Waktu Pengambilan Darah (Menit) Konsentrasi Plasma (mcg/ml) Intravena AUC

0 56.12 274.625
5 53.73 260.6
10 50.51 481.6
20 45.81 436.55
30 41.50 1158.15
60 35.71 2011.8
120 31.35 1828.8
180 29.61 866.85
210 28.18 817.5
240 26.32 13160

PERSAMAAN FARMAKOKINETIKA

y= 42.292 e(-0.002.t)
 KOMPARTEMEN 1
100

10

1
0 50 100 150 200 250 300

ELIMINASI
30
29 f(x) = 42.2917434409 exp( - 0.0019630506 x )
R² = 0.991593558
28
27
26
25
24
170 180 190 200 210 220 230 240 250
Waktu Pengambilan Darah (Menit) Konsentrasi Plasma (mcg/mL) Intramuskular Cp Terminal
0 0 47.693
5 0.16 45.8229307215
10 3.36 44.0261879082
20 5.71 40.6412937272
30 7.42 37.5166425778
60 10.96 29.5116363054
120 14.02 18.2613104108
180 10.17
210 8.42
240 6.12

Absorpsi
50
48
f(x) = 48.2719175744 exp( - 0.0159387653 x )
46 R² = 0.9356616764
44
42
40
38
36
0 2 4 6

PERSAMAAN FARMAKOKINETIKA
y= 47.693 e(-0.008.t) - 48.272 e (-0.016.t)
 Cp 1 Residual
47.693
kompartemen 2
45.6629307215 100
40.6661879082
34.9312937272
30.0966425778
18.5516363054 10
4.2413104108

1
0 50 100 150 200 250 300

Absorpsi ELIMINASI
12
10
9175744 exp( - 0.0159387653 x ) f(x) = 47.6930225296 exp( - 0.0084646686 x )
16764 R² = 0.9785579046
8
6
4
2
0
4 6 8 10 12 170 180 190 200 210 220 230 240 250
0 250 300

4646686 x )

230 240 250

Waktu Pengambilan Darah (Menit) konsentrasi plasma peroral (mcg/ml)peroral Cp Terminal
0 0 10.734
5 11.26 10.6271949155
10 21.56 10.5214525593
20 37.29 10.3131138399
30 20.41 10.1089005035
60 11.39 9.5202039677
120 9.05 8.4436634607
180 8.20
210 7.78
240 7.49

PERSAMAAN FARMAKOKINETIKA
y= 18.089 e(-0.03.t) + 10.734 e(-
 Cp 1 Residual Cp Distribusi Cp 2 Residual
-10.734 18.089 28.823
0.6328050845 15.569346586 14.936541501 KOMPARTEMEN 2
11.0385474407 13.400660794 2.3621133532 40
26.9768861601 9.9274536853 35
30
10.3010994965
25
1.8697960323
20
0.6063365393 15
10
5
0
0 50 100 150 200

ELIMINASI
8.40
8.20
f(x) = 10.7338093462 exp( - 0.001509422
8.00 R² = 0.9914229001
7.80
MAAN FARMAKOKINETIKA
7.60
089 e(-0.03.t) + 10.734 e(-0.002.t) - 35.128 e (-0.25.t)
7.40
7.20
7.00
170 180 190 200 210 220 230
OMPARTEMEN 2 DISTRIBUSI
12
10
8
f(x) = 18.0893861051 exp( - 0.0296581724 x )
6 R² = 0.9081830111
4
2
0
100 150 200 250 300 20 40 60 80 100 120 140

ELIMINASI ABSORPSI
35
f(x) = 35.1276593292 exp( - 0.2501616973 x )
30 R² = 0.9302030418
38093462 exp( - 0.0015094226 x )
229001 25
20
15
10
5
200 210 220 230 240 250 0
0 2 4 6 8 10 12
Waktu Pengambilan Darah (Menit) Konsentrasi Plasma (mcg/ml) Intravena AUC
0 56.12 274.625
5 53.73 260.6
10 50.51 481.6
20 45.81 436.55
30 41.50 1158.15
60 35.71 2011.8
120 31.35 1828.8
180 29.61 866.85
210 28.18 817.5
240 26.32 13160

AUC Total 8136.475

AUC Tak Hingga 21296.475
Waktu Pengambilan Darah (Menit) Konsentrasi Plasma (mcg/mL) Intramuskular AUC
0 0 0.4
5 0.16 8.8
10 3.36 45.35
20 5.71 65.65
30 7.42 275.7
60 10.96 749.4
120 14.02 725.7
180 10.17 278.85
210 8.42 218.1
240 6.12

AUC Total 2367.95

AUC Tak Hingga 3132.95
Waktu Pengambilan Darah (Menit) konsentrasi plasma peroral (mcg/ml)peroral AUC
0 0 28.15
5 11.26 82.05
10 21.56 294.25
20 37.29 288.5
30 20.41 477
60 11.39 613.2
120 9.05 517.5
180 8.20 239.7
210 7.78 229.05
240 7.49

Auc Total 2769.4

AUC Tak Hingga 6514.4
 Ke eliminasi (jam-1) K Distribusi (jam-1)
INTRAVENA 0.002 -
INTRAMUSKULAR 0.008 -
ORAL 0.002 0.03

AUC IV 21296.475
AUC IM 3132.95
AUC Oral 6514.4
ka(jam-1) Cl T1/2 D (mcg) Tmax
- 118.4 346.57359028 59200 -
0.016 - 86.64339757 143000 86.5461237534
0.25 - 346.57359028 150500 9.6375615282

Bioavailabilitas absolut Biovailabilitas Relatif

ORAL & IV 12.0323901029 IM & ORAL
IM & IV 6.0901979436 ORAL & IM
 Cmax Vd
- 0
11.7782673123 -
20.9192897376 -

ailabilitas Relatif
50.6150306926
197.5697705436