally, casing photosensitive skin reac
fons and severe inflamrpation, especially YPo ect with eyes or open cuts. "The tonicity £2
vovain high even in dried plant material, Prolonged and regulac contact with the sap js inadvis-
wave because of its carcinogenic nature (ONIPO 2012, Micromedex 2012).
“Written by R. ALVERO
Reviewed by S14
Clinical evidence in support 0
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