I    Pathology

Tiffany M. Graham, M.D.

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Gynecomastia
Updated: Aug 16, 2018

General

Gynecomastia simply refers to an

increased amount of breast tissue in
a male
Uncommon condition.
A minority of cases are associated
with BRCA2 mutation.

Clinical picture
1. Young boy with enlarged breasts (can be
unilateral).

May be idiopathic & resolve

spontaneously. Some require surgery

2. Old man with enlarged breasts

Due to high estrogen levels:

1. Cirrhosis (decreased hepatic clearance

of estrogen)
2. Some drugs
3. Klinefelter syndrome (XXY)
4. Leydig cell tumor of testis

3. Other

Can be seen in hyperthyroidism, prolactinomas, or AIDS patients on HAART therapy

Histology
 Abundant collagenous dense stroma with only small ductular tissue with loss of lobular
units

End ducts without lobules

Can have well or poorly de ned borders

Can see ductal epithelial hyperplasia or prominent periductular edema

looks similar to desmoplastic stromal reaction or pseudoangiomatous stromal

hyperplasia

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Breast, [Right/Left], mammoplasty:
- Benign breast tissue, (weight) g.

AP Topics • Surg Path • Breast

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