PMID- 31505241

OWN - NLM
STAT- Publisher
LR - 20190910
IS - 1872-7972 (Electronic)
IS - 0304-3940 (Linking)
DP - 2019 Sep 7
TI - Updated mechanisms underlying sickle cell disease-associated pain.
PG - 134471
LID - S0304-3940(19)30574-9 [pii]
LID - 10.1016/j.neulet.2019.134471 [doi]
AB - Sickle cell disease (SCD) is one of the most common severe genetic diseases
around the world. A majority of SCD patients experience intense pain, leading
to
hospitalization, and poor quality of life. Opioids form the bedrock of pain
management, but their long-term use is associated with severe side effects
including hyperalgesia, tolerance and addiction. Recently, excellent research
has
shown some new potential mechanisms that underlie SCD-associated pain. This
review focused on how transient receptor potential vanilloid 1, endothelin-1/
endothelin type A receptor, and cannabinoid receptors contributed to the
pathophysiology of SCD-associated pain. Understanding these mechanisms may
open a
new avenue in managing SCD-associated pain and improving quality of life for
SCD
patients.
CI - Copyright (c) 2019. Published by Elsevier B.V.
FAU - Du, Shibin
AU - Du S
AD - Department of Anesthesiology, New Jersey Medical School, Rutgers, The State
University of New Jersey, Newark, NJ 07103, USA.
FAU - Lin, Corinna
AU - Lin C
AD - Rutgers Graduate School of Biomedical Sciences, New Jersey Medical School,
Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.
FAU - Tao, Yuan-Xiang
AU - Tao YX
AD - Department of Anesthesiology, New Jersey Medical School, Rutgers, The State
University of New Jersey, Newark, NJ 07103, USA; Rutgers Graduate School of
Biomedical Sciences, New Jersey Medical School, Rutgers, The State University
of
New Jersey, Newark, NJ 07103, USA. Electronic address:
yuanxiang.tao@njms.rutgers.edu.
LA - eng
PT - Journal Article
PT - Review
DEP - 20190907
PL - Ireland
TA - Neurosci Lett
JT - Neuroscience letters
JID - 7600130
SB - IM
OTO - NOTNLM
OT - Endothelin type A receptor, Cannabinoid receptors
OT - Endothelin-1
OT - Pain
OT - Sickle cell disease
OT - TRPV1
EDAT- 2019/09/11 06:00
MHDA- 2019/09/11 06:00
CRDT- 2019/09/11 06:00
PHST- 2019/03/05 00:00 [received]
PHST- 2019/08/27 00:00 [revised]
PHST- 2019/08/29 00:00 [accepted]
PHST- 2019/09/11 06:00 [entrez]
PHST- 2019/09/11 06:00 [pubmed]
PHST- 2019/09/11 06:00 [medline]
AID - S0304-3940(19)30574-9 [pii]
AID - 10.1016/j.neulet.2019.134471 [doi]
PST - aheadofprint
SO - Neurosci Lett. 2019 Sep 7:134471. doi: 10.1016/j.neulet.2019.134471.