Status of the Thyroid Ultrasound Examination (July 8, 2019)

1. Preliminary Baseline Screening (First Round) (Tallied as of March 31, 2018)

【Conducted in FY2011-2013】
Primary examination (completed on April 30, 2015)
• Target population 367,637
• Participants 300,472 (81.7% participation rate)
• Completed test results 300,472 (100.0% completion rate)
• Test result categories
A (A1) : 154,605 (51.5%)
(A2): 143,573 (47.8%)
B: 2,293 ( 0.8%)
C: 1 ( 0.0%)

Confirmatory examination (as of March 31, 2018)

• Target population 2,293
• Participants 2,130 (92.9% participation rate)
• Completed test results 2,091 (98.2% completion rate)
547 participants underwent fine-needle aspiration cytology (FNAC)
Summary of FNAC results
• Suspicious or malignant 116
• Male : Female 39 : 77
• Average age 17.3±2.7 (8-22), 14.9±2.6 (6-18) at the accident time
 Average tumor diameter 13.9±7.8 mm (5.1-45.0 mm)

Age and sex distribution of 116 suspicious or malignant cases

[Age as of March 11, 2011]

[Age at the date of confirmatory examination]

1
2. Full-Scale Screening (Second Round) (as of March 31, 2018)
【Conducted in FY2014-2015】
Primary examination
• Target population 381,244
• Participants 270,540 (71.0% participation rate)
• Completed test results 270,529 (100.0% completion rate)
• Test result categories
A (A1): 108,718 (40.2%)
(A2): 159,584 (59.0%)
B: 2,227 ( 0.8%)
C: 0 ( 0.0%)

Confirmatory examination
• Target population 2,227
• Participants 1,874 (84.1% participation rate)
• Completed test results 1,826 (97.4% completion rate)
207 participants underwent FNAC
Summary of FNAC results
• Suspicious or malignant 71
• Male : Female 32 : 39
• Average age 16.9±3.2 (9-23), 12.6±3.2 (5-18) at the accident time
 Average tumor diameter 11.1±5.6 mm (5.3-35.6 mm)

Age and sex distribution of 71 suspicious or malignant cases

[Age as of March 11, 2011]

[Age at the date of confirmatory examination]

2
3. Full-Scale Screening (Third Round) (as of March 31, 2019)
【Conducted in FY2016-2017】
Primary examination
• Target population 336,669
(Excluding those born in FY1992-1993, eligible for Age 25 Milestone Screening)
• Participants 217,702 (64.7% participation rate)
• Completed test results 217,687 (100.0% completion rate)
• Test result categories
A (A1): 76,327 (35.1%)
(A2): 139,870 (64.3%)
B: 1,490 ( 0.7%)
C: 0 ( 0.0%)

Confirmatory examination
• Target population 1,490
• Participants 1,081 (72.6% participation rate)
• Completed test results 1,019 (94.3% completion rate)
67 participants underwent FNAC
Summary of FNAC results
• Suspicious or malignant 24
• Male : Female 8 : 13
• Average age 16.6±3.0 (12-23), 10.0±3.0 (5-16) at the accident time
 Average tumor diameter 13.9±6.9 mm (5.6-33.0 mm)

Age and sex distribution of 24 suspicious or malignant cases

[Age as of March 11, 2011]

[Age at the date of confirmatory examination]

3
4. Full-Scale Screening (Fourth Round) (as of March 31, 2019)
【Conducted in FY2018-2019】
Primary examination
• Target population 294,127
(Excluding those born in FY1992-1995, eligible for Age 25 Milestone Screening)
• Participants 104,154 (35.4% participation rate)
• Completed test results 89,807 (86.2% completion rate)
• Test result categories
A (A1): 31,022 (34.5%)
(A2): 58,194 (64.8%)
B: 591 ( 0.7%)
C: 0 ( 0.0%)

Confirmatory examination
• Target population 591
• Participants 311 (52.6% participation rate)
• Completed test results 224 (72.0% completion rate)
11 participants underwent FNAC
Summary of FNAC results
• Suspicious or malignant 5
• Male : Female 2:3
• Average age 14.6±3.3 (11-19), 7.2±3.3 (4-12) at the accident time
 Average tumor diameter 11.1±4.1 mm (6.9-17.1 mm)

5. Age 25 Milestone Screening (as of March 31, 2019)

【Conducted in FY2017-】
Primary examination
• Target population 44,542 (those born in FY1992-1993)
• Participants 3,161 ( 7.1% participation rate)
• Completed test results 2,288 (72.4% completion rate)
• Test result categories
A (A1): 943 (41.2%)
(A2): 1,240 (54.2%)
B: 105 ( 4.6%)
C: 0 ( 0.0%)

Confirmatory examination
• Target population 105
• Participants 83 (79.0% participation rate)
• Completed test results 80 (96.4% completion rate)
3 participants underwent FNAC
Summary of FNAC results
• Suspicious or malignant 2
• Male : Female 1:1

4
The numbers of suspicious or malignant cases and surgically confirmed cases

Overall status from the first through fourth rounds as well as Age 25 Milestone Screening
Malignant or suspicious cases 218
Surgically confirmed cases 174
[1 benign nodule, 171 papillary thyroid cancer (PTC), 1 poorly differentiated thyroid
cancer (PDTC), and 1 other thyroid cancer]

First round (as of March 31, 2018) 【Conducted in FY2011-2013】

Total 116 (39 males : 77 females)
(102 surgically confirmed cases: 1 benign nodule, 100 PTC, 1 PDTC)

Second round (as of March 31, 2018) 【Conducted in FY2014-2015】

Total 71 (32 males : 39 females)
(52 surgically confirmed cases: 52 PTC, 1 other thyroid cancer)

Third round (as of March 31, 2019) 【Conducted in FY2016-2017】

• FY2016 municipalities 12 (6 males, 6 females)
(11 surgically confirmed cases: 11 PTC)
• FY2017 municipalities 12 (3 males : 9 females)
(7 surgically confirmed cases: 7 PTC)

Total 24 (9 males : 15 females)

(18 surgically confirmed cases: 18 PTC)

Fourth round (as of March 31, 2019) 【Conducted in FY2018-2019】

• FY2016 municipalities 5 (2 males : 3 females)
(1 surgically confirmed case: 1 PTC)
• FY2017 municipalities 0 (0 male : 0 female)
(0 surgically confirmed case: 0 PTC)

Total 5 (2 males : 3 females)

(1 surgically confirmed case)

Age 25 Milestone Screening (as of March 31, 2019) 【Conducted in FY2017-】

Total 2 (1 male : 1 female)
(1 surgically confirmed case)

Translator’s note: This translation has an additional pieces of information—the average age
and tumor diameter for the FNAC results of the fourth round—which were not included in
the original Japanese version.