Prodi : Profesi Apoteker 37 / Kelas A

Judul Jurnal : Drug Use Evaluation of Three Widely Prescribed Antibiotics in a

Teaching Hospital in East of Iran

KERTAS KERJA EVALUASI PENGGUNAAN OBAT

STEP DESKRIPSI HASIL REVIEW PAPER

1. Penanggung o Internal Rumah Sakit (KFT/IFRS)
jawab/pelaksana o Peneliti dari luar (universitas)
DUE o Kolaborasi
o Lembaga lain
Keterangan :
1. Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of
Medical Sciences, Tehran, Iran.
2. Assistant Professor of Clinical Pharmacy, Pharmacy School, Zabol University
of Medical Sciences, Zabol, Iran.
2 Selection of o High-volume medicine use
agents o Medicines with a low therapeutic index
o Medicines with a high incidence of ADRs
o Expensive medicines
o Medicines that are critically important, including those in the following
categories: cardiovascular, emergency, toxicology, oncology, intravenous
medicines, and narcotic analgesics
o Antimicrobial medicines, both prophylactic and therapeutic
o Injections
o Medicines undergoing evaluation for addition to the formulary
o Medicines used for off-label indications
o Medicines used for high-risk patients
3 & 4. Indikator, Indikator proses Ceftazidim, Vancomycin dan (Amikasin)
kriteria dan nilai Indikator Criteria
ambang batas Indications Indications :
evaluasi Pneumonia || (Infeksi Sal. Kemih)
Adults & Children < 12 years
Indications to discontinue : -
Dose (mean dose) Adults:
Ceftazidim  3803 mg/day
Vancomycin  1734 mg/day
Children:
 695 mg/day
 303 mg/day
Amikasin Adults | Children
 783 mg/hari | 247 mg/hari
Quantity -
dispensed
Preparation -
Vancomycin Ceftazidim Amikacin
Monitoring Monitoring/ Clinical parameters
N (%) N (%) N (%)
27(54) 15(30) 31(62) Culture
6(12) 0(0) 8(16) Antibiogram
39(78) 32(64) 28(56) Blood Urea Nitrogen/Creatinin
44(88) 45(90) 7(14) Empiric therapy
8(16) 11(22) 12(24) Prescription based on guideline
 6(12) 5(10) 43(86) Definite Therapy
37(74) 31(62) 42(84) Therapeutic response
7(14) 17(34) 8(16) Therapeutic failure
6(12) 2(4) 0(0) Death
-
Contraindications
-
Drug interactions
-
Administration
-
Patient education

Indikator outcome (TD, KGD, EFIKASI, dll) : -

…………………………………………………………………………………………

Indikator administrative farmasi:

o Correct cost to patient
o Accurate billing records
o Accurate dispensing records
o Appropriate use of generic medicines or therapeutic equivalents
o Appropriate use of formulary medicines
o Appropriate quantity dispensed

5 Pengambilan Prospektif / retrospektif

data Jenis data : Medical records
Jumlah pasien/resep : 2755
Periode pengambilan data : Desember 2010 hingga Mei 2011
Pengolahan data : SPSS
6 Penyajian o Grafik
hasil evaluasi o Diagram
o Narasi
o Lain-lain

7 Rekomendasi o Appropriate/inappropriate
hasil evaluasi - Mengoptimalkan metode pengambilan sampel dan teknik
laboratorium dapat meningkatkan hasil kultur
o Acceptable/unacceptable
- Penyesuaian dosis diperlukan untuk sekitar 14 persen pasien
karena berkurangnya fungsi ginja
- Perlunya seorang apoteker konsultan klinis untuk penyesuaian
dosis dapat meningkatkan standarisasi pengobatan
o Other drug use problem
8 Intervensi o In-service/continuing education programs
o Written guidelines for drug use
o Development of special drug order forms
o Changes in hospital policies and procedures
o Formulary additions and deletions
o Prescribing restrictions
o Formal and informal counseling