CHI

NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

SUBJECT CONTENTOUTLI
NE TEXTBOOKSAND

LECTUREMATERI
AL

Phy
sicsI 1.Vi
brati
onandWaves:Hooke’sLaw,Elast
icPotenti
alener
gy, HuangJi
wuetal
.;
Col
l
ege
vel
oci
tyasafuct
ionofposit
ion;Waveforms,Frequency,
Cr
edi
t:2 Phy
sics7thEdi
ti
ti
on
ampli
tudeandwavel
ength;
superposi
ti
onandi nter
ferenceof
Hour
s:34 waves

2.Sound:Product
ionofsoundwaves;
char
act
erist
icsofsound
waves;speedenergyandint
ensi
ty;
Doppl
eref
fect;
Soundquali
ty

3.Elect
ri
cit
y:Pr
oper
ti
esofel
ect
ri
ccharges;el
ect
ri
cfi
eldsand
forces;
Coulomb’
sLaw;El
ect
ri
cpotent
ialandpot
enti
al
diff
erence

4.Curr
entandResi
stance:
Elect
ri
cCur
rent
;Ohm’
sLaw,
Elect
ri
c
ener
gyandpower

5.
Dir
ectCur
rentCi
rcui
ts

6.Magneti
sm: Ef
fectofmagnet
icf
iel
dsonchar
ges;
sour
ceof
magneti
cfiel
ds;Ampere’
sLaw;Magneti
cfl
ux

I
norgani
c 1.Aci
dsandBases:
Buf
fer
s,Wat
er. 1.Di
seherLA,
Modem
Chemist
ry
2.GasesBehav
iour
:Kinet
ict
heor
yofgases,
dev
iat
ionf
rom I
nor cPhar
gani maceut
ica
Cr
edi
t:4 behavi
our
sandexplanati
on;
Chemi
str
y.
Hour
s:68 3.Li
quids:
Proper
ti
es(
surf
acet
ensi
on,viscosi
ty,
,opti
cal
rot
ati
on,di
polemoment
sandchemical
constit
uents)
. 2.Bl
ockJH,
RocheE,

4.Sol
uti
ons: I
dealandr
ealsol
uti
ons,sol
utionsofgasesin SoineT0andWi lsonC
l
iqui
ds,absolut
etemperat
urescal
e,ther
mochemi calequat
ions, Medici
naland
phaseequil
ibri
aandphaserul
e;Adsorpt
ion;
Pharmaceuti
cal
Chemist
5.Phot
ochemi
str
y:Lamber
t-
BeerLaw,
Quant
um ef
fi
ciency
;

6.ChemicalKi
netics:Zer
o,fi
rstandsecondor derreacti
ons,
SEMESTE
complexreact
ions,theor
iesofreact
ionkineti
cs,charact
eri
sti
cs
R
ofhomogeneousandhet erogeneouscatalysi
s,acidbaseand
enzymecataly
sis;
1 7.Atoms: st
ruct
ure,orbitals,wav eequat i
on, Molecul
arorbi
tal
s,
BondingandAnt i
bondingor bi
tals,Covalentbond, Hybr
id
orbit
als,I
ntr
amolecul
arf orces, Bonddi ssociati
onenergy,
Polari
tyofbonds,Pol
arityofmol ecules,structur
eandphy si
cal
properti
es,I
nter
molecularf orces,Acidsandbases.

8.I
ntr
oduct
iont
oQuant
um Mechani
cs

PRACTI
CALS:
(Cr
edi
t:1,
Hour
s:34)

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 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

1.Determinat
ionofuni
for
mit
yofwei
ghtoft
abl
etsandof
capsules.

2.Standar
disat
ionof1M NaOHusingsul
phur
icaci
d(pr
imar
y
st
andard)andassayofvi
negar(
aceti
caci
d).

3.
Det
ermi
nat
ionofper
cent
agepur
it
yofacet
icaci
dinv
inegar

4.Doubl
eindi
cat
ort
it
rat
ion

5.Backt
it
rat
ion.Assayofl
act
icaci
d.Assayofaspi
ri
n.

6.Complexomet
ricti
trat
ion;
Standar
disat
ionofEDTAsolut
ion,
i
tsusetoassayelementsofpharmaceuti
cali
nter
estand
deter
minati
onofhardnessofwater.

7.Basi
candLi mitt
est
.Testt
oassur
equal
i
tyof
pharmaceut
icals

SUBJECT CONTENTOUTLI
NE TEXTBOOKSAND

LECTUREMATERI
ALS

Basi
csof 1.I
ntr
oduct
iont
oComput
ers; Jur
sPC,
Comput
er
Computer
2.Hi
stor
yofComput
erdev
elopment; Sof
twar
eAppl
i
cat
ioni
n
Appl
icat
ions
3.ComputerCl
assi
ficati
on:
Mainframe,Mini
andMicr
o Chemi
str
y,JohnWi
l
ey&
Cr
edi
t:3
Computer
s;comparisonofAnal
og&Di git
alComput
ers,
Sons,
NewYor
k.
Hour
s:77 Hardwar
eandSof t
war e;
Operat
ingSyst
ems;

4.
Progr
ammi
ngLanguages;
Dat
aSt
ruct
ure;
Comput
erGr
aphi
cs;

5.Comput
erappl
i
cat
ionsi
nphar
maceut
ical
andcl
i
nical
studi
es.

Adv
anced 1.Algebra: Equati
ons,simult
aneousequat i
ons(l
inearand
Mathemat
icsI quadrati
c),mat r
ices,pharmaceut
icalappl
icati
onsof
determinantsandmat r
ices.mensurat
ionanditspharmaceut
ical
Cr
edi
t:3
appli
cations;Central
Val ueMeasures;
Hour
s:51
Tri
gonomet
ry;
Logar
it
hmsi
nphar
maceut
ical
comput
ati
ons;
Cal
cul
us;

2.Di
ff
erent
ial
:Li
mit
sandf
unct
ions,
dif
fer
ent
ial
coef
fi
cient
,

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 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

dif
fer
enti
ationofst andardfuncti
ons, i
ncludi
ngf unct
ionofa
funct
ion(Chainr ul
e).Dif
fer
ent i
ati
onofi mplici
tfuncti
ons,
l
ogarit
hmicdi ff
erenti
ati
on,Integrati
onasi nver
seof
dif
fer
enti
ation,indefi
nit
eintegral
sofst andardforms, i
ntegr
ati
on
byparts,
subst i
tuti
onandpar tialfr
acti
ons, f
ormal ev
aluati
onof
defi
nit
eintegrals.

SEMESTE
R

Advanced 1.I
ntegralcalcul
usr evision;
MathematicsI
I
2.Dif
fer
ent i
alequat i
ons: defini
ti
onandf ormation;
fir
storder
Credi
t:3 anddegreeequat ion;lineardi f
fer
enti
alequat i
ons;li
near
di
ffer
entialequati
onsgr eaterthanfi
rstorderwithconstant
Hours:51
coeff
ici
ents;simultaneousl ineardi
ff
erentialequat
ions;
pharmaceut i
calapplications.

3.Lapl
acet
ransf
orms;

Phy
sicsI
I 1.
Far
aday
’sLaw HuangJi
wuetal
.;
Col
l
ege

Cr
edi
t:3 2.Al
ter
nat
ingCur
rentCi
rcui
ts:
Power
;Resonance Phy
sics7t
hEdi
ti
ti
on

Hour
s:51 3.
Elect
romagneti
cWaves:Spect
rum ofEM Wav
es;
Ener
gy,
moment um andr
adi
ati
on

4.
NatureofLi
ghtandGeometr
icOpt
ics:
SpeedofLi
ght
;
Ref
lect
ionandRefr
act
ion;
Lenses

5.Opti
calI
nst
ruments:
Camer
a,Humaney
e;compound
micr
oscope,t
elesc
SEMESTE
R

SUBJECT CONTENTOUTLI
NE TEXTBOOKSAND

LECTUREMATERI
AL

Mathematical 1.I
ntroducti
onofDi scret
eRandom v ar
iabl
es;
Proper
ti
esand 1.
Rice’
sMat
hemat
ical
St
atist
ics Appl
icationsofPr obabili
tyDi
str
ibuti
ons;Bi
nomialDi
str
ibuti
on
St
ati
sti
csandDat
a
asaModel ;ExpectationandVarianceofaRandom Variabl
e;
Cr
edi
t:3
Normal Dist
ri
bution; Anal
ysi
sThi
rdEdi
ti
on

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 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

Hour
s:34 2.Biomet ri
cs: datacollection, r
andom andnon- random 2.
Rosner ’
sFundament
als
sampl ingmet hods, sampl esi ze,dataor ganization,
ofBiostat
ist
ics
diagrammat i
cr epresentat i
onofdat a,bar,pi
e, 2-Dand3-D
diagrams, measur esofcent raltendency ,measur esof SeventhEdit
ion
dispersion, Standar dDev iati
onandst andarder rorofmeans,
coefficientofv ari
ati
on, confidencel i
mi t
s,probabi l
it
yand
events, probabi li
tytheorems, kurt
osi sandskewness, corr
elat
ion
andr egr essionanal ysi
s, met hodofl eastsquar es,st
ati
sti
cal
i
nf er
ence, Student '
sandpai redt-test,F-t
est;

3.Appl
icat
ionandI
nter
pret
ati
onofSt
ati
sti
cal
resul
tsi
n
Medici
ne

SEMESTE
R

Organi
c 1.St
ruct
ure&Nomencl
atur
e; Rober
tsJDandCaser
io
Chemistr
yI
2.React i
onsof:Al
kanes, Alkenes,Al
kynes;Cy cl
oalkanes, M C,
BasicPri
nci
plesof
Cr
edi
t:3 Dienes,Benzene,Polynucleararomati
ccompounds, Ar
enes,
Or
ganicChemist
ry
Alkylhali
des,Al
cohols,Ethers,Epoxi
des,Ami nes,Phenols,
Hour
s:51
Aldehydesandket ones,Carboxy l
i
cacids,Functionalderi
vat
ives
of'carboxyl
icaci
ds,Reactiveintermedi
ates-car bocati
ons,
carbanions,car
benes,nitr
eneandni tr
enium ions.

3.St er
eochemistr
y:Isomer i
sm andnomenclatureand
associatedphysi
cochemi calpr
operti
es;opti
calactiv
ity
;
stereoisomer
ism;specif
icati
onofconf i
gurat
ion;Reacti
ons
i
nv olvi
ngster
eoisomers,chir
ali
ty,chi
ralr
eagentsconformati
ons
SEMESTE
R
PRACTI
CALS:
(Cr
edi
t:
1.5,
Hour
s:51)

3
1.Var i
ouslabor ator
ytechniquesthroughdemonstrat
ions
i
nv olv
ingsy nthesisofsel
ect edorgani
ccompounds( e.g.aspi
ri
n,
p-bromoacet anili
de,ant
hraquinonefrom ant
hraci
ne,reducti
on
ofnitrobenzeneet c)

2.I
dent
if
icat
ionofor
gani
ccompoundsandt
hei
rder
ivat
ions.

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 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

SUBJECT CONTENTOUTLI
NE TEXTBOOKSAND

LECTUREMATERI
AL

Anal
yti
cal 1.AnOv er
viewofAnal
ytical
Chemistr
y:GoodLabor
ator
y Har
ri
s’Quant
it
ati
ve
Chemist
ryI Pract
ices;Makingdeci
sionwithdat
a;
Chemi
cal
Anal
ysi
s
Cr
edi
t:2.
5 2.ChemicalAct
ivi
tyandChemicalEqui
li
bri
um;Acid-
base
Ei
ght
hEdi
ti
on
Reacti
onsandAcid-baseTi
tr
ati
ons;Chemical
Solubi
li
tyand
Hour
s:42
Preci
pit
ati
on

Gr
avi
met
ri
cAnal
ysi
s;

3.
AnIntr
oduct
iontoChemical
Separat
ion:
Preci
pitat
ion
Ti
tr
ati
ons;Complexomet
ri
cReacti
ons&Titrat
ions;

4.Analy
ticalTechniques&Tools:Fl
uorescenceSpectra&
Fl
uoromet ry
; GasChromatography;Li
qui
dChr omatography;
IR
Spect
ra&I nterpr
etati
ons;
Electr
ochemicalAnaly
sis;Redox
Reacti
ons&Ti tr
ati
ons

Medi
cal 1.
Under st
andingLaboratoryandDiagnost
icTest
s:Blood Moi
si
o’sUnder
standi
ng
Di
agnost
ics ChemistryTests;
Mor phologyandSt r
uct
ureofBacteri
a;
Labor
ator
yand
Bact
erialmorphologi
calex aminat
ion;
Cr
edi
t:3
Di
agnost
icsTest
s:
2.
Endoscopy
:Pur
poseandt
hest
ruct
uresi
nvol
vedi
n
Hour
s:51

~5~
 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

endoscopicst
udi
es;Indicati
onsandcont r
aindi
cati
onsforeach Del
mar’
sHeal
th
endoscopicst
udy;Compl i
cationsassoci
atedwitheachspecif
ic
I
nfor
mati
onManagemen
endoscopicpr
ocedure;Relatespecif
icdi
agnosesandt r
eatment
i
ntervent
ionst
ospecifi
cendoscopi cstudi
es;Organiz
e
endoscopicst
udi
esaccor dingtotheorganorsy st
em bei
ng
eval
uated.

3.
Molecul
arImagingTechnol ogyf
orDiagnost
ics:X-Ray
ComputedTomogr aphy;Positr
onEmissi
onTomogr aphy;
Radi
oacti
vedecay;Molecularimagi
ngindrugdevelopment

SEMESTE
R

SUBJECT CONTENTOUTLI
NE TEXTBOOKAND

LECTUREMATERI
AL

Anal
yti
cal 1.Ul traviol
etandv isi
blespect r
ophotometry: Absorpti
onof
Chemist
ryI
I radiationbymol eculesandi tsrel
ati
ont omol ecularstr
uct ure;
Quant it
ativ
ecal culat
ions(r
elati
ngtheamountofr adi
ation
Cr
edi
t:
2
absor bedt ot heconcent r
ati
onofanabsor binganal yt
e);
Hour
s:34 Instrument at
ion
2.Infraredspect rophotometry:BasicIRSpect raInter
pret at
ion;
Principles;ModesofVi br
ati
ons: I
nstr
ument ation;Str
uct ure
det ermi nat
ionofcompounds;Di ff
erencesbet weenUV- Visand
IR

3.
Fluori
metry:Fluorescence;Pr
inci
ple-Multipl
i
cit
yofmolecul
e;
EnergyLevel
s;Pat hwaysandwav elengthsofemi t
tedr
adiat
ion;
Exci
tati
on&Emi ssionSpect r
um; Chemi calStr
uctur
esand
Fl
uorescence;Instrumentati
on;

4.MassSpectrometr
y;NuclearMagneti
cResonance
spect
roscopy(i
ncl
uding13CNMR)Fl amePhotometry;
Emi
ssi
on
Spect
roscopy;
X- r
ayDiff
racti
on;Radi
oimmunoassay

PRACTI
CAL:
(Cr
edi
t:
1.2,
Hour
s:42)

~6~
 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

1.Quant
it
ati
veanal
ysi
soff
ormul
ati
onscont
aini
ngsi
ngl
edr
ug
ormorethanonedr
ug.

2.Est
imat
ionofNa+,
K+,
Ca++i
onsusi
ngf
lamephot
omet
ry.

3.I
Rofsampl
eswit
hdi
ff
erentf
unct
ional
groups(
-COOH,
-
COOR.-
OH,et
c.)
.

4.I
nter
pret
ati
onofsi
mpl
eor
gani
ccompoundsst
ruct
ures’
usi
ng
UV,I
R.NMRandMS.

Organi
c 1.Nucleophi ll
i
car omaticsubstit
utions;αβunsat urat
edcar l 1.Rober
bony tsJDandCase
Chemistr
yII compounds; Conservati
onofor bit
al symmet ryandr ules.
,
Electr
ocycl ic,Cycl
oaddition;Neighbouringgr oupef f
ects; BasicPr
inci
plesofOrga
Cr
edi
t:
2 Chemist
ry,W ABenjami
Stereoselect i
veandst ereospeci
ficreactions;
Hour
s:34
York.
SEMESTE 2.Heterocy cli
cCompounds: Chemi stry
,pr eparat
ionsand
R properti
esofhet erocycl
iccontaini
ng3, 4,5,6&7at omswi thone
ortwohet eroatomsl i
ke0, N,S.

3.Chemi
str
yofCar
bohy
drat
es,
Prot
einsandNucl
eicaci
ds.
4
4.Newor
gani
creagent
susedi
ndr
ugsy
nthesi
s.;

SUBJECT CONTENTOUTLI
NE TEXTBOOKAND

LECTUREMATERI
AL

Bi
ochemist
ry& 1.Aminoacids,
pepti
des,andpr ot
eins:Molecul
arcomposit
ions 1.
Lippi
ncot
tIl
l
ustrated
Molecul
ar ofprot
eins;
Protei
nstruct
ureandf unct
ion;
Pr ot
einphysi
co-
Revi
ews:Bi
ochemi str
y
Bi
ology chemicalpr
operti
esandpurif
icati
on;Natur
allyoccur
ri
ngami no
aci
ds; 2.
ChemicalPr
inci
ples,Th

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 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

Cr
edi
t:
4 2.
Globul
arandFibr
ousProtei
ns:
Hemepr
otei
ns;
Col
l
agen; QuestForI
nsi
ght
,
El
asti
n;St
ruct
uralf
unct
ion
Hour
s:68 Fi
ft
hEdi
ti
on
3.Enzymes:Nomencl
atur
e;Proper
ti
es;Mechani
sm ofact
ion
(dynamics)
;Ki
net
ics;
Inhi
bit
ion;Regul
ati
onofenzy
meact iv
ity
;

Appl
i
cat
ioni
ncl
i
nics

4.Bi
oener
get
icsandoxi
dati
vephosphory
lat
ion:
Freeenergy;
Freeener
gychange;
Adenosi
netri
phosphat
easanener gy
carr
ier

El
ect
ront
ranspor
tchai
n;Phosphor
ylat
ionofADPt
oATP

5.
Int
roduct
iont
ocar
bohy
drat
es:
Classi
fi
cat
ionandst
ruct
ure

Di
gest
ionofdi
etar
ycar
bohy
drat
es;

6.
Int
roducti
ontomet aboli
sm andglycolysi
s:I
ntr
oductiont
o
Metabol
ism;Regulat
ionofmet abol
ism; Gly
col
ysis;
Transportof
gl
ucoseintocel
ls;
React i
onsofglycoly
sis;Hormonalregul
ati
on
ofgl
ycolysi
s;Al
ter
natefatesofpyruvate

7.
Tri
carboxyl
icacidcy
cleandpyruv
atedehydr
ogenasecomplex:
Over
view;Reacti
onsofthecycl
e;
Energypr
oducedbythecycl
e;

Regul
ati
onoft
hecy
cle.
SEMESTE 8.Gl
uconeogenesis:
Substr
ateforgl
uconeogenesi
s;React
ions
R uni
quetogluconeogenesi
s;Regul
ati
onofgluconeogenesi
s.

9.Gl
ycogenmet
abol
i
sm:
Str
uct
ureandf
unct
ionofgl
ycogen;
4 Synthesi
sofgl
ycogen(
gly
cogenesis)
;Degradat
ionofgl
ycogen
(gl
ycogenol
ysi
s);
Regul
ati
onofglycogenesi
sand
gly
congenol
ysi
s;

Gl
ycogenst
oragedi
seases

10.
Diet
aryLi
pidmet
abol
i
sm:
Digest
ion;
absor
pti
on;
Secr
eti
on;

ut
il
izat
ionofdi
etar
yli
pids.

11.Fatt
yAid,
KetoneBodiesandTrigl
ycer
idemetaboli
sm:
str
uctureoff
attyacids;
Denov osy
nthesi
soffatt
yacids;
Mobi l
i
zati
onofstoredfatsandoxi
dati
onoffat
tyacids;Ket
one
bodies:
analt
ernatefuelf
orcell
s

12.Phospholipi
d,glycosphi ngoli
pidandei cosanoi dmet abol
ism:
str
uctureofphosphol ipids; Phospholi
pidsy nthesis;Degradati
on
ofphosphol i
pid;Structureofgl ycosphingolipi
d; Synthesi
sand
degradationofglycosphi ngolipi
d;Eicosanoid:prostaglandi
ns
andrelatedcompounds

13.Chol
ester
ol,Lipoprot
einandsteroi
dmetabol
ism:
Str
uct
ureof
cholest
erol
;Synthesisofcholest
erol
;Degr
adati
onof

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 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

chol
est
erol
;

Bi
l
eaci
dsandbi
l
esal
ts;
Plasmal
i
popr
otei
ns;
Ster
oidhor
mones

14.PPPandNADPH: Ir
rever
sibl
eoxi
dat
ivereact
ions;Rever
sibl
e
nonoxi
dati
vereact
ions;UsesofNADPH;Glucose6-phosphate
dehydr
ogenasedefici
ency

15.Aminoaci
ds:Disposal
OfNitr
ogenAndConver
sionTo
Speci
ali
zedProduct
s:Overal
lni
tr
ogenmetabol
i
sm;Digest
ionof
di
etar
yprotei
ns

Tr
ansportofaminoaci
dsint
ocel
ls;
Removal
ofni
tr
ogenf
rom
aminoacids;
Ureacycl
e;Met
abol
i
sm ofammoni
a;

16.Nucleoti
demetabol
i
sm:Nucleoti
destructure;Synthesi
sof
puri
nenucleoti
des;
Synt
hesi
sofdeoxy r
ibonucleoti
des;
Degradati
onofpuri
nenucl
eot
ides;Pyri
midinesy nthesi
sand
degradati
on

17.
Met
abol
i
cef
fect
sofI
nsul
i
nandGl
ucagon;

18.Vi
tami
ns:
Wat
ersol
ubl
evi
tami
ns;
Fatsol
ubl
evi
tami
ns

19.DNASt r
uctur
eandRepli
cati
on;RNAPr ocessi
ngand
Transl
ati
on;GeneRegul
ati
on,Bi
otechnol
ogy

SUBJECT CONTENTOUTLI
NE TEXTBOOKSAND

LECTUREMATERI
AL

Medicinal NaturalProduct
s( i
ncludingthest
ructur
eandcl assif
ication,
Chemi st
ryof physicalandchemi calpr
operti
es,
extract
ionandi sol
ation, t
ests,
Natural spectroscopycharacteri
sti
cs(Chr
omot ography,1H-NMR
Products spectrum,13C-NMRspect rum;MSi nstr
uctureidenti
ficati
on)of
thefoll
owingclasses:
Cr
edi
t:
2

Hour
s:34
Al
kaloids:(
Pyridi
neandpi peri
dinealkal
oids,Pyrr
oleand
py
rroli
dine,Tropanes,Quinoli
nes, I
soqui
nolines,I
ndoles,
Er
golines,β–car bol
ines)
; Fl
avonoids;Terpenoi
dsandv ol
ati
l
e
oi
l
s; Phenyl
propanoids;Coumar ins;Gl
ycosides;Qui
nones.

Biogenesi
sandpharmacologicalact
ivi
tyofmedici
nal
ly
i
mpor t
antmonot
erpenes,sesquit
erpenes,di
ter
penes,
and
t
ri
terpenoi
ds

PRACTI
CALS:
(Cr
edi
t:
1,Hour
s:34)

1)I
sol
ati
on,
separ
ati
on,
pur
if
icat
ionofv
ari
ousgr
oupsof

~9~
 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

chemi
cal
const
it
uent
sofphar
maceut
ical
signi
fi
cance.

2)Paper
,si
li
cagelcol
umnchromatographyandthi
nlay
er
chromat
ographi
ceval
uati
onsofherbaldr
ugconst
it
uent
s(e.
g.
Il
exchi
nensisSi
ms,Ruti
nandQuerceti
n)

Human 1.
Basi
cter
minol
ogy
; Vanderetal
.:
Human
SEMESTE Anatomy&
2.BasicFunctionsofCel l
s;Membr anePotenti
alsAndAction Phy
siol
ogy
:The
R Physiol
ogy
Potenti
als;Synapt i
cTransmissi
onandCont r
acti
onofmuscle;
Mechani
sm ofBody
Cr
edi
t:
3 3.El
ement ar
yTi ssuesoftheBody :
Epithel
ial
,connect
ive,
muscularandner v
oustissues,t
heirsub-t
ypesandtheir Funct
ion,
Eight
hEdi
ti
on
5 Hour
s:51
charact
erist
ics.

4.OsseousSy stem:Str
uct
ure,
composit
ionandf
uncti
onsof
skeletonClassifi
cati
onofj
oint
s,t
ypesofmovementsofj
oint
s,
Disordersofjoints.

5.Haemopoieti
cSystem:Composi t
ionandfuncti
onsofblood
anditsel
ement s,
thei
rdisorder
s,bl
oodgroupsandt hei
r
si
gnifi
cance,mechanism ofcoagul
ati
on,di
sordersofpl
atel
ets
andcoagulati
on.

6.LymphandLy mphat
icSystem:Composi
ti
on,f
ormulat
ionand
ci
rculat
ionoflymph;di
sorder
soflymphandlymphat
icsystem.
Basicphysi
ologyandfuncti
onsofspl
een.

7.Cardi
ov ascul
arSystem &PumpFunct ionOfTheHear t:
Basi
c
anatomyoft hehear
t,Phy si
ologyofheart
,bloodvessel
sand
ci
rculat
ion;Cardi
accycle,heartsounds,
electr
ocardi
ogr
am;
Bloodpressureanditsregulati
on;Cardi
ovasculardi
sor
ders

8.TheRegul
ati
onofBodyTemper
atur
e;

9.
Locomot
orSy
stem;

10.Digesti
veSyst
em: Gr
ossanatomyofthegast
ro-
intest
inal
tr
act,functi
onsofit
sdif
fer
entpart
s;Di
sorder
sofdigesti
ve
system

11.Respir
atorySystem:Anatomyofr espi
rat
oryor
gans&its
functi
ons,respir
ati
on,mechanism andregul
ati
onofrespi
rat
ion,
respi
rator
yv olumesandv i
talcapaci
ty.

12.Nervoussy
stem:Physi
ologyandf
unct
ionofCent
ral
and
Autonomicner
voussyst
em

13.Ci
rcul
ator
ysy
stem;

14.Endocri
neSyst
em:Pi
tui
tary
,Thyr
oid,
Par
athy
roi
d.Adrenal
s,
Pancreas,
Test
esandovary
,thei
rhor
monesandfunct
ions.

15.
Repr
oduct
iveSy
stem:
Mal
eandf
emal
erepr
oduct
ive

~10~
 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

systemsandtheirhormones;
Phy si
ologyofmenst
ruat
ion,
coit
usandfer
til
izati
on;Sexdi
ffer
enti
ation,
sper
matogenesi
s&
oogenesi
s;Pr
egnancy

16.TheUri
narySystem:struct
uresandf
unct
ionsoft
hekidney
anduri
nar
ytract.Physi
ologyofuri
nefor
mati
onandacid-
base
bal
ance.

SUBJECT CONTENTOUTLI
NE TEXTBOOKSAND

LECTUREMATERI
AL

Phar
maceut
ics 1.Int
roduct
ion:
hist
oryofpharmacydevel
opment;def
ini
ti
on 1.Ansel
’
sPhar
maceut
ica
ofpharmaceuti
cs,t
heclassi
fi
cat
ionofdosagefor
ms; Tobe
Cr
edi
t:
3 DosageFor
msand
famil
iarwit
hthepharmacopoei
a,GMP,GSP, GLPandGCP.
SEMESTE Hour
s:51 Dr
ugDel
i
ver
ySy
st 9t
ems,
R 2.Preformulat
ionStudies:conceptandthesignif
icanceof
pref
ormul at
ionstudy;processofformuladesigni
ng; 2.Moder
nPhar
maceut
ics
Understandthecommonmet hodoff or
mulaopt i
mizati
on.
Vol
ume1Basi
cPr
inci
ples
5 3.Thestabi
li
tyresearchondosagef orms:signif
icanceof andSy
stems
pharmaceuti
calpreparationsst
abil
i
tystudi
es; t
heinf l
uence
fact
orsofthepreparationsandstabil
i
zati
onmet hod; 3.Mar
ti
n’
sPhy
sical
pri
ncipl
eoftheconst anttemperat
ureaccelerat
edt est Phar
macyand
methodsandpr edict
ionmet hodsofthevali
dity
;pat hwayof
drugchemicaldegradation. Phar
maceut
ical
Sci
ences

4.Surf
actants:
defi
nit
ion,cl
assi
fi
cat
ionandchar
act
eri
stcof Phy
i si
calChemi
caland
surf
actantandappl
icati
ons Bi
opharmaceut
ical
5.Pol
ymers:
nameandapplicati
onofcommonlyused Pr
inci
plesi
nthe
pol
ymers;st
ruct
ureandcharact
eri
sti
csofpol
ymer
Phar
maceut
ical
Sci
ences
6.Powder ,Granules,
Capsul es,Pil
lsandFi
lms: def
ini
ti
onand th
6 EDITI
ON
character
isti
cofpowder ,gr
anules,capsul
es,pil
lsandfi
lm
agent;generalpreparati
onpr ocess,t
ounderstandthei
r
qual
ityinspecti
onmet hods.

7.Tablet
s:gener alcompositionofthetablets;
classifi
cati
on
androleoft hetabletexci
pients;
processofwetgr anulat
ion;
tabl
etquali
tyr equir
ementsanddet ermi nat
ionmet hods;
tabl
etcoatingmet hodsandmat eri
als;
f act
orsaffecti
ngthe
quali
ty;t
ounder standthedirectcompr essi
onandot her
prepar
ationmet hods.

8.LiquidPr epar
ati
ons:themeani ngofthel
iquidpreparati
on,
classi
ficati
onandappl i
cati
on;graspthemet hodstoincrease
thesolubi l
i
tyofdrug;f
ormulati
on, pr
eparat
ionandst abil
it
yof
thesuspensi onandemul si
on;preparat
ionmet hodofliqui
d
preparationandcolloi
dsoluti
on.

9.Supposi
tor
yandOi
ntment
,Gel
andAer
osol
:def
ini
ti
onand

~11~
 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

characteri
sti
csofsuppositor
yandointmentandaer osol;
defini
ti
onofgels;prescri
pti
oncomponentandpr eparati
on
technologyofsuppositor
y,oi
ntmentandaerosol;quali
ty
requir
ement sofsupposit
ory,oi
ntmentandaerosol.

10.NewTechnol ogiesinPrepar ati

ons: defi
nit
ionand
characteri
sti
csofinclusiont echniqueandsol iddisper
sion
technique;cat
egoriesofv ehiclesandt hecommon
preparati
onmet hodsofi nclusionandsol i
ddispersi
on
technique;characteri
sti
csandpr eparationmet hodsof
mi cr
oencapsulati
ont echnology .

11.Sust ainedandCont r
ol l
edr eleasePr epar ations,Tar get i
ng
drugDel iverysy st
em, andTr ansder mal Prepar at i
ons:
definit
ion,categories,andchar act eri
sticsoft ransder mal
preparationsaswel last hebasi cconcept i
on; charact eristics
ofsust ainedandcont rol
ledr el
easepr epar ationsand
targeti
ngdr ugdeliverysy stem; theoryandi nfluencef act or s
oft hetransder malabsor ptionofdr ugs, aswel lasthet heor y
SEMESTE andpr epar ati
onmet hodsofcont r
olledr eleasedr ugs;
R met hodst opr epareandst udyt ransder mal prepar ations, as
wel lasthef ormulationchar acteri
stics;manuf acturing
techniquesofsust ainedandcont roll
edr el
easepr epar ations.
5

PRACTI
CALS:
(Cr
edi
t:
1,Hour
s:51)

1.Pr
epar
ati
onofNony
lpheny
lpol
yet
hyl
enegl
ycol
etherf
il
ms
Objecti
ves:Tomastert
hebasicmethodsofwat
er-
sol
ubl
efi
l
m
pr
eparati
on;Tounderst
andthefunct
ionoff
il
ms-
for
ming
materi
alssuchaspol
yvi
nylal
cohol

2.Pr
epar
ati
onofVi
tami
nCI
nject
ion

Objecti
ves:Tomast ert
hekeypoi nt
sinVitC prepar
ationsand
rel
atedmanuf act
uringprocesses;Tobef amili
arwiththe
standardsandmet hodsofqual i
tycont
rolandunder st
and
factor
saffect
ingthequal i
tyofendproducts;tobef amili
arwi
th
theway stoenhancet hestabil
i
tyofoxi
disabledrugs;
manuf act
uri
ngprocessofst er
il
epreparat
ions

3.Pr
epar
ati
onofMi
crocapsul
e

Obj
ect
ives:Tomast
ert
hebasi
cpr
inci
pleandmet
hodsof

~12~
 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

simplecoacerv
ationandcomplexcoacer
vati
on;Tounder
stand
thefact
orsthatinfl
uencemi
crocapsul
es’f
orming.

4.Pr
epar
ati
onofaspi
ri
ntabl
ets

Objecti
ves:Tomast erthebasict
echnol
ogicalcourseoftabl
ets
thr
ought hepreparati
onofaspiri
ntabl
ets.;
Tobef amil
iarwit
h
thequali
tycontrol
oft abl
ets;Tobefamili
arwi
ththebasic
str
uctureandoperationmet hodofsi
ngle-
punch.

5.Supposi
tor
ies

6.Di
ssol
uti
onTest
s

7.Li
qui
ds

SUBJECT CONTENTOUTLI
NE TEXTBOOKSAND

LECTUREMATERI
AL

I
dentifi
catonof Medi
i cinal Agents( incl
udi ngLat inNames, Descr ipti
on,
Tradit
ional Processing,Act i
onsandI ndi cti
ons)oft hefollowingnames:
Chinese
Medicine ChineseAngel ica,Mi l
tvetchRoot ,Calamine,Saf ffl
ower,
CassiaSeed, Gol denThr ead, ChineseCaterpil
larFungus,
Credit
:2 Eucommi aBark, Thunber gFr i
ti
laryBulb,Ganor derma,
Hours:34 Ginseng,Liquor i
ceRoot ,Isat isRoot ,DwarfLil
y turfTuber,
Amer i
canGi nseng, Pl
atycodonRoot ,Fl
eeceflowerRoot ,
Rhubarb, DanshenRoot ,Bl ackTai lSnake,Ginkgobi l
oba,
Cinnamomum camphor a, Eucommi aulmoides,
Lagerstr
oemi ai ndica,Cornusof f
ici
nali
s,Eri
obot r
yajaponica

Phar
maceut
ical Thi
scourseent
ail
sstudi
esofthepharmaceuti
cal
system on
Law agl
obalscal
ewithcompari
sonstotheChinesesyst
em
Cr
edi
t:
2

Hour
s:34 1.I
ntr
oduct
ionandbr
iefr
evi
ewof
:

a.Phar
maceut
ical
Legi
slat
ions

b.Dr
ugs&Phar
maceut
ical
Indust
ry

c.Phar
maceut
ical
Educat
ion

2.Anel
abor
atest
udyoft
hef
oll
owi
ng

a.Phar
maceut
ical
Ethi
cs

b.Nar
cot
icDr
ugs&Psy
chot
ropi
cSubst
ancesAct
s.

c.Dr
ugsPr
iceCont
rol
SEMESTE d.GoodSuppl
yPr
act
ice

~13~
 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

SUBJECT CONTENTOUTLI
NE TEXTBOOKSAND

LECTUREMATERI
ALS

Li
teratur
e 1.I
ntroductiontoInf or
mationRetri
evalContent
s:Basi
c
Retri
evalof Concepts;Searcht oolsandsearchlanguage;Accesst
o
Pharmaceuti
cal Li
ter
at ure;
Infl
uenceonacademi cresearch
Sciences
2.I
ntroductiontoE- book:Over
view;E-booksyst
em and
Credit
:1.
5 websites;Mobilereading
Hour
s:34 3.
Dat
abases:
Spr
inger
Link;
Elsev
ier
;JohnWi
l
ey;
ACS;
Ovi
d

4.Pat
enti
nfor
mat
ionsear
chi
ngandusi
ng

5.
Sci
fi
nderWeb

6.
Howt
ouseSCI

7.Accessofpr
ofessi
onal
li
ter
atur
e

PRACTI
CALAI
MS:

1.Togetf
ami
l
iarwi
thSpr
inger
li
nk、El
sev
ier
、Wi
l
ey

2.Tomast
ert
hesear
chi
ngt
echni
que

2.
1br
owse

2.
2basi
csear
ch

2.
3advancedsear
ch(
alsouseconnect
orst
oper
for
m an
exper
tsear
ch)

3.Tof
indanddownl
oaddesi
reddocument
s

4.readanddigestthemat er
ial
sr el
atedt
oyourr
esear
ch
focus/i
nter
estandusethem tohelpanaly
zethet
rendand
developmentoftherel
evantfi
eld

~14~
 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

SEMESTE
R

Medici
nal Dr
ugMet
abol
i
sm: 1.
Foy
e’sPr
inci
plesof
Chemist
ry
1.
pat
hway
sofmet
abol
i
sm Medi
ci
nal
Chemi
str
y
Cr
edi
t:
3
2.Mechani
sm ofBi
otr
ansf
ormat
ion Si
xthEdi
ti
on
Hour
s:51
3.Mechani
sm ofConj
ugat
ion:
glucur
oni
caci
d,sul
fat
e, no 2.G.
ami L.Patr
ickAn
aci
d I
ntroducti
ontoMedi
cinal
4.
Cli
nical
Signi
fi
cance Chemi
str
y

Medicinal Agents( i
ncludingCl assif
icati
on,Pr i
ncipl
esof
Nomencl ature,Mechanism ofAct i
on, St
ructure,
Physiochemi calPr
operti
es,Chemi cal Pr
oper t
ies,
Struct
ure,
SynthesisI ndicati
ons,Cli
nicalAppl icati
ons;Pharmacological
Eff
ects, Structur
eAct i
vit
yRel ationship(SAR) ,
SEMESTE Pharmacoki neti
cs,Metabolism, SideEf f
ects,Common
R
Exampl es)oft hefoll
owingcl asses:

~15~
CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

1.Anti
biot
ics:
(β-Lactams,Tet
racy
cli
nes,Ami
nogl
ycosi
des,
Macrol
ides,Miscel
laneous)

2.
Antivi
ral
s:Vir
usSt r
uctur
e,Cl
assif
icat
ion,andLi
feCy cl
e;
Ant
inonretr
ovir
alAgents(Amantadi
ne,Rimantadi
ne,
Acyclov
ir,
etc)I
nter
feron;Neur
oaminidaseInhi
bit
ors;
Ant
iretr
ovir
alAgents(Zi
dovudi
ne,Abacavir
,Never
apine,et
c)

3.Sy
nthet
icAnt
imi
crobi
alAgent
s:Sul
fonami
des,
Qui
nol
ones

Ox
azol
i
dinones,
Miscel
l
aneous;

4.CancerandChemot herapy:The
Cell
Generati
onCy cl
e;Int
roducti
ontocancer
;Aimsof
tr
eatment;Cl
assif
icati
onofAnticancerDr
ugs(Al
kyl
ati
ng
Agents,
Antimetaboli
te

Anti
biot
ics,
PlantExtr
act
s,Hormones,
Others)
;Chemother
apy
DrugResist
anceandToxici
ty;I
mmunomodul ati
ngDr
ugs
(I
mmunosuppr essi
ves&Immunopotenti
ator
s)

5.Ant i
ulcerAgents:TheDigest
iveSy
stem;For
mationof
Ulcers;RationalDrugDesi
gn;H2ReceptorAnt
agonist
s;
ProtonPumpI nhi
bit
ors

6.DrugsAff
ecti
ngNervousSy
stem:
Anest
het
ics,
Sedati
ve—hypnot
ics,

Anti
psy choti
cDr ugs; Centr
al andPer i
pheralNervousSyst
em;
Characterist
icsoft heidealanesthetic;GeneralandLocal
Anesthet i
cs;physico-chemi calpropert
yofv olati
l
e
anestheticsandt heiranestheticpotency;Psychosis
di
sorder s;

7.DrugsAf fectingtheCardi
ovascul
arSy st
em:
Cardi
ov ascularDiseases,Hyper
cholester
olemi
a,
Hyperl
ipidaemi a,Bi
leacidsequest
rants,HMGCoAReduct
ase
I
nhibit
or s

8.Agent
sAf f
ect i
ngt heReni n-Angiot
ensinPathwayand
Calci
um Bl
ocker s:Hypertension;Renin-
Angiot
ensinSystem
(Ras)
;Conceptionofpr odrug;Angiotensi
n-Convert
ing
EnzymeInhi
bitors;AngiotensinIIReceptorAntagonist
s

9.OpioidAnalgesics:Pai nanditsor
igi
n;Painreli
evi
ng
agents(Nonst eroi
dal ant
i-
inf
lammatoryagents,Anesthet
ics,
CentralNervousSy stem Depressant
s);Morphineandits
modificati
ons( substi
tuentandscaff
old);Endogenic
Analgesics;Antipyr
etics;
Select
iveCOX-2Inhibit
ors;

~16~
 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

SUBJECT CONTENTOUTLI
NE TEXTBOOKSAND

LECTUREMATERI
ALS

Phar
macognos 1.
Int
roduct
ionToPharmacognosyAndPhar
macognosy Tr
easeandEv
ans
y I
denti
fi
cati
on;2.
Sour
cesofDrugs
Phar
macognosySi
xteent
Cr
edi
t:2 3.Pl
antTaxonomy(withstudi
esofthefol
lowingfamil
i
es
Edi
ti
on
Apocynacae,Sol
anaceae,
Rutacease,Umbell
ifer
ae,
Hour
s:34
Leguminosae,Rubi
aceae,
Lili
aceae,
Graminae)

4.
Cul
ti
vat
ion,
Col
l
ect
ion,
Processi
ngandst
orageofcr
udedr
ugs;

5.Acti
veconst
it
uent
sofdr
ugs:
isol
ati
on,
classi
fi
cat
ionand
proper
ti
es
SEMESTE
R 6.
Int
roduct
ionToAnal
yti
cal
Techni
ques

7.Qual
i
tyRegul
ati
onOfCr
udeDr
ugs

6 8.Anti
diabet
icDrugs(Russiant
arr
agon,ci
nnamon,Ginseng
,Fenugr
eekseed, Gy
mnemasy l
vest
re,Gar
li
c,Nopal
orpr i
ckl
y
pearcactus,
Ivygourd,Aloever
a)

9.
Tradi
ti
onal
PlantMedi
cinesAsASour
ceOfNewDr
ugs

PRACTI
CALS:
(Cr
edi
t:
0.5,
Hour
s:17)

1.Mor
phol
ogi
cal
char
act
eri
sti
csofpl
antf
ami
l
ies.

2.Micr
oscopicmeasurement
sofcel
l
sandcel
lcont
ent
se.
g.
cal
ci
um oxalatecr
yst
als

3.St
andar
dizat
ionofsomet
radi
ti
onal
drugf
ormul
ati
ons.

4.
Draf
tqual
i
tyst
andar
dsofdr
ugsment
ionedi
ntheor
y

SUBJECT CONTENTOUTLI
NE TEXTBOOKSAND

LECTUREMATERI
ALS

Phar
macol
ogy 1.GeneralPri
ncipl
esOfPharmacology :Routesof Li
ppi
ncot
tIl
l
ust
rat
ed
administ
rati
on;Drugabsor
ptionanddi st
ri
but i
on;
Cr
edi
t:3 Rev
iews:
Phar
macol
ogy
Biot
ransfor
mat i
on(Metabol
ism ofdrugs);Excret
ionofdr
ugs;
Hour
s:51 Pharmacokineti
cs;Drugdel
iverysystems; Pri
ncipl
esofdrug Si
xthEdi
ti
on
acti
on;Pharmacogenomics&Dev el
opmentofdr ug

2.SignallingMechani sm: Mai npri

ncipleofcellsignalli
ng;
Dif
ferentway sofsi gnalli
ng; Ext
racell
ularsignal
s: Hor mones,
Cytokines, andgr owthf actors;Detecti
onofExt racellular
si
gnals: ther oleofrecept ors;Prot
einphosphor ylati
on, ki
nases,
andphosphat ases;
Cy cli
cnucl eoti
des, cy
clases,andGpr oteins;
Reactiveoxy genspeci es,reacti
venitrogenspecies, andr edox
si
gnalling; Li
fe,death, andapopt osis

~17~
 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

3.TheAutonomi cNervousSy stem:Synthesisandmet abol

ism
ofautonomicneurotr
ansmi tters;Cholinergicdrugs;Muscar i
nic
bl
ockingdrugs;Cholinesterasesandant i
-chol
inesterases;
Gangli
onicblocki
ngandNeur omuscul arblockingdr ugs;
Adrenergi
cagonists,
Adr energicantagonists

4.CardiovascularSyst
em: Di
gital
isandcardi
acglycosi
des;
Antihy
per t
ensivedrugs;Anti
anginalandVasodi
l
atordrugs,
i
ncludingcalcium channelbl
ockersandbetaadrenergi
c
antagonists;

Anti
arr
hythmi
cdrugs;Ant
ihy
per
li
pedemi
cdr
ugs;
Drugsusedi
n
thet
herapyofshock.

5.Cent r
al NervousSy stem: Neur ohumor al tr
ansmi ssioni nthe
C.N.S.;General Anesthetics;Alcoholsanddi sul
fi
ram; Sedatives,
hypnot i
cs,Anti-anxi
etyagent sandCent rallyacti
ngmuscl e
rel
axant s;Psychophar macol ogicalagents( anti
-psy chotics)
antidepressantsant i
-mani acsandhal lucinogens; Ant i
-epil
eptics
drugs;Ant i
-ParkinsonianDr ugs;Analgesics, Anti
py reti
cs, Anti
-
SEMESTE i
nflammat oryandAnt i-goutdrugs; Narcoticanalgesi csand
R antagoni st
s;C.N. S.stimulants;DrugAddi cti
onandDr ugAbuse.

6.Hemopoi
eticSy st
em:Anti
coagul
ant
s,Vit
aminKand
hemost
ati
cagent s;Fi
bri
nol
yti
candanti
-pl
atel
etdr
ugs;
Blood
6
andpl
asmav olumeexpanders.

7.Ur
inar
ysy
stem:
Flui
dandel
ect
rol
ytebal
ance;
Diur
ect
ics

8.Autocoids:Hi
stamine,
5-HTandtheirantagoni
sts;
Prost
aglandins,
thromboxanesandleukotr
ienes;Angiot
ensi
n,
Brady
kininandSubstanceP.

9.Chemot herapy:Pri
ncipl
es;Sulfonami desandcot rimoxazol
e;
Anti
biot
ics-Penici
l
lins,Cephalosporins,Chlor
ampheni col
Ery
thromy cin,Qui
nolonesandMi scellaneousAnt i
biot
ics;
Chemother apyoftuberculosi
s,leprosy ,f
ungaldiseases,vi
ral
di
seases,ur i
narytr
actinfecti
onsandsexual l
ytransmi tt
ed
di
seases;Immunosuppr essiv
eAgent s.

PRACTI
CALS:
(Cr
edi
t:
1.5,Hour
s:51)

1.I
ntr
oduct
iont
oExper
iment
alPhar
macol
ogy:

Prepar at
ionofdiff
erentsol ut
ionsforexperi
ment s.;
Dr ug
dil
utions,useofmol arandw/ vsolut
ions;Commonl aborat
ory
animal sandanestheticsusedi nanimal st
udies.Commonl y
usedi nstrument
sandst andardtechniques;Bleedi
ngand
i
ntrav enousinj
ecti
on,intragastri
cadmi ni
str
ation.Procedures
forrender i
nganimalsunconsci ous.

~18~
 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

2.Studyofdi
ff
erentr
out
esofadmi
nist
rat
ionofdr
ugsi
n
mice/rat
s.

3.Experi
mentsonCentralNerv
oussy st
em: Recor
dingof
spontaneousmotoract
ivi
ty,
analgesi
a,ant
iconvul
santact
ivi
ty,
anti
-inf
lammator
yactiv
ity
,andmuscl erel
axantact
ivi
tyof
drugs.

4.Ef
fectsofvar
iousagoni
stsandantagoni
stsandt
hei
r
char
acteri
zat
ionusi
ngisol
atedprepar
ati
ons.

5.Pharmacol
ogyofCardi
ovascularSyst
em: Tostudythe
i
onotropi
candchronot
ropi
ceffectsofdrugsonisolat
edfrog
hear
t;theeff
ect
sofdrugsonnor malandhy podynamicfr
og
hear
t.

6.BloodPressureofanaest
heti
zedDog/
Cat/
Rat:To
demonst r
atetheeff
ectsofvar
iousdr
ugsontheB.
P.and
respi
rat
ion.

7.
Diur
eti
cEf
fect
sofdr
ugs

8.Pharmacol
ogyoftheGastroint
est
inal
Tr act
:Tost
udyt
heAnt
i
-secr
etar
yandanti
-ulceract
ivi
tyusi
ngpylorus

SUBJECT CONTENTOUTLI
NE TEXTBOOKSAND

LECTUREMATERI
ALS

Pharmaceut
ical 1.Moder nPharmaceuti
calAnaly
sis:AnOv erv
iew: Medical 1.
Hansen,
S.,
etal
.,
Analysi
s Product s,Act
ivePharmaceuti
calIngr
edient
s,Researchand
I
ntr
oduct
iont
o
Dev el
opment
Credi
t:2
Phar
maceut
ical
Anal
ysi
s
2.Internati
onalPharmacopoei
as,Regulati
onsandGui del
ines:
Hours:34
Qual i
ty 2.Er
mer
,J.
,etal
.,
St
andar
d,Gener
alQual
i
tySy
stem Document
s,Rel
atedLi
ter
atur
e Met
hodVal
i
dat
ioni
n
3.Vali
dati
onofPharmaceut
ical
TestMet
hods:
Fact
ors Phar
maceut
ical
Anal
ysi
s
I
nfluenci
nganaly
sis;Val
i
dati
onProt
ocol
s
3.
Ahuj
i
a,S.
,etal
.,
4.Sampl
ePr
epar
ati
on:
Liqui
d-l
i
qui
dext
ract
ion,
super
cri
ti
cal
HandbookofModer
n
Fl
uidsext
ract
ion,
sol
i
d-phaseext
ract
ion,
sol
i
d-phase
Phar
maceut
ical
Anal
ysi
s
mi
croext
ract
ion
(
1stEd.
)
5.Degradati
onandI mpurit
yAnalysi
sforPhar
maceuti
calDrug
Candidates:Classi
fi
cat
ionandsourcesofimpuri
ti
es; 4.
Ahuj
i
a,S.
,etal
.,

SEMESTE Deter
mi nati
onofimpuri
ties;Li
mitTest
s;Resi
dualSol
vent
s; HandbookofModer
n
R Rel
atedSubst ances
Phar
maceut
ical
Anal
ysi
s
6.Anal
ysi
sofSel
ect
edDr
ugSubst
ances
(
2ndEd.
)5.Hang,
T.,
6 7.Anal
ysi
sofFi
nal
Phar
maceut
ical
Product
s
Phar
maceut
ical
Anal
ysi
s

~19~
 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

8.Anal
ysi
sofDr
ugsi
nBi
ologi
cal
Mat
ri
x (
7thEd.
)

9.St
abi
l
ityTest
ingofDr
ugSubst
ancesandPr
oduct
s

10.Liqui
dChromat
ogr
aphy
–MassSpect
romet
ry:
An
I
ntroduct
ion

SUBJECT CONTENTOUTLI
NE TEXTBOOKSAND

LECTUREMATERI
ALS

I
ntrr
oducti
ont
o 1.IntroductiontoCl i
nical Pharmacy . 1.Appl
i
edTher
apeut
ics:
Cl
ini
cal
2.BasicConcept sofPhar macother apy:Cl
inical TheCl
i
nical
UseofDr
ugs
Medici
ne
Phar macoki neti
csandi ndivi
duali
zat i
onofDr ugTher apy; Dr
ug
Appl
i
edTher
apeut
ics,
Inc
Cr
edit:
3 Del i
verySyst emsandt heirBiopharmaceut i
cal &Ther apeuti
c
Consi derati
ons;Paedi at ri
cs&Ger iatri
csDrugUse; Druguse 2.Her
fi
ndal
ETand
Hours:54
dur i
ngPr egnancy ;Dr
ugi nducedDi seases;DrugI nter
actions;
Gener alPrincipl
esofCl i
nicalToxicology;I
nterpretati
onof Hi
rschmanJL.
,Cl
i
nical
Clini
cal Labor at
oryTest s. Phar
macyand
3.Ther
apeut
icDr
ugMoni
tor
ing Ther
apeut
ics.
4.ConceptofEssent
ial
DrugsandRat
ional
Druguse

Mi
crobi
ology 1.
Int
roducti
ontothescopeofmi
crobi
ologyand Pr
escot
tetal
.:
micr
oorganisms
Cr
edi
t:2 Mi
crobi
ologyFi
ft
hEdi
ti
on
2.Mi
crobi
alMor
phol
ogyandI
dent
if
icat
ion.
Hour
s:34
3.Cl
assi
fi
cati
onofmicrobesandtheirt
axonomy.
Acti
nomycet
es,bact
eri
a,ri
cket
tsi
ae,spi
rochet
esandv
iruses.

4.Identi
ficat
ionofMicr
obes: St
ainsandt
ypesofst
aini
ng
techniques,elect
ronmi
croscopy.

5.Nutr
it
ion,cul
ti
vat
ion,i
sol
ati
on,i
nocul
ati
onofbact
eri
a,
act
inomy cet
es,f
ungi,
vir
uses,
etc.

6.Mi
crobi
algenet
icsandv
ari
ati
on.

7.Cont
rol
ofmi
crobesbyphy
sical
andchemi
cal
met
hods.
SEMESTE
R a.Di
si
nfect
ion,
fact
orsi
nfl
uenci
ngdi
sinf
ect
ant
s,dy
nami
csof

~20~
 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

di
si
nfect
ion,
disi
nfect
ant
sandant
isept
icsandt
hei
rev
aluat
ion.
6 b.St
eri
li
zat
ion,
dif
fer
entmet
hods,
val
i
dat
ionofst
eri
l
izat
ion
methods&equipments.

8.St
eri
l
ityt
est
ingofal
lphar
maceut
ical
product
s.

9.Immuni t
y,pri
mar yandsecondar
y,def
ensivemechanismsof
body,hypersensi
ti
vity
,thecomplementsyst
em micr
obial
resi
stance,i
nterf
eron.

10.Mi
crobi
alassay
sofant
ibi
oti
cs,
vit
ami
ns&ami
noaci
ds.

11.Appl
i
cat
ionofi
mmunol
ogy

PRACTI
CALS:
(Cr
edi
ts:
1,Hour
s:34)

1.Howt
ouseBr
ight
-Fi
eldMi
croscope

2.Micr
obi
alMor
phol
ogy
:Si
mpl
eSt
ain,
Gram’
sSt
ain,
Spor
e
Stai
n

3.Pr
epar
ati
onofcul
tur
emedi
aandSt
eri
l
izat
ion

4.I
nocul
ati
onAndCul
tur
alChar
act
eri
sti
csOfBact
eri
a

5.I
sol
ati
onofAnt
ibi
oti
c-Pr
oduci
ngAct
inomy
cet
esf
rom Soi
l

6.Bi
ochemical
TestsofBacteri
a:Hydrol
ysi
sofSt
archand
Prot
ein,
Uti
l
izat
ionofCarbohydrat
es,
IMViCSer
ies

7.
Steri
l
izati
onandPreser
vati
onofCult
ures:Di
sinf
ect
ion,
Ul
trav
ioletLi
ghtandDryHeatSt
eri
l
izat
ionandPreser
vati
on

SUBJECT CONTENTOUTLI
NE TEXTBOOKSAND

LECTUREMATERI
ALS

Phar
macoki
net
i 1.Concept
sOfPhar
macoki
net
ics:
DrugTr
anspor
t;Si
gni
fi
cance Shar
gel
etal
.;
Appl
i
ed

~21~
 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

cs ofplasmadr ugconcentrat
ionmeasur ement
;Compar t
ment Bi
ophar
maceuti
cs&
model -
Defi
niti
onandScope; Pharmacokinet
icsofdrug
Cr
edi
t:2 Phar
macoki
net
ics
absorpti
on-Zer oorderandfi
rstorderabsor
ptionrateconst
ant
Hour
s:34 usi
ngWagner-Nel sonandLoo-Rei gelmanmet hod; Sevent
hEdi
ti
on
2.Non-
Compar t
mentalAnal
ysi
s:KeyParameter
sOfNon-
CompartmentModel
; Vol
umeofdistr
ibut
ionanddist
ri
buti
on
coef
fi
cient
;Compart
mentkineti
cs-Onecompar tmentandtwo
compartmentmodel
s;

3.Det erminat
ionofphar
macokinet
icparametersfrom plasma
andur inedataaft
erdrugadmini
str
ati
onbyintravascularand
oralroute;Curvef
it
ti
ng(methodofResidual
s),regressi
on
procedur es;

4.Clearanceconcept:Mechanism ofrenalcl
earance,cl
ear
ance
rati
o,determinati
onofrenalcl
earance;Ext
racti
onr at
io,
hepat
ic
clear
ance, bi
l
iaryexcr
eti
on,Extrahepat
icci
rcul
ation;

5.Nonl
i
nearPharmacoki
neti
cs(specialr
eferencetoone
compartmentmodelaft
erIVdr
ugadmi nistr
ation,
Michael
es
MentenEquati
on,det
ecti
onofnon-l
ineari
ty)
;

6.RolesOfPhar
macoki
net
icsI
nDr
ugDev
elopmentAnd
Biol
ogical
Sci
ence

PRACTI
CALS:(
Credi
t:
0.5,
Hour
s:17)

1.Exper
imentsdesi
gnedf
ortheest
imati
onofvar
ious
pharmacoki
neti
cparamet
erswit
hgivendat
a.

2.Anal
ysi
sofbiol
ogi
calspeci
fi
cat
ionsf
ordr
ugcont
entand
est
imati
onofparamet
ers.

3.I
nvi
tr
oev
aluat
ionofdi
ff
erentdosagef
ormsf
ordr
ugr
elease.

4.Absor
pti
onst
udi
es
SEMESTE
5.St
ati
sti
cal
treat
mentofphar
maceut
ical
dat
a
R
Drug 1.I
ntr
oducti
onToToxicology
;Essenti
alConceptsOf
Toxi
col
ogy Toxi
cology
;Fact
orsI
nfluenci
ngToxicEff
ects;Gener
alToxi
cit
y;
7
Cr
edi
t:2 2.Defi
nit
ionofpoison,gener
alprinci
plesoftr
eat
mentof
poisoni
ngwi t
hpar t
icul
arref
erencetobarbit
urat
es,opi
oids,
Hour
s:34
organophosphorousandat r
opinepoisoni
ng;Heavymetalsand
heavymet al
antagonists;

3.Mut
agenesi
s

4.I
ndepthstudyofthefoll
owingtypesoftoxicol
ogy:
Devel
opmentalAndTerat
ogenesis;Regulat
ory;
I
mmunot oxi
cology
;Li
ver;Bl
ood;Kidney;NervousSyst
em;

~22~
 CHI
NAPHARMACEUTI
ALUNI
VERSI
TYCI
RRI
CULUM FORBSc.PHARMACY

Car
diov
ascul
ar;

GMPWor kshop Studentstov i

sitschool
’
smanuf act
uringcent
erforgr
eat
er
understandingofthefol
lowingconcepts:
Cr
edi
t:1
1.
Qual i
tymanagementi ntheDrugIndustry
Hour
s:17
2.
GoodPr acti
ceinproducti
onandQual i
tyContr
ol

3.Good Manufactur
ing Practi
ces:f oractive pharmaceuti
cal
i
ngr edi
ent
s( bul
k dr ug substances).
Generalconsi der
ati
ons,
personnel
,premises,equipment ,sanitat
ion,document ati
on,
retenti
onofr
ecordsandreferencesamples,producti
ons.

4.
Mi crobi
ologi
calaspects ofGood Manuf act
uri
ng Practi
ce:
Steri
lepharmaceuti
calpr
oducts.Gener
almanufact
ureofsteri
le
preparati
ons,personnel
,pr emises,equi
pment,steri
l
izati
on,
fi
l
trati
on,Quali
tyContr
ol

Pharmacother
a ImportantDisor
dersofOrganSy st
emsandt heirManagement: Di
Pir
o’sPhar
macot
her
ap
py
1.Cardiovascul
arDisor
ders:Hypertensi
on,Congest i
veHear
t APat
hophy
siol
ogi
c
Credi
t:3 Fai
lure,Angina,
AcuteMy ocardi
alInfar
cti
on,Car di
ac
Appr
oach
arr
hythmi as.
Hours:51
2.CNSDi sorders:
Epil
epsy,Parki
nsonism,Schizophreni
a,
Depression.

3.
Respi
rat
oryDi
sease:
Ast
hma;Chr
oni
cObst
ruct
ivePul
monar
y
Di
sease

4.Gast
roint
esti
nalDi
sor
der
s:Pept
icul
cer
,Ul
cer
ati
vecol
i
tis,
Hepati
ti
s,Cir
rhosi
s.

5.Endocri
neDi
sor
der
s:Di
abet
esmel
l
itusandThy
roi
d
Disor
ders.

6.I
nfect
iousDiseases-
Tuber
cul
osi
s,Ur
inaryTractInfect
ion,
Ent
ericInfect
ions,
Upperg)Hemat
opoiet
icDisorders-Anemias.

7.Joi
ntandConnect
iveTi
ssueDi
sor
der
s-Rheumat
icDi
seases,
GoutandHyper
uri
cemia.

8.Neopl
ast
icDi
seases-Acut
eLeukaemi
as,
Hodgki
n'
sdi
sease

9.Gui
del
i
nesForDr
ugTher
apyI
nShock

~23~