QUADRO® - THE ORIGINATOR, INVENTOR

AND INNOVATOR OF CONICAL MILLS

Model 196
Quadro® Comil®: Scale Up Reproducibility Whitepaper
Model U30
Scalability within Comil® models is ensured by maintaining key parameters
constant for all mills (from lab scale to larger production machines).

Equipment Tolerances – optimized tolerances between components

are maintained constant to ensure similar milling efficiencies
Model 197

Tooling Selection – the same screen hole diameters, screen hole
types and impeller profiles are available for all Comil® models to
ensure powders are exposed to the same milling forces Model 194
Model U20 Model U10

Impeller Tip Speed – maintained constant to ensure particles are
subjected to the same impact/attrition velocities Model SLS-U5

The ability to offer the same milling conditions, regardless of model, results in
repeatable and scalable particle size distributions (PSDs). The only variable left is
capacity, which increases or decreases proportionally to the screen volume. As
machines get bigger, the screens increase in size, but their 60O angle is constant.

Tip Speed Scale Up Calculations

As machines increase in size, screens are larger and impellers increase in
diameter. However, equipment RPMs are designed to ensure tip speeds
are kept constant.
196|U30

RPM RPM 194|U20

197|U10
20x
SLS-U5 10x
2x
VTIP VTIP (benchmark) Capacity Scale Up
Overdriven Underdriven
VTIP = RPM x 2πr/60s PSD Scale-Up Representative Results for
Tip Speed Scale Up Lactose Placebo Granulation
35
197 194 196
Model SLS-U5 30
U10 U20 U30
U10
Std. Impeller 3500 rpm 2400 rpm 1400 rpm 900 rpm 25
RPM at 60 Hz (14 m/s) (14 m/s) (14 m/s) (14 m/s)
U20
% retention

20
197
Half Speed 1750 rpm 1400 rpm 700 rpm 450 rpm
194 15
(30 Hz) (7 m/s) (7 m/s) (7 m/s) (7 m/s)
196 10
1.5 x Std. 5250 rpm 3600 rpm 2100 rpm 1350 rpm
Speed (90 Hz) (21 m/s) (21 m/s) (21 m/s) (21 m/s) 5

Example Calculations: 0
197 or U10 VTIP = 2400 Rev/min x 2 π x U10 Imp. radius m/60s = 14 m/s pan 75 106 150 180 250 425
194 or U20 VTIP = 1400 Rev/min x 2 π x U20 imp. radius m/60s = 14 m/s
PSD (micron)